THEORETICAL MEDICINE
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Shuprovych A.A., Zinych O.V., Kushnareva N.M., Komisarenko K.P. Study of the relationships of polymorphisms of the folate cycle genes with the levels of homocysteine and folic acid as risk factors of cardiovascular disorders in the post-covid period
https://doi.org/10.26641/2307-0404.2024.3.313071
Abstract
Enzymes of the folate cycle participate in the process of remethylation of homocysteine (HC) to methionine, where folates are coenzymes for methyl transfer. The aim of the work was to identify the interrelationships of gene polymorphisms of associations between folate cycle enzyme gene polymorphisms and cardiometabolic risk factors such as increased serum homocysteine levels and folic acid deficiency in patients in the post-covid period. In 51 patients who suffered from COVID-19, a general clinical and laboratory examination, and assessment of serum homocysteine and folic acid concentrations by immunoenzymatic method was carried out. Polymorphisms of the genes: methylenetetrahydrofolate reductase (677C>T and 1298A>C), methionine synthase-reductase (66A>G) and methionine synthase (2756A>G) were determined by real time polymerase chain reaction. For each of the named polymorphisms, the examined patients were divided into 3 groups according to the nucleotide alleles in the corresponding position: 1) homozygous dominant, 2) heterozygous and 3) homozygous recessive. For the methylenetetrahydrofolatereductase gene at position 677, serum levels of homocysteine and folate did not differ between the groups 1 and 2 with genotypes 677 C/C (n=26) and 677C/T (n=21), (p>0.05); in group 3, the recessive genotype 677 T/T was found in only 4 people (8%), that did not allow comparison of indices. The distribution of patients into 3 groups according to the genotype of the same gene at position 1298 revealed that the recessive 1298 C/C mutation in group 3 (n=9) associated with an increased homocysteine level (19.56±1.89 μmol/l), versus 10.68±0.76 (p=0.012) and 11.63±1.25 μmol/l (p=0.013) in groups 1 and 2, with no difference in folate levels between groups. Group 3 differed by a higher degree of obesity, a higher frequency of hypertension disease and chronic heart failure (in 85% of patients in group 3, against 41 and 50% in groups 1 and 2), a higher number of platelets, a longer duration of hospitalization due to COVID-19, a higher level of D-dimer. The study of groups of patients, divided depending on the genotype of methioninesynthase reductase at position 66, showed that carriers of the recessive homozygous 66 G/G mutation (group 3, n=15) had increased serum homocysteine level (16.56±1.64 μmol/l) in comparison with individuals of group 1 (n=17) 66 A/A (10.28±1.17 μmol/l; p=0.004) and group 2 (n=19) 66 A/G (11.32±1.17 μmol/l, p=0.013). In group 3, a longer duration of hospitalization due to COVID-19 was noted (17.15±1.65 vs. 11.88±0.97 days, p=0.008), higher frequency of hypertension (67% vs. 35%) and heart failure (67% against 29%) compared to group 1. The use of a molecular genetic approach made it possible to establish that the presence of recessive mutations of the folate cycle genes is associated with a potential predisposition to hyperhomocysteinemia, thrombophilia, severe forms of cardiometabolic complications and coronavirus disease.
Key words: enzymes of the folate cycle, polymorphisms, recessive homozygous mutations, homocysteine, folic acid, cardiometabolic risk, coronavirus disease
References
- Perła-Kaján J, Jakubowski H. COVID-19 and One-Carbon Metabolism. Int J MolSci. 2022 Apr;23(8):4181. doi: https://doi.org/10.3390/ijms23084181
- Liu F, Chen J, Li Z, Meng X. Recent advances in epigenetics of age-related kidney diseases. Genes. 2022;13(5):796. doi: https://doi.org/10.3390/genes13050796
- Kern B, Podkrajšek K, Kovač J, Šket R, Bizjan B, Tesovnik T, et al. The Role of epigenetic modifications in late complications in type 1 diabetes. Genes (Basel). 2022 Apr;13(4):705. doi: https://doi.org/10.3390/genes13040705
- Andreichyn M, Nychyk N, Zavidniuk N, Yosyk Ya, Ishchuk I, Ivakhiv O. [COVID-19: epidemiology, clinic, diagnosis, treatment and prevention]. Infektsiini khvoroby. 2020;2(100):41-55. doi: https://doi.org/10.11603/1681-2727.2020.2.11285
- Sun J, Jiang X, Zhao M, Ma L, Pei H, Liu N, et al. Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis. Behav 2021;2021:2962792. doi: https://doi.org/10.1155/2021/2962792
- Raina JK, Panjaliya RK, Dogra V, Sharma S, Anupriya KP. Association of МТГФР and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case-control study encompassing meta-analysis and trial sequential analysis. BMC 2022 Apr 25;22(1):223. doi: https://doi.org/10.1186/s12887-022-03227-z
- Ren ZJ, Zhang YP, Ren PW, Yang B, Deng S, Peng ZF, et al. Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility. Medicine (Baltimore). 2019 Dec;98(51):e18273. doi: https://doi.org/10.1097/MD.0000000000018273
- Santilli F, Davì G, Patrono C. Homocysteine, methylenetetrahydrofolatereductase, folate status and atherothrombosis: A mechanistic and clinical perspective. Vascul Pharmacol.2016 Mar;78:1-9. doi: https://doi.org/10.1016/j.vph.2015.06.009
- Ponti G, Pastorino L, Manfredini M, Ozben T, Oliva G, Kaleci S, et al. COVID‐19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase gene prevalence. J Clin Lab Anal. 2021;35(7):e23798. doi: https://doi.org/10.1002/jcla.23798
- Gogu AE, Jianu DC, Dumitrascu V, Ples H, Stroe AZ, et al. MTHFR Gene Polymorphisms and Cardiovascular Risk Factors, Clinical-Imagistic Features and Outcome in Cerebral Venous Sinus Thrombosis. Brain Sci. 2020;11(1):23. doi: https://doi.org/10.3390/brainsci11010023
- Kovács E, Bereczky Z, Kerényi A, Laczik R, Nagy V, Kovács DÁ, et al. Clinical /Investigation of Hereditary and Acquired Thrombophilic Factors in Patients with Venous and Arterial Thromboembolism. Int J Gen Med. 2023 Nov 22;16:5425-37. doi: https://doi.org/10.2147/IJGM.S412551
- Ponti G, Ruini C, Tomasi A. Homocysteine as a potential predictor of cardiovascular risk in patients with COVID‐19. Med 2020;143:109859. doi: https://doi.org/10.1016/j.mehy.2020.109859
- Si T, Zhang W, Fu X, Wang Y, Liu D, Wu Q. Reference intervals of homocysteine in apparently healthy Chinese Han ethnic adults. J Lab Med 2022;46(2):125-32. doi: https://doi.org/10.1515/labmed-2021-0135
- Keskin O, Seremet Keskin A, Nilgün Seremet. Association between low serum folic acid and vitamin B12 levels with COVID-19 prognosis. Progr Nutr [Internet]. 2022 Sep. 27 [cited 2024 Mar 4];24(3):e2022104.
- Abildgaard A, et al. Reference intervals for plasma vitamin B12 and plasma/serum methylmalonic acid in Danish children, adults and elderly. Clinica chimica acta; international journal of clinical chemistry. 2022;525:62-8. doi: https://doi.org/10.1016/j.cca.2021.12.015
- Galukande M, Jombwe J, Fualal J, Baingana R, Gakwaya A. Reference values for serum levels of folic acid and vitamin B12 in a young adult Ugandan population. Afr Health Sci. 2011 Jun;11(2):240-3. PMID: 21857855; PMCID: PMC3158514.
- Golovanova IA, Belikova IV, Lyakhova NO. [Fundamentals of medical statistics. Study guide for graduate students and clinical residents]. Poltava; 2017. 113 p. Ukrainian.
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Shuprovych A.A. SI “V.P. Komissarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Science”, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org /0000-0002-7437-0309
Zinych O.V. SI “V.P. Komissarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Science”, Kyiv, Ukraine https://orcid.org/0000-0002-0516-0148
Kushnareva N.M. SI “V.P. Komissarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Science”, Kyiv, Ukraine https://orcid.org/0000-0002-5390-6784
Komisarenko K.P. "Adonis-Lab" medical center, "Top Clinic Denys" medical center, Kyiv, Ukraine https://orcid.org/0000-0002-6318-755X
Cite
Shuprovych A.A., Zinych O.V., Kushnareva N.M., Komisarenko K.P. Study of the relationships of polymorphisms of the folate cycle genes with the levels of homocysteine and folic acid as risk factors of cardiovascular disorders in the post-covid period. Medicni perspektivi. 2024;29(3):4-11. DOI: https://doi.org/10.26641/2307-0404.2024.3.313071
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Chuikova P.O., Shtrygol’ S.Yu. Effect of celecoxib and paracetamol on the functional state of the central nervous system, pain sensitivity, and physical endurance of rats with acute heat injury
https://doi.org/10.26641/2307-0404.2024.3.313072
Abstract
Acute heat injury (AHI) is a serious condition caused by an excessive increase in body temperature, usually due to prolonged exposure to high environmental temperatures or intense physical activity in the heat. Without timely treatment, heat stroke can lead to severe damage to the central nervous system with cerebral edema, profound disturbances in the water-salt balance and internal organs, coma and death. Since the effectiveness of drugs for the treatment of thermal injuries has not been proven, the search for new thermoprotective agents with different mechanisms of action, in particular inhibitors of the arachidonic acid cascade, is urgent. In a preliminary screening study on the AHI model in rats, it was found that among cyclooxygenase (COX) inhibitors, the highly selective COX-2 inhibitor celecoxib and the analgesic-antipyretic paracetamol are the most effective in preventing hyperthermia and improving the course of the recovery period. The purpose of this study was to determine the impact of the specified screening leaders on the functional state of the central nervous system, pain sensitivity and physical endurance in the recovery period of heat injury. The AHI model was reproduced on adult white male rats according to the previously proposed and validated method by means of a 30-minute exposure at +55°C. Animals were divided into 4 groups with 8 rats in each group: intact control, control pathology, paracetamol group and celecoxib group. Based on the results of the study, it was established that celecoxib exhibits a pronounced thermoprotective effect, probably improves the state of the central nervous system in terms of behavioral reactions and physical endurance of animals in the recovery period after acute heat injury. At the same time, paracetamol after acute heat injury does not have a distinct positive effect on the functional state of the central nervous system, moderately improves the physical endurance of rats and is inferior to celecoxib in all the studied parameters. These results open new opportunities for the development of approaches to the treatment of AHI and confirm the different effectiveness of the use of celecoxib and paracetamol in thermal injuries.
Key words: acute heat injury, cyclooxygenase inhibitors, celecoxib, paracetamol, central nervous system, pain sensitivity, physical endurance
References
- Garcia CK, Renteria LI, Leite-Santos G, Leon LR, Laitano O. Exertional heat stroke: pathophysiology and risk factors. BMJ 2022 Oct 11;1(1):e000239. doi: https://doi.org/10.1136/bmjmed-2022-000239
- Stillman JH. Heat Waves, the New Normal: Summertime Temperature Extremes Will Impact Animals, Ecosystems, and Human Communities. Physiology (Bethesda).2019 Mar 1;34(2):86-100. doi: https://doi.org/10.1152/physiol.00040.2018
- Périard JD, DeGroot D, Jay O. Exertional heat stroke in sport and the military: epidemiology and mitigation. Exp Physiol. 2022 Oct;107(10):1111-21. doi: https://doi.org/10.1113/EP090686
- Kiatkitroj K, Arphorn S, Tangtong C, Maruo SJ, Ishimaru T. Risk factors associated with heat-related illness among sugarcane farmers in Thailand. Ind Health. 2022 Oct 1;60(5):447-58. doi: https://doi.org/10.2486/indhealth.2021-0161
- How V, Singh S, Dang T, Fang Lee L, Guo HR. The effects of heat exposure on tropical farm workers in Malaysia: six-month physiological health monitoring. Int J Environ Health Res. 2023 Apr;33(4):413-29. doi: https://doi.org/10.1080/09603123.2022.2033706
- Alari A, Letellier N, Benmarhnia T. Effect of different heat wave timing on cardiovascular and respiratory mortality in France. Sci Total Environ. 2023 Sep 20;892:164543. doi: https://doi.org/10.1016/j.scitotenv.2023.164543
- Bauman J, Spano S, Storkan M. Heat-Related Illnesses. Emerg Med Clin North Am. 2024 Aug;42(3):485-92. doi: https://doi.org/10.1016/j.emc.2024.02.010
- Knapik JJ, Epstein Y. Exertional Heat Stroke: Pathophysiology, Epidemiology, Diagnosis, Treatment, and Prevention. J Spec Oper Med. 2019 Summer;19(2):108-16. doi: https://doi.org/10.55460/5P2Q-1MBQ
- Sorensen C, Hess J. Treatment and Prevention of Heat-Related Illness. N Engl J Med. 2022;387(15):1404-13. doi: https://doi.org/10.1056/NEJMcp2210623
- Chuykova P, Shtrygol’ S, Taran A, Yudkevych T, Lebedinets I, Oklei D. Acute heat trauma model in rats, gender-dependent thermoresistance, and screening of potential thermoprotectors. ScienceRise: Pharmaceutical Science. 2024 Apr;2(48):4-11. doi: https://doi.org/10.15587/2519-4852.2024.301620
- Hock FJ, editor. Drug Discovery and Evaluation: Pharmacological Assays. B.: Springer Berlin Heidelberg; 2014. 2071 р.
- Koval A, Shtrygol' S. 1-(5-Aetyl-3-methyl-6-phenyl-5h-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazin-7-yl)-ethanone: dose-dependence of analgesic effect, lack of opioidergic mechanism of action, effect on behavioral reactionsand acute toxicity. Acta Medica Leopoliensia. 2023;29(3-4):192-203. doi: https://doi.org/10.25040/aml2023.3-4.192
- Bonm AV, Elezgarai I, Gremel CM, Viray K, Bamford NS, Palmiter RD, et al. Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons. Eur J Neurosci. 2021 Aug;54(3):4934-52. doi: https://doi.org/10.1111/ejn.15381
- Karna SR, Kongara K, Singh PM, Chambers P, Lopez-Villalobos N. Evaluation of analgesic interaction between morphine, dexmedetomidine and maropitant using hot-plate and tail-flick tests in rats. Vet Anaesth Analg. 2019 Jul;46(4):476-82. doi: https://doi.org/10.1016/j.vaa.2018.12.009
- Armario A. The forced swim test: Historical, conceptual and methodological considerations and its relationship with individual behavioral traits. Neurosci Biobehav Rev. 2021 Sep;128:74-86. doi: https://doi.org/10.1016/j.neubiorev.2021.06.014
- Habibzadeh F. Data Distribution: Normal or Abnormal? Journal of Korean medical science. 2024 Jan 22;39(3):e35. doi: https://doi.org/10.3346/jkms.2024.39.e35
- Zhang Z, Wu X, Zou Z, Shen M, Liu Q, Zhangsun Z, et al. Heat stroke: Pathogenesis, diagnosis, and current treatment. Ageing Res Rev. 2024 Jul 8;100:102409. doi: https://doi.org/10.1016/j.arr.2024.102409
- Phillis JW, Horrocks LA, Farooqui AA. Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. Brain Res Rev. 2006 Sep;52(2):201-43. doi: https://doi.org/10.1016/j.brainresrev.2006.02.002
- Calderwood SK, Bornstein B, Farnum EK, Stevenson MA. Heat shock stimulates the release of arachidonic acid and the synthesis of prostaglandins and leukotriene B4 in mammalian cells. J Cell Physiol. 1989 Nov;141(2):325-33. doi: https://doi.org/10.1002/jcp.1041410214
- Rossi A, Coccia M, Trotta E, Angelini M, Santoro MG. Regulation of cyclooxygenase-2 expression by heat: a novel aspect of heat shock factor 1 function in human cells. PloS One. 2012;7(2):e31304. doi: https://doi.org/10.1371/journal.pone.0031304
- Cruz JV, Rosa JMC, Kimani NM, Giuliatti S, Dos Santos CBR. The Role of Celecoxib as a Potential Inhibitor in the Treatment of Inflammatory Diseases – A Review. Curr Med Chem. 2022;29(17):3028-49. doi: https://doi.org/10.2174/0929867328666210910125229
- Przybyła GW, Szychowski KA, Gmiński J. Paracetamol – An old drug with new mechanisms of action. Clin Exp Pharmacol Physiol. 2021 Jan;48(1):3-19. doi: https://doi.org/10.1111/1440-1681.13392
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Chuikova P.O., Shtrygol’ S.Yu. Effect of celecoxib and paracetamol on the functional state of the central nervous system, pain sensitivity, and physical endurance of rats with acute heat injury. Medicni perspektivi. 2024;29(3):11-19. DOI: https://doi.org/10.26641/2307-0404.2024.3.313072
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Ovchynnikov O.M., Bludova M.O., Merkulova T.V. Effectiveness of extracorporeal shock wave therapy in comparison with other methods of treatment of patients with plantar fasciitis: literature review
https://doi.org/10.26641/2307-0404.2024.3.313479
Abstract
Plantar fasciitis (PF) is one of the most common causes of pain in the heel area, which is associated with the presence of inflammation in the plantar fascia and is most often localized in the medial part of the heel area. Extracorporeal shock wave therapy (ESWT) is a method of hardware treatment that has been used in orthopedics and traumatology for the past decades. One of the main diseases successfully treated with this method is plantar fasciitis. The aim of the work was to determine the effectiveness of extracorporeal shock wave therapy in the treatment of plantar fasciitis compared to other methods of conservative treatment based on the literature review. Research literary sources from scientific electronic databases PubMed, Medline and other sources of scientific and medical information were analyzed. A literature search was performed using search queries specifying the method under study and plantar fasciitis, namely: «Extracorporeal Shockwave Therapy», «Plantar Fasciitis», «Conservative Treatment», «Physiotherapy». During the search, 473 scientific articles devoted to the treatment of plantar fasciitis were selected. Given the large number of articles and the desire to present up-to-date data, the query was limited to the last 9 years (from 2015 to 2023) and 417 articles were selected. Articles devoted to other methods of treatment of PF (conservative and surgical) and articles devoted to the use of ESWT in orthopedic and traumatological diseases of other localizations were excluded from the search results. At the second stage of the search, articles devoted exclusively to the treatment of PF by the ESWT method were excluded, and sources comparing the effectiveness of ESWT treatment with other methods of conservative treatment were selected (31 articles). The main results – it was determined that extracorporeal shock wave therapy continues to remain one of the main methods of conservative treatment of PF, which has been used for the last decades. It has proven its high efficiency and safety in the treatment of PF. Compared with other methods of conservative treatment of PF, extracorporeal shock wave therapy remains one of the most effective, it is successfully used in the treatment of PF.
Key words: plantar fasciitis, extracorporeal shock wave therapy, comparison, conservative treatment, physiotherapy
References
- Tseng WC, Chen YC, Lee TM, Chen WS. Plantar Fasciitis: An Updated Review. J Med Ultrasound. 2023;6;31(4):268-74. doi: https://doi.org/10.4103/jmu.jmu_2_23
- Auersperg V, Trieb K. Extracorporeal shock wave therapy: an update. EFORT Open Rev. 2020;26;5(10):584-92. doi: https://doi.org/10.1302/2058-5241.5.190067
- Charles R, Fang L, Zhu R, Wang J. The effectiveness of shockwave therapy on patellar tendinopathy, Achilles tendinopathy, and plantar fasciitis: a systematic review and meta-analysis. Front Immunol. 2023;14:1193835. doi: https://doi.org/10.3389/fimmu.2023.1193835
- Melese H, Alamer A, Getie K, Nigussie F, Ayhualem S. Extracorporeal shock wave therapy on pain and foot functions in subjects with chronic plantar fasciitis: systematic review of randomized controlled trials. Disabil Rehabil. 2022;44(18):5007-14. doi: https://doi.org/10.1080/09638288.2021.1928775
- Tognolo L, Giordani F, Biz C, Bernini A, Ruggieri P, Stecco C, et al. Myofascial points treatment with focused extracorporeal shock wave therapy (f-ESWT) for plantar fasciitis: an open label randomized clinical trial. Eur J Phys Rehabil Med. 2022;58(1):85-93. doi: https://doi.org/10.23736/s1973-9087.21.06814-3
- Kapusta J, Domżalski M. Long Term Effectiveness of ESWT in Plantar Fasciitis in Amateur Runners. J Clin Med. 2022;24;11(23):6926. doi: https://doi.org/10.3390/jcm11236926
- Giordani F, Bernini A, Müller-Ehrenberg H, Stecco C, Masiero S. A global approach for plantar fasciitis with extracorporeal shockwaves treatment. Eur J Transl Myol. 2019;29(3):8372. doi: https://doi.org/10.4081/ejtm.2019.8372
- Nazim BT, Seow D, Vig KS. Extracorporeal Shockwave Therapy for Foot and Ankle Disorders: A Systematic Review and Meta-Analysis. J Am Podiatr Med Assoc. 2022;112(3):118-91. doi: https://doi.org/10.7547/18-191
- De la Corte-Rodríguez H, Román-Belmonte JM, Rodríguez-Damiani BA, Vázquez-Sasot A, Rodríguez-Merchán EC. Extracorporeal Shock Wave Therapy for the Treatment of Musculoskeletal Pain: A Narrative Review. Healthcare (Basel). 2023;26;11(21):2830. doi: https://doi.org/10.3390/healthcare11212830
- Li T, Lv H, Lin T. Comparison of efficacy of eight treatments for plantar fasciitis: A network meta-analysis. J Cell Physiol. 2018;234(1):860-70. doi: https://doi.org/10.1002/jcp.26907
- Akınoğlu B, Köse N. A comparison of the acute effects of radial extracorporeal shockwave therapy, ultrasound therapy, and exercise therapy in plantar fasciitis. J Exerc Rehabil. 2018;14(2):306-12. doi: https://doi.org/10.12965/jer.1836048.024
- Sun K, Zhou H, Jiang W. Extracorporeal shock wave therapy versus other therapeutic methods for chronic plantar fasciitis. Foot Ankle Surg. 2020;26(1):33-8. doi: https://doi.org/10.1016/j.fas.2018.11.002
- Erden T, Toker B, Cengiz O, Ince B, Asci S, Toprak A. Outcome of Corticosteroid Injections, Extracorporeal Shock Wave Therapy, and Radiofrequency Thermal Lesioning for Chronic Plantar Fasciitis. Foot Ankle Int. 2021;42(1):69-75. doi: https://doi.org/10.1177/1071100720949469
- Yapici F, Gur V, Sari IF, Karakose R, Tardus I, Ucpunar HJ. which treatment method is better in the treatment of chronic plantar fasciitis: corticosteroid injection, extracorporeal shock wave therapy, or radiofrequency thermal lesioning? Am Podiatr Med Assoc. 2023;113(5):21-049. doi: https://doi.org/10.7547/21-049
- Yinilmez Sanmak ÖD, Geler Külcü D, Mesci N, Altunok EÇ. Comparison of effects of low-level laser therapy and extracorporeal shock wave therapy in plantar fasciitis treatment: A randomized, prospective, single-blind clinical study. Turk J Phys Med Rehabil. 2018;65(2):184-90. doi: https://doi.org/10.5606/tftrd.2019.3528
- Akinoglu B, Köse N, Kirdi N, Yakut Y. Comparison of the Acute Effect of Radial Shock Wave Therapy and Ultrasound Therapy in the Treatment of Plantar Fasciitis: A Randomized Controlled Study. Pain Med. 2017;18(12):2443-52. doi: https://doi.org/10.1093/pm/pnx113
- Koz G, Kamanli A, Kaban N, Harman H. Efficacies of extracorporeal shockwave therapy and low-level laser therapy in patients with plantar fasciitis. Foot Ankle Surg. 2023;29(3):223-7. doi: https://doi.org/10.1016/j.fas.2023.01.009
- Timurtaş E, Çinar E, Selçuk Н, Avci EE, Batar S, Demirbüken İ, et al. Polat MG. Extracorporeal shock wave therapy versus low level laser therapy in the treatment of plantar fasciitis: a randomized controlled trial. J Am Podiatr Med Assoc. 2022;20:1-27. doi: https://doi.org/10.7547/22-095
- Al-Siyabi Z, Karam M, Al-Hajri E, Alsaif A, Alazemi M, Aldubaikhi AA. extracorporeal shockwave therapy versus ultrasound therapy for plantar fasciitis: a systematic review and meta-analysis. 2022;14(1):e20871. doi: https://doi.org/10.7759/cureus.20871
- Li S, Wang K, Sun H, Luo X, Wang P, Fang S, et al. Clinical effects of extracorporeal shock-wave therapy and ultrasound-guided local corticosteroid injections for plantar fasciitis in adults: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018;97(50):e13687. doi: https://doi.org/10.1097/MD.0000000000013687
- Xu D, Jiang W, Huang D, Hu X, Wang Y, Li H, et al. Comparison Between Extracorporeal Shock Wave Therapy and Local Corticosteroid Injection for Plantar Fasciitis. Foot Ankle Int. 2020;41(2):200-5. doi: https://doi.org/10.1177/1071100719891111
- Mishra BN, Poudel RR, Banskota B, Shrestha BK, Banskota AK. Effectiveness of extra-corporeal shock wave therapy (ESWT) vs methylprednisolone injections in plantar fasciitis. J Clin Orthop Trauma. 2019;10(2):401-5. doi: https://doi.org/10.1016/j.jcot.2018.02.011
- Eslamian F, Shakouri SK, Jahanjoo F, Hajialiloo M, Notghi F. Extra corporeal shock wave therapy versus local corticosteroid injection in the treatment of chronic plantar fasciitis, a single blinded randomized clinical trial. Pain Med. 2016;17(9):1722-31. doi: https://doi.org/10.1093/pm/pnw113
- Mardani-Kivi M, Karimi Mobarakeh M, Hassanzadeh Z, Mirbolook A, Asadi K, Ettehad H, et al. Treatment outcomes of corticosteroid injection and extracorporeal shock wave therapy as two primary therapeutic methods for acute plantar fasciitis: a prospective randomized clinical trial. J Foot Ankle Surg. 2015;54(6):1047-52. doi: https://doi.org/10.1053/j.jfas.2015.04.026
- Lai TW, Ma HL, Lee MS, Chen PM, Ku MC. Ultrasonography and clinical outcome comparison of extracorporeal shock wave therapy and corticosteroid injections for chronic plantar fasciitis: A randomized controlled trial. J Musculoskelet Neuronal Interact. 2018;18(1):47-54. PMID: 29504578; PMCID: PMC5881128.
- XiongY, Wu Q, Mi B, Zhou W, Liu Y, Liu J, et al. Comparison of efficacy of shock-wave therapy versus corticosteroids in plantar fasciitis: a meta-analysis of randomized controlled trials. Arch Orthop Trauma Surg. 2019;139:529-36. doi: https://doi.org/1007/s00402-018-3071-1
- Çağlar Okur S, Aydın A. Comparison of extracorporeal shock wave therapy with custom foot orthotics in plantar fasciitis treatment: A prospective randomized one-year follow-up study. J Musculoskelet Neuronal Interact. 2019;19(2):178-86. PMID: 31186388
- Eun SS, Chachan S, Lee SH. Effectiveness of a double air-cushioned shoe compared with physiotherapy in the treatment of plantar fasciitis. Biomed Res Int. 2020;2020:9468302. doi: https://doi.org/10.1155/2020/9468302
- Bahar-Ozdemir Y, Atan T. Effects of adjuvant low-dye Kinesio taping, adjuvant sham taping, or extracorporeal shockwave therapy alone in plantar fasciitis: A randomised double-blind controlled trial. Int J Clin Pract. 2021;75(5):e13993. doi: https://doi.org/10.1111/ijcp.13993
- Ordahan B, Türkoğlu G, Karaha AY, Akkurt HE. extracorporeal shockwave therapy versus kinesiology taping in the management of plantar fasciitis: a randomized clinical trial. Arch Rheumatol. 2017;32(3):227-33. doi: https://doi.org/10.5606/ArchRheumatol.2017.6059
- Tezel N, Umay E, Bulut M, Cakci A. Short-Term Efficacy of Kinesiotaping versus Extracorporeal Shockwave Therapy for Plantar Fasciitis: A Randomized Study. Saudi J Med Sci.2020;8(3):181-7. doi: https://doi.org/10.4103/sjmms.sjmms_624_19
- Pandey S, Kumar N, Kumar A, Biswas A, Sinha U, Pandey J, et al. Extracorporeal shockwave therapy versus platelet rich plasma injection in patients of chronic plantar fasciitis: a randomized controlled trial from a tertiary center of eastern India.2023;15(1):e34430. doi: https://doi.org/10.7759/cureus.34430
- Haddad S, Yavari P, Mozafari S, Farzinnia S, Mohammadsharifi G. Platelet-rich plasma or extracorporeal shockwave therapy for plantar fasciitis. Int J Burns Trauma. 2021;11(1):1-8. PMID: 33824779
- Roca B, Mendoza MA, Roca M. Comparison of extracorporeal shock wave therapy with botulinum toxin type A in the treatment of plantar fasciitis. Disabil Rehabil. 2016;38(21):2114-21. doi: https://doi.org/10.3109/09638288.2015.1114036
- Kesikburun S, Uran Şan A, Kesikburun B, Aras B, Yaşar E, Tan AK. Comparison of Ultrasound-Guided Prolotherapy Versus Extracorporeal Shock Wave Therapy in the Treatment of Chronic Plantar Fasciitis: A Randomized Clinical Trial. J Foot Ankle Surg. 2022;61(1):48-52. doi: https://doi.org/10.1053/j.jfas.2021.06.007
- Asheghan M, Hashemi SE, Hollisaz MT, Roumizade P, Hosseini SM, Ghanjal A. Dextrose prolotherapy versus radial extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: A randomized, controlled clinical trial. Foot Ankle Surg. 2021;27(6):643-9. doi: https://doi.org/10.1016/j.fas.2020.08.008
- Pisirici P, Cil ET, Coskunsu DK, Saylı U, Subasi F. Extracorporeal shockwave therapy versus graston instrument-assisted soft-tissue mobilization in chronic plantar heel pain: a randomized controlled trial. J Am PodiatrMed 2022;112(6):21-36. doi: https://doi.org/10.7547/21-036
- Ozan F, Koyuncu Ş, Gürbüz K, Öncel ES, Altay T. Radiofrequency thermal lesioning and extracorporeal shockwave therapy: a comparison of two methods in the treatment of plantar fasciitis. Foot Ankle Spec. 2017;10(3):204-9. doi: https://doi.org/10.1177/1938640016675408
- Tas NP, Kaya O. Treatment of plantar fasciitis in patients with calcaneal spurs: radiofrequency thermal ablation or extracorporeal shock wave therapy? J Clin Med.2023;13,12(20):6503. doi: https://doi.org/10.3390/jcm12206503
- Wheeler PC, Dudson C. Similar benefits seen after radial extracorporeal shockwave therapy or autologous blood injection in patients with chronic plantar fasciitis-a retrospective cohort study. Clin J Sport Med. 2022;32(2):107-15. doi: https://doi.org/10.1097/JSM.0000000000000930
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Ovchynnikov O.M. Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0006-4486-5163
Bludova M.O. Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine https://orcid.org/0009-0003-9977-3854
Merkulova T.V. Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine; Kharkiv National Medical University, Kharkiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0003-2362-9226
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Ovchynnikov O.M., Bludova M.O., Merkulova T.V. Effectiveness of extracorporeal shock wave therapy in comparison with other methods of treatment of patients with plantar fasciitis: literature review. Medicni perspektivi. 2024;29(3):20-26. DOI: https://doi.org/10.26641/2307-0404.2024.3.313479
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Marfiian O.V., Demkovych A.Ye., Bondarenko Yu.I., Yaremchuk O.Z. Modern views on the etiology and role of microbial persistence in the development of inflammatory processes in the periodontal complex (review)
https://doi.org/10.26641/2307-0404.2024.3.313482
Abstract
Alveolar tissue diseases cause the appearance of dentition defects, thereby reducing the patients' work capacity and quality of life. The purpose of this research was to investigate, modern views on the etiology of periodontitis and the role of microbial persistence in the development of inflammatory processes of periodontal complex basing on a review of literary sources. Literature review was conducted using PubMed, Web of Science, Scopus, Google Scholar from 2018 to March 2024. There were no restrictions on the date of publication or the language of scientific sources. Searches were conducted according to MeSH (Medical Subject Headings) with using the following search terms: "periodontitis", "oral mucosa", "gums", "dental plaque", "periodontium", "traumatic occlusion", "microorganisms". In total, during the initial analysis 82 literary sources were selected and processed, after further systematization of the selected information using general scientific methods, 70 of them remained. Used methods: bibliographic and analytical. Generalized periodontitis is a chronic inflammatory-dystrophic process that occurs as a result of various factors. In the pathogenesis of this disease, the key role is played by the inflammatory process, which is a complex interaction of microcirculatory, hematological and connective tissue reactions to the lesion. Local (exogenic) and general (endogenic) causative factors are distinguished. The main factors that cause pathological changes in periodontium are bacterial biofilm, traumatic occlusion and various anatomical anomalies. Dental plaque occupies a special and main place among the causes of periodontitis. At present, leading pathogenetic links in the development of the inflammation in the periodontium, in particular, the disruption of free radical oxidation, the processes of peroxide oxidation of lipids and proteins, the disorder of the functional state of the antioxidant system, the formation of oxidative stress, as well as the humoral link of adaptive immune protection and cytokinesis, have not been sufficiently studied. There is no doubt about the role of the microbial factor in the etiology of periodontal diseases, but the penetration of microbes into the periodontium does not always lead to the development of the disease, because the organism has a number of protective mechanisms that counteract the development of inflammation.
Key words: periodontitis, oral mucosa, gums, dental plaque, periodontium, traumatic occlusion, microorganisms
References
- Lippert Chapter 3: Macroelements: Ca, Na, K, P, Cl. Monographs in oral science. 2020;28:22-31. doi: https://doi.org/10.1159/000455369
- DemkovychA, Rubas L, Luchynskyi V, Luchynska Y, Stoikevych H, Machogan Changes of ultrastructural organization in periodontal complex components in experimental periodontitis and its correction with quercetin. Pharmacia. 2022;69(2):563-9. doi: https://doi.org/10.3897/pharmacia.69.e82128
- BandrivskyY, Bandrivska O, Bandrivska N, Bedenyuk O, Kuchyrka L, Zmarko Medication correction of the main clinical symptoms of generalized periodontitis in patients with different blood groups. Pharmacia. 2023;70(3):499-507. doi: https://doi.org/10.3897/pharmacia.70.e102850
- DankoЕМ, Pantio VV, Nesterenko МL. [Assessment of risk factors in patients with diseases of periodontal tissues]. Bulletein of problems in biology and medicine. 2022;2:81-2. doi: https://doi.org/10.29254/2077-4214-2022-2-164/addition-81-82
- KononovaОV. [The effectiveness of the treatment of patients with exacerbative course of generalized periodontitis with manifestations of psychoemotional stress]. Actual Dentistry. 2020;2:24-8. Ukrainian. doi: https://doi.org/10.33295/1992-576X-2020-2-24
- SavelevaNN, Sokolova II, German SI, Tomilina [Some aspects of the eatiology of parodontus diseases (literature review)]. Ukrainian Dental Almanac. 2018:2;54-9. Ukrainian. doi: https://doi.org/10.31718/2409-0255.2.2018.13
- HasiukP, Kindiy D, Vorobets A, Kindiy V, Demkovych A, Odzhubeiska Analysis of the advisability of using different types of base plastics by studying the needs of the population in removable prosthesis. Wiadomosci Lekarskie. 2022;75(12):3055-9. doi: https://doi.org/10.36740/WLek202212128
- Lysokon Y, Bandrivsky YL, Luchynskyi MA. Analysis of the results of treatment of destructive forms of apical periodontitis with osteotropic drugs in a short term. Wiadomosci 2022;75(1):228-31. doi: https://doi.org/10.36740/WLek202201214
- Hasiuk P, Kindiy D, Radchuk V, Kindiy V, Demkovych A, Yarkoviy V. Biological compatibility of metal structures of dentures made from multiple melted alloys. Polski Merkuriusz Lekarski. 2022;50(296):114-7. doi: http://dx.doi.org/10.36740/wlek202110111
- Sluchevska OO, Pavlenko OV, Mochalov IO, Shupyatsky IM. [Some aspects of the prevalence of severe forms of generalized periodontitis in the population of Ukraine]. Bulletin of Social Hygiene and Health Protection Organization of Ukraine. 2021;4(90):19-24. doi: https://doi.org/10.11603/1681-2786.2021.4.12848
- Nibali L, Almofareh SA, Bayliss-Chapman J, Zhou Y, Vieira AR, Divaris K. Heritability of periodontitis: A systematic review of evidence from animal studies. ArchOral 2020 Jan;109:104592. doi: https://doi.org/10.1016/j.archoralbio.2019.104592
- Petrushanko TO, Popovych IY, Moshel TM. [Evaluation of the impact of pathogenic factors in patients with generalized periodontitis]. Clinical dentistry. 2020;2:24-32.
doi: https://doi.org/10.11603/2311-9624.2020.2.11398
- Schestakow A, Meyer-Probst CT, Hannig C, Hannig M. Prevention of Dental Biofilm Formation with Polyphenols: A Systematic Review. Planta Med. 2023 Sep;89(11):1026-33.
doi: https://doi.org/10.1055/a-1939-7615
- Sabancı A, Karasu B, Sabancı HI, Kuku İ, Kırmızıgul OA. Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy. ClinOral 2022 Oct;26(10):6341-6. doi: https://doi.org/10.1007/s00784-022-04588-6
- Pinto KP, Fidalgo TKDS, de Lima CO, Lopes RT, Freitas-Fernandes LB, Valente AP, et al. Chronic alcohol and nicotine consumption as catalyst for systemic inflammatory storm and bone destruction in apical periodontitis.Int Endod 2024 Feb;57(2):178-94. doi: https://doi.org/10.1111/iej.13994
- Nemesh OM, Honta ZM, Slaba OM, Shylivskyi IV. Pathogenetic mechanisms of comorbidity of systemic diseases and periodontal pathology. Wiad Lek. 2021;74(5):1262-7. doi: https://doi.org/10.36740/WLek202105140
- Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D'Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases: Consensus report. J Clin 2020 Mar;47(3):268-88. doi: https://doi.org/10.1111/jcpe.13189
- González DA, Bianchi ML, Armada M, Escalante AC, Salgado PA, Seni S, et al. Hyposalivation and periodontal disease as oral non-articular characteristics in rheumatoid arthritis. Clin Rheumatol. 2024 Jan;43(1):95-102. doi: https://doi.org/10.1007/s10067-023-06718-1
- Dankevych-Kharchyshyn IS, Vynogradova OM, Malko NV, Gnid RM, Skalat AP, Minko LY, et al. Periodontal diseases and atherosclerosis (literature review). Wiad 2019;72(3):462-5. doi: https://doi.org/10.36740/WLek201903127
- Chukur OO. [Dynamics of morbidity and expansion of pathology of the thyroid gland among adult population of Ukraine]. Bulletin of Social Hygiene and Health Protection Organization of Ukraine. 2018;4:19-25. Ukrainian.
doi: https://doi.org/10.11603/1681-2786.2018.4.10020
- Li F, Wang G, Zhang Y. Association between carotenoid intake and periodontitis in diabetic patients. J Nutr 2024 Feb 28;13:e11. doi: https://doi.org/10.1017/jns.2023.116
- Serón C, Olivero P, Flores N, Cruzat B, Ahumada F, Gueyffier F, et al. Diabetes, periodontitis, and cardiovascular disease: towards equity in diabetes care. FrontPublic 2023 Dec 21;11:1270557. doi: https://doi.org/10.3389/fpubh.2023.1270557
- Bitencourt FV, Nascimento GG, Costa SA, Andersen A, Sandbæk A, Leite FRM. Co-occurrence of Periodontitis and Diabetes-Related Complications. J Dent Res.2023 Sep;102(10):1088-97. doi: https://doi.org/10.1177/00220345231179897
- Aldulaijan HA, Cohen RE, Stellrecht EM, Levine MJ, Yerke LM. Relationship between hypothyroidism and periodontitis: A scoping review. Clin Exp Dent Res. 2020 Feb;6(1):147-57. doi: https://doi.org/10.1002/cre2.247
- Shcherba V, Kyryliv M, Bekus I, Krynytska I, Marushchak M, Korda M. A comparative study of connective tissue metabolism indices in experimental comorbidity-free periodontitis and periodontitis combined with thyroid dysfunction. J Med Life. 2020 Apr-Jun;13(2):219-24. doi: https://doi.org/10.25122/jml-2019-0113
- Twardowski SE, Wactawski-Wende J, Hovey KM, Andrews CA, Banack HR, LaMonte MJ, et al. Plasma 25-Hydroxyvitamin D Concentrations and Serum and Salivary C-Reactive Protein in the Osteoporosis and Periodontal Disease Study. Nutrients. 2021 Mar 31;13(4):1148. doi: https://doi.org/10.3390/nu13041148
- Prots H, Rozhko M, Ozhogan Z, Hajoshko O, Nychyporchuk H. Diagnostic value of biochemical markers of bone remodeling for predicting the results of dental implantation in patients with generalized periodontitis. Georgian Med News. 2021 Jul-Aug;316-317:83-8.
- Fedoce ADG, Ferreira F, Bota RG, Bonet-Costa V, Sun PY, Davies KJA. The role of oxidative stress in anxiety disorder: cause or consequence? Free Radic Res. 2018 Jul;52(7):737-750. doi: https://doi.org/10.1080/10715762.2018.1475733
- Botelho J, Machado V, Proença L, Delgado AS, Mendes JJ. Vitamin D Deficiency and Oral Health: A Comprehensive Nutrients. 2020 May 19;12(5):1471. doi: https://doi.org/10.3390/nu12051471
- Sun C, Janjic Rankovic M, Folwaczny M, Otto S, Wichelhaus A, Baumert U. Effect of Tension on Human Periodontal Ligament Cells: Systematic Review and Network Analysis. Front Bioeng Biotechnol. 2021 Aug 27;9:695053. doi: https://doi.org/10.3389/fbioe.2021.695053
- Navarro BG, Salas EJ, López JL, Sala XP. Is there a relationship between dental and/or periodontal pathology and values of Creactive protein, homocysteine and lipoprotein (a) in patients with cardiovascular disease? A Case Control Study. Journal of Current Medical Research and Opinion.2020;3(5):451-8. doi: https://doi.org/10.15520/jcmro.v3i05.285
- Borysenko AV, Batig IV, Kuzniak NB, Batig VM. [Influence of orthodontic treatment on periodont (literature review)]. Actual Dentistry. 2022;1-2:68-75. Ukrainian. doi: https://doi.org/0.33295/1992-576X-2022-1-2-68
- Fastovets OO, Masheiko IV, Lucash AY. Evaluation of bone resorptive potential in the treatment of generalized periodontitis. Wiad Lek. 2020;73(11):2396-402. doi: https://doi.org/10.36740/WLek202011112
- Shchepanskii BF. [Status of prooxidant-antioxidant system in periodontal tissues under conditions of the development of experimental bronchial asthma]. Achievements of Clinical and Experimental Medicine. 2018;2:218-21. doi: https://doi.org/10.11603/1811-2471.2018.v0.i2.8673
- Hasiuk PA, Malko NV, Vorobets AB, Ivanchyshyn VV, Rosolovska SO, Korniienko MM, et al. The intensity of chronic catarrhal gingivitis in children depending on the age. Wiad Lek. 2020;73(5):846-9. doi: https://doi.org/10.36740/WLek202005102
- Toczewska J, Konopka T. Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature. Dent Med Probl. 2019 Oct-Dec;56(4):419-26. doi: https://doi.org/10.17219/dmp/112151
- Garmash OV. [The dynamics of biochemical indices of the oral fluid as a marker of different courses of the periodontal tissue diseases in persons who were born macrosomic]. Bulletin of problems biology and medicine. 2020;2(156):340-9. doi: https://doi.org/10.29254/2077-4214-2020-2-156-340-349
- Demkovych A. Endogenous intoxication in development of experimental periodontitis of bacterial-immune genesis. Folia Med (Plovdiv). 2023 Feb 28;65(1):149-54. doi: https://doi.org/10.3897/folmed.65.e71970
- Zhu J, Fan J, Xia Y, Wang H, Li Y, Feng Z, et al. Potential therapeutic targets of macrophages in inhibiting immune damage and fibrotic processes in musculoskeletal diseases. Front Immunol. 2023 Jul 20;14:1219487. doi: https://doi.org/10.3389/fimmu.2023.1219487
- Rawdhah R, Mahmood MS. Salivary lactate dehydrogenase and salivary total protein as potential biomarkers for screening periodontal disease. Saudi Dent J.2023 Nov;35(7):827-33. doi: https://doi.org/10.1016/j.sdentj.2023.07.011
- Hajishengallis G. New developments in neutrophil biology and periodontitis. Periodontol 2000. 2020 Feb;82(1):78-92. doi: https://doi.org/10.1111/prd.12313
- Ansari Moghadam S, Ahmadi Moghadam FS, Alijani E. Diagnostic Accuracy of Salivary Biomarkers including Lactate Dehydrogenase and Hemoglobin A1c forScreening Chronic Periodontitis. Dis Markers. 2022 Apr 26;2022:1119038. doi: https://doi.org/10.1155/2022/1119038
- Avdeev OO, Drevnitska RO, Gevkaliuk NO, Bandrivsky YL, Boykiv AB. Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel. Ukrainian Biochemical Journal. 2022;94(5):59-68. doi: https://doi.org/10.15407/ubj94.05.05
- Mizoguchi T, Ono N. The diverse origin of bone-forming osteoblasts. J Bone Miner Res. 2021 Aug;36(8):1432-47. doi: https://doi.org/10.1002/jbmr.4410
- Rasaei N, Ghadiri A, Peighan M, Rekabi A, Atashkar N. Evaluation of alkaline phosphatase in gingival crevicular fluid and saliva of patients with periodontitis and healthy individuals. J Family Med Prim Care. 2022 Nov;11(11):6983-7. doi: https://doi.org/10.4103/jfmpc.jfmpc_477_22
- Koppolu P, Sirisha S, Mishra A, Deshpande K, Lingam AS, Alotaibi DH, et al. Alkaline phosphatase and acid phosphatase levels in saliva and serum of patients with healthy periodontium, gingivitis, and periodontitis before and after scaling with root planing: A clinico-biochemical study.Saudi J Biol 2021 Jan;28(1):380-5. doi: https://doi.org/10.1016/j.sjbs.2020.10.016
- Sczepanik FSC, Grossi ML, Casati M, Goldberg M, Glogauer M, Fine N, et al. Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way. Periodontol 2000. 2020 Oct;84(1):45-68. doi: https://doi.org/10.1111/prd.12342
- Demkovych A, Kalashnikov D, Hasiuk P, Zubchenko S, Vorobets A. The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues. Frontiers in Oral Health. 2023 Aug 7;4:1237448. doi: https://doi.org/10.3389/froh.2023.1237448
- Sharma N, Bhatia S, Sodhi AS, Batra N. Oral microbiome and health. AIMS Microbiol. 2018 Jan 12;4(1):42-66. doi: https://doi.org/10.3934/microbiol.2018.1.42
- Dessirier F, Arnault JP, Denamps J, Sevestre H, Attencourt C, Lok C. [Actinomycosis revealed by ulceration of the palate and gingiva]. Ann Dermatol Venereol. 2018 Mar;145(3):173-7. doi: https://doi.org/10.1016/j.annder.2017.11.002
- Almeida-da-Silva CLC, Alpagot T, Zhu Y, Lee SS, Roberts BP, Hung SC, et al. Chlamydia pneumoniae is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells.Microb 2019 Mar 11;6(4):197-208. doi: https://doi.org/10.15698/mic2019.04.674
- Van Dyke TE, Sima C. Understanding resolution of inflammation in periodontal diseases: Is chronic inflammatory periodontitis a failure to resolve? Periodontol 2000. 2020 Feb;82(1):205-13. doi: https://doi.org/10.1111/prd.12317
- Butt K, Butt R, Sharma P. The burden of periodontal disease. Dental Update. 2019;46(10):907-13. doi: https://doi.org/10.12968/denu.2019.46.10.907
- Mi J, Zhi M, Kang W, Liang Q, Tang D, Wang T, et al. Succession of the oral microbiome with the increasing severity of periodontitis. VIEW. 2024;5:20230118. doi: https://doi.org/10.1002/VIW.20230118
- Kushkevych I, Coufalová M, Vítězová M, Rittmann SKR. Sulfate-Reducing Bacteria of the Oral Cavity and Their Relation with Periodontitis-Recent Advances. J Clin 2020 Jul 23;9(8):2347. doi: https://doi.org/10.3390/jcm9082347
- Jakubovics NS, Goodman SD, Mashburn-Warren L, Stafford GP, Cieplik F. The dental plaque biofilm matrix. Periodontol 2000. 2021 Jun;86(1):32-56. doi: https://doi.org/10.1111/prd.12361
- Stanisic D, Jovanovic M, George AK, Homme RP, Tyagi N, Singh M, et al. Gut microbiota and the periodontal disease: role of hyperhomocysteinemia. Can J Physiol 2021 Jan;99(1):9-17. doi: https://doi.org/10.1139/cjpp-2020-0215
- Iwauchi M, Horigome A, Ishikawa K, Mikuni A, Nakano M, Xiao JZ, et al. Relationship between oral and gut microbiota in elderly people. Immun Inflamm Dis. 2019 Sep;7(3):229-36. doi: https://doi.org/10.1002/iid3.266
- Lemus AA, Valm AM. In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses. Curr Protoc.2023 Oct;3(10):e902. doi: https://doi.org/10.1002/cpz1.902
- Gasmi Benahmed A, Kumar Mujawdiya P, Noor S, Gasmi A. Porphyromonas Gingivalis in the Development of Periodontitis: Impact on Dysbiosis and Inflammation. Arch Razi Inst. 2022 Oct 31;77(5):1539-51. doi: https://doi.org/10.22092/ARI.2021.356596.1875
- Amer L, Retout M, Jokerst JV. Activatable prodrug for controlled release of an antimicrobial peptide via the proteases overexpressed in Candida albicans and Porphyromonas Theranostics. 2024 Feb 17;14(4):1781-93. doi: https://doi.org/10.7150/thno.91165
- Polishchuk TV, Lokhmatova NM, Sheshukova OV, Tkachenko IM, Bauman SS, Maksymenko AI. Influence of microbiota on the clinical and immuno-histochemical characteristics of chronic generalized catarrhal gingivitis in children. Wiad Lek. 2021;74(1):39-42. doi: https://doi.org/10.3897/pharmacia.68.e7088310.36740/WLek202101107
- Hegde R, Awan KH. Effects of periodontal disease on systemic health. Dis Mon. 2019 Jun;65(6):185-92. doi: https://doi.org/10.1016/j.disamonth.2018.09.011
- Demkovych A, Bondarenko Y, Shcherba V, Luchynskyi V, Vitkovskyy V, Machogan V. Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis. Pharmacia. 2021;68:877-82. doi: https://doi.org/10.3897/pharmacia.68.e70883
- Lobão WJM, Carvalho RCC, Leite SAM, Rodrigues VP, Batista JE, Gomes-Filho IS, et al. Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy. An Acad Bras 2019 May 23;91(2):e20170652. doi: https://doi.org/10.1590/0001-3765201920170652
- Borisy GG, Valm AM. Spatial scale in analysis of the dental plaque microbiome. Periodontol 2000. 2021 Jun;86(1):97-112. doi: https://doi.org/10.1111/prd.12364
- Demkovych A, Bondarenko Y, Hasiuk P. Effects of quercetin on antioxidant potential in the experimental periodontitis development. Interv Med Appl Sci. 2019;11(1):60-4. doi: https://doi.org/10.1556/1646.11.2019.06
- Baker JL, Mark Welch JL, Kauffman KM, McLean JS, He X. The oral microbiome: diversity, biogeography and human health. Nat Rev Microbiol. 2024 Feb;22(2):89-104. doi: https://doi.org/10.1038/s41579-023-00963-6
- Shcherba VV, Krynytska IYa, Korda MM. [Changes in the cytokine profile in rats with periodontitis on the background of hyper- and hypothyroidism]. Medical and Clinical 2019;21(2);36-43. Ukrainian. doi: https://doi.org/10.11603/mcch.2410-681X.2019.v.i2.10291
- Gooty JR, Shashirekha A, Guntakala VR, Palaparthi R. Estimation of phagocytic activity of polymorphonuclear leukocytes in chronic and aggressive periodontitis patients with nitroblue tetrazolium test. J Indian Soc Periodontol. 2019 Jul-Aug;23(4):316-21. doi: https://doi.org/10.4103/jisp.jisp_399_18
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Marfiian O.V., Demkovych A.Ye., Bondarenko Yu.I., Yaremchuk O.Z. Modern views on the etiology and role of microbial persistence in the development of inflammatory processes in the periodontal complex (review). Medicni perspektivi. 2024;29(3):27-35. DOI: https://doi.org/10.26641/2307-0404.2024.3.313482
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Sydorenko A.Yu., Spindler H. Promoting a culture of respect in cardiothoracic surgery: navigating challenges in understanding unethical behaviour
https://doi.org/10.26641/2307-0404.2024.3.313484
Abstract
Unprofessional behaviour in the workplace, such as bullying, harassment, and discrimination, remains common in the cardiothoracic surgery unit. Despite its prevalence, there is little consensus on what constitutes unprofessional behaviour in the workplace of a cardiothoracic surgeon. In this review, we aim to narrow down the definition of unprofessional behaviour among cardiothoracic surgeons, identify its prevalence and the factors contributing to it, as well as explore potential preventive and support measures. We searched the MEDLINE and Web of Science databases (2000-2022), focusing on publications within psychology, medicine, general surgery, and cardiothoracic surgery for inclusion in a focused review. The current review identified 89 papers that highlight the complexity of defining unprofessional behaviour and its prevalence in cardiothoracic surgery units. Psychosocial professional challenges, hierarchical relationships within the medical team, and a high-stress environment may prompt unprofessional behaviour, which can manifest in both overt and covert actions. Such behaviour negatively impacts medical services for patients, the psycho-emotional state of employees, and the overall functioning of the medical institution. The most effective support measures are characterized by being proactive, anticipating potential problems before they occur. Unprofessional behaviour should be considered an organizational concern, not merely an issue between individual team members. This perspective is essential for fostering a healthy work environment. The leaders of cardiothoracic surgery, given their high status and authority, play a pivotal role in this regard; their focus on inclusiveness of employees with lower status or responsibility is crucial for promoting a culture of psychosocial safety. This culture should be characterized by trust, honesty, and mutual respect, ensuring that every team member feels valued and respected. By prioritizing these values, leaders can minimize the risk of unprofessional behaviour, ultimately leading to an improvement in the quality of medical services for patients, an improvement in the psycho-emotional state of employees and the functioning of the organization as a whole.
Key words: bullying, discrimination, harassment, cardiothoracic surgery
References
- Carpenter AJ. We Stand on the Shoulders of Giants: Let's Look Up. Ann Thorac Surg. 2019;108(3):657-61. doi: https://doi.org/10.1016/j.athoracsur.2019.03.097
- Fingerhut A. Surgical ego, the good, the bad, and the Surg Innov. 2011;18(2):97-8. doi: https://doi.org/10.1177/1553350611411470
- Bolsin SN. Professional misconduct: the Bristol case. Medical Journal of Australia. 1998;169(7):369-72. doi: https://doi.org/10.5694/j.1326-5377.1998.tb126806.x
- Taylor-Robinson SD, De Sousa Lopes PA, Zdravkov J, Harrison R. A Personal Perspective: Is Bullying Still a Problem in Medicine? Advances in Medical Education and 2021;12:141-5. doi: https://doi.org/10.2147/AMEP.S297835
- Seemann NM, Webster F, Holden HA, Moulton C-aE, Baxter N, Desjardins C, et Women in academic surgery: why is the playing field still not level? The American Journal of Surgery. 2016;211(2):343-9. doi: https://doi.org/10.1016/j.amjsurg.2015.08.036
- Nakayama DK. Pioneering women in American pediatric surgery. J Pediatr Surg. 2018;53(11):2361-8. doi: https://doi.org/10.1016/j.jpedsurg.2018.08.038
- Ceppa DP, Dolejs SC, Boden N, Phelan S, Yost KJ, et Sexual Harassment and Cardiothoracic Surgery: UsToo? The Annals of Thoracic Surgery. 2020;109(4):1283-8. doi: https://doi.org/10.1016/j.athoracsur.2019.07.009
- Freedman-Weiss MR, ChiuAS, Heller DR, Cutler AS, Longo WE, Ahuja N, et Understanding the Barriers to Reporting Sexual Harassment in Surgical Training. Annals of Surgery. 2020;271(4):608-13. doi: https://doi.org/10.1097/SLA.0000000000003295
- Singh A, Alberti Why UK medical students change career preferences: an interview study. Perspect Med Educ. 2021;10(1):41-9. doi: https://doi.org/10.1007/S40037-020-00636-7
- Shapiro J. Confronting unprofessional behaviour in BMJ. 2018;360:k1025. doi: https://doi.org/10.1136/bmj.k1025
- Crebbin W, Campbell G, Hillis DA, Watters DA. Prevalence of bullying, discrimination and sexual harassment in surgery in Australasia. ANZ Journal of Surgery.2015;85(12):905-9. doi: https://doi.org/10.1111/ans.13363
- Halim UA, Riding DM. Systematic review of the prevalence, impact and mitigating strategies for bullying, undermining behaviour and harassment in the surgical workplace. British Journal of Surgery. 2018;105(11):1390-7. doi: https://doi.org/10.1002/bjs.10926
- Einarsen SV, HoelH, Zapf D, Cooper CL, eds. Bullying and Harassment in the Workplace: Theory, Research and Practice. 3rd ed. CRC Press; 2020. doi: https://doi.org/10.1201/9780429462528-2
- Wood DE. How can men be good allies for women in surgery? #HeForShe. J Thorac Dis. 2021;13(1):492-501. doi: https://doi.org/10.21037/jtd-2020-wts-11
- Ayyala MS, Chaudhry S, WindishD, Dupras D, Reddy ST, Wright SM. Awareness of Bullying in Residency: Results of a National Survey of Internal Medicine Program Directors. Journal of Graduate Medical Education. 2018;10(2):209-13. doi: https://doi.org/10.4300/JGME-D-17-00386.1
- Rimmer A. Trainees removed from cardiac surgery unit following concerns about “interpersonal behaviours”. 2021;375:n2436. doi: https://doi.org/10.1136/bmj.n2436
- Pei KY, Cochran A. Workplace Bullying Among Surgeons-the Perfect Crime. Annals of Surgery. 2019;269(1):43-4. doi: https://doi.org/10.1097/SLA.0000000000003018
- Myers CG, Lu-Myers Y, Ghaferi AA. Excising the “surgeon ego” to accelerate progress in the culture of surgery. 2018;363:k4537. doi: https://doi.org/10.1136/bmj.k4537
- Lagoo J, Berry WR, Miller K, Neal BJ, Sato L, Lillemoe KD, et al. Multisource Evaluation of Surgeon Behavior Is Associated With Malpractice Claims. Ann Surg. 2019;270(1):84-90. doi: https://doi.org/10.1097/SLA.0000000000002742
- HeslinMJ, Singletary BA, Benos KC, Lee LR, Fry C, Lindeman B. Is Disruptive Behavior Inherent to the Surgeon or the Environment? Analysis of 314 Events at a Single Academic Medical Center. Annals of Surgery. 2019;270(3):463-72. doi: https://doi.org/10.1097/SLA.0000000000003469
- Meloni M, Austin M. Implementation and outcomes of a zero tolerance of bullying and harassment program.Aust Health 2011;35(1):92-4. doi: https://doi.org/10.1071/AH10896
- Methangkool E, Brodt J, Kolarczyk L, Ivascu NS, HicksMH, Herrera E, et al. Perceptions of Gender Disparities Among Women in Cardiothoracic Anesthesiology. Journal of Cardiothoracic and Vascular Anesthesia. 2022;36(7):1859-66. doi: https://doi.org/10.1053/j.jvca.2021.11.015
- Mortensen M, Baarts CA. Killing ourselves with laughter … mapping the interplay of organizational teasing and workplace bullying in hospital work life. Qualitative Research in Organizations and Management: An International 2018;13(1):10-31. doi: https://doi.org/10.1108/QROM-10-2016-1429
- Dupré KE, Barling J. Predicting and preventing supervisory workplace aggression. Journal of Occupational Health 2006;11:13-26. doi: https://doi.org/10.1037/1076-8998.11.1.13
- Matthiesen SB, Einarsen S. Bullying in the workplace: definition, prevalence, antecedents and consequences. International Journal of Organization Theory & 2010;13(2):202-48. doi: https://doi.org/10.1108/IJOTB-13-02-2010-B004
- Kawase K, Nomura K, Tominaga R, Iwase H, Ogawa T, Shibasaki I, et al. Analysis of gender-based differences among surgeons in Japan: results of a survey conducted by the Japan Surgical Society. Part. 2: personal life. Surgery 2018;48(3):308-19. doi: https://doi.org/10.1007/s00595-017-1586-7
- Kawase K, Nomura K, Nomura S, Akashi-Tanaka S, Ogawa T, Shibasaki I, et al. How pregnancy and childbirth affect the working conditions and careers of women surgeons in Japan: findings of a nationwide survey conducted by the Japan Surgical Society. Surgery Today. 2021;51(2):309-21.
doi: https://doi.org/10.1007/s00595-020-02129-w
- Lewis D. Perceptions of bullying in organisations. International Journal of Management and Decision Making.2001;2(1):48-64. doi: https://doi.org/10.1504/IJMDM.2001.001221
- OdellDD, Edwards M, Fuller S, Loor G, Antonoff The Art and Science of Mentorship in Cardiothoracic Surgery: A Systematic Review of the Literature. The Annals of Thoracic Surgery. 2022;113(4):1093-100. doi: https://doi.org/10.1016/j.athoracsur.2020.06.051
- Albuainain HM, Alqurashi MM, Alsadery HA, AlghamdiTA, Alghamdi AA, Alghamdi RA, et al. Workplace bullying in surgical environments in Saudi Arabia: A multiregional cross-sectional study. Journal of Family and Community 2022;29(2):125-31. doi: https://doi.org/10.4103/jfcm.jfcm_392_21
- Peltzer K, Nqeketo A, Petros G, Kanta X. Evaluation of a safer male circumcision training programme for traditional surgeons and nurses in the Eastern Cape, South Africa. Afr J Tradit Complement Alt M. 2008;5(4):346-54. doi: https://doi.org/10.4314/ajtcam.v5i4.31289
- Rogers D, Lingard L, Boehler ML, Espin S, Klingensmith M, Mellinger JD, et al. Teaching operating room conflict management to surgeons: clarifying the optimal approach.Med 2011;45(9):939-45. doi: https://doi.org/10.1111/j.1365-2923.2011.04040.x
- Johnson AH, Benham‐Hutchins M. The Influence of Bullying on Nursing Practice Errors: A Systematic Review.AORN 2020;111(2):199-210. doi: https://doi.org/10.1002/aorn.12923
- Bruce AN, Battista A, Plankey MW, Johnson LB, Marshall MB. Perceptions of gender-based discrimination during surgical training and practice. Medical Education Online.2015;20(1):25923. doi: https://doi.org/10.3402/meo.v20.25923
- Colenbrander L, Causer L, Haire B. ‘If you can’t make it, you’re not tough enough to do medicine’: a qualitative study of Sydney-based medical students’ experiences of bullying and harassment in clinical settings. BMCMedical Education. 2020;20(1):86. doi: https://doi.org/10.1186/s12909-020-02001-y
- Dulaney P, Zager LR. Lateral violence update: we are still listening & we thank you. South Carolina nurse. 2010;173:11.
- Gianakos AL, Freischlag JA, Mercurio AM, Haring RS, Laporte DM, Mulcahey MK, et al. Bullying, Discrimination, Harassment, Sexual Harassment, and the Fear of Retaliation During Surgical Residency Training: A Systematic Review. World Journal of Surgery. 2022;46(7):1587-99.
doi: https://doi.org/10.1007/s00268-021-06432-6
- Moon Equal means equal: Cardiothoracic surgery in its second century. Journal of Thoracic and Cardiovascular Surgery. 2021;161(4):1381-9. doi: https://doi.org/10.1016/j.jtcvs.2020.12.030
- Zhu C, McCloskey D, Sandilos G, Zilberman B, Crudeli C, Hunter K, et al. The State of Racial and Gender Diversity in Cardiothoracic Surgery Training. The Annals ofThoracic 2022;114(4):1492-9. doi: https://doi.org/10.1016/j.athoracsur.2022.02.083
- Backhus LM, Fann BE, Hui DS, Cooke DT, Berfield KS, Moffatt-Bruce SD. Culture of Safety and Gender Inclusion in Cardiothoracic Surgery. The Annals of Thoracic 2018;106(4):951-8. doi: https://doi.org/10.1016/j.athoracsur.2018.07.011
- Vosloo Realities and challenges for female cardiothoracic surgeons: an African perspective. Journal of Thoracic Disease. 2021;13(1):448-55. doi: https://doi.org/10.21037/jtd-2020-wts-03
- ClementsJM, King M, Nicholas R, Burdall O, Elsey E, Bucknall V, et Bullying and undermining behaviours in surgery: A qualitative study of surgical trainee experiences in the United Kingdom (UK) & Republic of Ireland (ROI). International Journal of Surgery. 2020;84:219-25. doi: https://doi.org/10.1016/j.ijsu.2020.07.031
- Pompili C, Opitz I, Backhus L, Leschber G, Veronesi G, LaukO, et The impact of gender bias in cardiothoracic surgery in Europe: a European Society of Thoracic Surgeons and European Association for Cardiothoracic Surgery survey. Eur J Cardio-Thorac Surg. 2022;61(6):1390-9. doi: https://doi.org/10.1093/ejcts/ezac034
- Bleakley A, Marshall R, Levine D. He drove forward with a yell: anger in medicine and Homer. Medical Humanities.2014;40(1):22-30. doi: https://doi.org/10.1136/medhum-2013-010432
- Orlino JP, Sura TA, Kevin YP, Smeds MR. Bullying of vascular surgery trainees. Journal of Vascular Surgery.2022;75(6):2065-71.e3. doi: https://doi.org/10.1016/j.jvs.2022.01.123
- Morrison EW, Milliken FJ. Organizational silence: A barrier to change and development in a pluralistic world. The Academy of Management Review. 2000;25:706-25. doi: https://doi.org/10.2307/259200
- BurrisER, Rockmann KW, Kimmons The Value of Voice to Managers: Employee Identification and the Content of Voice. Academy of Management Journal. 2017;60(6):2099-125. doi: https://doi.org/10.5465/amj.2014.0320
- Sexton Error, stress, and teamwork in medicine and aviation: cross sectional surveys. BMJ. 2000;320(7237):745-9. doi: https://doi.org/10.1136/bmj.320.7237.745
- Campos M, Lira MJ, Mery P, Calderón M, Sepúlveda M, Pimentel F, et al. Disruptive behavior in the operating room: Systemic over individual determinants. International Journal of Surgery Open. 2022;43:100492. doi: https://doi.org/10.1016/j.ijso.2022.100492
- Hsiao CJ, Akhavan NN, Singh Ospina N, Yagnik KJ, Neilan P, Hahn P, et al. Sexual Harassment Experiences Across the Academic Medicine Hierarchy. Cureus. 2021;13(2):е13508. doi: https://doi.org/10.7759/cureus.13508
- KMS, Hallberg LR. The origin of workplace bullying: experiences from the perspective of bully victims in the public service sector. J Nurs Manag. 2007;15(3):332-41. doi: https://doi.org/10.1111/j.1365-2834.2007.00662.x
- RosatiCM, Koniaris LG, Molena D, Blitzer D, Su KW, Tahboub M, et al. Characteristics of cardiothoracic surgeons practicing at the top-ranked US institutions. Journal of Thoracic Disease. 2016;8(11):3232-44. doi: https://doi.org/10.21037/jtd.2016.11.72
- Johan HaugeL, Skogstad A, Einarsen S. Relationships between stressful work environments and bullying: Results of a large representative study. Work & Stress. 2007;21(3):220-42. doi: https://doi.org/10.1080/02678370701705810
- Spiliopoulos K, Gansera L, Weiland HC, SchusterT, Eichinger W, Gansera B. Chronic stress and coping among cardiac surgeons: a single center study. Rev Bras Cir 2014;29(3):308-15. doi: https://doi.org/10.5935/1678-9741.20140083
- Benetis R, Sirvinskas E, Mikalauskas A, MarchertieneI, Macas A, Kinduris S, et al. Burnout Among Lithuanian Cardiac Surgeons and Cardiac Anesthesiologists. Medicina-Lithuania. 2012;48(9):478-84. doi: https://doi.org/10.3390/medicina48090071
- Amini K, Miyanaji H, Mohamadi Bullying and burnout in critical care nurses: A cross-sectional descriptive study. Nurs Crit Care. 2023;28(2):202-10. doi: https://doi.org/10.1111/nicc.12744
- Behaviors that undermine a culture of safety. Sentinel Event Alert. 2008;40:1-3.
- CooperWO, Spain DA, Guillamondegui O, Kelz RR, Domenico HJ, Hopkins J, et al. Association of Coworker Reports About Unprofessional Behavior by Surgeons With Surgical Complications in Their Patients. JAMA 2019;154(9):828. doi: https://doi.org/10.1001/jamasurg.2019.1738
- Pogue CA, LiP, Swiger P, Gillespie G, Ivankova N, Patrician PA. Associations among the nursing work environment, nurse‐reported workplace bullying, and patient outcomes. Nursing Forum. 2022;57(6):1059-68.. doi: https://doi.org/10.1111/nuf.12781
- CochranA, Elder Effects of disruptive surgeon behavior in the operating room. American Journal of Surgery. 2015;209(1):65-70. doi: https://doi.org/10.1016/j.amjsurg.2014.09.017
- Carter M, Thompson N, Crampton P, MorrowG, Burford B, Gray C, et al. Workplace bullying in the UK NHS: a questionnaire and interview study on prevalence, impact and barriers to reporting. BMJ open. 2013;3:6. doi: https://doi.org/10.1136/bmjopen-2013-002628
- Shemanski KA, Ding L, Kim AW, Blackmon SH, WightmanSC, Atay SM, et Gender representation among leadership at national and regional cardiothoracic surgery organizational annual meetings. Journal of Thoracic and Cardiovascular Surgery. 2021;161(3):733-42. doi: https://doi.org/10.1016/j.jtcvs.2020.11.157
- HuY-Y, Ellis RJ, Hewitt DB, Yang AD, Cheung EO, Moskowitz JT, et al. Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training. New England Journal of Medicine. 2019;381(18):1741-52. doi: https://doi.org/10.1056/NEJMsa1903759
- IyerMS, Way DP, MacDowell DJ, Overholser BM, Spector ND, Jagsi R. Bullying in Academic Medicine: Experiences of Women Physician Leaders. Academic 2023;98(2):255-63. doi: https://doi.org/10.1097/ACM.0000000000005003
- Ajoudani F, Baghaei R, Lotfi M. Moral distress and burnout in Iranian nurses: The mediating effect of workplace bullying. Nursing Ethics. 2019;26(6):1834-47. doi: https://doi.org/10.1177/0969733018779210
- Lallukka T, Rahkonen O, Lahelma E. Workplace bullying and subsequent sleep problems--the Helsinki Health Study. Scand J Work Environ Health. 2011;37(3):204-12. doi: https://doi.org/10.5271/sjweh.3137
- Giorgi G, Mancuso S, Fiz Perez F, Castiello D'Antonio A, Mucci N, Cupelli V, et al. Bullying among nurses and its relationship with burnout and organizational climate. International Journal of Nursing Practice. 2016;22(2):160-8. doi: https://doi.org/10.1111/ijn.12376
- Paice E, Smith D. Bullying of trainee doctors is a patient safety issue. The Clinical Teacher. 2009;6(1):13-7. doi: https://doi.org/10.1111/j.1743-498X.2008.00251.x
- Aristidou L, Mpouzika M, Papathanassoglou EDE, MiddletonN, Karanikola Association Between Workplace Bullying Occurrence and Trauma Symptoms Among Healthcare Professionals in Cyprus. Front Psychol. 2020;11:575623. doi: https://doi.org/10.3389/fpsyg.2020.575623
- ChowOS, Sudarshan M, Maxfield MW, Seese LM, Watkins AA, Fleishman A, et al. National Survey of Burnout and Distress Among Cardiothoracic Surgery Trainees. The Annals of Thoracic Surgery. 2021;111(6):2066-71. doi: https://doi.org/10.1016/j.athoracsur.2020.06.062
- Reason Safety paradoxes and safety culture. Injury Control and Safety Promotion. 2000;7(1):3-14. doi: https://doi.org/10.1076/1566-0974(200003)7:1;1-V;FT003
- Edmondson Speaking Up in the Operating Room: How Team Leaders Promote Learning in Interdisciplinary Action Teams. Journal of Management Studies. 2003;40(6):1419-52.
doi: https://doi.org/10.1111/1467-6486.00386
- Nembhard IM, Edmondson Making It Safe: The Effects of Leader Inclusiveness and Professional Status on Psychological Safety and Improvement Efforts in Health Care Teams. Springer Netherlands; 2009. p. 77-105. doi: https://doi.org/10.1007/978-90-481-2605-7_5
- Illing J, Carter MM, Thompson N, Crampton PES, Morrow G, Howse JH, et al., editors. Evidence synthesis on the occurrence, causes, consequences, prevention and management of bullying and harassing behaviours to inform decision-making in the NHS2013 [Internet]. Durham Research Online (DRO). 2013 [cited 2024 Apr 21].Availablefrom: http://www.nets.nihr.ac.uk/projects/hsdr/10101201
- Preece R, Ben-David E, Rasul S, Yatham S. Are we losing future talent? A national survey of UK medical student interest and perceptions of cardiothoracic surgery. Interactive Cardiovascular and Thoracic Surgery. 2018;27(4):525-9. doi: https://doi.org/10.1093/icvts/ivy119
- Lavelle-JonesM. Bullying and Undermining Campaign – Let’s Remove it The Royal College of Surgeons of Edinburgh [Internet]. 2017 [cited 2024 Apr 21]. Available from: https://www.rcsed.ac.uk/news-public-affairs/news/2017/june/bullying-and-undermining-campaign-let-s-remove-it
- Time'sUP [Internet]. No more sexual harassment and gender discrimination in health care; 2022 [cited 2024 Apr 21]. Available from: https://timesupnow.org/work/times-up-healthcare
- Trudell AM, Frankel WC, Luc JGY, Blackmon SH, Kane L, Varghese TK, et al. Enhancing Support for Women in Cardiothoracic Surgery Through Allyship and Targeted Initiatives. Ann Thorac Surg. 2022;113(5):1676-83. doi: https://doi.org/10.1016/j.athoracsur.2021.06.064
- Ortmeyer KA, Raman V, Tiko-Okoye CS, Espinosa JA, Cooke DT, Starnes SL, et al. Goals, organizational change, advocacy, diversity literacy, and sustainability: A checklist for diversity in cardiothoracic surgery training programs. The Journal of Thoracic and Cardiovascular Surgery. 2021;162(6):1782-7. doi: https://doi.org/10.1016/j.jtcvs.2020.11.112
- Nina V, Mendes AG, Sevdalis N, Marath A, Mejia OV, Brandão CMA, et al. Applicability of the Disruptions in Surgery Index in the Cardiovascular Management Scenarios — A Marker for Developing Functionally Efficient Teams. Brazilian Journal of Cardiovascular Surgery. 2021;36(4):445-52. doi: https://doi.org/10.21470/1678-9741-2020-0685
- Ling M, Young CJ, Shepherd HL, Mak C, Saw RPM. Workplace Bullying in Surgery. World Journal of Surgery. 2016;40(11):2560-6. doi: https://doi.org/10.1007/s00268-016-3642-7
- Gostlow H, Vega CV, Marlow N, Babidge W, Maddern G. Do Surgeons React?: A Retrospective Analysis of Surgeons’ Response to Harassment of a Colleague During Simulated Operating Theatre Scenarios. Annals of Surgery. 2018;268(2):277-81. doi: https://doi.org/10.1097/SLA.0000000000002434
- Abi-Jaoudé JG, Kennedy-Metz LR, Dias RD, Yule SJ, Zenati MA. Measuring and Improving Emotional Intelligence in Surgery: A Systematic Review. Ann Surg. 2022;275(2):e353-e60. doi: https://doi.org/10.1097/SLA.0000000000005022
- Arora S, Aggarwal R, Moran A, Sirimanna P, et al. Mental practice: effective stress management training for novice surgeons. J Am Coll Surg. 2011;212(2):225-33. doi: https://doi.org/10.1016/j.jamcollsurg.2010.09.025
- Sinskey JL, Chang JM, Shibata GS, Infosino AJ, Rouine-Rapp K. Applying Conflict Management Strategies to the Pediatric Operating Room. Anesth Analg. 2019;129(4):1109-17. doi: https://doi.org/10.1213/ANE.0000000000003991
- Brinkert R. Conflict coaching training for nurse managers: a case study of a two-hospital health system. J Nurs Manag. 2011;19(1):80-91. doi: https://doi.org/10.1111/j.1365-2834.2010.01133.x
- Kim JS, Hernandez RA, Smink DS, Yule S, Jackson NJ, Shemin RJ, et al. Nontechnical skills training in cardiothoracic surgery: A pilot study. Journal of Thoracic and Cardiovascular Surgery. 2022;163(6):2155. doi: https://doi.org/10.1016/j.jtcvs.2021.01.108
- Stagg SJ, Sheridan D, Jones RA, Speroni KG. Evaluation of a workplace bullying cognitive rehearsal program in a hospital setting. J Contin Educ Nurs. 2011;42(9):395-401. doi: https://doi.org/10.3928/00220124-20110823-22
- Wilson JL, Whyte RI, Gangadharan SP, Kent MS. Teamwork and Communication Skills in Cardiothoracic Surgery. The Annals of Thoracic Surgery. 2017;103(4):1049-54. doi: https://doi.org/10.1136/bmjopen-2017-017389
- Dahl AB, Ben Abdallah A, Maniar H, Avidan MS, Bollini ML, Patterson GA, et al. Building a collaborative culture in cardiothoracic operating rooms: pre and postintervention study protocol for evaluation of the implementation of teamSTEPPS training and the impact on perceived psychological safety. BMJ Open. 2017;7(9):e017389. doi: https://doi.org/10.1136/bmjopen-2017-017389
- DiMeglio K, Padula C, Piatek C, Korber S, Barrett A, Ducharme M, et al. Group cohesion and nurse satisfaction: examination of a team-building approach. J Nurs Adm. 2005;35(3):110-20. doi: https://doi.org/10.1097/00005110-200503000-00003
- Barrett A, Piatek C, Korber S, Padula C. Lessons learned from a lateral violence and team-building intervention. Nurs Adm Q. 2009;33(4):342-51. doi: https://doi.org/10.1097/NAQ.0b013e3181b9de0b
- King HB, Battles J, Baker DP, Alonso A, Salas E, Webster J, et al. Advances in Patient Safety. TeamSTEPPS(™): Team Strategies and Tools to Enhance Performance and Patient Safety. In: Henriksen K, Battles JB, Keyes MA, Grady ML, editors. Advances in Patient Safety: New Directions and Alternative Approaches. Vol. 3: Performance and Tools. Rockville (MD): Agency for Healthcare Research and Quality (US); 2008.
- Lim MC, Jeffree MS, Saupin SS, Giloi N, Lukman KA. Workplace violence in healthcare settings: The risk factors, implications and collaborative preventive measures. Annals of Medicine and Surgery. 2022;78:103727. doi: https://doi.org/10.1016/j.amsu.2022.103727
- Bulutlar F, Öz EÜ. The Effects of Ethical Climates on Bullying Behaviour in the Workplace. Journal of Business Ethics. 2009;86(3):273-95. doi: https://doi.org/10.1007/s10551-008-9847-4
- Dimarino TJ. Eliminating Lateral Violence in the Ambulatory Setting: One Center's Strategies. AORN Journal. 2011;93(5):583-8. doi: https://doi.org/10.1016/j.aorn.2010.10.019
- Wild JR, Ferguson HJ, McDermott FD, Hornby ST, Gokani VJ. Undermining and bullying in surgical training: A review and recommendations by the Association of Surgeons in Training. Int J Surg. 2015;23(Suppl 1):S5-9. doi: https://doi.org/10.1016/j.ijsu.2015.09.017
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https://doi.org/10.26641/2307-0404.2024.3.313488
Abstract
The aim of the work was to evaluate the pharmacological effects and therapeutic potential of individual compounds and extracts of B. monnieri based on the analysis of data from scientific periodicals regarding chemical composition and biological action. Theoretically significant were the studies of the materials of the scientific-metric database PubMed and Google Scholar over the last five years regarding the chemical composition and biological action of extracts based on B. monnieri and their individual components. The search query was carried out by the Latin name of the plant, with the exception of publications related to botanical research. In separate PubChem searches, names of individual phytocompounds were used to establish structure and distribution in plants. The SuperPred web server was used to predict therapeutic potential. The authors analyzed the chemical composition of the extracts, presented the structural and pharmacological characteristics of bacosides and their aglycones: bacosin and juubogenin, cucurbitacin E, loliolide, betulinic and asiatic acids and the flavonoid oroxindin. The mechanism of action of bacoside on β-amyloid is characterized and illustrated. Using machine learning, the prospects for using the main compounds of bacopa to create drugs were calculated taking into account the ATC classification, their biological effects and alternative plant sources were given. Experimental animal studies of whole aqueous or ethanolic extracts of B. monnieri have been found to support a cognitive enhancement effect. The extract was not toxic to humans. Numerous clinical trials show the effectiveness of the use of extracts in the treatment of anhedonia, depression, Alzheimer's disease, Parkinson's disease, dementia and hyperactivity. An analysis of clinical studies in Ukraine shows that drugs based on B. monnieri can be used in the complex treatment of cognitive impairment associated with dyscirculatory encephalopathy in adults and perinatal CNS damage in children. Considering the amphiphilicity of bacosides and the non-toxicity of extracts, they can be involved in the development of various dosage forms with a wide range of therapeutic applications. Further study of the pharmacological action of B. monnieri and the development of drug technology for solid and liquid dosage forms based on it are promising.
Key words: Bacopa monnieri, phytocompounds, bacosides, nootropic properties, cognitive disorders
References
- Chaachouay N, Zidane L. Plant-Derived Natural Products: A Source for Drug Discovery and Development. DrugsDrug 2024;3:184-207. doi: https://doi.org/10.3390/ddc3010011
- Thakral S, Yadav A, Singh V, Kumar M, et al. Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs. Ageing Res Rev. 2023 Jul;88:101960. doi: https://doi.org/10.1016/j.arr.2023.101960
- Nopparat J, Sujipuli K, Ratanasut K, Weerawatanakorn M, Prasarnpun S, Thongbai B, et al. Exploring the excellence of commercial Brahmi products from Thai online markets: Unraveling phytochemical contents, antioxidant properties and DNA damage protection. Heliyon.2024;10(2):e24509. doi: https://doi.org/10.1016/j.heliyon.2024.e24509
- Shalini VT, Neelakanta SJ, Sriranjini JS. Neuroprotection with Bacopa monnieri-A review of experimental evidence. Mol Biol Rep. 2021;48(3):2653-68. doi: https://doi.org/10.1007/s11033-021-06236-w
- Fatima U, Roy S, Ahmad S, Ali S, Elkady WM, Khan I, et al. Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation. Front 2022;9:972379. doi: https://doi.org/10.3389/fnut.2022.972379
- Sekhar VC, Viswanathan G, Baby S. Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I. Curr Neuropharmacol. 2019;17(5):438-46. doi: https://doi.org/10.2174/1570159X16666180419123022
- Delgado-Tiburcio EE, Cadena-Iñiguez J, Santiago-Osorio E, Ruiz-Posadas LDM, Castillo-Juárez I, Aguiñiga-Sánchez I, et al. Pharmacokinetics and Biological Activity of Cucurbitacins. Pharmaceuticals (Basel). 2022;15(11):1325. doi: https://doi.org/10.3390/ph15111325
- Sekhar CV, Gulia KK, Deepti A, Chakrapani PSB, Baby S, Viswanathan G. Protection by Nano-Encapsulated Bacoside A and Bacopaside I in Seizure Alleviation and Improvement in Sleep- In Vitro and In Vivo Evidences. Mol Neurobiol. 2024;61(6):3296-313. doi: https://doi.org/10.1007/s12035-023-03741-w
- Bala SD, Saravanan R, Mahalakshmi G, Murali R, Ashokkumar N. Bacoside-A Improves Antioxidant Enzymes and Alleviates Oxidative Stress Coexist with Markers of Renal Function in a Rat Model of Type 2 Diabetes Mellitus. Saudi J Kidney Dis Transpl. 2023 Nov 1;34(6):537-47. doi: https://doi.org/10.4103/sjkdt.sjkdt_163_21
- Nishanth BJ, Vijayababu P, Kurian NK. Bacopa monnieri Extract As a Neuroprotective and Cognitive Enhancement Agent. Int J Drug Discov Pharmacol. 2023;2(4):44-56. doi: https://doi.org/10.53941/ijddp.2023.100015
- Abdul Manap AS, Vijayabalan S, Madhavan P, Chia YY, Arya A, Wong EH, et al. Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies. Drug Target Insights. 2019;13:1177392819866412. doi: https://doi.org/10.1177/1177392819866412
- Ramesh T, Shahid M. Bacoside-A repressed the differentiation and lipid accumulation of 3T3-L1 preadipocytes by modulating the expression of adipogenic genes. Biotechnol Appl Biochem. 2024;71(1):1-239. doi: https://doi.org/10.1002/bab.2573
- Rauf K, Subhan F, Sewell RD. A Bacoside containing Bacopa monnieri extract reduces both morphine hyperactivity plus the elevated striatal dopamine and serotonin turnover. Phytother Res. 2012;26(5):758-63. doi: https://doi.org/10.1002/ptr.3631
- Ferrucci M, Busceti CL, Lazzeri G, Biagioni F, Puglisi-Allegra S, Frati A, et al. Bacopa Protects against Neurotoxicity Induced by MPP+ and Methamphetamine. Molecules.2022;27(16):5204. doi: https://doi.org/10.3390/molecules27165204
- Cheng Y, Li R, Lin Z, Chen F, Dai J, Zhu Z, et al. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators. Bioorg Med Chem Lett. 2020;30(17):127364. doi: https://doi.org/10.1016/j.bmcl.2020.127364
- Ruan W, Liu J, Zhang S, Huang Y, Zhang Y, Wang Z. Sour Jujube (Ziziphus jujuba var. spinosa): A Bibliometric Review of Its Bioactive Profile, Health Benefits and Trends in Food and Medicine Applications. Foods.2024;13(5):636. doi: https://doi.org/10.3390/foods13050636
- Sangsopha W, Lekphrom R, Schevenels FT, Kanokmedhakul K, Kanokmedhakul S. Two new bioactive triterpenoids from the roots of Colubrina asiatica. Nat Prod Res.2020;34(4):482-8. doi: https://doi.org/10.1080/14786419.2018.1489385
- Huangteerakul C, Aung HM, Thosapornvichai T, Duangkaew M, Jensen AN, Sukrong S, et al. Chemical-Genetic Interactions of Bacopa monnieri Constituents in Cells Deficient for the DNA Repair Endonuclease RAD1 Appear Linked to Vacuolar Disruption. Molecules. 2021 Feb 24;26(5):1207. doi: https://doi.org/10.3390/molecules26051207
- Souto EB, Dias-Ferreira J, Craveiro SA, Severino P, Sanchez-Lopez E, Garcia ML, et al. Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems. Pathogens.2019;8(3):119. doi: https://doi.org/10.3390/pathogens8030119
- Ríos JL, Máñez S. New Pharmacological Opportunities for Betulinic Acid. Planta Med. 2018;84(1):8-19. doi: https://doi.org/10.1055/s-0043-123472
- Aswathy M, Vijayan A, Daimary UD, Girisa S, Radhakrishnan KV, Kunnumakkara AB. Betulinic acid: A natural promising anticancer drug, current situation, and future perspectives. J Biochem Mol Toxicol. 2022 Dec;36(12):e23206. doi: https://doi.org/10.1002/jbt.23206
- Ossowicz-Rupniewska P, Klebeko J, Georgieva I, Apostolova S, Struk Ł, Todinova S, et al. Tuning of the Anti-Breast Cancer Activity of Betulinic Acid via Its Conversion to Ionic Liquids. Pharmaceutics. 2024;16(4):496. doi: https://doi.org/10.3390/pharmaceutics16040496
- SousaJLC, Freire CSR, Silvestre AJD, Silva Recent Developments in the Functionalization of Betulinic Acid and Its Natural Analogues: A Route to New Bioactive Compounds. Molecules. 2019 Jan 19;24(2):355. doi: https://doi.org/10.3390/molecules24020355
- JoshiDD, Deb L, Somkuwar BG, Rana Relevance of Indian traditional tisanes in the management of type 2 diabetes mellitus: A review. Saudi Pharm J. 2023 May;31(5):626-38. doi: https://doi.org/10.1016/j.jsps.2023.03.003
- YeggoniDP, Rachamallu A, Subramanyam Comparative binding studies of bacosine with human serum albumin and α-1-acid glycoprotein biophysical evaluation and computational approach. J Pharm Biomed Anal. 2022 Feb 5;209:114478. doi: https://doi.org/10.1016/j.jpba.2021.114478
- JeyasriR, Muthuramalingam P, Suba V, Ramesh M, Chen Bacopa monnieri and Their Bioactive Compounds Inferred Multi-Target Treatment Strategy for Neurological Diseases: A Cheminformatics and System Pharmacology Approach. Biomolecules. 2020;10(4):536. doi: https://doi.org/10.3390/biom10040536
- WicińskiM, Fajkiel-Madajczyk A, Kurant Z, Gajewska S, Kurant D, Kurant M, et al. Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?-A Review. Cancers (Basel). 2024;16(7):1317. doi: https://doi.org/10.3390/cancers16071317
- DinizLRL, Calado LL, Duarte ABS, de Sousa Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential. Metabolites. 2023;13(2):276. doi: https://doi.org/10.3390/metabo13020276
- RoyS, Rakshit S, Shanmugam G, Sarkar Participation of Brahmi (Bacopa monnieri L.) plant in regulation of cancer. South African Journal of Botany.2024;168:236-45. doi: https://doi.org/10.1016/j.sajb.2024.03.017
- ZhanF, Song W, Fan Y, Wang F, Wang Cucurbitacin E Alleviates Colonic Barrier Function Impairment and Inflammation Response and Improves Microbial Composition on Experimental Colitis Models. J Inflamm Res. 2024;17:2745-56. doi: https://doi.org/10.2147/JIR.S456353
- ZhengX, Tang P, Li H, Ye T, Zhu X, He W, et al. Cucurbitacin E elicits apoptosis in laryngeal squamous cell carcinoma by enhancing reactive oxygen species-regulated mitochondrial dysfunction and endoplasmic reticulum stress. Am J Cancer Res. 2024 Aug 25;14(8):3905-21. doi: https://doi.org/10.62347/HPQQ9412
- SongH, Sui H, Zhang Q, Wang P, Wang Cucurbitacin E Induces Autophagy-Involved Apoptosis in Intestinal Epithelial Cells. Front Physiol. 2020;11:1020. doi: https://doi.org/10.3389/fphys.2020.01020
- HsuHL, Lin BJ, Lin YC, Tu CC, Nguyen NL, Wang CC, et al. Cucurbitacin E Exerts Anti-Proliferative Activity via Promoting p62-Dependent Apoptosis in Human Non-Small-Cell Lung Cancer A549 Cells. Curr Issues Mol 2023;45(10):8138-51. doi: https://doi.org/10.3390/cimb45100514
- ZieniukB, Pawełkowicz Recent Advances in the Application of Cucurbitacins as Anticancer Agents. Metabolites. 2023;13(10):1081. doi: https://doi.org/10.3390/metabo13101081
- LiuZ, Kumar M, Devi S, Kabra The Mechanisms of Cucurbitacin E as a Neuroprotective and Memory-Enhancing Agent in a Cerebral Hypoperfusion Rat Model: Attenuation of Oxidative Stress, Inflammation, and Excitotoxicity. Front Pharmacol. 2021 Dec 10;12:794933. doi: https://doi.org/10.3389/fphar.2021.794933
- ZhengS, Shi B, Li X, Yuan H, Feng Cucurbitacin E reduces the cognitive dysfunction induced by sevoflurane in rats by regulating NF-κB pathway. Acta Biochim Pol. 2022;69(2):387-91. doi: https://doi.org/10.18388/abp.2020_5817
- PercotA, Yalcin A, Aysel V, Erduğan H, Dural B, Güven Loliolide in marine algae. Nat Prod Res. 2009;23(5):460-5. doi: https://doi.org/10.1080/14786410802076069
- SunyamurthiIGNA, Jawi IM, Wijaya IN, Darmawati IAP, Suada IK, Krisnandika Phytochemical Analysis and Molecular Identification of Green Macroalgae Caulerpa spp. from Bali, Indonesia. Molecules. 2022;27(15):4879. doi: https://doi.org/10.3390/molecules27154879
- ReynoldsD, Huesemann M, Edmundson S, Sims A, Hurst B, Cady S, et al. Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis. Algal Res. 2021;57:102331. doi: https://doi.org/10.1016/j.algal.2021.102331
- FernandoIPS, Dias MKHM, Madusanka DMD, Kim HS, Han EJ, Kim MJ, et al. Effects of (-)-Loliolide against Fine Dust Preconditioned Keratinocyte Media-Induced Dermal Fibroblast Inflammation. Antioxidants (Basel). 2021;10(5):675. doi: https://doi.org/10.3390/antiox10050675
- ChoDH, Yun JH, Heo J, Lee IK, Lee YJ, Bae S, et al. Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052. J Microbiol Biotechnol. 2023;33(9):1250-6. doi: https://doi.org/10.4014/jmb.2304.04044
- SilvaJ, Alves C, Martins A, Susano P, Simões M, Guedes M, et al. Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum. Int J Mol Sci. 2021;22(4):1888. doi: https://doi.org/10.3390/ijms22041888
- HarahapU, Syahputra RA, Ahmed A, Nasution A, Wisely W, Sirait ML, et al. Current insights and future perspectives of flavonoids: A promising antihypertensive approach. Phytother 2024;38(6):3146-68. doi: https://doi.org/10.1002/ptr.8199
- Ahmed SS, Rahman MO, Alqahtani AS, Sultana N, Almarfadi OM, Ali MA, et al. Anticancer potential of phytochemicals from Oroxylum indicum targeting Lactate Dehydrogenase A through bioinformatic approach. Toxicol 2022;10:56-75. doi: https://doi.org/10.1016/j.toxrep.2022.12.007
- Mehta J, Utkarsh K, Fuloria S, Singh T, Sekar M, Salaria D, et al. Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens-An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections. Molecules. 2022;27(15):4971. doi: https://doi.org/10.3390/molecules27154971
- Geetha PS, Kanchana S, Pasupathi E, Murugan M, Rohini C. A review on putative mechanism of action of nootropic herb Bacopa monnieri. Pharma Innovation. 2021;10(5):672-81.
- Nikitina OO, Robak AYu, Tsyba DS. [Innovative approaches to the use of medicinal plants in modern pharmaceuticals]. Tekhnolohii ta inzhynirynh. 2024;2:110-26. doi: https://doi.org/10.30857/2786-5371.2024.3.9
- Muchhara J, Vachhani K, Dave S, Patel R, Lavle N, Kukadia D, et al. Safety evaluation of the genotoxicity and subchronic toxicity of standardized Bacopa extract (Bacognize®) from Bacopa monnieri. Toxicology Research and Application. 2023;7:23978473231162859. doi: https://doi.org/10.1177/2397847323116285
- Valotto Neto LJ, Reverete de Araujo M, Moretti Junior RC, Mendes Machado N, Joshi RK, Dos Santos Buglio D, et al. Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis. Antioxidants(Basel). 2024;13(4):393. doi: https://doi.org/10.3390/antiox13040393
- Slobodin T. Comprehensive metabolic correction in cognitive impairment: theoretical background for using citicoline and Bacopa monnieri combination. International neurological 2021;16(7):48-54. doi: https://doi.org/10.22141/2224-0713.16.7.2020.218247
- Mishchenko TS, Sokolik VV, Mishchenko VM, et al. [New opportunities in the treatment of patients with dyscirculatory encephalopathy: emphasis on nerve growth factor]. Psykhiatriia, nevrolohiia ta medychna psykholohiia.2020;13:79-88. doi: https://doi.org/10.26565/2312-5675-2020-13-11
- Sukhonosova OYu, Koreniev SM, Prykhodko TM, et al. [Optimizing the correction of sleep, speech and cognitive development disorders in children due to perinatal damage to the central nervous system]. Psykhiatriia, nevrolohiia ta medychna psykholohiia. 2020;15:64-72.
doi: https://doi.org/10.26565/2312-5675-2020-15-07
- SuperPred, which is a prediction webserver for ATC code and target predicition of compounds [Internet]. SuperPred. 2024 Jul 22 [cited 2024 Apr 22 ]. Available from: https://prediction.charite.de/
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Sychov O.S., Stasyshena O.V. Clinical course of atrial fibrillation in patients who experienced coronavirus disease (COVID-19): results of a 6-month follow-up
https://doi.org/10.26641/2307-0404.2024.3.313515
Abstract
Atrial fibrillation (AF) is the most common extrapulmonary complication of the past SARS-CoV-2 infection. According to experts, almost 20% of patients with past COVID-19 have a history of atrial fibrillation and the incidence of new paroxysms of this arrhythmia ranges from 10 to 18%. Referring to the studied patients who experienced COVID-19 more than 6 months ago, the subjective perception of cardiac arrhythmia is the most frequent complaint, reported by approximately two-thirds of patients. The aim of our study was to determine the course of atrial fibrillation in patients after past 2019 coronavirus disease (COVID-19) during a dynamic 6-month follow-up after the initial hospitalization for atrial fibrillation in the specialized department of cardiac arrhythmias of the SI “National Scientific Center” “M.D. Strazhesko Institute of cardiology, clinical and regenerative medicine of the National Academy of Medical Sciences of Ukraine” depending on the clinical and anamnestic, demographic, anthropometric factors, the results of laboratory research methods and the received treatment. 36 patients were included in the study, 27 of them formed the first group, which included patients in whom the course of atrial fibrillation improved against the background of recommended antiarrhythmic treatment after initial hospitalization for AF and past COVID-19, who at the time of hospitalization had a negative PCR test, of which 17 were women and 10 were men, aged 62.38±1.83 years. The second group consisted of 9 patients including 4 women and 5 men, aged 69.88±2.60 years in whom the course of atrial fibrillation neither changed nor worsened. We determined that the number of patients in whom the course of atrial fibrillation improved during the 6-month follow-up was three times greater than those in whom the course of this arrhythmia neither changed nor worsened (75% and 25%, respectively). Patients with a more favorable course of atrial fibrillation were younger (on average by 7.5 years), three times less likely to suffer from diabetes and not often had arterial hypertension of the III stage, than those examined, in whom the course of this arrhythmia did not change or worsen. Systemic inflammation and severity of heart failure significantly worsen the course of AF within 6 months after the hospital stage of treatment. However signs of deterioration of lipid metabolism are characteristic of patients with an unfavorable course of atrial fibrillation during 6 months after hospitalization, which is probably caused by the activation of systemic inflammation in them. The improvement of the prognosis of the examined patients was probably influenced by the appointment of antiarrhythmic drugs, such as: amiodarone, flecainide, beta-blockers, statins – from the "up-stream" therapy drugs.
Key words: arterial fibrillation, coronavirus disease, arterial hypertension, systemic nflammation, thrombosis, bleeding, heart failure
References
- Gunawardene MA, Willems S. Atrial fibrillation progression and the importance of early treatment for improving clinical outcomes. Europace. 2022;24(2):1122-8. doi: http://doi.org/10.1093/europace/euab257
- Donniacuo M, De Angelis A, Rafaniello C, Cianflone E, Paolisso P, Torella D, et al. COVID-19 and atrial fibrillation: Intercepting lines. Front Cardiovasc Med. 2023;10(1):1-8. doi: http://doi.org/10.3389/fcvm.2023.1093053
- Gupta A, Madhavan M, Sehgal K, Nair N, Mahajan S, Sehrawat T, et al. Extrapulmonary manifestations of COVID-19. 2020;26(7):1017-32. doi: http://doi.org/10.1038/s41591-020-0968-3
- Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et. al. Attributes and predictors of long COVID. 2021;27(4):626-31. doi: http://doi.org/10.1038/s41591-021-01292-y
- Barron E, Bakhai C, Kar P. Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol. 2020;8(1):813-22. doi: http://doi.org/10.1016/S2213-8587(20)30272-2
- Sychov OS, Stasyshena OV. [The influence of a transferred infection of COVID-19 on the development of atrial fibrillation and changes in its course depending on clinical and anamnestic data]. Ukrainskyi kardiolohichnyi zhurnal. 2023;30(5-6):31-9. Ukrainian. doi: https://doi.org/10.31928/2664-4479-2023.5-6.3139
- Mohammad M, Emin M, Bhutta A, Gul EH, Voorhees E, Afzal MR. Cardiac arrhythmias associated with COVID-19 infection: state of the art review. Expert Rev Cardiovasc Ther. 2021;19(10):881-9. doi: https://doi.org/10.1080/14779072.2021.1997589
- Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62. doi: https://doi.org/10.1016/S0140-6736(20)30566-3
- Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498. doi: https://doi.org/10.1093/eurheartj/ehaa612
- Ibdah R, Obeidat O, Khader Y, Al-Nusair J, Abusurrah O, Obeidat A, et al. Validation of CHA2DS2 VASc Score Predictability of Stroke and Systemic Embolization in a Middle Eastern Population with AF: The Jordan Atrial Fibrillation (JoFib) Study. Vasc Health Risk Manag. 2023;19(1):255-64. doi: https://doi.org/10.2147/VHRM.S404575
- Abowali H, Pacifico A, Erdinc B, Elkholy K, Burkhanova U, Aroriode T, et al. Assessment of Bleeding Risk in Hospitalized COVID-19 Patients: A Tertiary Hospital Experience during the Pandemic in a Predominant Minority Population—Bleeding Risk Factors in COVID-19 Patients. J Clin Med. 2022;11(1):27-54. doi: https://doi.org/10.3390/jcm11102754
- Sweatt K, Garvey WT, Martins C. Strengths and Limitations of BMI in the Diagnosis of Obesity: What is the Path Forward? Curr Obes Rep. 2024;13(3):584-95. doi: https://doi.org/10.1007/s13679-024-00580-1
- McElroy E, Herrett E, Patel K, Piehlmaier DM, Gessa GD, et al. Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic. BMJ Ment Health. 2023;26(1):300842. doi: https://doi.org/10.1136/bmjment-2023-300842
- Huseynov A, Akin I, Duerschmied D, Scharf RE. Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment. Viruses. 2023;15(2):389. doi: https://doi.org/10.3390/v15020389
- Yong SJ. Long COVID or post-COVID-19 syndrome: putativepathophysiology, risk factors, and treatments. Infect Dis (Lond). 2021;53(10):737-54. doi: https://doi.org/10.1080/23744235.2021.1924397
- Thompson EJ, Williams DM, Walker AJ, Mitchell RE, Niedzwiedz CL, Yang TC, et al. Long COVID burden and risk factors in 10 UK longitudinalstudies and electronichealthrecords. Nat Commun. 2022;13(1):3528. doi: https://doi.org/10.1038/s41467-022-30836-0
- Al-Aly Z, Xie Y, Bowe B. High-dimensional characterization of post-acute sequelae of COVID-19. Nature. 2021;594(7862):259-64. doi: https://doi.org/10.1038/s41586-021-03553-9
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Sychov O.S. SI “National Scientific Center “M.D. Strazhesko Institute of cardiology, clinical and regenerative medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0001-8432-7403
Stasyshena O.V. SI “National Scientific Center “M.D. Strazhesko Institute of cardiology, clinical and regenerative medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-2992-4640
Cite
Sychov O.S., Stasyshena O.V. Clinical course of atrial fibrillation in patients who experienced coronavirus disease (COVID-19): results of a 6-month follow-up. Medicni perspektivi. 2024;29(3):59-67. DOI: https://doi.org/10.26641/2307-0404.2024.3.313515
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Bahan U.R., Kovalchuk R.A., Svitlyk H.V. Ventricular arrhythmias occurring in myocardial infarction patients with acute ST-segment elevation within the first 24 hours after primary percutaneous coronary intervention and their prognostic value
https://doi.org/10.26641/2307-0404.2024.3.313516
Abstract
Reperfusion therapy in myocardial infarction patients with acute ST-segment elevation significantly reduced the frequency of ventricular tachycardia and ventricular fibrillation, however, such arrhythmias still occur in 6-8% of patients, posing a threat to their lives.The aim of the study was to determine the nature of ventricular arrhythmias occurring in myocardial infarction patients with acute ST-segment elevation within the first 24 hours after primary percutaneous coronary intervention, and their prognostic value regarding the development of complications during the inpatient treatment phase. The study involved 82 individuals (mean age: 62,4±10,2 years; male: 69,23 (58,6-78,92)%, female: 30,77 (21,08-41,4)%). Within 24 hours after the infarct-related artery stenting, all patients underwent a 24-hour Holter ECG monitoring. The course of the disease was analyzed based on the presence of risk factors such as hypertension, diabetes mellitus, past COVID-19, and obesity. Ventricular rhythm disturbances were represented mainly by premature contractions. They occurred significantly more frequently in patients with arterial hypertension (883,71 (96,0; 986.0); p=0,02; p=0,03; p=0,02, compared to patients with a history of COVID-19, diabetes, and obesity, respectively) and in those with past COVID-19 (711,3 (125,0; 846,5); p=0,01; p=0,04, compared to individuals with diabetes and obesity, respectively). Isolated premature ventricular complexes, pairs, triplets were recorded, and in individuals with arterial hypertension and past COVID-19 “runs” of ventricular extrasystoles and episodes of nonsustained monomorphic and even polymorphic ventricular tachycardia, such as Torsades de Pointes, (under the condition of combined risk factors) were noted; predominantly in these patients during the hospital phase such сomplications as ventricular fibrillation and asystole,with sudden cardiac arrest developed. The obtained results is an evidence of electrical myocardial instability and indicate that myocardial infarction patients with acute ST-segment elevation, in addition to myocardial revascularization, require optimization of pharmacological treatment. The use of intravenous beta-blockers as part of complex treatment prevented the occurrence of life-threatening ventricular arrhythmias during the inpatient treatment phase.
Key words: acute myocardial infarction with ST-segment elevation, risk factors, primary percutaneous coronary intervention, daily electrocardiogram monitoring, ventricular arrhythmias, prognostic value
References
- Kyselov SM. [Clinical features of the acute period of myocardial infarction with ST segment elevation in patients after reperfusion therapy]. Zaporozhye medical journal.2020;22,5(122):597-603. doi: https://doi.org/10.14739/2310-1210.2020.5.214720
- Badiuk NV, Hrebenyk MV. [Cardiac arrhythmias in patients with acute myocardial ischemia, which developed on the background of comorbid hypertension and diabetes]. Bulletin of Medical and Biological Research. 2021;1:5-9. Ukrainian. doi: https://doi.org/10.11603/bmbr.2706-6290.2021.1.11789
- Makino T, Ichikawa T, Amino M, Nakamura M, Koshikawa M, Motoike Y, et al. Prognostic significance of the Holter-derived T-wave variability in patients with ventricular tachyarrhythmias complicating acute coronary syndrome-TWIST study. Ann Noninvasive Electrocardiol. 2023;28(6):e13069. doi: https://doi.org/10.1111/anec.13069
- Byrne R, Rossello X, Coughlan J, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC). European Heart 2023;44(38):3720-3826. doi: https://doi.org/10.1093/eurheartj/ehad191
- Liang JJ, Fender EA, Cha Y-M, Lennon RJ, Prasad A, Barsness GW. Long-term outcomes in survivors of early ventricular arrhythmias after acute st-elevation and non–st-elevation myocardial infarction treated with percutaneous coronary intervention. Am J Cardiol. 2016;117(5):709-13. doi: https://doi.org/10.1016/j.amjcard.2015.12.002
- Masuda M, Nakatani D, Hikoso S, Suna S, Usami M, Matsumoto S. Clinical impact of ventricular tachycardia and/or fibrillation during the acute phase of acute myocardial infarction on in-hospital and 5-year mortality rates in the percutaneous coronary intervention era. Circ J. 2016;80(7):1539-47.
doi: https://doi.org/10.1253/circj.CJ-16-0183
- Mehta RH, Yu J, Piccini JP, Tcheng JE, Farkouh ME, Reiffel J. Prognostic significance of postprocedural sustained ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention (from the horizons-ami trial). Am J Cardiol. 2012;109(6):805-12. doi: https://doi.org/10.1016/j.amjcard.2011.10.043
- Khederlou H, Azimi Pirsaraei SV, Rabbani E, Motedayen M. Correlations between cardiovascular risk factors and ventricular arrhythmias following primary percutaneous coronary intervention in patients with st-elevation myocardial infarction. J Tehran Heart Cent. 2023;2(18):122-8. doi: https://doi.org/10.18502/jthc.v18i2.13322
- Deshmukh T, Kovoor JG, Byth K, Chow CK, Zaman S, Chong JH, et al. Influence of standard modifiable risk factors on ventricular tachycardia after myocardial infarction. Front Cardiovasc Med. 2023;24:10. doi: https://doi.org/10.3389/fcvm.2023.1283382
- Kalarus Z, Svendsen JH, Capodanno D, Dan GA, De Maria E, Gorenek B, et al. Cardiac arrhythmias in the emergency settings of acute coronary syndrome and revascularization: an European Heart Rhythm Association (EHRA) consensus document, endorsed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Acute Cardiovascular Care Association (ACCA). Europace. 2019;21(10):1603-4. doi: https://doi.org/10.1093/europace/euz163
- Frampton J, Ortengren AR, Zeitler EP. Аrrhythmias after acute myocardial infarction. Yale J Biol Med. 2023;96(1):83-94. doi: https://doi.org/10.59249/LSWK8578
- Nalliah CJ, Zaman S, Narayan A, Sullivan J, Kovoor P. Coronary artery reperfusion for ST elevation myocardial infarction is associated with shorter cycle length ventricular tachycardia and fewer spontaneous arrhythmias. EP 2014;16(7):1053-60. doi: https://doi.org/10.1093/europace/eut307
- Pandozi C, Mariani MV, Chimenti C, Maestrini V, Filomena D, Magnocavallo M, et al. The scar: the wind in the perfect storm-insights into the mysterious living tissue originating ventricular arrhythmias. J Interv Card Electrophysiol. 2023;66(1):27-38. doi: https://doi.org/10.1007/s10840-021-01104-w
- Zhao BH, Ruze A, Zhao L, Li QL, Tang J, Xiefukaiti N, et al. The role and mechanisms of microvascular damage in the ischemic myocardium. Cell Mol Life Sci. 2023;80(11):341.
doi: https://doi.org/10.1007/s00018-023-04998-z
- Faxén J, Xu H, Evans M, Jernberg T, Szummer K, Carrero JJ. Potassium levels and risk of in-hospital arrhythmias and mortality in patients admitted with suspected acute coronary syndrome. Int J Cardiol. 2019;1(274):52-8. doi: https://doi.org/10.1016/j.ijcard.2018.09.099
- Podolecki TS, Lenarczyk RK, Kowalczyk JP, Jedrzejczyk-Patej EK, Chodor PK, Mazurek MH, et al. Risk stratification for complex ventricular arrhythmia complicating ST-segment elevation myocardial infarction. Coron Artery 2018;29(8):681-6. doi: https://doi.org/10.1097/MCA.0000000000000662
- Xu X, Wang Z, Yang J, Fan X, Yang Y. Burden of cardiac arrhythmias in patients with acute myocardial infarction and their impact on hospitalization outcomes: insights from China acute myocardial infarction (CAMI) registry. BMC Cardiovasc Disord. 2024;24(1):218. doi: https://doi.org/10.1186/s12872-024-03889-w
- Piers S, Wijnmaalen A, Borleffs C, van Huls, van Taxis C, Thijssen J, et al. Early reperfusion therapy affects inducibility, cycle length, and occurrence of ventricular tachycardia late after myocardial infarction. Circ Arrhythm Electrophysiol.2011;4(2):195-201. doi: https://doi.org/10.1161/CIRCEP.110.959213
- Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death developed by the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). European Heart Journal. 2022;43(40):3997-4126. doi: https://doi.org/10.1093/eurheartj/ehac262
- Gorenek B, et al. Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force. Europace. 2019;21(10):1518. doi: https://doi.org/10.1093/europace/euz242
- Majidi M, Kosinski AS, Al-Khatib SM, Lemmert ME, Smolders L, van Weert A, et al. Reperfusion ventricular arrhythmia 'bursts' predict larger infarct size despite TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction. Eur Heart J.2009;7(30):757-64. doi: https://doi.org/10.1093/eurheartj/ehp005
- Sau A, Kaura A, Ahmed A, Patel KK, Li X, Mulla A, et al. Prognostic significance of ventricular arhythmias in 13 444 patients with acute coronary syndrome: a retrospective cohort study based on routine clinical data (NIHR health informatics collaborative VA-ACS study). J Am Heart Assoc. 2022;11(6):e024260. doi: https://doi.org/10.1161/JAHA.121.024260
- Kovoor JG, Deshmukh T, von Huben A, Marschner SL, Byth K, Chow CK, et al. Optimizing electrophysiology studies to prevent sudden cardiac death after myocardial infarction. Europace. 2023;25(7):219. doi: https://doi.org/10.1093/europace/euad219
- Deshmukh T, Zaman S, Narayan A, Kovoor P. Duration of inducible ventricular tachycardia early after st-segment-elevation myocardial infarction and its impact on mortality and ventricular tachycardia recurrence. J Am Heart Assoc. 2020;9(13):e015204. doi: https://doi.org/10.1161/JAHA.119.015204
- Terkelsen CJ, Sørensen JT, Kaltoft AK, Nielsen SS, Thuesen L, Bøtker HE, et al. Prevalence and significance of accelerated idioventricular rhythm in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Am J Cardiol.2009;104(12):1641. doi: https://doi.org/10.1016/j.amjcard.2009.07.037
- Rymer JA, Wegermann ZK, Wang TY, Li S, Smilowitz NR, Wilson BH, et al. Ventricular arrhythmias after primary percutaneous coronary intervention for STEMI. JAMA New Open. 2024;7(5):e2410288. doi: https://doi.org/10.1001/jamanetworkopen.2024.10288
- Chang H, Chen E, Zhu T, Liu J, Chen C. Communication regarding the myocardial ischemia/reperfusion and cognitive impairment: a narrative literature review. J Alzheimers 2024;4(97):1545-70. doi: https://doi.org/10.3233/JAD-230886
- Silva RR, Magalhães CJ, Silva RD, Tavares de Albuquerque AL, Montenegro ST, Alencar Neto JN. Accelerated idioventricular rhythm as anginous substrate in elderly: Report of an unprecedented case. HeartRhythm Case 2023;10(3):217-21. doi: https://doi.org/10.1016/j.hrcr.2023.12.014
- Wu P, Han Y, Chen T, Tu XM. Causal inference for Mann-Whitney-Wilcoxon rank sum and other nonparametric statistics. Stat Med. 2014;33(8):1261-71. doi: https://doi.org/10.1002/sim.6026
- Neely JG, Hartman JM, Forsen JW Jr, Wallace MS. Tutorials in clinical research: VII. Understanding comparative statistics (contrast) — part B: application of T-test, Mann-Whitney U, and chi-square. Laryngoscope. 2010;10(113):1719-25. doi: https://doi.org/10.1097/00005537-200310000-00011
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Bahan U.R., Kovalchuk R.A., Svitlyk H.V. Ventricular arrhythmias occurring in myocardial infarction patients with acute ST-segment elevation within the first 24 hours after primary percutaneous coronary intervention and their prognostic value. Medicni perspektivi. 2024;29(3):68-77. DOI: https://doi.org/10.26641/2307-0404.2024.3.313516
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Chaika V.O., Karpenko S.I., Zavizion E.M. Clinical symptoms of combined abdominal and thoracic trauma in peacetime
https://doi.org/10.26641/2307-0404.2024.3.313518
Abstract
Combined thoracic and abdominal trauma is considered one of the most severe in the structure of polytrauma, which causes a high frequency of complications – 33-72% and a mortality rate of up to 34%. The purpose of the study was to ensure the quality of the provision of medical services to victims with combined abdominal and thoracic trauma, through clinical assessment of the most significant symptoms and systematization of their manifestations aimed at justifying diagnostic and treatment measures. We conducted a prospective analysis of clinical manifestations in 44 victims with combined abdominal and thoracic trauma, who were treated at the city clinical hospital 16 of Dnipro in the period from 2019 to 2023. The average age of the victims was 41.5±2.4 years, men predominated – 40 (90.9%) people. In 40 (90.9%) victims, only 2 anatomical sites were damaged, 3 anatomical sites were damaged in 3 (6.8%) victims, 4 or more anatomical sites were damaged in 1 (2.3%) injured person. All victims were operated on. Multiple injuries of abdominal organs were observed in 14 (31.2%) victims. Among the injuries of the chest cavity, the most common cause was a lung contusion – 36.4% of cases. Exclusion criteria from the study were craniocerebral injury and contusion or injury to the heart as components of a combined injury. Also, the study did not include victims who received resuscitation measures during admission or at the stage of emergency care. Collection of complaints and anamnesis, examination, palpation, percussion and auscultation were used as research methods. The obtained information made it possible to determine the sequence of use of hardware and instrumental diagnostic methods. For better systematization of clinical symptoms, the latter were divided into three components – abdominal, thoracic and hemodynamic. The most frequent complaint was pain in the abdomen and in the chest area, respectively 75.6% and 82.9%. In the structure of the hemodynamic component, the victims most often complained of a feeling of general weakness – 73.2%. The accuracy of the symptoms detected during the diagnosis of damage to the abdominal organs ranged from 6.8% (Kulenkampf's symptom) to 93.2% pain of the abdominal wall. The diagnostic accuracy of Rozanov's symptom, which indicated damage to the spleen was 68.2%. Despite the fact, that such a symptom as pain during palpation of the chest occurred in 81.8% of victims, its diagnostic efficiency remains quite low – 54.5%. On the other hand, such a symptom as bone crepitation, with an accuracy of 95.5%, allowed us to assert the presence of rib fractures in the victims and hint at the probability of injury to the chest or abdominal organs, which we observed in 44.4% and 88.9% of cases, respectively. Damage to the lungs was also ascertained due to the sufficiently high diagnostic accuracy of the auscultatory symptom – weakening of breathing – 70.5%. Hypotension below 90 mm Hg. (45%; 50%), tachycardia (81.8%; 59.1%) and pallor of the skin (56.8%; 65.9%) showed sufficiently high diagnostic accuracy during the diagnosis of possible intraabdominal and intrapleural bleeding, respectively. The combination of damage to the organs of the abdominal and thoracic cavities was characterized by multifaceted clinical manifestations and signs of multisymptoms. Most of the symptoms taken separately had low accuracy regarding the presence or absence of a certain intracavitary post-traumatic pathology (from 6.8% to 43.2%); however, the combination of several of them indicated the multiplicity of damage to the organs of the abdominal cavity (from 41.7% to 100%). The best diagnostic accuracy was shown by Rozanov's symptoms – 68.2%, which indicated damage to the spleen and crepitation of rib fragments – 95.5%, as well as auscultatory weakening of breathing – 70.5%, which indicated lung damage.
Key words: clinical symptoms, combined trauma, injury, diagnostic accuracy
References
- Leenellett E, Rieves A. Occult abdominal trauma. Emergency Medicine Clinics of North America. 2021 Nov;39(4):795-806. doi: https://doi.org/10.1016/j.emc.2021.07.009
- Tang A, Chehab M, Ditillo M, Asmar S, Khurrum M, Douglas M, et al. Regionalization of trauma care by operative experience: Does the volume of emergent laparotomy matter? Journal of Trauma and Acute Care Surgery. 2020 Sept 14;90(1):11-20. doi: https://doi.org/10.1097/TA.0000000000002911
- Hietbrink F, Smeeing D, Karhof S, Jonkers HF, Houwert M, van Wessem K, et al. Outcome of trauma-related emergency laparotomies, in an era of far-reaching specialization. World Journal of Emergency Surgery. 2019 Aug 14;14(1):40. doi: https://doi.org/10.1186/s13017-019-0257-y
- Klygunenko OM, Krishtafor DA, Yovenko IO. Influence of qualitative and quantitative changes of blood replacement on manifestations of multiple organ dysfunction syndrome in multiple trauma. Emergency medicine.2022 Jan 27;(5.84):91-9. doi: https://doi.org/10.22141/2224-0586.5.84.2017.109366
- Trutyak IR, Zarutskyi YL, Trutyak RI, Kalinovich NR, Obaranets OV. [Polytrauma and combined trauma: what is common and what are the differences?] Trauma.2019;20(5):97-101. doi: https://doi.org/10.22141/1608-1706.5.20.2019.185563
- Shojaee M, Sabzghabaei A, Heidari A. Efficacy of new scoring system for diagnosis of abdominal injury after blunt abdominal trauma in patients referred to emergency department. Chin J Traumatol. 2020 Jun;23(3):145-8. doi: https://doi.org/10.1016/j.cjtee.2020.03.003
- Girard E, Jegousso Q, Boussat B, François P, Ageron F-X, Letoublon C, et al. Preventable deaths in a French regional trauma system: A six-year analysis of severe trauma mortality. Journal of Visceral Surgery. 2019 Feb;156(1):10-6. doi: https://doi.org/10.1016/j.jviscsurg.2018.05.002
- Hogia MO. [Structure of abdominal injury and its consequences]. J VN Karazin Khark Nat Univ. Ser.: Med. 2021 Jun 30;42. Ukrainian. doi: https://doi.org/10.26565/2313-6693-2021-42-05
- Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. 2nd ed. Kyiv: Medinform; 2017. 578 р. Ukrainian.
- Boyko OV, Volkova YuV, Zamiatin PM, Litvishko VO, Tkachuk OYu. Zamiatin DP. [Diagnosis of post-traumatic disorders according to laboratory and instrumental research data in patients with combined thoracic trauma (literature review)]. Kharkiv surgical school. 2020;5-6:55-60. Ukrainian. doi: https://doi.org/10.37699/2308-7005.5-6.2020.10
- Zaporozhan SY, Khomenko VS. [Abdominal injury (literature review)]. Hospital surgery. Journal named by L.Ya. Kovalchuk. 2020;4:99-107. Ukrainian. doi: https://doi.org/10.11603/2414-4533.2020.4.11793
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Aslanyan S.A., Bily V.Ya., Sobko I.V., Davidyuk M.M. Abdominal vacuum therapy is a component of DAMAGE CONTROL SURGERY tactics for combat trauma to the abdomen
https://doi.org/10.26641/2307-0404.2024.3.313568
Abstract
The goal of the study was to improve the outcomes of surgical care and treatment for patients with combat-related abdominal injuries at different levels of medical support during combat operations by using abdominal vacuum therapy as a component of Damage Control Surgery tactics. At the II level of combat medical support within the Damage Control Surgery tactics, abdominal vacuum therapy was applied to 75 wounded male combatants with a combat abdominal injury, aged 37.4±8.3 years (main group). The comparison group consisted of 87 wounded patients aged 37.5±10.2 years, operated on using Damage Control Surgery tactics with drainage of the abdominal cavity and suturing of the skin only. 40.0% of the wounded in the main group and 46.0% of the comparison group were admitted with signs of traumatic shock of various degrees. According to the AdTS scale, 78.7% of the wounded in the main group were admitted in a serious condition, 21.3% – in an extremely serious condition; in the comparison group, 74.7% were in severe condition, 25.3% were in extremely severe condition. In 57.3% of the wounded of the main group, abdominal vacuum therapy was carried out in the irrigation-flow mode. 24.0% used standard bandages for abdominal vacuum therapy, 76.0% used partially improvised ones. The level of negative pressure was set in the range of 40-125 mm Hg in constant mode. Intra-abdominal pressure was measured by a standard method (through the bladder) at admission and after surgery. The assessment of the state of the abdominal cavity in the I and III phases of Damage Control Surgery was carried out according to the Abdominal Cavity Index scale – an integral assessment expressed in points based on factors that can be assessed visually during surgery. The volume of surgical interventions in the 1st phase of the Damage Control Surgery tactic depended on the nature of the damage to the abdominal organs and the condition of the wounded. After the completion of Phase I of Damage Control Surgery tactics, all wounded were evacuated by road medical transport and medical helicopters to the next level of medical support, with abdominal vacuum therapy during evacuation in the main group and Damage Control Resuscitation measures. Under the effect of abdominal vacuum therapy, the reduction of intra-abdominal pressure in the main group was pronounced (Δ=9.2; p<0.01) than in the comparison group (Δ=6.1; p<0.01). Abdominal vacuum therapy during the II phase of the Damage Control Surgery tactic made it possible to clean the abdominal cavity better (p<0.0001) than in the comparison group and provided better preparation for the implementation of the III phase of this tactic. As a result, reliable protection from external factors, active prevention of intra-abdominal pressure and rehabilitation of the abdominal cavity during the application of abdominal vacuum therapy during the II phase of Damage Control Surgery tactics in the main group of wounded after obstructive resections of the small intestine in the I phase made it possible to completely abandon terminal stomas in the III phase (in the comparison group – 5) in favor of the formation of small bowel intestinal anastomoses, and during obstructive colon resections, the number of terminal colostomas in the main group was reduced to 50.0% (in the comparison group -90.9%, р=0.004), also in favor of the formation anastomoses, which significantly improved the functional results of providing assistance to the wounded with a combat abdominal injury. The use of abdominal vacuum therapy during phases I-II of the Damage Control Surgery (DCS) tactics allows for the optimization of the scope of surgical interventions in phase III of Damage Control Surgery and significantly improves the functional outcomes of surgical care and treatment for patients with combat abdominal injuries at various levels of medical support during combat operations.
Key words: abdominal VAC-therapy, DCS tactics, combat abdominal trauma
References
- Skoroplit SM, Mykhnevich KG, Zamyatin PM, Khoroshun EM, Borodai VO, Tertyshny SV, et al. [Features of modern combat trauma and the organization of medical care]. Kharkivska khirurhichna shkola. 2022 Dec 30;6:51-3. doi: https://doi.org/10.37699/2308-7005.6.2022.10
- Zarutskyi YaL, Klishevych BA, Poleizjaev GO. [Combat closed abdominal trauma, diagnosis and treatment at the stages of medical and evacuation support]. Viiskova medytsyna Ukrainy. 2019;19(3):46-55.
- Polovyi VP, Railyanu SI, Palyanitsa AS, Chepega IG. [Application of "damage control" tactics in surgical treatment of victims with severe abdominal trauma]. Shpytalna khirurhiia. 2020;(3),63-9. doi: https://doi.org/10.11603/2414-4533.2020.3.11463
- Boychak MP, Yurchenko BV, Moshkivskyi VM, Fedorova OO. Development of the principles of treatment of patients with gunshot wounds according to the modern strategy of Damage Control Resuscitation. Ukrainskyi zhurnal viiskovoi medytsyny. 2022;2(3):120-8. Ukrainian. doi: https://doi.org/10.46847/ujmm.2022.2(3)-120
- Rotondo MF, Schwab CW, McGonigal MD, Phillips GR, Fruchterman TM, Kauder DR. “Damage control”: an approach for improved survival in exsanguinating penetrating abdominal injury. Journal Trauma. 1993;35(3):375-82. doi: https://doi.org/10.1097/00005373-1993000-00008
- Hirshberg A, Walden R. Damage Control for abdominal trauma. Surgical Clinics of North America. 1997;4(77):813-20.
doi: https://doi.org/10.1016/S0039-6109(05)70586-7
- Volpin G, Pfeifer R, Saveski J, Hasani I, Cohen M, Pape HC. Damage control orthopaedics in polytraumatized patients – current concepts. Journal of Clinical Orthopaedics and Trauma. 2021;12(1):72-82. doi: https://doi.org/10.1016/j.jcot.2020.10.018
- Coccolini F, Montori G, Ceresoli M, Catena F, Ivatury R, Sugrue M, et. al. IROA: International Register of Open Abdomen, preliminary results. World Journal of Emergency Surgery. 2017;(12):10. doi: https://doi.org/10.1186/s13017-017-0123-8
- Roberts DJ, Bobrovitz N, Zygun DA, Kirkpatrick AW, Ball CG, Faris PD. Evidence for use of damage control surgery and damage control interventions in civilian trauma patients: a systematic review. World Journal of Emergency Surgery. 2021;16(1):10. doi: https://doi.org/10.1186/s13017-021-00352
- Pfeifer R, Pape HC. Trends in nomenclature to describe concepts in trauma patients: time for standardization. Injury.2020;51(11):2353-5. doi: https://doi.org/10.1016/j.injury.2020.10.061
- Padar M, Reintam BA, Talving P, Lipping E, Starkopf J. Abdominal Compartment Syndrome: Improving Outcomes With A Multidisciplinary Approach – A Narrative Review. J Multidiscip Healthc. 2019;12:1061-74. doi: https://doi.org/10.2147/JMDH.S205608
- Pape HC, Halvachizadeh S, Leenen L, Velmahos GD, Buckley R, Giannoudis PV. Timing of major fracture care in polytrauma patients - An update on principles, parameters and strategies for 2020. Injury. 2019;50(10):1656-70. doi: https://doi.org/10.1016/j.injury.2019.09.021
- Loftus TJ, Efron PA, Bala TM, Rosenthal MD, Croft CA, Walters MS, et al. The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy. J Trauma Acute Care Surg. 2019;86:670-8. doi: https://doi.org/10.1097/TA.0000000000002170
- Roberts DJ, Leppäniemi A, Tolonen M, Mentula P, Björck M, Kirkpatrick AW, et al. The open abdomen in trauma, acute care, and vascular and endovascular surgery: comprehensive, expert, narrative review. BJS Open.2023;7(5):zrad084. doi: https://doi.org/10.1093/bjsopen/zrad084
- Fernández Treatment of Complex Thoracic and Abdominal Trauma Patients: A Review of Literature and Negative Pressure Wound Therapy Treatment Options. Advances in Wound Care. 2023;13(8):1-8. doi: https://doi.org/10.1089/wound.2023.0113
- Zarutskyi YaL, Aslanyan SA, Zhovtonozhko OI, Oliynyk YuM, Forostyany PP, Honcharuk VS, et al. [Anatomic-functional scale for assessing the severity of injury in the wounded with thoraco-abdominal injuries in the conditions of the Joint Forces Operation]. Clinical surgery. 2020;87(1-2):3-7. doi: https://doi.org/10.26779/2522-1396.2020.1-2.03
- Savelyev VS, Gelfand BR, Filimonov MI, Podachin PV, Sergeeva NA. [Criteria for choosing effective tactics for surgical treatment of widespread peritonitis]. Annals of Surgery. 2013;2:48-54. Russian.
- Antomonov MJ, Korobeinikov GV, Hmelnytska IV, Harkovliuk-Balakina NV. [Mathematical methods of processing and modeling the results of experimental research: a study guide]. Kyiv: Olimpiiska literatura; 2021. 216 p. Ukrainian.
- Crumley C. Abdominal Negative Pressure Wound Therapy Devices for Management of the Open Abdomen: A Technologic Analysis. Journal of Wound, Ostomy and Continence Nursing. 2022;49(2):124-7. doi: https://doi.org/10.1097/WON.0000000000000862
- Fernandez LG, Sibaja Alvarez P, Kaplan MJ, et al. Application of Negative Pressure Wound Therapy with Instillation and Dwell Time of the Open Abdomen: Initial Experience. Cureus.2019;11(9):e5667. doi: https://doi.org/10.7759/cureus.5667
- KocaaslanFND, Ozkan MC, Akdeniz Z, Sacak B, Erol B, Yuksel M, et al. Use of abdominal negative pressure wound therapy in different indications: a case series. Journal of Wound Care. 2019;28:4. doi: https://doi.org/10.12968/jowc.2019.28.4.240
- MansoorJ, Ellahi I, Junaid Z, Habib A, Ilyas Clinical evaluation of improvised gauze-based negative pressure wound therapy in military wounds. International Wound Journal. 2013;12(50):559-63. doi: https://doi.org/10.1111/iwj.12164
- Alhan D, Şahin I, Güzey S, Aykan A, Zor F, Öztürk S, et al. Staged repair of severe open abdomens due to high-energy gunshot injuries with early vacuum pack and delayed tissue expansion and dual-sided meshes. Turkish Journal of Trauma and Emergency Surgery. 2015;21(6):457-62. doi: https://doi.org/10.5505/tjtes.2015.05942
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Aslanyan S.A. Ukrainian Military Medical Academy, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-4122-775X
Bily V.Ya. Ukrainian Military Medical Academy, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0002-5731-7159
Sobko I.V. Ukrainian Military Medical Academy, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0003-9177-0237
Davidyuk M.M. Ukrainian Military Medical Academy, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0003-2941-1524
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Aslanyan S.A., Bily V.Ya., Sobko I.V., Davidyuk M.M. Abdominal vacuum therapy is a component of DAMAGE CONTROL SURGERY tactics for combat trauma to the abdomen. Medicni perspektivi. 2024;29(3):85-96. DOI: https://doi.org/10.26641/2307-0404.2024.3.313568
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Panaskin D.V., Stirenko S.H., Babko D.S. Respiratory disease detection in lung auscultation with convolutional neural networks and CVAE augmentation
https://doi.org/10.26641/2307-0404.2024.3.313569
Abstract
The main purpose of this work was to investigate the possibility of detecting respiratory diseases in audio recordings of lung auscultation using modern deep learning tools, as well as to explore the possibility of using data augmentation by generating synthetic spectral representations of audio samples. The ICBHI (International Conference on Biomedical and Health Informatics) dataset was used for training, validation and augmentation. The dataset includes lung auscultations of 126 different subjects, there are a total of 920 sounds, of which 810 have signs of chronic diseases, 75 of non-chronic diseases and 35 with no pathology. The stage of data preprocessing includes discretization to 4kHz frequency, as well as filtering of frequency bands that do not carry information value for the task. In the next step, each sample was transformed into a frequency spectrum and Melspectrograms were generated. To solve the problem of class imbalance, the required number of synthetic spectrograms generated by convolutional variation autoencoders was added. At the stage of building the model, the methods of classical convolutional neural networks were used. The quality of the obtained algorithm was evaluated using a 10-fold cross-validation. Also, to assess the generalization of the proposed method, experiments were performed with the split of audio recordings into training and test sets using patient grouping. Qualitative evaluation of the model was performed using sensitivity, specificity, F1-score and Cohen’s kappa. A score of 98.45% F1-score was achieved for the 5-class classification problem which can contribute to the development of ways to synthesize and augment sensitive medical data. In addition, a cons of existing methods in the generalization of the obtained predictions were revealed, which opens the way for further research in the direction of clinical respiratory diseases detection.
Key words: pulmonary diseases, lung sounds, deep learning, convolutional neural network, conditional variational auto encoder
References
- Abbas A, Fahim A. An automated computerized auscultation and diagnostic system for pulmonary diseases. JMed 2010;34:1149-55. doi: https://doi.org/10.1007/s10916-009-9334-1
- Fraiwan L, Hassanin O, Fraiwan M, Khassawneh B, Ibnian AM, Alkhodari M. Automatic identification of respiratory diseases from stethoscopic lung sound signals using ensemble classifiers. Biocybern Biomed Eng. 2021;41(1):1-14. doi: https://doi.org/10.1016/j.bbe.2020.11.003
- Fraiwan M, Fraiwan L, Alkhodari M, Hassanin O. Recognition of pulmonary diseases from lung sounds using convolutional neural networks and long short-term memory. J Ambient Intell Humaniz Comput. 2021;13(10):1-13. doi: https://doi.org/10.1007/s12652-021-03184-y
- Gibson GJ, Loddenkemper R, Lundback B, Sibille Y. Respiratory health and disease in Europe: The new European lung white book. Eur Respir J. 2013;42(3):559-63. doi: https://doi.org/10.1183/09031936.00105513
- Kim Y, Hyon Y, Jung SS, Lee S, Yoo G, Chung C, et al. Respiratory sound classification for crackles, wheezes, and rhonchi in the clinical field using deep learning. Sci 2021;11(1):1-11. doi: https://doi.org/10.1038/s41598-021-96724-7
- Kingma DP, Welling M. Stochastic gradient vb and the variational auto-encoder. In: Second International Conference on Learning Representations. 2014. p. 121.
- Lema GF, Berhe YW, Gebrezgi AH, Getu AA. Evidence-based perioperative management of a child with upper respiratory tract infections (urtis) undergoing elective surgery: A systematic review. Int J Surg Open. 2018;12:17-24. doi: https://doi.org/10.1016/j.ijso.2018.05.002
- Ma Y, Xu X, Li Y. LungRN+ NL: An improved adventitious lung sound classification using non-local block resnet neural network with mixup data augmentation. In:Interspeech; doi: https://doi.org/10.21437/Interspeech.2020-2487
- Minami K, Lu H, Kim H, Mabu S, Hirano Y, Kido S. Automatic classification of large-scale respiratory sound dataset based on convolutional neural network. In: 2019 19th International Conference on Control, Automation and Systems (ICCAS). 2019. p. 804-7. doi: https://doi.org/10.23919/ICCAS47443.2019.8971689
- Monaco A, Amoroso N, Bellantuono L, Pantaleo E, Tangaro S, Bellotti R. Multi-time-scale features for accurate respiratory sound classification. Appl Sci. 2020;10(23):8606. doi: https://doi.org/10.3390/app10238606
- Pham L, Phan H, Palaniappan R, Mertins A, McLoughlin I. Cnn-moe based framework for classification of respiratory anomalies and lung disease detection. IEEE J Biomed Health Inform. 2021;25(8):2938-47. doi: https://doi.org/10.1109/JBHI.2021.3064237
- Priftis KN, Hadjileontiadis LJ, Everard ML. BreathSpringer; 2018. 319 р. doi: https://doi.org/10.1007/978-3-319-71824-8
- Reyes B, Charleston-Villalobos S, Gonza´lez-Camarena R, Aljama-Corrales T. Assessment of time–frequency representation techniques for thoracic sounds analysis. Comput Methods Programs Biomed. 2014;114(3):276-90. doi: https://doi.org/10.1016/j.cmpb.2014.02.016
- Rocha BM, Filos D, Mendes L, Serbes G, Ulukaya S, Kahya YP, et al. An open access database for the evaluation of respiratory sound classification algorithms. Physiol Meas. 2019;40(3):035001. doi: https://doi.org/10.1088/1361-6579/ab03ea
- Sarkar M, Bhardwaz R, Madabhavi I, Modi M. Physical signs in patients with chronic obstructive pulmonary disease. Lung India. 2019;36(1):38-47. doi: https://doi.org/10.4103/lungindia.lungindia_145_18
- Tasar B, Yaman O, Tuncer T. Accurate respiratory sound classification model based on piccolo pattern. Appl Acoust. 2022;188:108589. doi: https://doi.org/10.1016/j.apacoust.2021.108589
- Wu YS, Liao CH, Yuan SM. Automatic auscultation classification of abnormal lung sounds in critical patients through deep learning models. In: 2020 3rd IEEE International Conference on Knowledge Innovation and Invention. 2020. p. 9-11. doi: https://doi.org/10.1109/ICKII50300.2020.9318880
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Authors and affiliations
Panaskin D.V. Ihor Sikorsky Kyiv polytechnic institute, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0008-2867-5399
Stirenko S.H. Ihor Sikorsky Kyiv polytechnic institute, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0003-2674-3590
Babko D.S. Ihor Sikorsky Kyiv polytechnic institute, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0006-5829-1906
Cite
Panaskin D.V., Stirenko S.H., Babko D.S. Respiratory disease detection in lung auscultation with convolutional neural networks and CVAE augmentation. Medicni perspektivi. 2024;29(3):96-107. DOI: https://doi.org/10.26641/2307-0404.2024.3.313569
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Sokolenko M.O., Sydorchuk L.P., Sokolenko L.S., Sokolenko A.A. General immunologic reactivity of patients with COVID-19 and its relation to gene polymorphism, severity of clinical course of the disease and combination with comorbidities
https://doi.org/10.26641/2307-0404.2024.3.313570
Abstract
The aim of the study is to identify and evaluate the general immunological reactivity of patients with COVID-19 and its relationship with gene polymorphism, severity of the clinical course of the disease and combination with comorbidities. A cohort study was conducted involving 204 patients with COVID-19 diagnosed with community-acquired pneumonia of mild, moderate, and severe degrees who also had comorbidities: endocrinopathies (46 patients), cardiovascular diseases (82 patients), and comorbidities of the ENT organs, connective tissue, gastrointestinal tract, chronic kidney disease (CKD), which were grouped into the group "other comorbidities (76 patients). Among the patients there were 51.97% (106) women and 48.03% (98) men. The average age of patients was 55.93±8.75 years. The polymorphism of the NOS3 (rs2070744), FGB (rs1800790) and TMPRSS2 (rs12329760) genes was determined by real-time polymerase chain reaction (qualitative determination). The overall immunological reactivity was detected and evaluated based on the analysis of 14 integral leukocyte indices: leukocyte shift index, absolute leukocyte count/erythrocyte sedimentation rate (ESR) ratio index, lymphocyte-granulocyte index, lymphocyte index, immunological resistance and reactivity index, and others. The overall immunological reactivity of the body of patients with coronavirus infection increases in the presence of the wild-type T-allele of the eNOS gene (rs2070744) in the patient's genotype, especially the CC genotype, by 21.98-57.89% (p≤0.029-0.001), against the background of a decrease in the index of nonspecific reactivity and the ratio of agranulocytes to ESR – by 23.0 (p=0.039) and 15.74% (p=0.044), indicating the onset of specific immunological reactions in the active infectious process. Carriers of the mutational A-allele of the FGB gene (rs1800790) and the TT genotype of the TMPRSS2 gene (rs12329760) showed higher immune reactivity and resistance, which was significantly confirmed by the level of increase in immune reactivity by 6.31-17.21% (p=0.007) and 22.05-35.78% (p≤0.06-0.004), respectively, against the background of a slightly higher rate of allergy (especially in owners of the AG genotype of the FGB gene – by 68.18%, PAG=0.017), a higher ratio of agranulocytes and ESR – by 18.30-21.84% (p≤0.008-0.007) and 19.46-31.07% (p=0.023), with a higher ratio of lymphocytes and eosinophils – by 13.35-19.20% (p≤0.002-0.001). The influence of the wild-type T-allele of the eNOS gene (rs2070744), the A-allele of the FGB gene (rs1800790) and the TT genotype of the TMPRSS2 gene (rs12329760) on the immunological reactivity of the body of a patient with coronavirus infection was revealed.
Key words: COVID-19, immunological reactivity, immune resistance, genotype, comorbidities
References
- Azkur AK, Akdis M, Azkur D, Sokolowska M, van de Veen W, Brüggen MC, et al. Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19. Allergy. 2020 Jul;75(7):1564-81. doi: https://doi.org/10.1111/all.14364
- Paces J, Strizova Z, Danie SM, Cerny J. COVID-19 and the immune system. Physiological research. 2020;69(3):379. doi: https://doi.org/10.33549/physiolres.934492
- Shi Y, Wang Y, Shao C, Huang J, Gan J, Huang X, et al. COVID-19 infection: the perspectives on immune responses. Cell Death & Differentiation. 2020;27(5):1451-4. doi: https://doi.org/10.1038/s41418-020-0530-3
- Siracusano G, Pastori C, Lopalco L. Humoral immune responses in COVID-19 patients: a window on the state of the art. Frontiers in immunology. 2020;11:551868. doi: https://doi.org/10.3389/fimmu.2020.01049
- Mortaz E, Tabarsi P, Varahram M, Folkerts G, Adcock IM. The immune response and immunopathology of COVID-19. Frontiers in immunology. 2020;11:558378. doi: https://doi.org/10.3389/fimmu.2020.02037
- Ravindran R, McReynolds C, Yang J, Hammock BD, Ikram A, Ali A, et al. Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses. PloS one. 2021;16(7):e0254367. doi: https://doi.org/10.1371/journal.pone.0254367
- Boechat JL, Chora I, Morais A, Delgado L. The immune response to SARS-CoV-2 and COVID-19 immunopathology–current perspectives. Pulmonology. 2021;27(5):423-37. doi: https://doi.org/10.1016/j.pulmoe.2021.03.008
- Jafarzadeh A, Jafarzadeh S, Nozari P, Mokhtari P, Nemati M. Lymphopenia an important immunological abnormality in patients with COVID‐19: possible mechanisms. Scandinavian journal of immunology. 2021;93(2):e12967. doi: https://doi.org/10.1111/sji.12967
- Oliveira DS, Medeiros NI, Gomes JA. Immune response in COVID-19: What do we currently know? Microbial pathogenesis. 2020;148:104484. doi: https://doi.org/10.1016/j.micpath.2020.104484
- Sydorchuk lP, Syrota BS, Sydorchuk AR, Gerush OV, Muzyka NY, Sheremet MI, et al. Clinical markers of immune disorders in the pathogenesis of Escherichia coli enteritis. Arch Balk Med Union. 2019;54(1):89-96. doi: https://doi.org/10.31688/ABMU.2019.54.1.1
- Moody R, Wilson K, Flanagan KL, Jaworowski A, Plebanski M. Adaptive immunity and the risk of autoreactivity in COVID-19. International journal of molecular sciences. 2021;22(16):8965. doi: https://doi.org/10.3390/ijms22168965
- Schön MP, Berking C, Biedermann T, Buhl T, Erpenbeck L, Eyerich K, et al. COVID‐19 and immunological regulations-from basic and translational aspects to clinical implications. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2020;18(8):795-807. doi: https://doi.org/10.1111/ddg.14169
- Elshazli RM, Toraih EA, Elgaml A, El-Mowafy M, El-Mesery M, Amin MN, Diagnostic and prognostic value of hematological and immunological markers in COVID-19 infection: A meta-analysis of 6320 patients. PloS one. 2020;15(8):e0238160. doi: https://doi.org/10.1371/journal.pone.0238160
- Sydorchuk A, Sydorchuk L, Gutnitska A, Vasyuk V, Tkachuk O, Dzhuryak V, et al. The role of NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients. General Physiology & Biophysics. 2023;42(2):179-90. doi: https://doi.org/10.4149/gpb_2022060
- [Protocol "Provision of medical assistance for the treatment of coronavirus disease (COVID-19)". Approved by the Order of the Ministry of Health of Ukraine of April 2, 2020 No. 762 (as amended by the Order of the Ministry of Health of Ukraine of May 17, 2023 No. 913)]. [Internet]. 2023 [cited 2024 Mar 2024]. Ukrainian. Available from: https://moz.gov.ua/uploads/9/46447-dn_913_17052023_dod.pdf
- [Medical care standards "Coronavirus disease (COVID-19)". Approved by Order No. 722 of the Ministry of Health of Ukraine dated March 28, 2020]. [Internet]. 2020 [cited 2024 Mar 2024]. Ukrainian. Available from: https://www.dec.gov.ua/wp/content/uploads/2022/02/2020_722_standart_covid_19.pdf
- CDC 24/7: saving lives, protecting people. Prevention Actions to Use at All COVID-19 Community Levels [Internet]. Center for Disease Control and Prevention. 2023 [cited 2024 Mar 2024]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html
- Artika IM, Dewi YP, Nainggolan IM, Siregar JE, Antonjaya U. Real-Time Polymerase Chain Reaction: Current Techniques, Applications, and Role in COVID-19 Diagnosis. Genes (Basel). 2022 Dec 16;13(12):2387. doi: https://doi.org/10.3390/genes13122387
- Usul E, Şan İ, Bekgöz B, Şahin A. Role of hematological parameters in COVID-19 patients in the emergency room. Biomark Med. 2020 Sep;14(13):1207-15. doi: https://doi.org/10.2217/bmm-2020-0317
- Dwivedi AK. How to write statistical analysis section in medical research. J Investig Med. 2022 Dec;70(8):1759-70.
doi: https://doi.org/10.1136/jim-2022-002479
- Yuan X, Huang W, Ye B, Chen C, Huang R, Wu F, et al. Changes of hematological and immunological parameters in COVID-19 patients. Int J Hematol. 2020 Oct;112(4):553-9. doi: https://doi.org/10.1007/s12185-020-02930-w
- Birindelli S, Tarkowski MS, Gallucci M, Schiuma M, Covizzi A, Lewkowicz P, et al. Definition of the immune parameters related to COVID-19 severity. Frontiers in Immunology. 2022;13:850846. doi: https://doi.org/10.3389/fimmu.2022.850846
- Qin R, He L, Yang Z, Jia N, Chen R, Xie J, et al. Identification of parameters representative of immune dysfunction in patients with severe and fatal COVID-19 infection: a systematic review and meta-analysis. Clinical Reviews in Allergy & Immunology. 2023;64(1):33-65. doi: https://doi.org/10.1007/s12016-021-08908-8
- Chatterjee S, Nalla LV, Sharma M, Sharma N, Singh AA, Malim FM, et al. Association of COVID-19 with comorbidities: an update. ACS Pharmacology & Translational Science. 2023;6(3):334-54. doi: https://doi.org/10.1021/acsptsci.2c00181
- Kamyshnyi A, Krynytska I, Matskevych V, Marushchak M, Lushchak O. Arterial hypertension as a risk comorbidity associated with COVID-19 pathology. International journal of hypertension. 2020 Dec 4:2020:8019360. doi: https://doi.org/10.1155/2020/8019360
- Fishchuk L, Rossokha Z, Pokhylko V, Cherniavska Y, Dubitska O, Vershyhora V, et al. NOS3 (rs61722009) gene variants testing in prediction of COVID-19 pneumonia severity. Nitric Oxide. 2023;134:44-8. doi: https://doi.org/10.1016/j.niox.2023.04.002
- Stopsack KH, Mucci LA, Antonarakis ES, Nelson PS, Kantoff PW. TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?. Cancer discovery. 2020;10(6):779-82.
doi: https://doi.org/10.1158/2159-8290.CD-20-0451
- Rezaei-Tavirani M, Nejad MR, Arjmand B, Tavirani SR, Razzaghi M, Mansouri V. Fibrinogen dysregulation is a prominent process in fatal conditions of COVID-19 infection; a proteomic analysis. Archives of Academic Emergency Medicine. 2021;9(1):e26. doi: https://doi.org/10.22037/aaem.v9i1.1128
- Sur S, Khatun M, Steele R, Isbell TS, Ray R, Ray RB. Exosomes from COVID-19 patients carry tenascin-C and fibrinogen-β in triggering inflammatory signals in cells of distant organ. International Journal of Molecular Sciences. 2021;22(6):3184. doi: https://doi.org/10.3390/ijms22063184
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Sokolenko M.O. Bukovinian State Medical University, Chernivtsi, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-7150-7146
Sydorchuk L.P. Bukovinian State Medical University, Chernivtsi, Ukraine https://orcid.org/0000-0001-9279-9531
Sokolenko L.S. Pavlo Tychyna Uman State Pedagogical University, Uman, Cherkasy region, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-1285-1596
Sokolenko A.A. Bukovinian State Medical University, Chernivtsi, Ukraine https://orcid.org/0000-0003-0010-2771
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Sokolenko M.O., Sydorchuk L.P., Sokolenko L.S., Sokolenko A.A. General immunologic reactivity of patients with COVID-19 and its relation to gene polymorphism, severity of clinical course of the disease and combination with comorbidities. Medicni perspektivi. 2024;29(3):108-117. DOI: https://doi.org/10.26641/2307-0404.2024.3.313570
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Safarova S.S. Gender-associated features in diabetic kidney disease
https://doi.org/10.26641/2307-0404.2024.3.313578
Abstract
Diabetic kidney disease (DKD) is the leading cause of end-stage renal failure. Evidence indicates gender differences in the progression of this disease. This study aimed to determine gender differences in prevalence and identify gender-associated risk factors contributing to the development of diabetic kidney disease in individuals with type 2 diabetes mellitus (T2DM). The cross-sectional study included 132 patients with T2DM ranging in age from 50 to 65 years. Subjects were stratified by sex (80 women and 52 men). Gender differences have been studied in relation to the incidence and prevalence of DKD, their phenotypes and clinical manifestations, and several risk factors that have different effects on both sexes. The outcome of clinical kidney function assessment showed that 70% subjects were diagnosed with DKD (71% of women and 67% of men). The study indicated an association between the duration of T2DM and urinary albumin levels, as well as between arterial hypertension and triglyceride levels, which are independent risk factors for DKD development. Notably, older women with T2DM have a higher prevalence of DKD than older men. The albuminuric component of DKD was more frequently observed in men. Additionally, men were more likely to have adverse risk factors, including dyslipidemia, lower high-density lipoprotein cholesterol, and glomerular filtration rate, which are factors involved in the mechanisms of DKD. In summary, the results indicate that: 1) women with type 2 diabetes mellitus are at a higher risk of developing a normoalbuminuric phenotype of diabetic kidney disease, while men are at a higher risk of developing an albuminuric phenotype of diabetic kidney disease leading to renal failure and end-stage renal disease; 2) gender differences are most noticeable among older adults and may have significant implications for the development of more effective diagnostic and treatment methods for diabetic kidney disease, tailored to individual needs.
Key words: diabetic kidney disease, diabetes mellitus type 2, gender
References
- Xia L, Cheng L, Jiang T, et al. Estimation of the prevalence of type 2 diabetes in combination with diabetic kidney disease and identification of the associated factors in patients attending primary hospitals in Anhui Province, China. J International Medical Research. 2021;49(10):3000605211051225. doi: https://doi.org/10.1177/03000605211051225
- Huang JX, Liao YF, Li YM. Clinical features and microvascular complications risk factors of early-onset type 2 diabetes mellitus. Current Medical Science. 2019;39(5):754-8.
doi: https://doi.org/10.1007/s11596-019-2102-7
- Deng L, Li W, Xu G. Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency. Euro Journal of Medical Research. 2021;26(1):144. doi: https://doi.org/10.1186/s40001-021-00612-9
- Fritz J, Brozek W, Concin H, et al. The association of excess body weight with risk of ESKD is mediated through insulin resistance, hypertension, and hyperuricemia. Journal of the American Society of Nephrology. 2022;33(7):1377-89. doi: https://doi.org/10.1681/ASN.2021091263
- Bae EH, Lim SY, Kim B, et al. Effects of blood pressure according to age on end-stage renal disease development in patients with diabetes: a nationwide population-based cohort study. Hypertension. 2022;79(8):1765-76. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.18881
- Sabbatini AR, Kararigas G. Estrogen-related mechanisms in sex differences of hypertension and target organ damage. Biology of Sex Differences. 2020;11(1):31. doi: https://doi.org/10.1186/s13293-020-00306-7
- Bensken WP, Ho VP, Pieracci FM. Basic Introduction to Statistics in Medicine, Part 2: Comparing Data. Surg Infect (Larchmt). 2021;22(6):597-603. doi: https://doi.org/10.1089/sur.2020.430
- Piani F, Melena I, Tommerdahl KL, et al. Sexrelated differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications. Journal of Diabetes Complications. 2021;35(4):107841. doi: https://doi.org/10.1016/j.jdiacomp.2020.107841
- Giandalia A, Giuffrida AE, Gembillo G, et al. Gender differences in diabetic kidney disease: focus on hormonal, genetic and clinical factors. International J Molec Sciences. 2021;22(11):5808. doi: https://doi.org/10.3390/ijms22115808
- Menendez-Castro C, Cordasic N, Fahlbusch FB, et al. Sex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis. Molecular and Cellular Pediatrics. 2023;10(1):8. doi: https://doi.org/10.1186/s40348-023-00164-4
- Rajabi S, Saberi S, Najafipour H, et al. Interaction of estradiol and renin-angiotensin system with microRNAs-21 and -29 in renal fibrosis: focus on TGF-β/smad signaling pathway. Molecular Biology Reports. 2024;51(1):137. doi: https://doi.org/10.1007/s11033-023-09127-4
- Schexnayder CD, Agbahiwe S, Emelogu O. Burnt out? The phenomenon of type 2 diabetes mellitus in end-stage renal disease. Federal Practitioner. 2020;37(12):580-5. doi: https://doi.org/10.12788/fp.0076
- Xu AR, Jin Q, Shen Z, et al. Association between the risk of hypertension and triglyceride glucose index in Chinese regions: a systematic review and dose-response meta-analysis of a regional update. Front Cardiovascular Medicine. 2023;10:1242035. doi: https://doi.org/10.3389/fcvm.2023.1242035
- Swartling O, Rydell H, Stendahl M, et al. CKD Progression and mortality among men and women: a nationwide study in Sweden. Am J Kidney Dis. 2021;78(2):190-9. doi: https://doi.org/10.1053/j.ajkd.2020.11.026
- Wang K, Xu W, Zha B, et al. Fibrinogen to albumin ratio as an independent risk factor for type 2 diabetic kidney disease. Diabetes Metab Syndr Obes. 2021;14:4557-67. doi: https://doi.org/10.2147/DMSO.S337986
- Bernstein SR, Kelleher C, Khalil RA. Gender-based research underscores sex differences in biological processes, clinical disorders and pharmacological interventions. Biochemical Pharmacology. 2023;215:115737. doi: https://doi.org/10.1016/j.bcp.2023.115737
- Christofides EA, Desai N. Optimal early diagnosis and monitoring of diabetic kidney disease in type 2 diabetes mellitus: addressing the barriers to albuminuria testing. Journal of Primary Care and Community Health. 2021;12:21501327211003683. doi: https://doi.org/10.1177/21501327211003683
- Li S, Li N, Li L, Zhan J. Sex difference in the association between serum versican and albuminuria in patients with type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity. 2023;16:3631-9. doi: https://doi.org/10.2147/DMSO.S434287
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Safarova S.S. Azerbaijan Medical University, Baku, Republic of Azerbaijan, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-7131-3878
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Pertseva N.O., Turlyun T.S., Sanina N.A. Dynamics of endothelial function in patients with arterial hypertension with different cardiovascular risk against the background of antihypertensive therapy
https://doi.org/10.26641/2307-0404.2024.3.313592
Abstract
The aim of the work was to investigate the dynamics of endothelial markers in patients with arterial hypertension with different cardiovascular risk under the influence of the prescribed treatment during a year of observation. The first group (with a moderate risk of cardiovascular events) included 48 patients with arterial hypertension (AH). The second group consisted of 54 patients with hypertension and a high risk of cardiovascular events, namely type 2 diabetes. Each group of patients was randomized into two subgroups by blood pressure (BP) medication. In patients of subgroup 1a (n=29) and subgroup 2a (n=35) – the main subgroups – the therapy necessarily included the angiotensin II receptor antagonist losartan potassium in a dosage of 50-150 mg/day, depending on the blood pressure level. Patients of subgroup 1b (n=19) and subgroup 2b (n=19) – comparison subgroups were treated with antihypertensive drugs of other first-line groups according to the data of the unified clinical protocol for the treatment of hypertension. According to the ROC analysis, it was determined that the dynamics of endothelin-1 (ET-1) indicators after 9 and 12 months of therapy (a decrease of 12% or more from the initial level) can predict the normalization of indicators of the coagulation and anticoagulation systems with indicators of sensitivity and specificity – 85% (95% CI 62.1-96.6%) and 92.9% (95% CI 76.5-98.9%), respectively. A decrease in the level of Willebrand factor (fV) by 23% or more due to such a treatment time can be used as a prognostic sign in determining the regression of endothelial dysfunction with sensitivity – 75% (95% CI 50.9-91.2%), specificity – 100% (95% CI 87.5-100%). According to the given data, both in the group with moderate and with high cardiovascular risk, there is a relationship between endothelial dysfunction (ED) and the duration of hypertension, indicators of the lipid spectrum and abdominal obesity – factors that increase the viscous resistance of the blood circulation, as well as platelet hyperactivity in the bloodstream. We have also established that according to the dynamics of ET-1 indicators after 9 and 12 months of therapy (decrease by 27% or more from the initial level), it is possible to predict the normalization of indicators of the coagulation and anticoagulation systems with indicators of sensitivity – 81.8% (95% CI 59.7-94.7%), specificity – 90.6% (95% CI 75-97.9%). A decrease in the level of fV by 24.5% or more after a year of treatment can be used as a prognostic sign in determining the regression of endothelial dysfunction with sensitivity – 68.2% (95% CI 45.1-86.1%), specificity – 71.9% (95% CI 53.3-86.2%). The obtained results testify to the dominant role of type 2 diabetes as a factor in platelet disorders of hemostasis. Taking into account the positive dynamics of the above-mentioned markers of ED during the year of treatment, their relationship with the reduction of blood pressure, indicators of the lipid spectrum and abdominal obesity, it should be noted the positive effect of angiotensin II receptor blockers (BRA II) as endothelioprotective drugs. Considering the irrefutable literary data about the absence of thrombomodulin in the blood stream, even its insignificant appearance indicates the presence of endothelial dysfunction. Determining the state and dynamics of changes in endothelial function under the influence of prescribed therapy will make it possible to improve the diagnosis of endothelial function disorders and increase the effectiveness of treatment of patients with hypertension and various cardiovascular risks.
Key words: arterial hypertension, endothelial dysfunction, cardiovascular risk, Diabetes Mellitus type 2, endothelin-1, thrombomodulin, von Willebrand factor
References
- Mancia G, et al. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). Journal of Hypertension. 2023;41(12):1874-2071. doi: https://doi.org/10.1097/HJH.0000000000003480
- Guanghong J, Sowers J. Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease. Hypertension.2021;78(1):1197-205. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.17981
- Jankowich M, Choudhary G. Endothelin-1 levels and cardiovascular events. Trends Cardiovasc Med. 2020 Jan;30(1):1-8. doi: https://doi.org/10.1016/j.tcm.2019.01.007
- Lancellotti S, Sacco M, Basso M, Cristofaro R. Mechanochemistry of von Willebrand factor.Biomolecular 2019;10(1):194-208. doi: https://doi.org/10.1515/bmc-2019-0022
- Giri H, Cai X, Panicker SR, Biswas I, Rezaie AR. Thrombomodulin Regulation of Mitogen-Activated Protein Kinases. Int J Mol Sci. 2019 Apr 15;20(8):1851. doi: https://doi.org/10.3390/ijms20081851
- Pertseva NO, Chub DI. [Peculiarities of the daily blood pressure profile in patients with diabetes depending on endothelial dysfunction]. International Journal of Endocrinology.2018;14(2):131-7. doi: https://doi.org/10.22141/2224-0721.14.2.2018.130556
- Yang Q, Wijerathne H, Langston JC, Kiani MF, Kilpatrick LE. Emerging Approaches to Understanding Microvascular Endothelial Heterogeneity: A Roadmap for Developing Anti-Inflammatory Therapeutics. International Journal of Molecular Sciences. 2021;22(15):7770. doi: https://doi.org/10.3390/ijms2215777
- Gerych MS, Sinyavska OO. [Mathematical statistics: a study guide]. Uzhhorod; 2021. 146 p. Ukrainian.
- Flack J, Adekola B. Blood pressure and the new ACC/AHA hypertension guidelines. Trends Cardiovasc Med.2020 Apr;30(3):160-4. doi: https://doi.org/10.1016/j.tcm.2019.05.003
- Drożdż D, Drożdż M, Wójcik M. Endothelial dysfunction as a factor leading to arterial hypertension. Pediatric Nephrology. 2023;38(9):2973-85. doi: https://doi.org/10.1007/s00467-022-05802-z
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Pertseva N.O., Turlyun T.S., Sanina N.A. Dynamics of endothelial function in patients with arterial hypertension with different cardiovascular risk against the background of antihypertensive therapy. Medicni perspektivi. 2024;29(3):123-128. DOI: https://doi.org/10.26641/2307-0404.2024.3.313592
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Proschenko A.M., Proschenko N.S., Zelinskaya N.A., Reshetnyk L.L., Chervonna N.V., Bida O.V. Peculiarities of the format of genetic blood systems in patients with oral lichen planus
https://doi.org/10.26641/2307-0404.2024.3.313595
Abstract
The number of patients with oral lichen planus (OLP) has increased due to the raise of aggressive forms of the disease (erosive, ulcerative and hyperkeratotic forms) with a possible risk of malignancy. There are isolated researches which indicate a genetic determinism to OLP, but more often these conclusions are based on insufficiently adequate and out of date methods, which make it impossible to correctly interpret the obtained data. The aim was to identify a genetical predisposition with a programmed risk to the oral lichen planus. The main group – 278 patients with the OLP (aged 26-65 years). The control group – 298 people (blood donors) who didn’t have dental diseases, as well as diseases of internal organs and systems. The groups were homogeneous by gender and age. In our research we used such methods: clinical, radiological, immunogenetic, statistical methods were used. The erosive form of OLP was associated with 0(I) group in 54.2±0.4% of cases, while the hyperkeratotic form was associated with group 0(I) only in 28.7±1.8% of cases. B(ІІІ) and AB(ІB) groups were less often associated with the erosive form of OLP and were observed in 17.3±0.1% and 2.0±0.1% of cases, respectively. The integration of A(ІІ) group in the erosive form of OLP was 30.5±0.1%, but the indicator was higher than in individuals with B(III) and AB(IV) groups. Hyperkeratotic form of OLP was more often observed in A(II) carriers than in 0(I) and was 44.1±0.1% versus 28.7±1.8%, respectively. With blood group B (ІІІ), the relationship with OLP is not traced. Correlative relationship with erythrocyte blood antigens of the ABO system in patients with oral lichen planus was established. Risk groups for the development of erosive and hyperkeratotic forms of lichen planus in patients with gastrointestinal tract pathology O(I)>A(II)>B(III) – with erosive form and A(II)>O(I)>B(III)) – with hyperkeratosis.
Key words: oral mucosa, oral lichen planus, erythrocyte blood systems, genetic determinism, occlusal correlation of the jaws
References
- Nicolas-Rodriguez E, Pons-Fuster E, López-Jornet P. Diagnostic Infrared Thermography of the Tongue and Taste Perception in Patients with Oral Lichen Planus: Case-Control Study. J Clin Med. 2024 Jan 12;13(2):435. doi: https://doi.org/10.3390/jcm13020435
- Jalenques I, Lauron S, Almon S, Pereira B, D'Incan M, Rondepierre F. Prevalence and Odds of Signs of Depression and Anxiety in Patients with Lichen Planus: Systematic Review and Meta-analyses. Acta Derm Venereol.2020 Nov 24;100(18):adv00330. doi: https://doi.org/10.2340/00015555-3660
- Birckel E, Lipsker D, Cribier B. [Efficacy of photopheresis in the treatment of erosive lichen planus: A retrospective study]. Ann Dermatol Venereol. 2020 Feb;147(2):86-92. doi: https://doi.org/10.1016/j.annder.2019.02.011
- Louisy A, Humbert E, Samimi M. Oral Lichen Planus: An Update on Diagnosis and Management. Am J Clin 2024 Jan;25(1):35-53. doi: https://doi.org/10.1007/s40257-023-00814-3
- González-Moles MÁ, Ruiz-Ávila I, González-Ruiz L, et al. Malignant transformation risk of oral lichen planus: a systematic review and comprehensive meta-analysis.Oral 2019;96:121-130. doi: https://doi.org/10.1016/j.oraloncology.2019.07.012
- Jalenques I, Lauron S, Almon S, Pereira B, D'Incan M, Rondepierre F. Prevalence and Odds of Signs of Depression and Anxiety in Patients with Lichen Planus: Systematic Review and Meta-analyses. Acta Derm Venereol.2020 Nov 24;100(18):adv00330. doi: https://doi.org/10.2340/00015555-3660
- Simons G, Caplan J, DiSantostefanoRL, Veldwijk J, Englbrecht M, Bywall KS, et al. Systematic review of quantitative preference studies of treatments for rheumatoid arthritis among patients and at-risk populations. Arthritis Res 2022 Feb 22;24(1):55. doi: https://doi.org/10.1186/s13075-021-02707-4
- Keller LM, Lombardi T. Gingival lichen planus: A clinical and pathological study. J Stomatol Oral Maxillofac Surg.2023 Feb;124(1S):101354. doi: https://doi.org/10.1016/j.jormas.2022.101354
- De Porras-Carrique T, González-Moles MÁ, Warnakulasuriya S, Ramos-García P. Depression, anxiety, and stress in oral lichen planus: a systematic review and meta-analysis. Clin Oral Investig. 2022 Feb;26(2):1391-408. doi: https://doi.org/10.1007/s00784-021-04114-0
- Kim TJ, Kim YG, Jung W, Jang S, Ko HG, Park CH, et al. Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Biomolecules. 2023 Nov 13;13(11):1646. doi: https://doi.org/10.3390/biom13111646
- Philipone EM, Peters SM. Ulcerative and Inflammatory Lesions of the Oral Mucosa. Oral Maxillofac Surg ClinNorth 2023 May;35(2):219-26. doi: https://doi.org/10.1016/j.coms.2022.10.001
- Antonenko M, Palamarchuk S, Reshetnyk L, Shemelko M, Palamarchuk M. Vitamin D3 and the system of oxidative stress-antioxidant protection in the pathogenesis and treatment of generalized parodontitis associated with anorexia nervosa. International Journal of Medical Dentistry [Internet]. 2023 Jan-Mar [cited 17 Dec 2023];(1):45-53. Available from: https://ijmd.ro/2023/vitamin-d3-and-the-system-of-oxidative-stress-antioxidant-protection-in-the-pathogenesis-and-treatment-of-generalized-parodontitis-associated-with-anorexia-nervosa/
- Proschenko AM, Proschenko NS, Shemelko ML, Reshetnyk LL, Chervonna NV, Sorokina KO. Assessment of the quality of treatment of patients with functional disorders of the dento-magular apparatus combined with dentoalveolar form of deep bite. Clin and prev med. [Internet]. 2024 Jun 17 [cited 17 Dec 2023];(4):26-32. Availablefrom: https://cp-medical.com/index.php/journal/article/view/418
doi: https://doi.org/10.31612/2616-4868.4.2024.04
- Shirobokov VP. [Medical microbiology, virology, immunology: a text book for English-speaking students of higher medical schools]. Vinnytsia: Nova Knyha; 2019. 744 p. Ukrainian.
- Hruzieva TS, Lekhan VM, Ohniev VA, Haliienko LI, Kriachkova LV, Palamar BI, et al. [Biostatistics]. Vinnytsia: New Book; 2020. 384 p. Ukrainian.
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Proschenko A.M. Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0003-0847-1408
Proschenko N.S. Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0001-7317-6590
Zelinskaya N.A. Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0003-0383-349X
Reshetnyk L.L. Bogomolets National Medical University, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0001-9295-7800
Chervonna N.V. Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0003-4499-5399
Bida O.V. Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0002-6038-6545
Cite
Proschenko A.M., Proschenko N.S., Zelinskaya N.A., Reshetnyk L.L., Chervonna N.V., Bida O.V. Peculiarities of the format of genetic blood systems in patients with oral lichen planus. Medicni perspektivi. 2024;29(3):128-137. DOI: https://doi.org/10.26641/2307-0404.2024.3.313595
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Somilo O.V., Makarov S.O., Kalbus O.I. Comorbidity in in patients with relapsing-remitting multiple sclerosis
https://doi.org/10.26641/2307-0404.2024.3.313600
Abstract
Multiple sclerosis is a chronic autoimmune inflammatory disease that affects the brain and spinal cord. The most common form of this disease according to the type of its course is relapsing-remitting multiple sclerosis. Comorbidity in multiple sclerosis is an urgent problem of modern neurology, since it can influence such factors as the time of diagnosis, the rate of disease progression and the rate of patient disability, the number of exacerbations and the patient’s quality of life. The purpose of the work was to study and characterize comorbidity in patients with relapsing multiple sclerosis. To conduct this study 105 patients with a diagnosis of relapsing-remitting multiple sclerosis were enrolled. All patients were assessed using the Multiple Sclerosis Neurological Disability Severity Scale (EDSS). Study participants were divided into two groups – Group 1 and Group 2 – based on EDSS scores. Separately, study participants were divided into groups based on the principle of receiving pain-modifying therapy. In the 1st study group, concomitant diseases were in 57 (78.1%) patients, in the 2nd group – in 100% (p=0.010). In patients who did not receive pain-modifying therapy, 57 (98.3%) of those examined had concomitant diseases, in those who received such treatment – in 32 (68.1%), which was statistically significantly less (p<0.001). In the first place in terms of the frequency of concomitant pathology among all examined patients were diseases of the gastrointestinal tract, which also dominated in the 1st and 2nd observation groups, in the second place – diseases of the urinary system, in the third place – eye diseases, and in the last place, by the frequency of concomitant diseases – cardiovascular diseases. Comorbidity in multiple sclerosis is an extremely relevant problem in modern neurology due to its significant impact on the clinical picture of the disease, its course and the degree of disability of the patient. Digestive system disease is one of the most common comorbid conditions in multiple sclerosis. The number of patients with comorbid conditions is higher among patients with a moderate degree of disability and among patients not taking disease-modifying therapy, but the relationship between the degree of disability, treatment and comorbid conditions requires further study.
Key words: comorbidity, relapsing-remitting multiple sclerosis, disability, concomitant diseases
References
- Somilo OV, Makarov SO, Kalbus OI, Sorokin AV. [Anxiety and depression in patients with multiple sclerosis]. Medicni perspektivi. 2023;28(2):106-11. Ukrainian. doi: https://doi.org/10.26641/2307-0404.2023.2.283349
- Dobson R, Giovannoni G. Autoimmune disease in people with multiple sclerosis and their relatives: a systematic review and meta-analysis. J Neurol. 2013;260:1272-85. doi: https://doi.org/10.1007/s00415-012-6790-1
- Gascoyne CR, Simpson S, Chen J, van der Mei I, Marck CH. Modifiable factors associated with depression and anxiety in multiple sclerosis. Acta Neurol Scand. 2019;140:204-11. doi: https://doi.org/10.1111/ane.13132
- Ge F, Huo Z, Li C, et al. Lung cancer risk in patients with multiple sclerosis: a mendelian randomization analysis. Mult Scler Relat Disord. 2021;51:102927. doi: https://doi.org/10.1016/j.msard.2021.102927
- Grytten N, Myhr KM, Celius EG, et al. Risk of cancer among multiple sclerosis patients, siblings, and population controls: a prospective cohort study. Mult Scler. 2020;26(12):1569-80. doi: https://doi.org/10.1177/1352458519877244
- Kosmidou M, Katsanos AH, Katsanos KH, et al. Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis. J Neurol. 2017;264:254-9. doi: https://doi.org/10.1007/s00415-016-8340-8
- Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology.1983;33(11):1444. doi: https://doi.org/10.1212/WNL.33.11.1444
- Lo LMP, Taylor BV, Winzenberg T, et al. Estimating the relative contribution of comorbidities in predicting health-related quality of life of people with multiple sclerosis.J 2021;268(2):569-81. doi: https://doi.org/10.1007/s00415-020-10195-w
- Marrie RA, Maxwell C, Mahar A, Ekuma O, McClintock C, Seitz D, et al. Cancer Incidence and Mortality Rates in Multiple Sclerosis: A Matched Cohort Study. Neurology.2021 Jan 26;96(4):e501-e512. doi: https://doi:10.1212/wnl.0000000000011219
- Marrie RA, Tremlett H, Kingwell E, et al. Disparities in management and outcomes of myocardial infarction in multiple sclerosis: a matched cohort study. MultipleSclerosis 2020;26(12):1560-8. doi: https://doi.org/10.1177/1352458519876038
- Nørgaard M, Veres K, Didden EM, Wormser D, Magyari M. Multiple sclerosis and cancer incidence: a Danish nationwide cohort study. Mult Scler Relat Disord. 2019;28:81-5.doi: https://doi.org/10.1016/j.msard.2018.12.014
- Ogino M, Shiozawa A, Ota H, et al. Treatment and comorbidities of multiple sclerosis in an employed population in Japan: analysis of health claims data. NeurodegenerativeDis 2018;8(2):97-103. doi: https://doi.org/10.2217/nmt-2017-0047
- Ohlmeier C, Gothe H, Haas J, et al. Epidemiology, characteristics and treatment of patients with relapsing remitting multiple sclerosis and incidence of high disease activity: Real world evidence based on German claims data.PloS 2020;15(5):e0231846. doi: https://doi.org/10.1371/journal.pone.0231846
- Palladino R, Marrie RA, Majeed A, Chataway J. Evaluating the risk of macrovascular events and mortality among people with multiple sclerosis in England. JAMA Neurol.2020;77(7):820-8. doi: https://doi.org/10.1001/jamaneurol.2020.0664
- Persson R, Lee S, Yood MU, et al. Incident cardiovascular disease in patients diagnosed with multiple sclerosis: a multi-database study. Mult Scler Relat Disord. 2020;37:101423. doi: https://doi.org/10.1016/j.msard.2019.101423
- Petrie A, Sabin C. Medical Statistics at a Glance. 4th edition. Wiley-Blackwell; 2019.
- Petruzzo M, Reia A, Maniscalco GT, et al. The framingham cardiovascular risk score and 5-year progression of multiple sclerosis. Eur J Neurol. 2021;28(3):893-900. doi: https://doi.org/10.1111/ene.14608
- Salter A, Kowalec K, Fitzgerald KC, Cutter G, Marrie RA. Comorbidity is associated with disease activity in Ms: findings from the combirx trial. Neurology. 2020;95(5):e446-e56. doi: https://doi.org/10.1212
- Thormann A, Sørensen PS, Koch-Henriksen N, et al. Comorbidity in multiple sclerosis is associated with diagnostic delays and increased mortality. Neurology. 2017;89(16):1668-75. doi: https://doi.org/10.1212
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Ogorenko V.V., Nikolenko A.E., Shusterman T.Y., Kokashynskyi V.O., Khotimska A.B., Koren M.H. Psychoeducation of higher education seekers with using of the resource-oriented model of stress resiliency in war conditions
https://doi.org/10.26641/2307-0404.2024.3.313660
Abstract
The article presents the study results of resiliency modalities and the content of psychoeducational measures for higher education seekers in war conditions. The purpose of the study was to increase the effectiveness and to balance resiliency modalities use by higher education seekers in war conditions while using psycho-educational measures. 174 seekers of higher education were examined, including 144 students of the 4th-6th year of the medical faculty and the faculty of medicine and pharmacy of the Dnipro State Medical University, specializing in 222 «Medicine» (main group) and 30 students of the 4th-5th year of the metallurgical and electro-metallurgical faculties of the Ukrainian State University of Science and Technology (comparison group). A psychodiagnostic method using the resource-oriented model of stress resiliency "BASIC Ph" was employed. The first stage involved a statistical analysis of resiliency modalities and their average scores in both groups. In all participants of the main group, it was found that the highest average score was registered in the resiliency modality “Cognitive strategy”. The lowest score was observed for the “Social support” modality. In all participants of the comparison group, it was found that the “Cognitive strategy” modality, as in the main group, had a clear advantage over other modalities, and the lowest score was already observed for the “Emotions” modality. These results formed the basis for creating psychoeducational measures for stress resiliency among higher education seekers in wartime. Psychoeducation for higher education seekers was conducted from September to November 2023, including lectures and individual conversations upon request. The «BASIC Ph» model of stress resiliency was utilized as a framework for determining optimal human resource utilization during crises, with six modalities forming individual style of resiliency. It is crucial to identify dominant modalities and develop those that are less effective. The identified stress resiliency modalities provided a conceptual basis for developing of psychoeducational measures to enhance their effective and balanced use in war situations among higher education seekers. During psychoeducational work with higher education seekers, their resiliency models were analyzed, interpreted, and balanced. Study results should be taken into account in psychological support efforts for higher education seekers in war and post-war time.
Key words: psychoeducation, higher education seekers, resiliency, resources, modalities, war
References
- Riad A, Drobov A, Krobot M, Antalová N, Alkasaby MA, Peřina A, et al. Mental Health Burden of the Russian-Ukrainian War 2022 (RUW-22): Anxiety and Depression Levels among Young Adults in Central Europe. Int J Environ Res Public Health. 2022 Jul 9;19(14):8418. doi: https://doi.org/10.3390/ijerph19148418
- Gardani M, Bradford DRR, Russell K, Allan S, Beattie L, Ellis JG, et al. A systematic review and meta-analysis of poor sleep, insomnia symptoms and stress in undergraduate Sleep Med Rev. 2022 Feb;61:101565. doi: https://doi.org/10.1016/j.smrv.2021.101565
- van Voren R, Andreescu C. Ukrainian Mental Health – A Report From the War. Am J Geriatr Psychiatry. 2022 Aug;30(8):940-3. doi: https://doi.org/10.1016/j.jagp.2022.04.004
- Danese A, Martsenkovskyi D. Editorial: Measuring and Buffering the Mental Health Impact of the War in Ukraine in Young People. J Am Acad Child Adolesc Psychiatry.2023 Mar;62(3):294-6. doi: https://doi.org/10.1016/j.jaac.2022.11.001
- Lahad M. From victim to victor: The development of the BASIC PH model of coping and resiliency. Traumatology. 2017;23:27-34. doi: https://doi.org/10.1037/trm0000105
- Ohorenko VV, Nikolenko AI, Shusterman TI, Kokashynskyi VO. [Resource-oriented model of stress management in higher education students in war conditions]. Medicni perspektivi. 2023;28(3):94-109. Ukrainian. doi: https://doi.org/10.26641/2307-0404.2023.3.289204
- Ang WHD, Shorey S, Hoo MXY, Chew HSJ, Lau Y. The role of resilience in higher education: A meta-ethnographic analysis of students' experiences. J Prof Nurs. 2021 Nov-Dec;37(6):1092-109. doi: https://doi.org/10.1016/j.profnurs.2021.08.010
- The Universal Declaration on Bioethics and Human Rights. International Social Science Journal. 2005;57(186):745-53.
doi: https://doi.org/10.1111/j.1468-2451.2005.00592.x
- World Medical Association Declaration of Helsinki. 2013;310(20):2191. doi: https://doi.org/10.1001/jama.2013.281053
- Cataldo R, Arancibia M, Stojanova J, Papuzinski C. General concepts in biostatistics and clinical epidemiology: Observational studies with cross-sectional and ecological designs. Medwave. 2019 Sep 25;19(8):e7698. doi: https://doi.org/10.5867/medwave.2019.08.7698
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Ogorenko V.V. Dnipro State Medical University, Dnipro, Ukraine https://orcid.org/0000-0003-0549-4292
Nikolenko A.E. Dnipro State Medical University, Dnipro, Ukraine https://orcid.org/0000-0001-5523-8858
Shusterman T.Y. Dnipro State Medical University, Dnipro, Ukraine https://orcid.org/0000-0001-5422-1624
Kokashynskyi V.O. Dnipro State Medical University, Dnipro, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-6191-3757
Khotimska A.B. Charitable organization «Charitable Foundation Resolute Hearts», Dnipro, Ukraine https://orcid.org/0009-0005-8806-7713
Koren M.H. Municipal Enterprise "Dnipropetrovsk multidisciplinary clinical hospital for the provision of psychiatric care" Dnipropetrovsk Regional Council”, Dnipro, Ukraine https://orcid.org/0009-0009-7072-3494
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Ogorenko V.V., Nikolenko A.E., Shusterman T.Y., Kokashynskyi V.O., Khotimska A.B., Koren M.H. Psychoeducation of higher education seekers with using of the resource-oriented model of stress resiliency in war conditions. Medicni perspektivi. 2024;29(3):144-150. DOI: https://doi.org/10.26641/2307-0404.2024.3.313660
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Sardykov Ye.A., Ishchenko O.V., Fastovets O.O. Oral microbiocenosis state under different approaches of replacing dental crown defects
https://doi.org/10.26641/2307-0404.2024.3.313603
Abstract
Dental caries is one of the most common health problems. The aim of the research was to study the spectrum of microbiota, which is part of the dental biofilm, and its biological properties. The study involved 90 participants of the study group and 20 of the control group. Dental plaque and saliva were used as principal clinical specimens. The main research method was bacteriological. All samples from study participants were positive for microbiota. At the initial collection of material, 395 unique isolates were obtained: 338 from patients with caries and 57 from healthy volunteers. The microbiocenosis of the oral cavity associated with the development of caries contained such eudodominants as Streptococcus mutans, Peptostreptococcus spp., Fusobacterium spp., Prevotella spp. and dominants Streptococcus pyogenes, Enterobacterales, Prevotella spp. and Candida albicans. In contrast the eudominants of the healthy oral cavity were microorganisms with known commensal properties, in particular Streptococcus salivarius, Aerococcus viridans, Veillonella spp. After the dental treatment, significant shifts in the taxonomic composition of the dental biofilm were observed. Therefore, the composition of the oral cavity microbiocenosis in participants who underwent restoration of the dental crown defects with zirconium inserts approached patients to the healthy cohort participants. The eudodominants of the oral microbiocenosis of the participants who underwent direct restoration were S. mitis, Peptostreptococcus spp. and Veillonella spp. In zirconium restoration, the commensals S. salivarius and A. viridans were eudodominants. The obtained isolates of opportunists possessed high virulence properties. Streptococcus spp. cultures were sensitive to norfloxacin screening in only 28.6% of cases. Among cultures of the genus Staphylococcus, 23.8% were methicillin resistant. Representatives of Enterobacterales had chemotherapeutic sensitivity that varied significantly depending on the group of antimicrobial agents. Using disks with phenylboronic acid, ethylenediaminetetraacetic acid and cloxacillin, it was established that Klebsiella spp. were producers of class A carbapenemases (n=3) and contained AmpC (n=3). Carbapenemases were also produced by at least 65.2% of the studied cultures of non-fermenting gram-negative microorganisms. In our study, all obtained isolates were also endowed with the ability to form a biofilm. Therefore, microbiological research in dentistry should be considered as one of the objective methods for assessment of health of the oral cavity and will also have advantages in choosing a method of correcting defects of dental crown parts and in some cases, making an informed decision about the prescription of antimicrobial treatment.
Key words: bacteria, fungi, microbiological study, microbiota, microbiocenosis, resistance, biofilms, adhesiveness
References
- Giacaman RA, Fernández CE, Muñoz-Sandoval C, León S, García-Manríquez N, Echeverría C, et al. Understanding dental caries as a non-communicable and behavioral disease: Management implications. Front Oral Health.2022;3:64479. doi: https://doi.org/10.3389/froh.2022.764479
- Thanetchaloempong W, Koontongkaew S, Utispan K. Fixed Orthodontic Treatment Increases Cariogenicity and Virulence Gene Expression in Dental Biofilm. J Clin 2022;11(19):5860. doi: https://doi.org/10.3390/jcm11195860
- Spatafora G, Li Y, He X, Cowan A, Tanner ACR. The Evolving Microbiome of Dental Caries. Microorganisms.2024;12(1):121. doi: https://doi.org/10.3390/microorganisms12010121
- Trottini M, Campus G, Corridore D, Cocco F, Cagetti MG, Vigo MI, et al. Assessing the Predictive Performance of Probabilistic Caries Risk Assessment Models: The Importance of Calibration. Caries Res. 2020;54(3):258-65. doi: https://doi.org/10.1159/000507276
- Carroll CK, Pfaller AM. Manual of Clinical Microbiology, 4 Volume Set. 13-st ed. ASM Books; 2023. 3456 p.
- Efimenko AO, Ishchenko OV. [Features of microbiological research in dental practice]. Perspektyvy ta innovatsiyi nauky. 2023;14(32):969-86. Ukrainian. doi: https://doi.org/10.52058/2786-4952-2023-14(32)-969-986
- The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 13.0 [Internet]. 2023 [cited2024 Mar 15]. Available from: http://www.eucast.org
- Ishchenko OV, Plotnikova MM, Stolyetova YuYu, Sharun OV, Stepanskyi DO. [The influence of different concentrations of pectin on the adhesive properties of clinical isolates obtained from patients with cystic fibrosis.] Vistnyk problem biolohiyi i medytsyny. 2020;1(155):137-40. doi: https://doi.org/10.29254/2077-4214-2020-1-155-137-140
- Toc DA, Csapai A, Popa F, Popa C, Pascalau V, et al. Easy and Affordable: A New Method for the Studying of Bacterial Biofilm Formation. Cells. 2022;11(24):4119. doi: https://doi.org/10.3390/cells11244119
- Ryzhov OA, Penkin YuM. [Statistical methods of processing the results of medical and biological research]. Magnolia; 2022. 160 p. Ukrainian.
- Zhang L, Chen X, Ren B, Zhou X, Cheng L. Helicobacter pylori in the Oral Cavity: Current Evidence and Potential Survival Strategies. Int J Mol Sci.2022 Nov 7;23(21):13646. doi: https://doi.org/10.3390/ijms232113646
- Zhu Y, Wang Y, Zhang S, Li J, Li X, Ying, et al. Association of polymicrobial interactions with dental caries development and prevention. Front Microbiol. 2023;14:1237596. doi: https://doi.org/10.3389/fmicb.2023.1237596
- Lei L, Long L, Yang X, Qiu Y, Zeng Y, Hu T, et al. The VicRK Two-component system regulates Streptococcus mutans virulence. Curr Issues Mol Biol. 2019;32:167-200. doi: https://doi.org/10.21775/cimb.032.167
- Acet Ö, Erdönmez D, Acet B, Odabaşı M. N-acyl homoserine lactone molecules assisted quorum sensing: Effects consequences and monitoring of bacteria talking inreal life. Arch Microbiol. 2021;203:3739-49. doi: https://doi.org/10.1007/s00203-021-02381-9
- Lu Y, Lin Y, Li M, He J. Roles of Streptococcus mutans-Candida albicans interaction in early childhood caries: a literature review. Front Cell Infect Microbiol. 2023 May 16;13:1151532.
doi: https://doi.org/10.3389/fcimb.2023.1151532
- Li Y, Huang S, Du J, Wu M, Huang X. Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm.Front Cell Infect Microbiol. 2023;13:1106231. doi: https://doi.org/10.3389/fcimb.2023.1106231
- Kim HE, Liu Y, Dhall A, Bawazir M, Koo H, Hwang G. Synergism of Streptococcus mutans and Candida albicans Reinforces Biofilm Maturation and Acidogenicity in Saliva: An In Vitro Study. Front Cell Infect 2021 Feb 19;10:623980. doi: https://doi.org/10.3389/fcimb.2020.623980
- Contaldo M, Lucchese A, Lajolo C, Rupe C, Di Stasio D, Romano A, et al. The Oral Microbiota Changes in Orthodontic Patients and Effects on Oral Health: An Overview.J Clin 2021;10(4):780. doi: https://doi.org/10.3390/jcm10040780
- Ionescu AC, Hahnel S, Delvecchio P, Ilie N, Moldovan M, Zambelli V, et al. Microbiological models for accelerated development of secondary caries in vitro. J Dent.2022;127:104333. doi: https://doi.org/10.1016/j.jdent.2022.104333
- Bollen C, Hakobayan G, Jörgens M. One-piece versus two-piece ceramic dental implants. Br Dent J. 2024;236(5):383-7.
doi: https://doi.org/10.1038/s41415-024-7123-3
- D’Ambrosio F, Santella B, Di Palo MP, Giordano F, Lo Giudice R. Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant-Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review. Microorganisms.2023;11(4):1041. doi: https://doi.org/10.3390/microorganisms11041041
- Antibiotic Resistance Threats in the United States, 2019. Atlanta, GA: U.S. Department of Health and Human Services, CDC [Internet]. 2019 [cited 2024 Mar 15]. doi:http://dx.doi.org/10.15620/cdc:82532
- Iskandar K, Molinier L, Hallit S, Sartelli M, Hardcastle TC, Haque M, et al. Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture. Antimicrob Resist Infect Control. 2021;10(1):63. doi: https://doi.org/10.1186/s13756-021-00931-w
- Kiros A, Saravanan M, Niguse S, Gebregziabher D, Kahsay G, Dhandapani R, et al. Bacterial Profile, Antimicrobial Susceptibility Pattern, and Associated Factors among Dental Caries-Suspected Patients Attending the Ayder Comprehensive Specialized Hospital and Private Dental Clinic in Mekelle, Northern Ethiopia. Biomed Res Int.2022;2022:3463472. doi: https://doi.org/10.1155/2022/3463472
- Philips OO, Timothy O, Charlse II, Osamuyimen I. Susceptibility Pattern of Bacterial Isolates from Dental Caries Patients Attending Clinic at Irrua Specialist Teaching Hospital, Irrua, Nigeria. J Biomed Res Environ Sci. 2021;2(9):784-9. doi: https://doi.org/10.37871/jbres1311
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Ismailov G.M. Demographic and clinical characteristics and effectiveness of treatment of patients with combined ocular pathologies by vitrectomy due to retinal detachment
https://doi.org/10.26641/2307-0404.2024.3.313666
Abstract
Purpose – to evaluate the demographic and clinical characteristics and treatment efficiency of patients by vitrectomy due to retinal detachment against the background of combined eye pathologies. The observation was conducted in the Clinic of Educational Surgery of the Azerbaijan State Medical Institute named after A. Aliyev. The case histories of 500 patients diagnosed with retinal detachment against the background of combined eye pathologies were studied by random sampling, 197 of whom underwent vitrectomy. Data on the demographic and clinical characteristics of these patients were collected. Before the operation, visual acuity and intraocular pressure were assessed. Information on registered complications after the operation, the results of optical coherence tomography on day 10 after treatment, as well as visual acuity indicators were provided for in the observation program and obtained in a standard manner for all patients. The obtained results were processed statistically using the "data analysis" package of the Excel program. The collected data were grouped by variants of features, the specific weight of each group and subgroup in the aggregate was calculated. The obtained data showed that in 197 (34.9±2.2%) patients with retinal detachment against the background of combined pathologies who underwent vitrectomy, the gender difference was not significant. The overwhelming majority of patients were admitted for treatment with a great delay. Basically, combined pathologies of the cornea (16.2%), lens (45.2%) and vitreous body (5.3%) prevailed. Combined eye pathologies in patients with retinal detachment during vitrectomy are often complicated by choroidal rupture (4.1%), increased intraocular pressure (7.6%), diplopia (3.6%), hemophthalmos (2.5%) and cataract (22.8%). The main etiologic factors of retinal detachment against the background of combined eye pathologies are myopia (50.3%), eye injuries (30.9%).
Key words: retinal detachment, vitrectomy, ocular pathology, demography
References
- Sindal MD, Gondhale HP, Srivastav K. Clinical profile: and outcomes of rhegmatogenous retinal detachment related to trauma in pediatric population. Can J Ophthalmol.2021;56(4):231-6. doi: https://doi.org/10.1016/j.jcjo.2020.12.001
- Lakshmi J, Faraz J, Reddy L. Clinical profile of patients presenting with rhegmatogenous retinal detachment. Med Pulse International Journal of Ophthalmology.2017;3(3):87-91. doi: https://doi.org/10.26611/10093311
- Awan MA, Hussain Z, Shaheen ZS, et al. Efficacy and safety profile of 25-Gauge Pars Plana vitrectomy in rhegmatogenous retinal detachment in Pakistan: A multicenter retrospective study. Cureus. 2022 Mar 24;14(3):23437. doi: https://doi.org/10.7759/cureus.23437
- Sung J, Lee M, Won Y, et al. Clinical characteristics and prognosis of total rhegmatogenous retinal detachment: a matched case-control Study. BMC Ophthalmology.2020;20:286. doi: https://doi.org/10.1186/s12886-020-01560-4
- Shchukin AD. Modern extrascleral surgery in the treatment of rhegmatogenous retinal detachment: assessment of the effectiveness of application and functional results. Ophthalmological Bulletin. 2019;12(4):23-8. doi: https://doi.org/10.17816/OV18780
- Arevalo F, Ong S, Sulaiman M. Retinal detachment: Vitrectomy, bucle, or both? Retina today. 2022;April:17-78.
- Zgolli H, Mabrouk S, Khayrallah O. Prognostic factors for visual recovery in idiopathic rhegmatogenous retinal detachment: a prospective Study of 90 patients. La Tunisie Medicale. 2021;99(10):972-9. PMID: 35288898. PMCID: PMC8972183.
- Chang JS, Smiddy W. Cost-effectivenes of retinal detachment repair. Ophthalmology. 2014;12(4):946-51. doi: https://doi.org/10.1016/j.ophtha.2013.11.003
- Liao L, Zhy X. Advances in the treatment of rhegmatogenous retinal detachment. Int J Ophthalmology. 2019;12(4):660-7. doi: https://doi.org/10.18240/ijo.2019.04.22
- Lv Z, Li Y, Wu Y. Surgical complications of primary rhegmatogenous retinal detachment: a meta-analysis. PLOS 2015;10(3):0116493. doi: https://doi.org/10.1371/journal.pone.0116493
- Bai Y, Song Q, Liu J. Vitrectomy for complicated retinal detachment without the use of perfluorocarbon liquid: a real-word date and retrospective study. Opthalmol Ther. 2022;11:857-68. doi: https://doi.org/10.1007/s40123-022-00479-x
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Ismailov G.M. Azerbaijan State Medical Institute named after A.Aliyev, Baku, Republic of Azerbaijan e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
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Ismailov G.M. Demographic and clinical characteristics and effectiveness of treatment of patients with combined ocular pathologies by vitrectomy due to retinal detachment. Medicni perspektivi. 2024;29(3):162-166. DOI: https://doi.org/10.26641/2307-0404.2024.3.313666
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S. Alekova Todorova The incidence of benign and malignant tumors among adults with long-term physical disabilities
https://doi.org/10.26641/2307-0404.2024.3.313671
Abstract
People with long-term physical disabilities also suffer from different types and nature of tumors as well as general population. Unfortunately, the information about the frequency of these diseases among the specified contingent is very deficient. The objectives of the study were to determine the incidence of benign and malignant neoplasia among the adults and elderly with physical disabilities and to indicate the risk factors for the appearance and development of tumors in this population. In this descriptive survey, 186 people, living in the largest home on the Balkan Peninsula for adults and elderly people with long-term physical disabilities were studied in 2021. 82.79% of the residents were over 51 years of age and almost all of them are inhabited by two residents. 42.47% of the respondents were men and 57.52% – women. Data on the demographic characteristics of the respondents, including their personal lifestyle and self-reported diagnosis of presence and/or history of a tumor formation, were collected through a semi-structured interview. The verification of the collected information about the incidence of benign and malignant lesions among adults with physical disabilities was carried out by means of the application of the second research method – content analysis based on the medical records. For processing and analysis of the collected data, it was used statistical software – IBM SPSS Statistics V21.0. The results showed a significantly high rate in the prevalence of tumor formations in the sample – 24.19%. The pre-cancerous formations have the highest incidence among residents – 42.22% with the most common variant – chronic form of cholecystitis combined with cholelithiasis (37.77%). Prostatic hyperplasia and uterine leiomyoma are the leading benign lesions in male residents – 11.11%, in female respondents – 11.11% respectively. The predominant form of cancer is breast carcinoma – 8.88%. The research found a high prevalence of tumor formations among adult patients with long-term physical disabilities. The harmful impact of a number of behavioral habits and health determinants significantly contributes to this negative tendency.
Key words: tumor formations, incidence, people with long-term physical disabilities
References
- Australian institute of health and welfare. People with disability in Australia [Internet]. 2020 [cited 2024 Mar 12].Available from: https://www.aihw.gov.au/reports/disability/people-with-disability-in-australia
- ICDR Toolkit-Health Disparities and Disabilities in Research [Internet]. 2020 [cited 2024 Mar 12]. Availablefrom: https://icdr.acl.gov/system/files/resources/HFW%20Toolkit%20Final.pdf
- Centers for disease control and prevention. Cancer screening prevalence among adults with disabilities [Internet]. 2019 [cited 2024 Mar 12]. Available from: https://www.cdc.gov/cancer/dcpc/research/articles/screening-disabilities.htm
- Fowler H, Belot A, Ellis L, et al. Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers. BMC Cancer. 2020;20(1):2. doi: https://doi.org/10.1186/s12885-019-6472-9
- Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Abate D, et al. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol.2019 Dec 1;5(12):1749-68. doi: https://doi.org/10.1001/jamaoncol.2019.2996. Erratum in: JAMA Oncol. 2020 Mar 1;6(3):444. doi: https://doi.org/10.1001/jamaoncol.2020.0224. Erratum in: JAMA Oncol. 2020 May 1;6(5):789. doi: https://doi.org/10.1001/jamaoncol.2020.0741. Erratum in: JAMA Oncol. 2021 Mar 1;7(3):466. doi: https://doi.org/10.1001/jamaoncol.2020.8307
- Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J Clin. 2024;74(3):229-63. doi: https://doi.org/10.3322/caac.21834
- Ubago-Guisado E, Rodríguez-Barranco M, Ching-López A, et al. Evidence Update on the Relationship between Diet and the Most Common Cancers from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: A Systematic Review. Nutrients. 2021;13(10):3582. doi: https://doi.org/10.3390/nu13103582
- Marino P, Mininni M, Deiana G, Marino G, Divella R, Bochicchio I, et al. Healthy lifestyle and cancer risk: modifiable risk factors to prevent cancer. Nutrients. 2024;16(6):800. doi: https://doi.org/10.3390/nu16060800
- de Martel C, Georges D, Bray F, Ferlay J, Clifford GM. Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health.2020;8(2):e180-e190. doi: https://doi.org/10.1016/S2214-109X(19)30488-7
- Dikova K, Yaneva R. National center for public health and analysis of the ministry of health. Sofia: Healthcare; 2021. р. 1313-1907.
- National strategy for long-term care in the Republic of Bulgaria, 2014-2020. 2020. p. 11-14.
- Kim YE, Lee YR, Yoon SJ, Kim YA, Oh IH. Years of Life Lost due to Premature Death in People with Disabilities in Korea: the Korean National Burden of Disease Study Framework. J Korean Med Sci. 2019;34(2):e22. doi: https://doi.org/10.3346/jkms.2019.34.e22
- S. Department of Health and Human Services. Healthy People 2020. Disparities [Internet]. 2020 [cited 2024 Mar 12].Available from: www.healthypeople.gov/2020/about/foundation-health-measures/Disparities
- National center on birth defects and developmental disabilities. (2020, April 23). Increasing physical activity among adults with disabilities. Centers for disease control and prevention [Internet]. 2020 [cited 2024 Mar 12]. Availablefrom: https://www.cdc.gov/ncbddd/disabilityandhealth/pa.html
- Centers for disease control and prevention. Disability and health data system (DHDS) [Internet]. 2023 [cited 2024 Mar 12]. Available from: http://dhds.cdc.gov
- Chiu TY. Predictors of use of preventative health services for people with disabilities in taiwan. Int J Environ ResPublic 2021;18(4):1661. doi: https://doi.org/10.3390/ijerph18041661
- Clina JG, Sayer RD, Gorczyca AM, et al. Weight history of individuals with and without physical disability in the International Weight Control Registry. Obes Sci Pract.2023;10(1):e733. doi: https://doi.org/10.1002/osp4.733
- Washburn RA, Ptomey LT, Gorczyca AM, et al. Weight management for adults with mobility related disabilities: Rationale and design for an 18-month randomized trial. Contemp Clin Trials. 2020;96:106098. doi: https://doi.org/10.1016/j.cct.2020.106098
- Carty C, van der Ploeg HP, Biddle SJ, Bull F, Willumsen J, Lee L, et al. The first global physical activity and sedentary behavior guidelines for people living with disability. Journal of Physical Activity and Health. 2021;18(1):86-93. doi: https://doi.org/10.1123/jpah.2020-0629
- PDQ Cancer genetics editorial board. Genetics of breast and gynecologic cancers (PDQ®): health professional version. 2024 Apr 4. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002 [cited 2024 Mar 12]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK65767/
- White MC, Kavanaugh-Lynch MM, Davis-Patterson S, Buermeyer N. An expanded agenda for the primary prevention of breast cancer: charting a course for the future. Int J Environ Res Public Health. 2020;17(3):714. doi: https://doi.org/10.3390/ijerph17030714
- Rodríguez-Palacios DÁ, Colorado-Yohar SM, Velten M, Vaamonde-Martín RJ, Ballesta M, Chirlaque MD. Incidence and trend of type I and II endometrial cancer in women from two population-based European Cancer Registries (1998-2012). Int J Environ Res Public Health.2022;19(7):3789. doi: https://doi.org/10.3390/ijerph19073789
- Weishaupt J. Endometrial cancer: Access denied– a review of the forgotten voice of mental and physical disability in gynaecology oncology in Australia. J Women's Health Care. 2019;8:476. doi: https://doi.org/10.35248/2167-0420.19.8.476
- Hutt S, Mihaies D, Karteris E, Michael A, Payne AM, Chatterjee J. Statistical meta-analysis of risk factors for endometrial cancer and development of a risk prediction model using an artificial neural network algorithm. Cancers (Basel). 2021;13(15):3689. doi: https://doi.org/10.3390/cancers13153689
- Katagiri R, Iwasaki M, Abe SK, et al. Reproductive Factors and Endometrial Cancer Risk Among Women. JAMA Netw Open. 2023;6(9):e2332296. doi: https://doi.org/10.1001/jamanetworkopen.2023.32296
- Simms KT, Yuill S, Killen J, et al. Historical and projected hysterectomy rates in the USA: Implications for future observed cervical cancer rates and evaluating prevention interventions. Gynecol Oncol. 2020;158(3):710-8. doi: https://doi.org/10.1016/j.ygyno.2020.05.030
- Gultekin M, Ramirez PT, Broutet N, et al. World Health Organization call for action to eliminate cervical cancer globally. International Journal of Gynecologic Cancer.2020;30:426-7.
doi: https://doi.org/10.1136/ijgc-2020-001285
- Abebe M, Eshetie S, Tessema B. Prevalence of sexually transmitted infections among cervical cancer suspected women at University of Gondar Comprehensive Specialized Hospital, North-west Ethiopia. BMC Infect Dis.2021;21(1):378.
doi: https://doi.org/10.1186/s12879-021-06074-y
- Kucuk S, Ercihan E, Ucar Uncu A, et A retrospecti̇ve evaluation of the epithelial lesions/neoplasms of the gallbladder in Uşak city and determination of the visual frequency. Med-Science. 2020;9(1):26-32. doi: https://doi.org/10.5455/medscience.2019.08.9129
- Jones MW, Gnanapandithan K, Panneerselvam D, Ferguson T. Chronic Cholecystitis. In: StatPearls. Treasure Island (FL): StatPearls Publishing [Internet]. 2023 [cited 2024 Mar 12].Available from: https://www.ncbi.nlm.nih.gov/books/NBK470236/
- Costanzo ML, D'Andrea V, Lauro A, Bellini MI. Acute cholecystitis from biliary lithiasis: diagnosis, management and treatment. Antibiotics (Basel). 2023;12(3):482. doi: https://doi.org/10.3390/antibiotics12030482
- Jones MW, Weir CB, Ghassemzadeh S. Gallstones (Cholelithiasis). In: StatPearls. Treasure Island (FL): StatPearls Publishing [Internet]. 2024 [cited 2024 Mar 12]. Availablefrom: https://www.ncbi.nlm.nih.gov/books/NBK459370/
- Di Mauro D, Orabi A, Myintmo A, Reece-Smith A, Wajed S, Manzelli A. Routine examination of gallbladder specimens after cholecystectomy: a single-centre analysis of the incidence, clinical and histopathological aspects of incidental gallbladder carcinoma. Discov Oncol. 2021;12(1):4. doi: https://doi.org/10.1007/s12672-021-00399-5
- Tinelli A, Vinciguerra M, Malvasi A, Andjić M, Babović I, Sparić R. Uterine Fibroids and Diet. Int J Environ Res Public Health. 2021;18(3):1066. doi: https://doi.org/10.3390/ijerph18031066
- Giuliani E, As-Sanie S, Marsh EE. Epidemiology and management of uterine fibroids. Int J Gynaecol Obstet. 2020;149(1):3-9. doi: https://doi.org/10.1002/ijgo.13102
- Yang Q, Ciebiera M, Bariani MV, et al. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocr Rev. 2022 Jul 13;43(4):678-719. doi: https://doi.org/10.1210/endrev/bnab039. Erratum in: Endocr 2022 Jul 13;43(4):761. doi: https://doi.org/10.1210/endrev/bnac007. Erratum in: Endocr Rev. 2022 Jul 13;43(4):762. doi: https://doi.org/10.1210/endrev/bnac006
- Qu Y, Chen L, Guo S, Liu Y, Wu H. Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study. Front. Endocrinol. 2023;14:1133260. doi: https://doi.org/10.3389/fendo.2023.1133260
- Huseman-Plascencia LA, Villa-Villagrana F, Ballesteros-Manzo A, Baptista Rosas RC, Mercado-Sesma AR, Arámbula-Chavolla MI. Body mass index and vitamin D as risk factors for the development of uterine leiomyomas in Mexican women. Journal of Endometriosisand Pelvic Pain Disorders. 2022;14(1):14-8. doi: https://doi.org/10.1177/22840265211065226
- GBD 2019 Benign Prostatic Hyperplasia Collaborators. The global, regional, and national burden of benign prostatic hyperplasia in 204 countries and territories from 2000 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Healthy Longev. 2022;3(11):e754-e776. doi: https://doi.org/10.1016/S2666-7568(22)00213-6
- Cannarella R, Condorelli RA, Barbagallo F, La Vignera S, Calogero AE. Endocrinology of the Aging Prostate: Current Concepts. Front Endocrinol (Lausanne). 2021;12:554078. doi: https://doi.org/10.3389/fendo.2021.554078
- Moussa M, Papatsoris A, Chakra MA, Fares Y, Dellis A. Lower urinary tract dysfunction in common neurological diseases. Turk J Urol. 2020;46(Supp 1):S70-S78. doi: https://doi.org/10.5152/tud.2020.20092
- Park S, Lee KS, Choi M, Lee M. Factors associated with quality of life in patients with benign prostatic hyperplasia, 2009-2016. Medicine (Baltimore). 2022;101(36):e30091. doi: https://doi.org/10.1097/MD.0000000000030091
- Wang YB, Yang L, Deng YQ, et al. Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study. J Transl Med. 2022;20:495. doi: https://doi.org/10.1186/s12967-022-03722-y
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S. Alekova Todorova Trakia University, Stara Zagora, Bulgaria, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-0443-5891
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Smashna O.Y. Transcranial electrical stimulation in post-traumatic stress disorder and brain injury: possibilities of tuning neuronal networks
https://doi.org/10.26641/2307-0404.2024.3.313673
Abstract
Transcranial direct current stimulation (tDCS) in the treatment of post-traumatic stress disorder (PTSD) is used to strengthen the inhibitory control of amygdala activity. However, there are still limited meta-analytic studies examining different tDCS protocols on core PTSD symptoms and the relationship between stimulation parameters and effect size. The objective is to investigate the effectiveness of such an intervention, which is a complex combination of a psychotherapy program with tDCS in the treatment of patients with PTSD and mild traumatic brain injury (mTBI) by assessing their level of functioning. 329 veterans (PTSD (n=109), mTBI (n=112), PTSD + mTBI (n=108) were examined using WHODAS 2.0. Standardized treatment was provided as well as psychotherapeutic intervention - a combination of psychoeducation with motivational interviewing and acceptance and commitment therapy for PTSD and tDCS. Clinical targets of therapy in the PTSD group were symptoms of intrusion, avoidance, hyperactivation and protocol of tDCS was dorsolateral prefrontal cortex arousing stimulation. In PTSD + TBI group clinical targets were neurocognitive symptoms, intrusion symptoms, avoidance, hyperactivation and tDCT protocol was motor cortex-supraorbital area inhibitory stimulation. The targest for TBI group was neurocognitive symptoms and tDCS protocol was occipital region exciting stimulation. The long-term effectiveness and the impact on neuroplasticity processes allow considering transcranial direct current stimulation as a promising method of neurorehabilitation of patients with a combination of posttraumatic stress disorder and mild traumatic brain injury.
Key words: posttraumatic stress disorder, traumatic brain injury, functioning, veteran, neuroimaging studies transcranial direct current stimulation
References
- Kunimatsu A, Yasaka K, Akai H, Kunimatsu N, Abe O. MRI findings in posttraumatic stress disorder. J Magn Reson Imaging. 2020 Aug;52(2):380-96. doi: https://doi.org/10.1002/jmri.26929
- Korgaonkar MS, Goldstein-Piekarski AN, Fornito A, Williams LM. Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder. Mol Psychiatry. 2020 Jul;25(7):1537-49. doi: https://doi.org/10.1038/s41380-019-0574-2
- Breukelaar IA, Bryant RA, Korgaonkar MS. The functional connectome in posttraumatic stress disorder. Neurobiol Stress. 2021 Mar 31;14:100321. doi: https://doi.org/10.1016/j.ynstr.2021.100321
- Porter KE, Stein MB, Martis B, Avallone KM, McSweeney LB, Smith ER, et al. Postconcussive symptoms (PCS) following combat-related traumatic brain injury (TBI) in veterans with posttraumatic stress disorder (PTSD): influence of TBI, PTSD, and depression on symptoms measured by the Neurobehavioral Symptom Inventory (NSI). Journal of psychiatric research. 2018;102:8-13. doi: https://doi.org/10.1016/j.jpsychires.2018.03.004
- Monsour M, Ebedes D, Borlongan CV. A review of the pathology and treatment of TBI and PTSD. Experimental Neurology. 2022;351:114009. doi: https://doi.org/10.1016/j.expneurol.2022.114009
- Loignon A, Ouellet MC, Belleville G. A Systematic Review and Meta-analysis on PTSD Following TBI Among Military/Veteran and Civilian Populations. Journal of Head Trauma Rehabilitation. 2020;35(1):E21-E35. doi: https://doi.org/10.1097/HTR.0000000000000514
- Khaustova О, Smashna O. Diagnostic Approaches to Verification of the Mild Traumatic Brain Injury in Patients with Posttraumatic Stress Disorder. Psychiatry, Psychotherapy and Clinical Psychology. 2019;10(3):408-16.
- Kéri S. Trauma and Remembering: From Neuronal Circuits to Molecules. Life (Basel). 2022 Oct 26;12(11):1707. doi: https://doi.org/10.3390/life12111707
- Li LM, Violante IR, Zimmerman K, Leech R, Hampshire A, Patel M, et al. Traumatic axonal injury influences the cognitive effect of non-invasive brain stimulation. Brain. 2019 Oct 1;142(10):3280-93. doi: https://doi.org/10.1093/brain/awz252
- De Freitas DJ, De Carvalho D, Paglioni VM, Brunoni AR, Valiengo L, Thome-Souza MS, et al. Effects of transcranial direct current stimulation (tDCS) and concurrent cognitive training on episodic memory in patients with traumatic brain injury: a double-blind, randomised, placebo-controlled study. BMJ Open. 2021 Aug 26;11(8):e045285. doi: https://doi.org/10.1136/bmjopen-2020-045285
- Galetto V, Sacco K. Neuroplastic Changes Induced by Cognitive Rehabilitation in Traumatic Brain Injury: A Review. Neurorehabil Neural Repair. 2017 Sep;31(9):800-13. doi: https://doi.org/10.1177/1545968317723748
- Dennis EL, Disner SG, Fani N, Salminen LE, Logue M, Clarke EK, et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Mol Psychiatry. 2021 Aug;26(8):4315-30. doi: https://doi.org/10.1038/s41380-019-0631-x
- Assonov D. PTSD is associated with structural disorders of neuronal connections between the right and left hippocampus. PMGP. 2020;5(1):e0501234.
- Joshi SA, Duval ER, Kubat B, Liberzon I. A review of hippocampal activation in post-traumatic stress disorder. Psychophysiology. 2020 Jan;57(1):e13357. doi: https://doi.org/10.1111/psyp.13357
- Sheynin J, Duval ER, King AP, Angstadt M, Phan KL, Simon NM, et al. Associations between resting-state functional connectivity and treatment response in a randomized clinical trial for posttraumatic stress disorder. Depress Anxiety. 2020 Oct;37(10):1037-46. doi: https://doi.org/10.1002/da.23075
- Abellaneda-Pérez K, Vaqué-Alcázar L, Perellón-Alfonso R, Bargalló N, Kuo MF, Pascual-Leone A, et al. Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity. Front Neurosci. 2020 Jan 17;13:1440. doi: https://doi.org/10.3389/fnins.2019.01440
- Zaninotto AL, El-Hagrassy MM, Green JR, Babo M, Paglioni VM, Benute GG, et al. Transcranial direct current stimulation (tDCS) effects on traumatic brain injury (TBI) recovery A systematic review. Dement Neuropsychol. 2019;13(2):2-179. doi: https://doi.org/10.1590/1980-57642018dn13-020005
- Bajbouj M, Aust S, Spies J, Herrera-Melendez AL, Mayer SV, Peters M, et al. PsychotherapyPlus: augmentation of cognitive behavioral therapy (CBT) with prefrontal transcranial direct current stimulation (tDCS) in major depressive disorder-study design and methodology of a multicenter double-blind randomized placebo-controlled trial. Eur Arch Psychiatry Clin Neurosci. 2018 Dec;268(8):797-808. doi: https://doi.org/10.1007/s00406-017-0859-x
- Ines K, Violante R, Zimmerman K, Leech R, Hampshire A, Patel MC, et al. Investigating the interaction between white matter and brain state on tDCS-induced changes in brain network activity. Brain Stimulation. 2021;14(5):1261-70. doi: https://doi.org/10.1016/j.brs.2021.08.004
- Dubreuil-Vall L, Chau P, Ruffini G, Widge AS, Camprodon JA. tDCS to the left DLPFC modulates cognitive and physiological correlates of executive function in a state-dependent manner. Brain Stimul. 2019 Nov-Dec; 12(6):1456-63. doi: https://doi.org/10.1016/j.brs.2019.06.006
- Li ML, Violante IR, Leech R, Ross E, Hampshire A, Opitz A, et al. Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation. Hum Brain Mapp. 2018;40(3):904-915. doi: https://doi.org/10.1002/hbm.24420
- Zaninotto AL, El-Hagrassy MM, Green JR, Babo M, Paglioni VM, Benute GG, et al. Transcranial direct current stimulation (tDCS) effects on traumatic brain injury (TBI) recovery: A systematic review. Dement Neuropsychol. 2019 Apr-Jun;13(2):172-9. doi: https://doi.org/10.1590/1980-57642018dn13-020005
- Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol. 2017 Jan;128(1):56-92. doi: https://doi.org/10.1016/j.clinph.2016.10.087
- van 't Wout-Frank M, Shea MT, Larson VC, Greenberg BD, Philip NS. Combined transcranial direct current stimulation with virtual reality exposure for posttraumatic stress disorder: Feasibility and pilot results. Brain Stimul. 2019 Jan-Feb;12(1):41-3. doi: https://doi.org/10.1016/j.brs.2018.09.011
- Kan RLD, Zhang BBB, Zhang JJQ, Kranz GS. Non-invasive brain stimulation for posttraumatic stress disorder: a systematic review and meta-analysis. Transl Psychiatry. 2020 May 28;10(1):168. doi: https://doi.org/10.1038/s41398-020-0851-5
- Üstün TB, Kostanjsek N, Chatterji S, Rehm J, editors. Measuring Health and Disability. Manual for WHO Disability Assessment Schedule (WHODAS 2.0). Disability evaluation. 2.Health status. 3.Human development. 4.Classification. 5.Manuals. I. World Health Organization; 2010. 88 р. ISBN 9789241547598 (NLM classification: W 15)
- Golovanova I, Bielikova I. [Fundamentals of medical statistics]. Poltava; 2017. 113 p. Ukrainian.
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Smashna O.Y. Ternopil National Medical University named after I.Ya. Horbachevskyi, Ministry of Health of Ukraine, Ternopil, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0001-6595-2940
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Zakharov S.V., Nekhanevych O.B., Rusakova O.O., Smolianova O.V. Socio-demographic portrait of the applicant and the main motives for choosing the "Therapy and rehabilitation" speciality
https://doi.org/10.26641/2307-0404.2024.3.313675
Abstract
Rehabilitation and psychological support are becoming today's most urgent issues due to russian armed aggression. These needs will be long-lasting and increasingly significant. Since 2023, the Program of Medical Guarantees in Ukraine has been expanded regarding rehabilitation assistance. Additionally, volumes of the state-commissioned training of bachelors and masters in the speciality of "Therapy and rehabilitation" have been increased. It is well known that the quality of specialists trained by higher educational institutions largely depends on the motives behind the career choice. Knowledge about a student's socio-demographic status and his/her motivations to become a physical therapy and occupational therapy specialist can help understand future challenges and opportunities for the profession's development. This information can aid in elaborating strategies to promote the profession in the educational services market and to attract more applicants to choose the speciality 227 "Therapy and rehabilitation". The research aimed to compose the socio-demographic characteristics of the applicant for training in the speciality 227 "Therapy and rehabilitation", to investigate the motivational aspects of career choice and to establish the factors significant for motivation formation. To achieve this goal, a voluntary anonymous survey of 39 domestic applicants enrolled to complete the bachelor's degree program in speciality 227 "Therapy and rehabilitation" at Dnipro State Medical University was conducted. It was determined that the contingent of applicants is represented mainly by persons aged 16-18 (74%) with an active life position (90%). Additionally, most are familiar with the specifics of medical professions (62%) and have had previous personal or professional contact with physical therapy and occupational therapy (78%). The future career decision was mostly independent (84%), conscious, and influenced by the balance of internal and external motivational factors. It was typically made one to two years before taking degree course (72%). The primary motives for choosing the speciality 227 "Therapy and rehabilitation" while understanding its demand in today's conditions by applicants (82%) were "interest in medical science" (95%), "the desire to help others" (95%), "the opportunity to obtain a prestigious profession" (90%), "possibility of guaranteed employment" (90%) and "material interest/financial independence" (87%). Future specialists are aware of the importance of controlled acquisition of knowledge and skills (90%), the need for daily independent work (80%), and the significance of gaining practical experience during training (95%). They aim to achieve professionalism (59%), enhance communication skills (31%), build endurance (31%), and cultivate persistence (28%) and empathy (28%). Most applicants entering the speciality 227 "Therapy and rehabilitation" are goal-oriented, highly motivated, and prepared for rigorous study, which is the key to developing into competent and competitive specialists.
Key words: applicants survey, career choice, motivation, therapy and rehabilitation, physical therapy, occupational therapy, medical education
References
- Gosling J, Golyk V, Mishra S, Skelton P. We must not neglect rehabilitation in Ukraine. eClinicalMedicine. 2022;50:101537.
doi: https://doi.org/10.1111/1440-1630.12929
- Armitage RC. War in Ukraine: public health, rehabilitation and assistive technologies. Disability and Rehabilitation: Assistive Technology. 2022;17(8):989-90. doi: https://doi.org/10.1080/17483107.2022.2110950
- Navarese EP, Grzelakowska K, Mangini F, Kubica J, Banach M, Benn M, et al. The spoils of war and the long-term spoiling of health conditions of entire nations. Atherosclerosis.2022;352:76-9. doi: https://doi.org/10.1016/j.atherosclerosis.2022.05.012
- Carra K, McKinstry C, Baillie L, Daniell R, Clews A. Enhancing occupational therapy service provision with military veterans through policy reform: Findings from a national survey. Aus Occup Therapy J. 2024;71(3):369-78. doi: https://doi.org/10.1111/1440-1630.12929
- [Free services in the Medical Guarantee Program 2023. Rehabilitation assistance.] NSZU [Internet]. 2023 [cited2024 Jan 28]. Available from: https://service.e-health.gov.ua/gromadyanam/besoplatni-poslygy/reab-dopomoga
- [About the state order for the training of specialists, scientific, scientific-pedagogical and labor personnel, for advanced training and retraining of personnel in 2023. Resolution of the Cabinet of Ministers of Ukraine dated 11.07.2023 No. 708]. [Internet]. 2023 [cited 2024 Jan 28]. Availablefrom: https://www.kmu.gov.ua/npas/pro-derzhavne-zamovlennia-na-pidhotovku-fakhivtsiv-naukovykh-naukovo-pedahohichnykh-ta-robitnychykh-kadriv-na-pidvyshchennia-kvalifikatsii-ta-perepidhotovku-kadriv-u-2023-rotsi-708-110723
- Bonsaksen T, Kvarsnes H, Dahl M. Who wants to go to occupational therapy school? Characteristics of Norwegian occupational therapy students. Scandinavian Journal of Occupational Therapy. 2016;23(4):297-303. doi: https://doi.org/10.3109/11038128.2015.1105293
- Zakharov SV, Rusakova OO, Smolianova OV. [Motivational and emotional aspects of choosing medical profession by medical university applicants]. Medychna osvita.2023;(1):35-41. doi: https://doi.org/10.11603/m.2414-5998.2023.1.13564
- Riffenburgh R, Gillen D. Statistics in medicine. Elsevier Inc. London; 2020. 822 p.
- Hassan M, Shahzad F, Waqar S. Seeking motivation for selecting Medical Profession as a Career Choice. PakJ Med 2020;36(5):941-5. doi: https://doi.org/10.12669/pjms.36.5.2799
- Byrne N. Exposure to occupational therapy as a factor influencing recruitment to the profession. Aus OccupTherapy 2015;62(4):228-37. doi: https://doi.org/10.1111/1440-1630.12191
- Ilnytska HS, Ilnytska LV, Ocheredko LV, et [Research of factors affecting the choice of the profession of physical therapist]. Osvitnii dyskurs: zbirnyk naukovykh prats. 2020;18(11-12):105-13. Ukrainian. doi: https://doi.org/10.33930/ed.2019.5007.18(11-12)-8
- Colaianni D, Tovar G, Wilson D, Zapanta H. Factors Influencing the Diversity of Occupational Therapy Students. Journal of Occupational Therapy Education.2022;6(1):2. doi: https://doi.org/10.26681/jote.2022.060102
- Tétreault S, Bétrisey C, Gulfi A, Brisset C, Kühne N, Leanza Y. Perceptions, Competencies and Motivation for Study Choice: Occupational Therapy and Social Work Student Perspectives. International Journal of Practice-based Learning in Health and Social Care. 2020;8(1):15-30. doi: https://doi.org/10.18552/ijpblhsc.v8i1.519
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Zakharov S.V., Nekhanevych O.B., Rusakova O.O., Smolianova O.V. Socio-demographic portrait of the applicant and the main motives for choosing the "Therapy and rehabilitation" speciality. Medicni perspektivi. 2024;29(3):183-192. DOI: https://doi.org/10.26641/2307-0404.2024.3.313675
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PREVENTIVE MEDICINE
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Yastrub T.O., Kravchuk O.P., Basanets A.V., Yastrub A.M., Shabalkov D.O. Toxicological characterization of the insecticide metofluthrin and assessment of the carcinogenic risk to human health due to its chronic inhalation effect
https://doi.org/10.26641/2307-0404.2024.3.313676
Abstract
The aim of the investigation is the toxicological characterization and analysis of the danger criteria of the insecticide metofluthrin with an assessment of the carcinogenic risk to health caused by chronic inhalation exposure to the substance at the level of the maximum possible concentrations in the air environment of human life. The analysis of scientific reports of the US Environmental Protection Agency (US EPA) and the European Chemicals Agency (ECHA) on the toxicological properties of metofluthrin was carried out. The assessment of the risk of the development of carcinogenic effects due to chronic inhalation exposure to metofluthrin was carried out taking into account the average daily dose of the substance that can enter the human body during the natural life span (LADD) and the carcinogenic potential factor (SF) in accordance with domestic guidelines. Classification of levels of carcinogenic risk was carried out using domestic and international approaches. It was established that the limiting criteria for the danger of metofluthrin are the average lethal concentration in air (LC50 =1080 mg/m³) and the size of the zone of chronic action (Zch=7.46), which characterizes the danger of occurrence of chronic intoxication due to long-term inhalation exposure. According to these indicators, metofluthrin is classified as a dangerous substance (hazard class 2). The key effects of the toxic action of metofluthrin are determined – neurotoxicity, hepatotoxicity and nephrotoxicity. The threshold non-genotoxic oncogenic potential of metofluthrin according to the phenobarbital type was established. Individual carcinogenic risk under different scenarios of chronic inhalation exposure to metofluthrin was calculated. The substance concentration of 3.54 mg/m³ leads to a high level of risk (1.5×10-3), which is considered unacceptable for production conditions and the population. At concentrations of 0.28 mg/m³ and 1.0 mg/m³, the risk is estimated as average and acceptable for production conditions (1.1-4.1×10-4). The risk of exposure to a concentration of 0.14 mg/m³ is classified as low and acceptable for the population (5.7×10-5). Thus, the results obtained in the study indicate that such concentrations of metofluthrin in the air as 0.14 – 0.28 – 1.0 mg/m³ are safe for human health, subject to compliance with medical and sanitary regulations at the stage of production and application of insecticides based on metofluthrin as prescribed.
Key words: metofluthrin, toxicological assessment, hazard criteria, carcinogenic risk, air environment
References
- Regulation (eu) no 528/2012 of the european parliament and of the council of 22 May 2012 concerning the making available on the market and use of biocidal products (Text with EEA relevance). Official Journal of the European Union [Internet]. 2012 [cited 2024 Mar 16];L167/1. EUR-Lex. Access to European Union law. Available from: https://eur-lex.europa.eu/eli/reg/2012/528/oj
- Product-type 18 (Insecticides, acaricides and products to control other arthropods). Аssessment Report (UK). Finalised in the Standing Committee on Biocidal Products at its meeting in May 2010 in view of its inclusion in Annex I to Directive 98/8/EC [Internet]. 2010 [cited 2024 Mar 16]; 70 р. Available from: https://dissemination.echa.europa.eu/Biocides/ActiveSubstances/0045-18/0045-18_Assessment_Report.pdf
- Committee for Risk Assessment (RAC). Opinion proposing harmonised classification and labelling at EU level of 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl (1R,3R)-2,2-dimethyl-3-[(1Z)-prop-1-en-1-yl] cyclopropanecarboxylate; Epsilon-metofluthrin. CLH-O-0000001412-86-111/F. ECHA [Internet]. 2016 [cited 2024 Mar 16]. Available from: https://www.echa.europa.eu/documents/10162/7d6db581-36a4-7a2a-a21e-5c3a5d39be4c
- Biocidal Active Substances. Information on biocides. ECHA. European Chemicals Agency [Internet]. 2024 [cited 2024 Mar 16]. Available from: https://echa.europa.eu/fr/information-on-chemicals/biocidal-active-substances
- Bibbs CS, Tsikolia M, Bernier UR, Bloomquist JB, Xue RD, Kaufman PE. Vapor toxicity of five volatile pyrethroids against Aedes aegypti, Ae. albopictus, Culex quinquefasciatus, and Anopheles quadrimaculatus (Diptera:Culicidae). PestManag 2018 Dec;74(12):2699-706. doi: https://doi.org/10.1002/ps.5088
- Parker C, Ramirez D, Connelly CR. State-wide survey of Aedes aegypti and Aedes albopictus (Diptera:Culicidae) in Florida. J Vector Ecol. 2019;44(2):210-5. doi: https://doi.org/10.1111/jvec.12351
- Tian N, Zheng JX, Guo ZY, Li LH, Xia S, Lv S, et al. Dengue incidence trends and its burden in major endemic regions from 1990 to 2019. Trop Med Infect Dis. 2022 Aug;7(8):180. doi: https://doi.org/10.3390/tropicalmed7080180
- com [Internet]. [cited 2024 Mar 16]. Available from: https://www.reuters.com/business/healthcare-pharmaceuticals/who-warns-dengue-risk-global-warming-pushes-cases-near-historic-highs-2023-07-21
- Sugano M, Ishiwatari T. The biological activity of a novel pyrethroid: metofluthrin. Top Curr Chem. 2012:314:203-20. doi: https://doi.org/10.1007/128_2011_259
- Zarella O, Ekwomadu U, Romer Y, Kirstein OD, Che-Mendoza A, Gonzaґlez-Olvera G, et al. Experimental evaluation of a metofluthrin passive emanator against Aedes albopictus. PLoS ONE. 2022;17(5):e0267278. doi: https://doi.org/10.1371/journal.pone.0267278
- Kim D-Y, Leepasert T, Bangs MJ, Chareonviriyaphap T. Dose–Response Assay for Synthetic Mosquito (Diptera: Culicidae) Attractant Using a High-Throughput Screening System. Insects.2021;12:355. doi: https://doi.org/10.3390/insects12040355
- SukkanonC, Bangs MJ, Nararak J, Hii J, Chareonviriyaphap Discriminating lethal concentrations for transfluthrin, a volatile pyrethroid compound for mosquito control in Thailand. J Am Mosq Control Assoc. 2019 Dec;35(4):258-66. doi: https://doi.org/10.2987/19-6832.1
- World Health Organization. Manual for Monitoring Insecticide Resistance in Mosquito Vectors and Selecting Appropriate Interventions [Internet]. World Health Organization: Geneva, Switzerland; 2022 [cited 2024 Mar 16]. Available from: https://www.who.int/publications/i/item/9789240051089
- Pesticide Fact Sheet. Metofluthrin. U.S. Environmental Protection Agency. [Internet]. 2006 [cited 2024 Mar 16]. 29 p. Available from:https://www3.epa.gov/pesticides/chem_search/reg_actions/registration/fs_PC-109709_01-Sep-06.pdf
- Metofluthrin: Exposure and Risk Assessment for Use as a Mosquito Repellent Strip and as a Personal Outdoor Insect Repellent. PC Code: 109709, Memorandum. U.S. Environmental Protection Agency. [Internet]. [cited 2024 Mar 16]. Available from:https://www3.epa.gov/pesticides/chem_search/cleared_reviews/csr_PC-109709_14-Sep-06_a.pdf
- Kim D-Y, Hii J, Chareonviriyaphap T. Transfluthrin and Metofluthrin as Effective Repellents against Pyrethroid-Susceptible and Pyrethroid-Resistant Aedes aegypti (L.) (Diptera: Culicidae). Insects. 2023;14(9):767. doi: https://doi.org/10.3390/insects14090767
- World Health Organization. Determining Discriminating Concentrations of Insecticides for Monitoring Resistance in Mosquitoes: Report of a Multi-Centre Laboratory Study and WHO Expert Consultations. World Health Organization: Geneva, Switzerland; 2023. p. 58-59.
- Chen CD, Chin AC, Lau KW, Low VL, Lee HL, Lee PKY, et al. Bioefficacy evaluation of commercial mosquito coils containing metofluthrin, d-allethrin, d-trans allethrin, and prallethrin against Aedes albopictus (Diptera: Culicidae) in Malaysia. J Med Entomol. 2018 Oct 25;55(6):1651-5. doi: https://doi.org/10.1093/jme/tjy130
- UjiharaK, Mori T, Iwasaki T, Sugano M, Shono Y, Matsuo Metofluthrin: a potent new synthetic pyrethroid with high vapor activity against mosquitoes. Biosci Biotechnol Biochem. 2004 Jan;68(1):170-4. doi: https://doi.org/10.1271/bbb.68.170
- Bibbs CS, Kaufman PE, Xue R-D. Comparative Evaluation of Metofluthrin as an Outdoor Residual Treatment for Barriers and Harborage Against Aedes albopictus (Diptera: Culicidae). Environmental Entomology.2020;49(2):435-43. doi: https://doi.org/10.1093/ee/nvz170
- Soderlund DM. Molecular mechanisms of pyrethroid insecticide neurotoxicity: Recent advances. Arch Toxicol.2012 Feb;86(2):165-81. doi: https://doi:10.1007/s00204-011-0726-x
- Yastrub T. [Identification of the hazard to workers from complex exposure to pyrethroid insecticides based on alpha-cypermethrin using new toxicological data]. Ukrainskyi zhurnal medytsyny pratsi. 2022;1:52-62.doi: https://doi.org/10.33573/ujoh2022.01.052
- ZhuQ, Yang Y, Zhong Y, Lao Z, O'Neill P, Hong D, et al. Synthesis, insecticidal activity, resistance, photodegradation and toxicity of pyrethroids (A review). Chemosphere. 2020 Sep:254:126779. doi: https://doi.org/10.1016/j.chemosphere.2020.126779
- SCJ-14-210857 (metofluthrin). U.S. Environmental Protection Agency [Internet]. 2015 [cited 2024 Mar 16]. 127 p. Available from: https://www.epa.govt.nz/assets/FileAPI/hsnoar/APP202155/20d0ec9a58/APP202155-APP202155-decision-Final.pdf
- Devine GJ, Vazquez-Prokopec GM, Bibiano-Marin W, Pavia-Ruz N, Che-Mendoza A, Medina-Barreiro A, et al. The entomological impact of passive metofluthrin emanators against indoor Aedes aegypti: A randomized field trial. PLoS Negl Trop Dis. 2021;15(1):e0009036. doi: https://doi.org/10.1371/journal.pntd
- Serdiuk AM, Chernychenko IO, Lytvychenko OM, Babii VF, Kondratenko OYe, Hlavachek DO. Carcinogenic substances in the atmospheric air of Dnipro and the risk to the population. Medicni perspektivi. 2021;1:226-31.doi: https://doi.org/10.26641/2307-0404.2021.1.228020
- Serdyuk AM, Gushchuk IV, Chernichenko IA, Litvichenko ON. Features of atmospheric air pollution in a non-industrial city: risk for the population. Medicni perspectivi.2019;4:154-9. doi: https://doi.org/10.26641/2307-0404.2019.4.189609
- Committee for Risk Assessment (RAC). Opinion proposing harmonised classification and labelling at EU level of 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl (1R,3R)-2,2-dimethyl-3-[(1Z)-prop-1-en-1-yl] cyclopropanecarboxylate; Epsilon-metofluthrin. EC Number: - CAS Number: 240494-71-7 [Internet]. 2016 [cited 2024 Mar 16]. Available from: https://echa.europa.eu/documents/10162/fa5dc212-bfdb-8a9b-a2a9-489168fa1d67
- Preliminary considerations for ECHA’s guidance on the “Methodology to assess the risk to bees and other non-target arthropod pollinators from the use of biocides”. Summary of consultation feedback. ECHA-20-H-24-EN [Internet]. 2020 [cited 2024 Mar 16]. р. 1-65. Available from: https://op.europa.eu/ga/publication-detail/-/publication/6bbc9246-15ca-11ec-b4fe-01aa75ed71a1/language-en
- CLH report Proposal for Harmonised Classification and Labelling Based on Regulation (EC) No 1272/2008 (CLP Regulation), Annex VI, Part 2. Substance Name: Epsilon-metofluthrin. ECHA [Internet]. 2015 [cited 2024 Mar 16]. Available from: https://echa.europa.eu/documents/10162/213dc625-4121-e5e9-81e7-70c2f2435b6c
- Pesticide Properties Data Base (PPDB) Epsilon-metofluthrin (Ref: S-1264) [Internet]. [cited 2024 Mar 16]. Available from: https://sitem.herts.ac.uk/aeru/ppdb/en/Reports/3175.htm
- Guidelines for Carcinogen Risk Assessment. 70 FR 17765-17817. U.S. Environmental Protection Agency [Internet]. 2005. [cited 2024 Mar 16]. Available from: https://www.epa.gov/risk/guidelines-carcinogen-risk-assessment
- Risk Characterization Handbook. U.S. Environmental Protection Agency [Internet]. 2000 [cited 2024 Mar 16]. Available from: https://www.epa.gov/risk/risk-characterization-handbook
- ncbi [Internet]. [cited 2024 Mar 16]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Metofluthrin
- ca [Internet]. [cited 2024 Mar 16]. Available from: https://oehha.ca.gov/media/downloads/crnr/101211metofluthrin.pdf
- ncats [Internet]. [cited 2024 Mar 16]. Available from: https://drugs.ncats.io/substance/WZX356S299
- Exposure Assessment Tools by Routes – Inhalation. U.S. Environmental Protection Agency [Internet]. 2024 [cited 2024 Mar 16]. Available from: https://www.epa.gov/expobox/exposure-assessment-tools-routes-inhalation
- [Hygienic regulations for the permissible content of chemical and biological substances in the air of the working area. Order of the Ministry of Health of Ukraine dated 2020 Jul 14, No. 1596]. [Internet]. 2020 [cited 2024 Mar 16]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/z0741-20#Text
- [Pesticides. Classification by degree of dander: DSanPin 8.8.1.002-98. Аpproved by the Ministry of Health of Ukraine on 1998 Aug 28, No. 2]. Collection of Important official materials on sanitary and anti-epidemic issues. 2000;9(1):249-66. Ukrainian.
- [Assessment of the carcinogenic and non-carcinogenic risk to public health from chemical air pollution: methodological recommendations approved by the Order of the Ministry of Health of Ukraine dated 18.10.2023, No. 1811]. Kyiv: Ministry of Health of Ukraine; 2023. 24 р. Ukrainian.
- Guidelines for Carcinogen Risk Assessment. 70 FR 17765-17817. U.S. Environmental Protection Agency [Internet]. 2005 [cited 2024 Mar 16]. Available from: https://www.epa.gov/risk/guidelines-carcinogen-risk-assessment
- Risk Characterization Handbook. U.S. Environmental Protection Agency [Internet]. 2000 [cited 2024 Mar 16]. Available from: https://www.epa.gov/risk/risk-characterization-handbook
- Lewandowska AM, et al. Environmental risk factors for cancer – review paper. Ann Agric Environ Med. 2019 Mar 22;26(1):1-7. doi: https://doi.org/10.26444/aaem/94299
- Birch R, Johansen M, Skakkebæk N, Andersson AM, Rehfeld A. In vitro investigation of endocrine disrupting effects of pesticides on Ca2+-signaling in human sperm cells through actions on the sperm-specific and steroid-activated CatSper Ca2+-channel. Environ Int. 2022;167:107399. doi: https://doi.org/10.1016/j.envint.2022.107399
- Yamada Т. Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action. Toxicol 2018;7:681-96. doi: https://doi.org/10.1039/c7tx00288b
- Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bel D, et al. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: a case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Crit Rev Toxicol. 2014 Jan;44(1):64-82. doi: https://doi.org/10.3109/10408444.2013.835786
- Yamada T, Kikumoto H, Lake BG, Kawamura S. Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes. Toxicol Res. 2015 Jul;4(4):901-13. doi: https://doi.org/10.1039/c4tx00217b
- Deguchi Y, Yamada T, Hirose Y, Nagahori H, Kushida M, Sumida K, et al. Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation. Тoxicol 2009 Mar;108(1):69-80. doi: https://doi.org/10.1093/toxsci/kfp006
- [On the approval of Amendments to the Hygienic Regulations of Chemical Substances in the Air of the Work Zone. Order of the Ministry of Health of Ukraine 2023 Aug 17, No. 1473]. [Internet]. 2023 [cited 2024 Mar 16]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/z1520-23#Text
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Yastrub T.O. SE "L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine", Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0002-5084-3773
Kravchuk O.P. SE "L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine", Kyiv, Ukraine https://orcid.org/0000-0003-3608-5555
Basanets A.V. SE "L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine", Kyiv, Ukraine https://orcid.org/0000-0001-8236-4251
Yastrub A.M. SE "L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine", Kyiv, Ukraine https://orcid.org/0000-0003-2674-5265
Shabalkov D.O. SE "L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine", Kyiv, Ukraine https://orcid.org/0009-0006-2599-8454
Cite
Yastrub T.O., Kravchuk O.P., Basanets A.V., Yastrub A.M., Shabalkov D.O. Toxicological characterization of the insecticide metofluthrin and assessment of the carcinogenic risk to human health due to its chronic inhalation effect. Medicni perspektivi. 2024;29(3):193-204. DOI: https://doi.org/10.26641/2307-0404.2024.3.313676
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SOCIAL MEDICINE
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Hutchenko K.S., Kozachuk V.L., Hutchenko O.A., Movchan O.M., Tymkiv O.A., Hrom V.A. Methodical approach to determining the main parameters of the evacuation system for the wounded with the use of different types of transport
https://doi.org/10.26641/2307-0404.2024.3.313682
Abstract
The timeframe for evacuating the wounded is a critical factor that largely determines the fate of a wounded soldier. Even at the initial stage of the war waged by the russian federation against Ukraine, there were almost no frontline ambulances, and there was a critical shortage of ambulances. At present, despite significant efforts to provide the Armed Forces of Ukraine with weapons and military equipment, as well as material and technical means, including medical equipment and property, in particular through international technical assistance, the problem of the lack of the required number of specialised medical evacuation vehicles has not been fully resolved. From this point of view, the issue of correct formulation of requirements for the rational composition and specially equipped various types of vehicles (including sanitary transporters, ambulances), including general use, the system of evacuation of the wounded, and determining the possibility of its further improvement through the methodological apparatus is relevant. The purpose of the article is to present a methodological approach to determining the main parameters of the system of evacuation of the wounded of an operational group of troops with the involvement of various types of transport. The formation of a model of the casualty evacuation system as a mass service network (MSN) will minimise the time spent waiting for medical care by wounded personnel, determine the rational composition of forces and means of the tactical casualty evacuation system. To model the system and processes of evacuation of the wounded from the battlefield during hostilities, including their transportation to medical facilities located in the depths of the third logistics zone, the mathematical apparatus of the theory of mass service was used. In particular, we are talking about the devices of queuing systems (QS) and MSN. The existing system of military evacuation of the wounded and sick is a four-tier system in which all wounded with moderate and severe severity are evacuated. Based on this, the system of evacuation of the wounded can be represented as an MSN, which has a number of features. First of all, this MSN is an open queuing network (OQN), i.e. the flow of requests to enter the network is unlimited, homogeneous and comes from an external independent source. As a result of the calculations, data were obtained on the values of network parameters (average number of applications in queues – 119.47 applications/hour, average number of applications in the network – 158.53 applications/hour, average waiting time for applications in queues for service – 11.95 hours, average time of application stay in the network – 15.85 hours) and the parameters of each QS operating in the MSN – transmission coefficient, incoming flow intensity, load factor, average number of busy channels, average number of applications per QS, average queue length, average waiting time for an application in the service queue, average time for an application to stay in the QS. Analysing the calculated data, from the point of view of creating a rational OQN, the casualty evacuation system achieves maximum efficiency when its productivity in processing the incoming flow of requests is maximised, and the minimum values of such parameters as the number of requests for service in the queue and the number of service channels operating in the network are minimal.
Key words: medical and evacuation support, Medical Forces of the Armed Forces of Ukraine, evacuation of the wounded, evacuation transport, parameters of the evacuation system, war, model
References
- Job Profile: Healthcare Management Manager. Best College [Internet]. 2022 Jul[cited 2022 Mar 17]. Availablefrom: https://www.bestcolleges.com/healthcare/healthcare-risk-management-manager-job/
- Donaldson L, Ricciardi W, Sheridan S, Tartaglia R. Textbook of Patient Safety and Clinical Risk Management.Springer; doi: https://doi.org/10.1007/978-3-030-59403-9
- Peterson A. General Perspective on the U.S. Military Conflicts in Iraq and Afghanistan after 20 years. Mil 2022;187(9-10):248-51. doi: https://doi.org/10.1093/milmed/usab496
- Bhat UN. An Introduction to Queueing Theory. Modeling and Analysis in Application. Birkhauser, Boston,MA; 138 p. doi: https://doi.org/10.1007/978-0-8176-4725-4
- Defense modeling and simulation [Internet]. 2023 [cited 2024 Jan 20]. Available from: https://www.anylogic.com/defense/
- de Lesquen H, Paris R, Fournier M, et al. Toward A Serious Game to Help Future Military Doctors Face Mass Casualty Incidents. J Spec Oper Med. 2023;23(2):88-93. doi: https://doi.org/10.55460/IJCP-BLY6
- [On the approval of the Emergency Medical Care Standard «Medical triage during mass admission of victims at the early hospital stage». Оrder of the Ministry of Health of Ukraine No. 368 from 2022 Feb 24]. [Internet] 2022[cited 2024 Jan 20]. Ukrainian. Available from: https://www.dec.gov.ua/wp-content/uploads/2022/03/2022_368_ms_.pdf
- Karamyshev D, Zhdan V, Dvornyk V, Hordiienko L, Kundii Z. Universally applicable approaches to the tactical level of aid and medical support for the personnel of the Armed Forces of Ukraine. World of Medicine and Biology.2022;4(82):74-79. doi: https://doi.org/10.26724/2079-8334-2022-4-82-74-79
- Khomenko I, Halushka A, Zhakhovskyi V, Livinskyi V. [The role and signifi cance of medical evacuation in the system of medical evacuation measures of medical support of the Armed Forces of Ukraine during ATO/JFO]. Ukrainian Journal of Military Medicine. 2020;1(2):5-14. Ukrainian. doi: https://doi.org/10.46847/ujmm.2020.2(1)-005
- [On the approval of the Strategy for the Development of the Medical Forces of the Armed Forces of Ukraine until 2035. Оrder of the General Staff of the Armed Forces of Ukraine dated 2020 Mar 12, No. 100]. (2020). Ukrainian.
- Cojocaru E, CojocaruC, Cojocaru E, Oancea Cl. Health risks during Ukrainian humanitarian crisis. Risk Mananger Health 2022;15:1775-81. doi: https://doi.org/10.2147/RMHP.S75021
- NATO STANDARD AJMedP-2. Allied joint medical doctrine for medical evacuation. Edition A Version 1 [Internet]. 2018 [cited 2024 Jan 20]. Available from: https://www.coemed.org/files/stanags/02_AJMEDP/AJMedP-2_EDA_V1_E_2546.pdf
- Medical Support. Chap. 16. In: NATO Logistics Handbook [Internet]. 1997 [cited 2024 Jan 20]. Available from:https://www.nato.int/docu/logi-en/1997/lo-1610.htm
- NATO STANDARD AJP-4.10. Allied joint doctrine for medical support. Edition C Version 1 [Internet]. 2019 [cited 2024 Jan 20]. Available from: https://www.coemed.org/files/stanags/01_AJP/AJP-4.10 EDC_V1_E_2228.pdf
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Hutchenko K.S. Central Research Institute of the Armed Forces of Ukraine, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0009-0008-6377-7745
Kozachuk V.L. Central Research Institute of the Armed Forces of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0002-0207-7461
Hutchenko O.A. Central Research Institute of the Armed Forces of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0001-5918-1545
Movchan O.M. Central Research Institute of the Armed Forces of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0001-5245-7051
Tymkiv O.A. Central Research Institute of the Armed Forces of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0002-2248-382X
Hrom V.A. Central Research Institute of the Armed Forces of Ukraine, Kyiv, Ukraine https://orcid.org/0009-0009-5415-9758
Cite
Hutchenko K.S., Kozachuk V.L., Hutchenko O.A., Movchan O.M., Tymkiv O.A., Hrom V.A. Methodical approach to determining the main parameters of the evacuation system for the wounded with the use of different types of transport. Medicni perspektivi. 2024;29(3):205-212. DOI: https://doi.org/10.26641/2307-0404.2024.3.313682
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Bereznytskyi Ya.S., Bereznytskyi V.Ya., Hudoshyna O.V., Chuhrienko N.D., Bereznytska G.V., Zalyhina Ye.V., Dianova Yu.B., Rynska E.A., Ksykevich L.N. Informatization of the processes of administration of the quality of medical services in surgical hospitals
https://doi.org/10.26641/2307-0404.2024.3.313685
Abstract
Among the various forms of quality control of the provision of medical care, self-control and internal control of the quality of medical services are the most effective and significant. Currently, there is no comprehensive information technology and algorithm for recording data on the provision of medical services and determining their quality. The goal is to develop and analyze the effectiveness of business processes and an algorithm for quality control of the performance of medical services in a surgical health care institution by establishing their daily accounting in the information system, control of indicators characterizing the safety and quality of their performance, as well as an opportunity to assess the dynamics changes in indicators for making management decisions. In the study, an analysis of literary sources was carried out, business processes were formulated, and on the materials of a retrospective analysis algorithms for the use of information technologies were developed based on the methods of generalization, comparison, content analysis, system-analytical and logical analysis, a graphic analysis was performed to increase the clarity of the presentation of the material. The research was approved by the Biomedical Ethics Committee. For the first time, as a result of the work of the internal quality commission, daily and summarized forms of reports on the work of the medical center, which have five sections are obtained. The statistical indicators of the operation of the surgical unit for any period are fixed, formed in an automated mode and analyzed. Clinical data characterizing all prescribed procedures applied are subject to analysis, and the results provide an opportunity to isolate from the records the disorders and complications reflected in the reports. The quality control of the use of antibiotics, the frequency of their use for preventive and therapeutic purposes is also carried out. The section that contains multivariate epidemiological control of the work of the treatment facility, as well as the section that shows the quality of medical record keeping and patient care is important. Together with the inpatient chart, e-mails of medical appointments are analyzed, patient falls are recorded, appointments and monitoring of patient care, pain assessment after surgery, allergic reactions are recorded, as well as a retrospective audit of the charts regarding the justification of the appointment of antimicrobial therapy. Control of patient safety and the quality of the provided medical services requires constant verification of their implementation and paying attention to be up to standards, the occurrence of deviations and complications. The application of a specially developed algorithm based on information technologies, aimed at daily accounting of medical services and obtaining data on deviations in their application, makes it possible to make urgent management decisions and influence the improvement of the qualifications of personnel who provide such services.
Key words: informatization of processes, administration, safety, quality of medical services in surgical hospitals
References
- int [Internet]. World Health Organization [cited 2024 Mar 21]. Available from: https://www.who.int
- who [Internet]. [European Health for All database]. [cited 2024 Mar 21]. Russian. Available from:http://www.euro.who
- gov.ua [Internet]. [Official website of the Ministry of Health of Ukraine]. [cited 2024 Mar 21].Ukrainian. Available from: https://moz.gov.ua/
- gov.ua [Internet]. [Official website of the Verkhovna Rada of Ukraine]. [cited 2024 Apr 11]. Ukrainian. Available from: https://www.rada.gov.ua
- gov.ua/ukr/main.html [Internet]. [State institution: Center for Medical Statistics of the Ministry of Health of Ukraine].[cited 2024 Apr 11]. Ukrainian. Available from: http://medstat.gov.ua/ukr/main.html
- National quality partners playbook: Antibiotic stewardship in acute care. [Internet]. National quality forum. 2016 [cited 2024 Apr 11]. Available from: http://www.qualityforum.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID=82501
- Baraka MA, et al. Health care providers’ perceptions regarding antimicrobial stewardship programs (AMS) implementation-facilitators and challenges: A cross-sectional study in the Eastern Province of Saudi Arabia. Ann Clin Microbiol 2019 Sep24;18(1):26.
doi: https://doi.org/10.1186/s12941-019-0325-x
- Baur D, et al. Effect of antibiotic stewardship on the incidence of infection and colonisation with antibioticresistant bacteria and Clostridium difficile infection: A systematic review and meta-analysis. Lancet infect dis. 2017 Sep;17(9):990-1001. doi: https://doi.org/10.1016/S1473-3099(17)30325-0
- Cai Y, et al. A multidisciplinary antimicrobial stewardship programme safely decreases the duration of broadspectrum antibioticprescription in Singaporean adult renal patients. Int J Antimicrob Agents. 2016 Jan;47(1):91-6. doi: https://doi.org/10.1016/j.ijantimicag.2015.10.021
- De With K, et al. Strategies to enhance rational use of antibiotics in hospital: A guideline by the German Society for Infectious Diseases. Infection. 2016 Jun;44(3):395-439. doi: https://doi.org/10.1007/s15010-016-0885-z
- Latin American Network for Antimicrobial Resistance Surveillance-ReLAVRA [Internet]. Pan American Health Organization. 2020 [cited 2024 Apr 07]. Available from:https://www.paho.org/hq/index.php?option=com_content&view=article&id=13682:relavra-h ome&Itemid=42427&lang=en
- Rennert-May E, et al. Clinical practice guidelines for creating an acute care hospital-based antimicrobial stewardship program: A systematic review. Am Jinfect Control.2019 Aug;47(8):979-93. doi: https://doi.org/10.1016/j.ajic.2019.02.010
- Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. 2-ed., Kyiv: MITs “Mininform”; 2018. 579 p. Ukrainian.
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Bereznytskyi Ya.S. Dnipro State Medical University; LLC "Endotechnomed" (surgical clinic "Garvis"), Dnipro, Ukraine, е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. http://orcid.org/0000-0003-2968-7443
Bereznytskyi V.Ya. LLC "Endotechnomed" (surgical clinic "Garvis"), Dnipro, Ukraine
Hudoshyna O.V. Department of Quality Control of Medical Care of the Ministry of Health of Ukraine, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. http://orcid.org/0000-0003-1901-0818
Chuhrienko N.D. Dnipro State Medical University, Dnipro, Ukraine http://orcid.org/0000-0003-2101-3882
Bereznytska G.V. LLC "Endotechnomed" (surgical clinic "Garvis"), Dnipro, Ukraine
Zalyhina Ye.V. Dnipro State Medical University; LLC "Endotechnomed" (surgical clinic "Garvis"), Dnipro, Ukraine http://orcid.org/0000-0002-0478-5664
Dianova Yu.B. LLC "Endotechnomed" (surgical clinic "Garvis"), Dnipro, Ukraine
Rynska E.A. LLC "Endotechnomed" (surgical clinic "Garvis"), Dnipro, Ukraine
Ksykevich L.N. LLC "Endotechnomed" (surgical clinic "Garvis"), Dnipro, Ukraine
Cite
Bereznytskyi Ya.S., Bereznytskyi V.Ya., Hudoshyna O.V., Chuhrienko N.D., Bereznytska G.V., Zalyhina Ye.V., Dianova Yu.B., Rynska E.A., Ksykevich L.N. Informatization of the processes of administration of the quality of medical services in surgical hospitals. Medicni perspektivi. 2024;29(3):213-225. DOI: https://doi.org/10.26641/2307-0404.2024.3.313685
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A CASE FROM PRACTICE
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Talash V.V., Palyokha Ya.V., Gromova A.M., Talash V.V., Martynenko V.B., Prylutska N.O., Mityunina N.I. Lipoleiomyoma of the uterus in a woman of reproductive age (clinical case)
https://doi.org/10.26641/2307-0404.2024.3.313686
Abstract
Uterine lipoleiomyoma is one of the variants of uterine leiomyoma, which is histologically represented by the presence of mature fat and smooth muscle cells. The relevance of the coverage of this clinical case is determined by the extreme rarity of the development of uterine lipoleiomyoma in women of reproductive age. The purpose of this work was to record this clinical case in the world statistics of lipoleiomyoma, to evaluate methods of diagnosis and differential diagnosis, to determine the role of early diagnosis of uterine lipoleioma in the subsequent tactics and scope of surgical treatment. Data from the medical records of a 41-year-old inpatient were analyzed. In addition to the generally accepted clinical and biochemical methods of blood and urine examination, electrocardiogram, ultrasound examination of the pelvic organs, the level of ovarian tumor markers in the blood (CA 125, HE4 and the ROMA index) was determined. The diagnosis of the disease was based on the data of pathohistological and immunohistochemical studies. Based on the results of a review of the medical literature, analysis of articles obtained as a result of a search of PubMed, SCOPUS, Web of Science, MedScape databases, the current state of the problem is highlighted, literary data related to the incidence, features of the clinical course, diagnosis and treatment of uterine lipoleiomyoma are summarized. The clinical case presented in the article demonstrates an incidental finding of a uterine lipoleiomyoma in a woman of reproductive age, measuring 30x25x20 cm, originated subserously from the body and cervix of the uterus, in the area of its isthmus. Under this condition, it occupied the entire Douglas space, the area of the sacro-uterine ligaments and the parietal peritoneum, intimately adjacent to the sigmoid and rectum, to the ureters and iliac vessels. The peculiarity of this clinical case is that sonographically uterine lipoleiomyoma was hidden under the "mask" of a dermoid cyst of the right ovary. Macroscopically, it differed from a typical lipoleiomyoma by the purple-bluish color of its outer surface and soot-colored, fine-lobed spongy structure on the section. The diagnosis of uterine lipoleiomyoma was verified only on the basis of pathohistological and immunohistochemical research. Microscopically, the lipoleiomyoma had a mesenchymal structure with a pronounced vascular component and consisted of mitotically inactive bundles of smooth muscle cells and mature adipocytes. Immunohistochemically, a positive reaction for caldesmon, desmin, smooth muscle actin alpha of tumor cells and for S.100 (DAKO, polyclonal) fatty cells was detected, which confirmed the hypothesis of direct transformation of smooth muscle cells existing in the leiomyoma of the uterus into fatty cells. This clinical case should complement the global statistical indicators of diagnosis of uterine lipoleiomyoma in women of reproductive age. Lipoleiomyoma should be considered as the primary diagnosis in case of detection of a large uterine tumor in women with excess body weight and be removed immediately after diagnosis, otherwise it is impossible to exclude its malignancy. For the planned diagnosis of neoplasms of the female genital organs, preference should be given to non-invasive research methods: magnetic resonance or computer tomography with contrast enhancement. The problem of these tumors lies in their unpredictable histogenesis, the unexpected presence of fat in the microscopic structure, and in the visual similarity to sarcomas. Verification of the diagnosis is carried out on the basis of pathohistological and immunohistochemical studies of the tumor preparation. Uterine lipoleioma can have a purplie-bluish color and develop by a broad base from the body and cervix of the uterus, as a result of "lipomatous" metaplasia of the uterine leiomyoma existing in a woman. Regular preventive examinations of women of all ages are crucial for timely detection of this rare neoplasm.
Key words: lipoleiomyoma, leiomyoma, mesenchymoma, uterus, ovarian dermoid cyst, laparoscopy
References
- Alsaif JM, Alali ZS, Elsharkawy T, Ahmed A. Uterine Lipoleiomyoma: A Case Report and Review of Literature. 2021 Dec 9;13(12):e20297. doi: https://doi.org/10.7759/cureus.20297
- Kim YS, Lee JH. A case report of pelviscopic resection of lipoleiomyoma originating from the uterine cervix in a postmenopausal woman. Medicine (Baltimore). 2022 Sep 30;101(39):e30665. doi: https://doi.org/10.1097/MD.0000000000030665
- Virk SK, Lopez E, Pardo KM, Gonzalez AM. Incidental Finding of a Lipoleiomyoma During Robotic Inguinal Hernia Repair: A Case Report. Cureus. 2023 Jun 19;15(6):e40635. doi: https://doi.org/10.7759/cureus.40635
- Saraf P, Thirunavukkarasu B, Kathuria P, Solanki V. Lipoleiomyoma: incidental finding in a postmenopausal woman. International journal of gynecological cancer.2021;31(7):1092-4. doi: https://doi.org/10.1136/ijgc-2021-002657
- Li Y, et al. HMGA2-mediated tumorigenesis through angiogenesis in leiomyoma. Fertility and sterility. 2020;114(5):1085-96. doi: https://doi.org/10.1016/j.fertnstert.2020.05.036
- Yuan Y, Chen L, Zhao T, Yu M. Pathogenesis, diagnosis and treatment of uterine lipoleiomyoma: A review. Biomedicine & pharmacotherapy. 2021;142:112013. doi: https://doi.org/10.1016/j.biopha.2021.112013
- Akbulut M, Soysal ME, Duzcan SE. Giant lipoleiomyoma of the uterine corpus. Archives of gynecology and 2008;278:291-93. doi: https://doi.org/10.1007/s00404-008-0580-0
- Bosoteanu M, et al. A Case of Giant Mesenchymal Uterine Tumor: Lipoleiomyoma. The American journal of case 2022;23:e934913. doi: https://doi.org/10.12659/AJCR.934913
- Rampersad FS, et al. Uterine Lipoleiomyoma Presenting With Pelvic Pain in a Post-Menopausal Woman. 2021;13(5):e14929. doi: https://doi.org/10.7759/cureus.14929
- Schaefer SL, et Large intraperitoneal lipoleiomyoma in a pre-menopausal woman: a case report. World journal of surgical oncology. 2021;19(1):144. doi: https://doi.org/10.1186/s12957-021-02256-9
- Carvalho JF, Morgado A, Ribeiro MF, Oliveira C. Imaging diagnosis of an uterine lipoleiomyoma, a rare entity. Acta radiológica portuguesa. 2014;26(102):55-7.
- Jamoulle JF, Brisbois D. L’image du mois. Le lipoléiomyome: une tumeur rare de l’utérus. Revue medicale de Liege. 2020;75(3):137-9.
- Rasmussen T, Sanchirico P, Pfeiffer D. Uterine Lipoleiomyoma in the Context of Adenocarcinoma. Journal of clinical imaging science. 2020;10:82. doi: https://doi.org/10.25259/JCIS_204_2020
- Sun D, Yang P, Liu Y, Yu G. Fallopian tube lipoleiomyoma with degeneration: a case report and literature review. International journal of clinical and experimental pathology. 2020;13(8):2163-8.
- Schaberg K. Mesenchymal tumors of the Uterus [Internet]. 2023 [cited 2023 Oct 24]. Available from: https://schaberg.faculty.ucdavis.edu/wp-content/uploads/sites/604/2023/06/Uterus-Mesenchymal.pdf
- Munro MG. Endometrial ablation. Best practice & research. Clinical obstetrics & gynaecology. 2018;46:120-39. doi: https://doi.org/10.1016/j.bpobgyn.2017.10.003
- Braganza JS, et al. Recurrent Large Extrauterine Lipoleiomyoma in a Postmenopausal Woman: A Case Report. 2023;15(8):e43193. doi: https://doi.org/10.7759/cureus.43193
- Palicelli A, et al. Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review. Journal of personalized 2022;12(11):1852. doi: https://doi.org/10.3390/jpm12111852
- Oh MH, et al. A case of retroperitoneal lipoleiomyoma. Journal of Korean medical science. 2001;16(2):250-2. doi: https://doi.org/10.3346/jkms.2001.16.2.250
- Scurry JP, Carey MP, Targett CS, Dowling JP. Soft tissue lipoleiomyoma. Pathology. 2021;23(4):360-2. doi: https://doi.org/10.3109/00313029109063606
- Reyna-Villasmil E, Rondon-Tapia M, Torres-Cepeda D. Uterine lipoleiomyoma. Revista Peruana de Ginecologíaand 2022;68(3):1-5. doi: https://doi.org/10.31403/rpgo.v68i2438
- Wilke S, Benson J, Roller L. Uterine lipoleiomyoma: Case report and review of the literature. Radiology case reports. 2022;17(3):954-8. doi: https://doi.org/10.1016/j.radcr.2022.01.012
- Park S, et al. Imaging uterine lipoleiomyomas: A case series and review of the literature. Heliyon. 2023;9(5):e15970. doi: https://doi.org/10.1016/j.heliyon.2023.e15970
- Kaur M, Sadashiva H, Madakshira MG. Lipoleiomyoma: Egg-yolk in the uterus. Medical journal, Armed Forces India. 2022;78(3):371-2. doi: https://doi.org/10.1016/j.mjafi.2021.10.004
- Limaiem F, Halouani A, Ben Aissia N. Laparoscopic resection of a uterine lipoleiomyoma. Clinical case reports. 2023;11:e6878. doi: https://doi.org/10.1002/ccr3.6878
- Alrasheed RK, Elhassan MA, Murad MA. Lipoleiomyoma with bizarre nuclei and abundant mast cells. Cureus. 2023;15(6):e40361. doi: https://doi.org/10.7759/cureus.40361
- Nishikawa S, et al. Characteristic of Concurrent Uterine Lipoleiomyoma and Hemangioma by Algorithm of Candidate Biomarkers for Uterine Mesenchymal Tumor. Diagnostics. 2022;12(10):2468. doi: https://doi.org/10.3390/diagnostics12102468
- Orlova YuA, et al. Pathogenetic role of macrophage colony-stimulating factor (csf-1) in predicting endometrioid disease. Wiadomości Lekarskie. 2021;74(8):1939-44. doi: https://doi.org/10.36740/WLek202108128
- Orlova YuA, et al. Aseptic inflammation as the essential link in the pathogenesis of endometrioid disease. Medicni perspektivi. 2023;28(3):55-61. doi: https://doi.org/10.26641/2307-0404.2023.3.288961
- Resta L, Maiorano E, Piscitelli D, Botticella MA. Lipomatous tumors of the uterus. Clinico-pathological features of 10 cases with immunocytochemical study of histogenesis. Pathology, research and practice. 1994;190(4):378-83. doi: https://doi.org/10.1016/S0344-0338(11)80410-3
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Talash V.V. Poltava State Medical University, Poltava, Ukraine
Palyokha Ya.V. CE “Perinatal center of II level of the Poltava city council”, Poltava, Ukraine, e-maіl: This email address is being protected from spambots. You need JavaScript enabled to view it.
Gromova A.M. Poltava State Medical University, Poltava, Ukraine https://orcid.org/0000-0003-1829-5399
Talash V.V. Poltava State Medical University, Poltava, Ukraine, e-maіl: This email address is being protected from spambots. You need JavaScript enabled to view it.
Martynenko V.B. Poltava State Medical University, Poltava, Ukraine https://orcid.org/0000-0001-7465-0215
Prylutska N.O. Poltava State Medical University, Poltava, Ukraine https://orcid.org/0009-0003-7378-1530
Mityunina N.I. Poltava State Medical University, Poltava, Ukraine https://orcid.org/0009-0001-9662-8681
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Talash V.V., Palyokha Ya.V., Gromova A.M., Talash V.V., Martynenko V.B., Prylutska N.O., Mityunina N.I. Lipoleiomyoma of the uterus in a woman of reproductive age (clinical case). Medicni perspektivi. 2024;29(3):226-234. DOI: https://doi.org/10.26641/2307-0404.2024.3.313686
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Panchenko O.A., Kabantseva A.V., Zhogina O.O., Serdyuk I.A. Comprehensive Medical and Psychological Rehabilitation in War Trauma (clinical case)
https://doi.org/10.26641/2307-0404.2024.3.313425
Abstract
The purpose of the work was to analyze a clinical case of the course of war trauma and present the experience of providing comprehensive medical and psychological clinical rehabilitation to a patient who suffered as a result of a terrorist attack. Patient D., 65 years old, sustained a mine-blast injury (MBI) of the right upper limb during shelling. The optimal restoration of the functions of the upper injured limb and the patient's health (physical, somatic, mental) was carried out according to the algorithm of comprehensive medical and psychological clinical rehabilitation. As a result of the course of comprehensive medical and psychological clinical rehabilitation, significant positive dynamics was observed, including a decrease in edematous, painful, and inflammatory syndromes. The range of motion in the right upper limb and cervical-thoracic spine increased. Supination and pronation of the right hand became better and less painful (from 8 to 2 points), movement in the fingers of the right hand increased and became more steady, a clear pulsation appeared in the area of the skin defect on the right forearm, regression of pain in the elbow and shoulder joints on the right was noted, and the patient began to walk without a mobilization bandage. The course of rehabilitation helped to reduce anxiety (from -1.82 to 0.85), asthenic symptoms (from 0.48 to 3.71), obsessive-phobic symptoms (from -1.96 to 1.74), and autonomic disorders (from -0.83 to 2.03). Low cortisol levels (61 nmol/l) against acute stress indicated the development of post-traumatic stress disorder. Upon completion of the rehabilitation course, cortisol levels rose to a healthy level (246 nmol/l), indicating the effectiveness of the process of restoring the psychophysiological state and adapting to a stressful situation. War trauma is a complex and severe condition that requires an integrated approach to treatment and rehabilitation, covering not only physical but also psychological and social aspects of patients' health.
Key words: military operations in Ukraine, neuropathy, post-traumatic stress disorder, clinical psychology, anxiety, stress, cortisol
References
- Karatzias T, Shevlin M, Ben-Ezra M, McElroy E, Redican E, Vang ML, et al. War exposure, posttraumatic stress disorder, and complex posttraumatic stress disorder among parents living in Ukraine during the Russian war. Acta Psychiatrica Scandinavica. 2023;147(3):276-85. doi: https://doi.org/10.1111/acps.13529
- Danese A, Martsenkovskyi D. Editorial: Measuring and buffering the mental health impact of the war in Ukraine in young people. Journal of the American Academy of Child and Adolescent Psychiatry. 2023;62(3):294-96. doi: https://doi.org/10.1016/j.jaac.2022.11.001
- Kelly BD. Trauma and displacement in Ukraine: The challenge to medicine and politics. QJM: An International Journal of Medicine. 2022;115(5):269-70. doi: https://doi.org/10.1093/qjmed/hcac090
- Murphy RNA, Elsayed H, Singh S, Dumville J, Wong JKF, Reid AJA. Quantitative Systematic Review of Clinical Outcome Measure Use in Peripheral Nerve Injury of the Upper Limb. Neurosurgery. 2021;89(1):22-30. doi: https://doi.org/10.1093/neuros/nyab060
- Tseilikman V, Dremencov E, Maslennikova E, Ishmatova A, Manukhina E, Yehuda R, et al. Post-Traumatic Stress Disorder Chronification via Monoaminooxidase and Cortisol Metabolism. Hormone and metabolic research. 2019;51(9):618-22. doi: https://doi.org/10.1055/a-0975-9268
- Engel S, Laufer S, Klusmann H, Schulze L, Schumacher S, Knaevelsrud C. Cortisol response to traumatic stress to predict PTSD symptom development – a systematic review and meta-analysis of experimental studies. European Journal of Psychotraumatology. 2023;14(2):2225153. doi: https://doi.org/10.1080/20008066.2023.2225153
- Prorok N, editor. [Basics of rehabilitation psychology: overcoming the consequences of the crisis : study guide]. Vol. 1. Kyiv; 2018. 208 р. Ukrainian.
- Hrytsiuk IM, Mahdysiuk LI. [Research methods in various fields of practical psychology: study guide]. Luts'k: Vezha-Druk; 2022. 248 р. Ukrainian.
- Kokun OM, Ahaiev NA, Pishko IO, Lozins'ka NS, Kornia LV. [Psychological assessment of suicidal risk in military personnel: methodical guide]. Kyiv: NDTs HP ZSU; 2019. 206 р. Ukrainian.
- Missile attack on the market in Kostyantynivka: everything that is known about the Russian shelling [Internet]. 2023 [сited 2024 May 3]. Ukrainian. Available from: https://tsn.ua/exclusive/ataka-raketami-po-rinku-v-kostyantinivci-vse-scho-vidomo-pro-rosiyskiy-obstril-foto-video-2404708.html
- Morgan A, Sinclair H, Tan A, Thomas E, Castle R. Can scuba diving offer therapeutic benefit to military veterans experiencing physical and psychological injuries as a result of combat? A service evaluation of Deptherapy UK. Disability and rehabilitation. 2019;41(23):2832-40. doi: https://doi.org/10.1080/09638288.2018.1480667
- Kozhyna HM, Stebliuk VV, Asieieva YO, Zelenska KS, Pronoza-Stebliuk KV. A comprehensive approach to medical-psychological support for service women in modern Ukraine. Wiadomości Lekarskie Medical Advances.2023;76(1):131-5. doi: https://doi.org/10.36740/WLek202301118
- Klifto KM, Dellon AL. Silas Weir Mitchell, MD, LLD, FRC: Neurological Evaluation and Rehabilitation of the Injured Upper Extremity. Hand. 2021;16(1):128-33. doi: https://doi.org/10.1177/1558944719843643
- Li X, Zhang T, Li C, Xu W, Guan Y, Li X, et al. Electrical stimulation accelerates Wallerian degeneration and promotes nerve regeneration after sciatic nerve injury. Glia.2023;71(3):758-74. doi: https://doi.org/10.1002/glia.24309
- Bismak O. [Algorithm for the use of physical therapy inpatients with compression-ischemic neuropathies of the upper limb]. Slobozans`kij naukovo-sportivnij visnik. 2019;6(74):37-42. Ukrainian. doi: https://doi.org/10.15391/snsv.2019-6.006
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Panchenko O.A. SI “Scientific and Practical Medical Rehabilitation and Diagnostic Centre of the Ministry of Health of Ukraine”, Kyiv, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. https://orcid.org/0000-0001-9673-6685
Kabantseva A.V. SI “Scientific and Practical Medical Rehabilitation and Diagnostic Centre of the Ministry of Health of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-7678-6052
Zhogina O.O. SI “Scientific and Practical Medical Rehabilitation and Diagnostic Centre of the Ministry of Health of Ukraine”, Kyiv, Ukraine https://orcid.org/0009-0007-3420-9581
Serdyuk I.A. SI “Scientific and Practical Medical Rehabilitation and Diagnostic Centre of the Ministry of Health of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-9840-7340
Cite
Panchenko O.A., Kabantseva A.V., Zhogina O.O., Serdyuk I.A. Comprehensive Medical and Psychological Rehabilitation in War Trauma (clinical case). Medicni perspektivi. 2024;29(3):235-244. DOI: https://doi.org/10.26641/2307-0404.2024.3.313425
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