THEORETICAL MEDICINE
|
Prymachenko V.I. Methods of modelling obesity in an animal experiment (analytical literature review)
https://doi.org/10.26641/2307-0404.2025.2.333079
Abstract
The aim of the study was to explore the most effective experimental models of obesity that have been used over many years to study this condition in animals, as well as the models that most closely resemble obesity in humans. The article analyzes the current scientific literature regarding the use of various models to study the most pressing and widespread medical issue of today – obesity. A literature review and analytical analysis were conducted, along with a synthesis of data from scientific literature, which allowed for the examination of various obesity models most commonly used in experimental research by scientists. With the increase in body mass index and the onset of morbid obesity, pathological modifications are observed in all organs and systems of the human body: non-alcoholic fatty liver disease, metabolic syndrome, type 2 diabetes, insulin resistance, dyslipidemia, cardiovascular pathologies, various types of cancer of internal organs, mental disorders, and others. Experimental models of obesity in research animals allow for a deeper understanding of the development and progression of this disorder, which can expand current knowledge about the mechanisms underlying its formation, establish key pathomorphological manifestations, potential complications, and optimize new approaches to the diagnosis and treatment of obesity. However, in contemporary scientific literature, the question of improved and adequate selection of obesity models in animal studies remains open, with results that can be extrapolated to humans. To date, no single animal model can fully represent the entire spectrum of diseases and metabolic disorders associated with obesity in humans. Fatty liver disease represents a spectrum of continuous conditions associated with obesity: type 2 diabetes, insulin resistance, and hyperlipidemia. A significant amount of contemporary scientific literature documents researchers' studies on the progression from simple steatosis to non-alcoholic steatohepatitis, as well as to fibrosis and ultimately to hepatocellular carcinoma. Over the past 5-10 years, researchers have described the most commonly used animal models of fatty liver disease: genetic, chemical, dietary, and others. However, the mechanisms underlying the pathogenesis of obesity and related diseases remain not fully understood, and currently there are few available effective therapeutic approaches in the scientific literature. A large number of different animal models of obesity have been developed and described by researchers to study the pathophysiology of non-alcoholic fatty liver disease. Scientific sources highlight their advantages and disadvantages, as well as provide recommendations for researchers in selecting appropriate animal models.
Key words: obesity, disease model, metabolic syndrome, non-alcoholic fatty live disease, rats, monosodium glutamate, diet
References
- Lin C, Chang Y, Cheng T, Lo K, Liu S, Yeh TL. The association between metabolically healthy obesity and risk of cancer: A systematic review and meta‐analysis of prospective cohort studies. Obesity Reviews. 2020Oct;21(10):e13049. doi: https://doi.org/10.1111/obr.13049
- Prymachenko Obesity as a topical medical problem of the 21st century: a modern view on the disease of the humanity. The Medical and Ecological Problems. 2018;22(Issue 5-6):28-30. doi: https://doi.org/10.31718/mep.2018.22.5-6.07
- Mongraw-ChaffinM, Foster MC, Anderson CAM, Burke GL, Haq N, Kalyani RR, et Metabolically Healthy Obesity, Transition to Metabolic Syndrome, and Cardiovascular Risk. Journal of the American College of Cardiology [Internet]. 2018 May [cited 2019 Oct 20];71(17):1857-65. Available from: https://www.sciencedirect.com/science/article/pii/S073510971833496
- Chernyshov [Metabolically healthy and unhealthy obesity: contemporary views on the main differences. Review]. Ukrainian Therapeutical Journal. 2022 Jun 30;1-2:78-86. Ukrainian. doi: http://doi.org/10.30978/UTJ2022-1-78
- FullerT, Newberry Z, Nasir M, Tondt Obesity. Primary Care: Clinics in Office Practice [Internet]. 2024 May 7 [cited 2024 Nov 15]. doi: https://doi.org/10.1016/j.pop.2024.04.007
- Geetha V, Kumar GS. Concentrates from tender coconut water and coconut testa beneficially modulates tissue lipid profiles in high-fat fed rats. J Food Sci Technol. 2022 Apr;59(4):1649-57. doi: https://doi.org/10.1007/s13197-021-05178-2
- Kravchun NO, Mysyura KV. [Overweight and obesity: state of the problem, associated diseases, preventive measures]. Health of Ukraine [Internet]. 2016 [cited 2024 Nov 15];4(36). Ukrainian. Available from: https://health-ua.com/article/26142-nadlishkova-masa-tla-ta-ozhirnnya-stanproblemi-suputn-zahvoryuvannya-profla
- The World Obesity Federation. History [Internet]. 2023 [cited 2024 Nov 15]. Available from: http://www.worldobesity.org/about/about-us/history
- Mazur OY. [Experimental alimentary obesity in mature mat rats using the model of passive tobacco smoking]. Morphologia. 2020 Oct 30;14(3):45-51. Ukrainian. doi: https://doi.org/10.26641/1997-9665.2020.3.45-51
- Shutova NA. [Comparative characteristics of current experimental models of obesity. Mechanisms of the development of pathological processes and diseases and their pharmacological correction]. In: Proceedings of the II Scientific and Practical Internet Conference with International Participation; 2019 Nov 21; Kharkiv, Ukraine. 2019. p. 383-4. Ukrainian. Available from: https://repo.knmu.edu.ua/handle/123456789/25244
- Khukhlina OS, Mandryk OE, Kotsiubiychuk ZYA, Rachynska IV, Molyn LR. [Main clinical and pathogenetic features of the comorbid course of non-alcoholic steatohepatitis, obesity and hypertension]. Zkem [Internet]. 2023 [cited 2024 Nov 15];(2):21-5. Ukrainian. Available from: https://ojs.tdmu.edu.ua/index.php/zdobutky-eks-med/article/view/13825
- Molina-Molina E, Krawczyk M, Stachowska E, Lammert F, Portincasa P. Non-alcoholic fatty liver disease in non-obese individuals: Prevalence, pathogenesis and treatment. Clinics and Research in Hepatology and Gastroenterology [Internet]. 2019 Jun [cited 2024 Nov 15]. Available from: https://www.sciencedirect.com/science/article/pii/S2210740119300956
- Naumova LV, Naumova UO, Krytskyi TI. [Body mass index as a key factor of life experience and methods of its correction]. Zkem [Internet]. 2023 [cited 2024 Nov 15];(3):13-8. Ukrainian. Available from: https://ojs.tdmu.edu.ua/index.php/zdobutky-eks-med/article/view/14070
- Knyazkova II. [On the issue of obesity in menopause]. Medicine of Ukraine. 2021 May 7;3(249):20-5. Ukrainian.
doi: https://doi.org/10.37987/1997-9894.2021.3(249).238035
- Sayehmiri K, Ahmadi I, Anvari E. Fructose Feeding and Hyperuricemia: a Systematic Review and Meta-Analysis. Clin Nutr Res. 2020 Apr 27;9(2):122-33. doi: https://doi.org/10.7762/cnr.2020.9.2.122
- Mai BH, Yan L-J. The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders. Diabetes Metab Syndr Obes. 2019;12:821-6. doi: https://doi.org/10.2147/DMSO.S198968
- Klevanova V, Trzhetsynskiy S. [Antidiabetic activity of blood burnet extract in high fructose fed insulin resistant rats]. Zsmueduua [Internet]. 2015 [cited 2024 Nov 15]. Ukrainian. Available from: http://dspace.zsmu.edu.ua/handle/123456789/8893
- Zhang X, Zhang Y, Wang J, Wang S, Wang Y, Zhang H. High-fructose diet-induced metabolic syndrome in rats: a systematic review and meta-analysis. Nutr Metab (Lond). 2020;17:45. doi: https://doi.org/10.1186/s12986-020-00462-y
- Zhao Y, Wang QY, Zeng LT, Wang JJ, Liu Z, Fan GQ, et Long-Term High-Fat High-Fructose Diet Induces Type 2 Diabetes in Rats through Oxidative Stress. Nutrients. 2022 May 24;14(11):2181. doi: https://doi.org/10.3390/nu14112181
- Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, et Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest. 2017 Nov 1;127(11):4059-74. doi: https://doi.org/10.1172/JCI94585 Erratum in: J Clin Invest. 2018 Mar 1;128(3):1199. doi: https://doi.org/10.1172/JCI94585
- SmithRL, Soeters MR, Wüst RCI, Houtkooper Metabolic flexibility as an adaptation to energy resources and requirements in health and disease. Endocr Rev. 2018;39(4):489-517. doi: https://doi.org/10.1210/er.2017-00211
- MamikuttyN, Thent Z, Sapri S, Sahruddin N, et The establishment of metabolic syndrome model by induction of fructose drinking water in male Wistar rats. Biomed Res Int. 2014;2014:1-8. doi: https://doi.org/10.1155/2014/263897
- PreguiçaI, Alves A, Nunes S, Fernandes R, Gomes P, Viana SD, et Diet-induced rodent models of obesity-related metabolic disorders: A guide to a translational perspective. Obes Rev. 2020;21(12):e13081. doi: https://doi.org/10.1111/obr.13081
- KuceraO, Cervinkova Experimental models of non-alcoholic fatty liver disease in rats. World J Gastroenterol. 2014;20(26):8364-78. doi: https://doi.org/10.3748/wjg.v20.i26.8364
- Prymachenko [Obesity as a topical medical problem of the 21st century: a modern view on the disease of humanity]. The Medical and Ecological Problems. 2018;22(5-6):25-7. Ukrainian. doi: https://doi.org/10.31718/mep.2018.22.5-6.06
- García-JaramilloM, Spooner MH, Löhr CV, Wong CP, Zhang W, Jump Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female Ldlr-/-mice. PLOS ONE. 2019;14(4):e0214387. doi: https://doi.org/10.1371/journal.pone.0214387
- KonopelnyukVV, Pribytko IY, Tsyryuk OI, et [Pathophysiology characteristics of the experimental model of obesity in female rats induced neonatal administration of monosodium glutamate]. ScienceRise: Biological Science. 2016 Nov 18;0(3(3)):14-8. Ukrainian.
doi: https://doi.org/10.15587/2519-8025.2016.83570
- Mazur [Experimental alimentary obesity in mature mat rats using the model of passive tobacco smoking]. Morphologia. 2020 Oct 30;14(3):45-51. Ukrainian. doi: https://doi.org/10.26641/1997-9665.2020.3.45-51.
- LalanzaJF, Caimari A, del Bas JM, Torregrosa D, Cigarroa I, Pallàs M, et Effects of a post-weaning cafeteria diet in young rats: metabolic syndrome, reduced activity and low anxiety-like behaviour. PLoS One. 2014;9(1):e85049. doi: https://doi.org/10.1371/journal.pone.0085049
- ReboucasEC, Leal S, Sa Regulation of NPY and α-MSH expression by estradiol in the arcuate nucleus of Wistar female rats: a stereological study. UNIPRO. 2016;38:740-7. doi: https://doi.org/10.1080/01616412.2016.1203124
- MarkhonNO, Mamchur VY, Zhilyuk VI, et [Comparative analysis of experimental approaches in reproduction of metabolic syndrome]. Herald of Problems of Biology and Medicine. 2015;1(117):156-62. Ukrainian.
- AlkhouriN, Dixon LJ, Feldstein Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol. 2019;13(9):879-87. doi: https://doi.org/10.1080/17474124.2019.1657826
- JensenT, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, et Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;68(5):1063-75. doi: https://doi.org/10.1016/j.jhep.2018.01.019
- ZhongF, Zhou X, Xu J, Gao Rodent models of nonalcoholic fatty liver disease. Digestion. 2020;101(5):522-35. doi: https://doi.org/10.1159/000501851
- MatiasAM, Estevam WM, Coelho PM, Haese D, Kobi JBBS, Lima-Leopoldo AP, et al. Differential effects of high sugar, high lard or a combination of both on nutritional, hormonal and cardiovascular metabolic profiles of rodents. Nutrients. 2018 Aug 11;10(8):1071. doi: https://doi.org/10.3390/nu10081071
- MatiasAM, Coelho PM, Marques VB, dos Santos L, de Assis ALEM, Nogueira BV, et Hypercaloric diet models do not develop heart failure, but the excess sucrose promotes contractility dysfunction. PLoS One. 2020 Feb 7;15(2):e0228860. doi: https://doi.org/10.1371/journal.pone.0228860
- NakamuraK, Miyoshi M, Ogawa High-Fat, High-Sucrose Diet Leads to Obesity, Liver Steatosis, and Hyperglycemia in Mice. Sci Rep. 2021;11(1):8764. doi: https://doi.org/10.1038/s41598-021-87645-6
- FarrellG, Schattenberg JM, Leclercq I, Yeh MM, Goldin R, Teoh N, et al. Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis. Hepatology (Baltimore, Md). 2019 May 1;69(5):2241-57. doi: https://doi.org/10.1002/hep.30333
- ChengHS, Ton SH, Phang SCW, Tan JBL, Abdul Kadir Increased susceptibility of post-weaning rats on high-fat diet to metabolic syndrome. J Adv Res. 2017 Nov;8(6):743-52. doi: https://doi.org/10.1016/j.jare.2017.10.002
- Eng JM, Estall JL. Diet-induced models of non-alcoholic fatty liver disease: food for thought on sugar, fat, and cholesterol. Cells.2021;10(7):1805. doi: https://doi.org/10.3390/cells10071805
- LaskerS, Rahman MM, Parvez F, Zamila M, Miah P, Nahar K, et High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation. Scientific Reports. 2019;9(1):20026. doi: https://doi.org/10.1038/s41598-019-56538-0
- KopchakNG, Pokotylo OS, Kukhtin MD, Koval [The influence of iodine on the parameters of the blood lipid profile of rats of different ages with experimental obesity]. Medical and Clinical Chemistry. 2017;19(4):123-8. Ukrainian. doi: https://doi.org/10.11603/mcch.2410-681X.2017.v0.i4.8437
- AydosL, Aparecida do Amaral L, Serafim de Souza R, Jacobowski AC, Freitas dos Santos E, Rodrigues Macedo Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in C57bl/6 Models. Nutrients. 2019;11(12):3067. doi: https://doi.org/10.3390/nu11123067
- SmithJ, Brown R, Johnson Progesterone-induced obesity in female mice: a model for studying metabolic dysregulation. Int J Obes (Lond). 2020;44(5):1123-32. doi: https://doi.org/10.1038/s41366-020-0581-z
- DanielsSJ, Leeming DJ, Detlefsen S, Bruun MF, Hjuler ST, Henriksen K, et Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2020;318(3):G410-G418. doi: https://doi.org/10.1152/ajpgi.00066.2019
- Aleksandrov [Biochemical and immunological parameters of rats under experimental model of progesterone-induced obesity. Qualifying scientific work on the rights of manuscripts]. 2019. 24 p. Ukrainian.
- CarreresL, Jílková ZM, Vial G, Marche PN, Decaens T, Lerat Modeling diet-induced NAFLD and NASH in rats: A comprehensive review. Biomedicines. 2021;9(4):378. doi: https://doi.org/10.3390/biomedicines9040378
- MaslovaGS, Skrypnyk RI, Shcherbak OV, Skrypnyk [Model diet-induced steatohepatitis in rats: morphological and pathogenetic features]. Suchasna Hastroeneterolohiya. 2020;2:11-7. Ukrainian. doi: https://doi.org/10.30978/MG-2020-2-11
- FukudaA, Sasao M, Asakawa E, Narita S, Hisano, Suruga K, et Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats. Pathol Res Pract. 2019;215(11):152599. doi: https://doi.org/10.1016/j.prp.2019.152599
- VatashchukMV, Demyanchuk OI, Bailyak [Effects of alpha-ketoglutarate on glucose tolerance and visceral fat accumulation in mice fed a high-calorie cafeteria diet]. In: Basics Med Sci Endocrinol. Materials of the scientific and practical conference; 2021 Nov 18-19; Ivano-Frankivsk. Ivano-Frankivsk: IFNMU; 2021. р. 57-60. Ukrainian.
- Gutiérrez-CuevasJ, Santos A, Armendariz-Borunda J. Pathophysiological molecular mechanisms of obesity: A link between MAFLD and NASH with cardiovascular diseases. Int J Mol Sci. 2021 Oct 27;22(21):11629. doi: https://doi.org/10.3390/ijms222111629
- de CastroJM, de Freitas JS, Stein DJ, de Macedo IC, Caumo W, Torres Transcranial Direct Current Stimulation (tDCS) promotes state-dependent effects on neuroinflammatory and behavioral parameters in rats chronically exposed to stress and a hyper-palatable diet. Neurochemical Research. 2023;48(10):3042-54. doi: https://doi.org/10.1007/s11064-023-03965-1
- SuY, Wang T, Wu N, Li D, Fan X, Xu Z, et Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK. Aging. 2019 Jun 26;11(12):4183-97. doi: https://doi.org/10.18632/aging.102045
- PivtorakVI, Sydorenko BV, Monastyrskyi VM, Pivtorak KV, Bulko [Efficacy of an experimental model of non-alcoholic fatty liver disease based on a high-fat diet with cholesterol]. Svit Medytsyny ta Biolohii. 2022;2(80):222-6. Ukrainian. doi: https://doi.org/10.26724/2079-8334-2022-2-80-222-226
- TavakoliR, Maleki MH, Vakili O, Taghizadeh M, Zal F, Shafiee Bilirubin, once a toxin but now an antioxidant alleviating non-alcoholic fatty liver disease in an autophagy-dependent manner in high-fat diet-induced rats: a molecular and histopathological analysis. Res Pharm Sci. 2024 Jul;19(4):475-88. doi: https://doi.org/10.4103/RPS.RPS_53_24
- Mateshuk-Vatseba LR, Garapko TV, Kyryk HA, Blyshchak NB, Prymachenko VI, Pidvalna UE, et al., inventors. [The method of modeling experimental alimentary obesity through the mediated effect of monosodium glutamate]. Patent of Ukraine for utility model u202002310. 2020 Sept 04. Ukrainian.
PDF
Look through: 
Authors and affiliations
Prymachenko V.I. Bogomolets National Medical University, Kyiv, Ukraine e-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-2783-8546
Cite
Metrics
|
Chaban V.O., Kozlova Yu.V. Repeated blast-induced neurotrauma: histopathological changes in the hippocampus and cerebellum of rats
https://doi.org/10.26641/2307-0404.2025.2.333132
Abstract
Repeated blast-induced neurotrauma impairs the quality of life of military personnel and civilians who have suffered from repeated blast wave exposure. The aim was to study histopathological changes in the hippocampus and cerebellum of rats after repeated 3-fold blast wave exposure. The study was conducted on 40 male rats, randomly divided into control (n=5) and experimental groups (n=35). The experimental group of rats was divided into 5 animals for each observation period: 30 minutes, 1st, 3rd, 7th, 14th, 21st and 28th days, to track the dynamics of morphological changes. Animals of the experimental group were anesthetized with halothane and fixed on the abdomen so that the muzzle was at a distance of 5 cm from the device outlet. They were exposed to an excess pressure of 31.6±4.8 kPa. Then the animals were decapitated, the brain was removed, the hippocampus and cerebellum were separated, fixed and stained with hematoxylin-eosin according to the standard method. Light microscopy of the hippocampus demonstrated signs of karyopyknosis already 30 minutes after 3-fold exposure to the blast wave, as well as signs of perivascular and pericellular edema, and hypochromia of pyramidal cells. These signs intensified during all subsequent periods of observation. Light microscopy of the cerebellum demonstrated signs of pericellular edema in the Purkinje layer area 30 minutes after repeated exposure to the blast wave, which increased on the 1st and 3rd days, and then began to decrease. Hypochromia of Purkinje cells was observed throughout the entire period of observation of the experimental animals. On the 7th, 21st and 28th days, clearly visible signs of engorgement of the cerebellar blood vessels were observed. Thus, our morphological study showed that after 30 minutes, on the 1st, 3rd, 7th, 14th, 21st and 28th day after repeated exposure to a blast wave, primary and secondary brain changes were observed. In the hippocampus, signs of karyopyknosis and chromatolysis of pyramidal cells, as well as perivascular and pericellular edema were observed. In the cerebellum, hypochromia of Purkinje cells, pericellular edema in the Purkinje layer zone and hyperemia of blood vessels were detected. These changes can serve as biomarkers of traumatic disorders after 3-fold exposure to a blast wave.
Key words: hippocampus, cerebellum, histopathology, repeated blast-induced neurotrauma, blast wave, rats
References
- Sachdeva T, Ganpule SG. Twenty Years of Blast-Induced Neurotrauma: Current State of Knowledge. Neurotrauma 2024 Mar 14;5(1):243-53. doi: https://doi.org/10.1089/neur.2024.0001
- Dickerson MR, Murphy SF, Urban MJ, White Z, VandeVord PJ. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma. Front Behav 2021 Dec 10;15:787475. doi: https://doi.org/10.3389/fnbeh.2021.787475
- Ravula AR, Rodriguez J, Younger D, Perumal V, Shao N, Rama Rao KV, et al. Animal model of repeated low-level blast traumatic brain injury displays acute and chronic neurobehavioral and neuropathological changes. Exp 2022 Mar;349:113938. doi: https://doi.org/10.1016/j.expneurol.2021.113938
- Hubbard WB, Velmurugan GV, Brown EP, Sullivan PG. Resilience of females to acute blood-brain barrier damage and anxiety behavior following mild blast traumatic brain injury. Acta Neuropathol Commun. 2022 Jun 27;10(1):93. doi: https://doi.org/10.1186/s40478-022-01395-8
- Elder GA, Gama Sosa MA, De Gasperi R, Perez Garcia G, Perez GM, Abutarboush R, et al. The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma. Int J Mol Sci. 2024 Jan 17;25(2):1150. doi: https://doi.org/10.3390/ijms25021150
- Kozlova YuV, Abdul-Ohly LV, Kosharnyi AV, Kytova IV, Korzachenko MA, inventors. [Device for studying the effect of the shock wave of an explosion on the body]. Ukraine patent U202100358. 2021 Mar 24. Ukrainian.
- Bagriy MM, Dibrova VA, Popadynets OG, Grischuk MI. [Methods of morphological research]. Vinnitsa: Nova Knyha; 2016. 328 p. Ukranian.
- Logsdon AF, Schindler AG, Meabon JS, Yagi M, Herbert MJ, Banks WA, et al. Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury. Sci Rep. 2020 Jun 10;10(1):9420. doi: https://doi.org/10.1038/s41598-020-66113-7
- Del Pilar C, Lebrón-Galán R, Pérez-Martín E, Pérez-Revuelta L, Ávila-Zarza CA, Alonso JR, et al. The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations. Front Cell Neurosci. 2021 Nov 30;15:773696. doi: https://doi.org/10.3389/fncel.2021.773696
- Özen I, Mai H, De Maio A, Ruscher K, Michalettos G, Clausen F, et al. Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits. Acta Neuropathol 2022 Sep 5;10(1):129. doi: https://doi.org/10.1186/s40478-022-01435-3
- Gama Sosa MA, De Gasperi R, Pryor D, Perez Garcia GS, Perez GM, Abutarboush R, et al. Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation. Acta Neuropathol Commun. 2021 Oct 15;9(1):167. doi: https://doi.org/10.1186/s40478-021-01269-5
- Neale KJ, Reid HMO, Sousa B, McDonagh E, Morrison J, Shultz S, et al. Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats. J Neuroinflammation. 2023 Oct 31;20(1):250. doi: https://doi.org/10.1186/s12974-023-02916-5
- Prabhakar NK, Khan H, Grewal AK, Singh TG. Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches. Int Immunopharmacol.2022 Jul;108:108902. doi: https://doi.org/10.1016/j.intimp.2022.108902
- Wu A, Zhang J. Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis. J 2023 Nov 27;20(1):283. doi: https://doi.org/10.1186/s12974-023-02964-x
- Bryden DW, Tilghman JI, Hinds SR 2nd. Blast-Related Traumatic Brain Injury: Current Concepts andResearch Considerations. J Exp Neurosci. 2019 Sep 12;13:1179069519872213. doi: https://doi.org/10.1177/1179069519872213
- Bell JD, Ai J, Chen Y, Baker AJ. Mild in vitro trauma induces rapid GluR2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells. Brain.2007 Oct;130(10):2528-42. doi: https://doi.org/10.1093/brain/awm164
- Godoy DA, Rubiano AM, Paranhos J, Robba C, Lazaridis C. Avoiding brain hypoxia in severe traumatic brain injury in settings with limited resources – A pathophysiological guide. J Crit Care. 2023 Jun;75:154260. doi: https://doi.org/10.1016/j.jcrc.2023.154260
PDF
Look through: 
Authors and affiliations
Cite
Metrics
|
Gudarian O.O., Cherednyk D.O. Methods for studying the state of bone metabolism in patients with diabetes who require comprehensive total rehabilitation of the oral cavity through dental implantation
https://doi.org/10.26641/2307-0404.2025.2.333358
Abstract
Replacement of dentition defects using the dental implantation method is today one of the most common operations in the practice of a dentist-surgeon. The purpose of the study is to substantiate the choice of diagnostic methods for patients with type 2 diabetes mellitus, complicated by generalized periodontitis and diabetic osteopathy, who require dental implantation for total replacement of dentition defects. An electronic search was performed in PubMed and Google Scholar in the time interval 2003-2023. The study found 3728, selected 1170 and analyzed 24 sources, according to which the most optimal and expediently recommended research methods for the above group of patients were established. When processing information, the inclusion criteria were the study design, which included books and documents, clinical studies, meta-analysis, randomized controlled trial, review, systematic review, etc. The exclusion criteria were publications that did not meet the purpose of this review. The keywords used were “periodontitis”, “periodontal pathology”, “diabetes mellitus”, “bone metabolism markers”, “dental implantation”, “bone metabolism”, “surgical dentistry”, “maxillofacial surgery”. In patients without general somatic pathology, the results of implant treatment are quite predictable, however, the treatment of patients with type 2 diabetes mellitus may be compromised by a large number of complications, especially if they have generalized periodontitis and diabetic osteopathy. There is no consensus in the literature among researchers regarding the nature of the combined effect of the above pathology and various variants of generalized periodontitis on the features of bone metabolism and the results of dental implantation, especially in those patients who require total rehabilitation, which in turn requires a more detailed study of their effect on the osseointegration of implants. This is of particular importance for the development of new approaches to preoperative diagnostics of personalized determination of indications and contraindications for dental implantation in this category of patients. In contrast to X-ray studies, cone-beam computed tomography and dual-energy X-ray absorptiometry have a more sensitive response to changes in the rate of balance between the processes of bone resorption and osteosynthesis, which makes their clinical use valuable for monitoring in the preoperative period and predicting osseointegration after dental implantation, as well as for assessing the response to the prescribed treatment. Diagnostics and planning of surgical interventions in patients with type 2 diabetes mellitus cannot be similar to those used in somatically healthy patients.
Key words: periodontitis, periodontal pathology, diabetes mellitus, bone metabolism markers, dental implantation, bone metabolism, surgical dentistry, maxillofacial surgery
References
- American Diabetes Association Professional Practice Committee 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024. Diabetes care. 2024;47(Suppl 1):S20-S42. doi: https://doi.org/10.2337/dc24-S002
- Khachatryan H, Hakobyan G. Diagnostic and prognostic value of indicators of markers of bone metabolism in type 2 diabetes mellitus patients with UV functionalised dental implants. Journal of stomatology, oral and maxillofacial surgery. 2023;124(6S):101608. doi: https://doi.org/10.1016/j.jormas.2023.101608
- Marchand F, Raskin A, Dionnes-Hornes A, Barry T, Dubois N, Valéro R, et al. Dental implants and diabetes: conditions for success. Diabetes & metabolism. 2012;38(1):14-9. doi: https://doi.org/10.1016/j.diabet.2011.10.002
- Peled M, Ardekian L, Tagger-Green N, Gutmacher Z, Machtei EE. Dental implants in patients with type 2 diabetes mellitus: a clinical study. Implant dentistry. 2003;12(2):116-22. doi: https://doi.org/10.1097/01.id.0000058307.79029.b1
- Fuster-Torres MÁ, Peñarrocha-Diago M, Peñarrocha-Oltra D, Peñarrocha-Diago M. Relationships between bone density values from cone beam computed tomography, maximum insertion torque, and resonance frequency analysis at implant placement: a pilot study. The International journal of oral & maxillofacial implants. 2011;26(5):1051-6.
- Park CS, Kang SR, Kim JE, Huh KH, Lee SS, Heo MS, et al. Validation of bone mineral density measurement using quantitative CBCT image based on deep learning. Scientific 2023;13(1):11921. doi: https://doi.org/10.1038/s41598-023-38943-8
- Al-Jamal MFJ, Al-Jumaily HA. Can the Bone Density Estimated by CBCT Predict the Primary Stability of Dental Implants? A New Measurement Protocol. The Journal of craniofacial surgery. 2021;32(2):e171-e174. doi: https://doi.org/10.1097/SCS.0000000000006991
- Isoda K, Ayukawa Y, Tsukiyama Y, Sogo M, Matsushita Y, Koyano K. Relationship between the bone density estimated by cone-beam computed tomography and the primary stability of dental implants. Clinical oral implants research. 2012;23(7):832-6. doi: https://doi.org/10.1111/j.1600-0501.2011.02203.x
- Massera D, Biggs ML, Walker MD, Mukamal KJ, Ix JH, Djousse L, et al. Biochemical Markers of Bone Turnover and Risk of Incident Diabetes in Older Women: The Cardiovascular Health Study. Diabetes care. 2018;41(9):1901-8. doi: https://doi.org/10.2337/dc18-0849
- Zoch ML, Clemens TL, Riddle RC. New insights into the biology of osteocalcin. Bone. 2016;82:42-9. doi: https://doi.org/10.1016/j.bone.2015.05.046
- Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456-69. doi: https://doi.org/10.1016/j.cell.2007.05.047
- Motyl KJ, McCabe LR, Schwartz AV. Bone and glucose metabolism: a two-way street. Archives of biochemistry and biophysics. 2010;503(1):2-10. doi: https://doi.org/10.1016/j.abb.2010.07.030
- Vimalraj S. Alkaline phosphatase: Structure, expression and its function in bone mineralization. Gene. 2020;754:144855. doi: https://doi.org/10.1016/j.gene.2020.144855
- Zhang Z, Nam HK, Crouch S, Hatch NE. Tissue Nonspecific Alkaline Phosphatase Function in Bone and Muscle Progenitor Cells: Control of Mitochondrial Respiration and ATP Production. International journal of molecular sciences. 2021;22(3):1140. doi: https://doi.org/10.3390/ijms22031140
- Chen H, Li J, Wang Q. Associations between bone-alkaline phosphatase and bone mineral density in adults with and without diabetes. Medicine. 2018;97(17):e0432. doi: https://doi.org/10.1097/MD.0000000000010432
- Al-Hariri M. Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes. Journal of diabetes research. 2016;2016:6969040. doi: https://doi.org/10.1155/2016/6969040
- Bergman A, Qureshi AR, Haarhaus M, Lindholm B, Barany P, Heimburger O, et al. Total and bone-specific alkaline phosphatase are associated with bone mineral density over time in end-stage renal disease patients starting dialysis. Journalof 2017;30(2):255-62. doi: https://doi.org/10.1007/s40620-016-0292-7
- Lumachi F, Camozzi V, Tombolan V, Luisetto G. Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus. Annals of the New York Academy of Sciences. 2009;1173(Suppl 1):E64-E67. doi: https://doi.org/10.1111/j.1749-6632.2009.04955.x
- Kuzniak NB, Boitsaniuk SI, Sukhovolets IO. [The use of biochemical markers of bone metabolism in dentistry]. Klinichna stomatolohiia. 2015;1:99-104. Ukrainian.
- Williams C, Sapra A. Osteoporosis Markers. In: Statpearls Knowledge Base. StatPearls Publishing; 2023.
- König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients. 2018;10(1):97. doi: https://doi.org/10.3390/nu10010097
- Roy M, Majid H, Khan P, Sharma N, Kohli S, Islam SU., et al. CTX-1 and TRACP-5b as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study. Journal of diabetes and metabolic disorders. 2024;23(2):2055-64. doi: https://doi.org/10.1007/s40200-024-01464-w
- Chen X, Kang S, Bao Z. Effects of Glimepiride Combined with Recombinant Human Insulin Injection on Serum IGF-1, VEGF and TRACP-5b Oxidative Stress Levels in Patients with Type 2 Diabetes Mellitus. Evidence-based complementary and alternative medicine: eCAM. 2022;2022:4718087. doi: https://doi.org/10.1155/2022/4718087
- Hygum K, Starup-Linde J, Harsløf T, Vestergaard P, Langdahl BL. Mechanisms in endocrinology: Diabetes mellitus, a state of low bone turnover – a systematic review and meta-analysis. European journal of endocrinology. 2017;176(3):R137-R157. doi: https://doi.org/10.1530/EJE-16-0652
- Klein KR, Walker CP, McFerren AL, Huffman H, Frohlich F, Buse JB. Carbohydrate Intake Prior to Oral Glucose Tolerance Testing. Journal of the Endocrine Society. 2021;5(5):bvab049. doi: https://doi.org/10.1210/jendso/bvab049
- Aghaloo T, Pi-Anfruns J, Moshaverinia A, Sim D, Grogan T, Hadaya D. The Effects of Systemic Diseases and Medications on Implant Osseointegration: A Systematic Review. The International journal of oral & maxillofacial implants. 2019;34:s35-s49. doi: https://doi.org/10.11607/jomi.19suppl.g3
- D'Ambrosio F, Amato A, Chiacchio A, Sisalli L, Giordano F. Do Systemic Diseases and Medications Influence Dental Implant Osseointegration and Dental Implant Health? An Umbrella Review. Dentistry journal. 2023;11(6):146. doi: https://doi.org/10.3390/dj11060146
- Gudaryan OO, Mashchenko IS, Kucherenko TO. [Treatment of aggressive (rapidly progressing) generalized periodontitis using systemic enzyme therapy in combination with osteoinductive medicines]. Medychni perspektyvy.2020;25(3):144-52. doi: https://doi.org/10.26641/2307-0404.2020.3.214852
- Al-Asali M, Alqutaibi AY, Al-Sarem M, Saeed F. Deep learning-based approach for 3D bone segmentation and prediction of missing tooth region for dental implant planning. Scientific reports. 2024;14(1):13888. doi: https://doi.org/10.1038/s41598-024-64609-0
- Zhang C, Fan L, Zhang S, Zhao J, Gu Y. Deep learning based dental implant failure prediction from periapical and panoramic films. Quantitative imaging in medicine and surgery. 2023;13(2):935-45. doi: https://doi.org/10.21037/qims-22-457
- Melerowitz L, Sreenivasa S, Nachbar M, Stsefanenka A, Beck M, Senger C, et al. Design and evaluation of a deep learning-based automatic segmentation of maxillary and mandibular substructures using a 3D U-Net. Clinical and translational radiation oncology. 2024;47:100780. doi: https://doi.org/10.1016/j.ctro.2024.100780
- Gudarian AA, Kucherenko TA. The state of bone metabolism in patients with different variants of the course of generalized periodontitis. Visnik problem biologii i meditsini.2020;3(157):314-18. doi: https://doi.org/10.29254/2077-4214-2020-3-157-314-318
- Liu M, Kurimoto P, Zhang J, Niu QT, Stolina M, Dechow PC, et al. Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss. Journal of dental 2018;97(9):1031-8. doi: https://doi.org/10.1177/0022034518766874
- Couto BADA, Fernandes JCH, Saavedra-Silva M, Roca H, Castilho RM, Fernandes GVO. Antisclerostin Effect on Osseointegration and Bone Remodeling. J Clin Med. 2023 Feb 6;12(4):1294. doi: https://doi.org/10.3390/jcm12041294
- Ominsky MS, Li C, Li X, Tan HL, Lee E, Barrero M, et al. Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones. J Bone Miner Res. 2011 May;26(5):1012-21. doi: https://doi.org/10.1002/jbmr.307
- Taut AD, Jin Q, Chung JH, Galindo-Moreno P, Yi ES, Sugai JV, et al. Sclerostin antibody stimulates bone regeneration after experimental periodontitis. J Bone Miner Res. 2013 Nov;28(11):2347-56. doi: https://doi.org/10.1002/jbmr.1984
- Virk MS, Alaee F, Tang H, Ominsky MS, Ke HZ, Lieberman JR. Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model. J Bone Joint Surg Am. 2013 Apr 17;95(8):694-701. doi: https://doi.org/10.2106/JBJS.L.00285
- Asokan AG, Jaganathan J, Philip R, Soman RR, Sebastian ST, Pullishery F. Evaluation of bone mineral density among type 2 diabetes mellitus patients in South Karnataka. J Nat Sci Biol Med. 2017 Jan-Jun;8(1):94-8. doi: https://doi.org/10.4103/0976-9668.198363
- Kang KY, Hong YS, Park SH, Ju JH. Increased serum alkaline phosphatase levels correlate with high disease activity and low bone mineral density in patients with axial spondyloarthritis. Semin Arthritis Rheum. 2015 Oct;45(2):202-7. doi: https://doi.org/10.1016/j.semarthrit.2015.03.002
- Kubihal S, Gupta Y, Goyal A, Kalaivani M, Tandon N. Bone microarchitecture, bone mineral density and bone turnover in association with glycemia and insulin action in women with prior gestational diabetes. Clin Endocrinol(Oxf). 2022 Apr;96(4):531-8. doi: https://doi.org/10.1111/cen.14641
- Akalın A, Yorulmaz G, Alataş İÖ, Onbaşı K, Efe FB. Bone turnover markers and bone mineral density in patients with type 2 diabetes. The European Research Journal. 2023;9(2):301-8. doi: https://doi.org/10.18621/eurj.1085838
PDF
Look through: 
Authors and affiliations
Cite
Gudarian O.O., Cherednyk D.O. Methods for studying the state of bone metabolism in patients with diabetes who require comprehensive total rehabilitation of the oral cavity through dental implantation. Medicni perspektivi. 2025;30(2):20-27. DOI: https://doi.org/10.26641/2307-0404.2025.2.333358
Metrics
|
Ayubi N., Wibawa J.C., Rizki A.Z., Afandi A., Callixte C. Physiological regulation of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in mitochondrial metabolism during physical exercises: a systematic review
https://doi.org/10.26641/2307-0404.2025.2.333361
Abstract
This study aims to analyze in depth the mechanism of physical exercises in increasing the expression of PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) as the most important part of mitochondrial biogenesis through a systematic review. Literature databases including PubMed, Web of Science, and Science Direct were searched for this systematic review study. The inclusion criteria for this study were articles published in the last five years. The articles discussed PGC-1α, exercises, and mitochondrial biogenesis. PubMed, Web of Science, and Science Direct databases were used to find 141 published articles. Finally, 13 articles that met the inclusion criteria were selected and analyzed for this systematic review. In this study, standard operating procedures were evaluated using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Exercises have been shown to increase PGC-1α expression, according to this systematic review. Increased biogenesis in mitochondria may be triggered by increased PGC-1α expression, which helps in the energy production process. On the other hand, it is not yet clear about the ideal intensity and type of physical activity to increase PGC-1α. This provides recommendations for further exploration in future experimental studies.
Key words: peroxisome proliferator-activated receptor gamma coactivator 1-alpha, physical exercises, mitochondrial, biogenesis
References
- Lancet T. Diabetes: a defining disease of the 21st century. Lancet.2023;401(10394):2087. doi: https://doi.org/10.1016/S0140-6736(23)01296-5
- Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi: https://doi.org/10.1016/j.diabres.2021.109119
- Ong KL, Stafford LK, McLaughlin SA, et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet.2023;402(10397):203-34. doi: https://doi.org/10.1016/S0140-6736(23)01301-6
- Khoramipour K, Hekmatikar AA, Sotvan H. An overview of Fatmax and MFO in exercise. Razi J Med Sci. 2020;27(3):49-59.
- Orumiyehei A, Khoramipour K, Rezaei MH, et al. High-Intensity Interval Training-Induced Hippocampal Molecular Changes Associated with Improvement in Anxiety-like Behavior but Not Cognitive Function in Rats with Type 2 Diabetes. Brain Sci. 2022;12(10):1280. doi: https://doi.org/10.3390/brainsci12101280
- Ebrahimnezhad N, Nayebifar S, Soltani Z, Khoramipour K. High-intensity interval training reduced oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes: The role of the PGC1α-Keap1-Nrf2 signaling pathway. Iran J Basic Med Sci. 2023;26(18):1313-9. doi: https://doi.org/10.22038/IJBMS.2023.70833.15387
- Laura J. McMeekin, Stephanie N. Fox SMB and RMC. Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and Opportunities. Cells.2021 Feb 9;10(2):352.
doi: https://doi.org/ 10.3390/cells10020352
- Piccinin E, Villani G, Moschetta A. Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators. Nat Rev Gastroenterol Hepatol.2019;16(3):160-74. doi: https://doi.org/10.1038/s41575-018-0089-3
- Dikalov SI, Dikalova AE. Crosstalk between Mitochondrial Hyperacetylation and Oxidative Stress in Vascular Dysfunction and Hypertension. Antioxidants Redox Signal. 2019;31(10):710-21. doi https://doi.org/10.1089/ars.2018.7632
- Wu L, Zhou M, Li T, et al. GLP-1 regulates exercise endurance and skeletal muscle remodeling via GLP-1R/AMPK pathway. Biochim Biophys Acta – Mol Cell Res. 2022;1869(9):119300. doi: https://doi.org/10.1016/j.bbamcr.2022.119300
- Zhu N, Yan X, Li H. Clinical significance of serum pgc-1 alpha levels in diabetes mellitus with myocardial infarction patients and reduced ros-oxidative stress in diabetes mellitus with myocardial infarction model. Diabetes, Metab Syndr Obes. 2020;13:4041-9. doi: https://doi.org/10.2147/DMSO.S276163
- Andrade C. Physical Exercise and Health, 4: the health care professional and patient's guide to understanding what to do, how, and why-part 2. J Clin Psychiatry. 2023;84(6):23f15187. doi: https://doi.org/10.4088/jcp.23f15187
- Marzuca-Nassr GN, Alegría-Molina A, SanMartín-Calísto Y, et al. Muscle mass and strength gains following resistance exercise training in older adults 65-75 years and older adults above 85 years. Int J Sport Nutr Exerc Metab. 2024;34(1):11-9. doi: https://doi.org/10.1123/ijsnem.2023-0087
- Pinckard K, Baskin KK, Stanford KI. Effects of Exercise to Improve Cardiovascular Health. Front Cardiovasc 2019;6(6):1-12. doi: https://doi.org/10.3389/fcvm.2019.00069
- Liu C, Wu X, Vulugundam G, Gokulnath P, Li G, Xiao J. Exercise promotes tissue regeneration: mechanisms involved and therapeutic scope. Sport Med – Open. 2023;9(1):27. doi https://doi.org/10.1186/s40798-023-00573-9
- Little JP, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ. An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle. Am J Physiol – Regul Integr Comp Physiol. 2011;300(6):1303-10. doi: https://doi.org/10.1152/ajpregu.00538.2010
- Fernandes MSDS, Aidar FJ, da Silva Pedroza AA, et al. Effects of aerobic exercise training in oxidative metabolism and mitochondrial biogenesis markers on prefrontal cortex in obese mice. BMC Sports Sci Med Rehabil. 2022;14(1):1-8. doi https://doi.org/10.1186/s13102-022-00607-x
- Hejazi K, Attarzadeh Hosseini SR, Fathi M, Mosaferi Ziaaldini M. The Regulation of the Concentrations of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha and Sirtuin 1 Protein in the Soleus Muscle by Aerobic Exercise Training in Obese Wistar Rats. J Kermanshah Univ Med Sci. 2020;24(3):22-7. doi: https://doi.org/10.5812/jkums.101849
- Gahramani M, Karbalaeifar S. Effect of eight weeks high intensity interval training on NRF-1, 2 and Tfam gene expressione levels in ST muscles in rats with myocardial infarction. Med J Tabriz Univ Med Sci Heal Serv. 2019;41(6):75-82. doi: https://doi.org/10.34172/mj.2020.009
- Shirvani H, Rahmati-Ahmadabad S, Broom DR, Mirnejad R. Eccentric resistance training and β-hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin in rats. J Exp 2019;222(10):jeb198424. doi: https://doi.org/10.1242/jeb.198424
- Hoseini Z, Behpour N, Hoseini R. Aerobic training with moderate or high doses of vitamin D improve liver enzymes, LXRα and PGC-1α levels in rats with T2DM. Sci 2024;14(1):1-11. doi: https://doi.org/10.1038/s41598-024-57023-z
- Guo Y, Zhou F, Fan J, et al. Swimming alleviates myocardial fibrosis of type II diabetic rats through activating miR-34a-mediated SIRT1/PGC-1α/FNDC5 signal pathway. PLoS 2024;19(9):1-24. doi: https://doi.org/10.1371/journal.pone.0310136
- Ghadery B, Ghazalian F, Hosseini SA, Abed Natanzy H, Shamsoddini A. The effect of six weeks of high intensity interval training on enos and pgc-1α gene expression in the heart tissue of male obese rats. Jundishapur J Heal 2020;12(2):1-5. doi: https://doi.org/10.5812/jjhs.100280
- Shoghi E, Safari T, Parsi-Moud A, Mirzaei I, Rad NS, Chahkandi M. Effects of moderate intensity training and lithium on spatial learning and memory in a rat model: The role of SIRT3 and PGC1-α expression levels and brain-derived neurotropic factor. Exp Gerontol. 2024;191(Apr):112442. doi: https://doi.org/10.1016/j.exger.2024.112442
- Sylviana N, Natalia C, Goenawan H, et al. Effect of short-term endurance exercise on Cox IV and PGC-1a mRNA expression levels in rat skeletal muscle. Biomed Pharmacol 2019;12(3):1309-16. doi: https://doi.org/10.13005/bpj/1759
- Cho E, Jeong DY, Kim JG, Lee S. The acute effects of swimming exercise on PGC-1α-FNDC5/irisin-UCP1 expression in male C57bL/6J mice. Metabolites. 2021;11(2):1-11. doi: https://doi.org/10.3390/metabo11020111
- Chou TJ, Lin LY, Lu CW, Hsu YJ, Huang CC, Huang KC. Effects of aerobic, resistance, and high-intensity interval training on thermogenic gene expression in white adipose tissue in high fat diet induced obese mice. Obes Res Clin Pract. 2024;18(1):64-72. doi: https://doi.org/10.1016/j.orcp.2024.01.003
- Luo J, Tang C, Chen X, et al. Impacts of aerobic exercise on depression-like behaviors in chronic unpredictable mild stress mice and related factors in the AMPK/PGC-1α pathway. Int J Environ Res Public Health. 2020;17(6):2042. doi: https://doi.org/10.3390/ijerph17062042
- Shelbayeh OA, Arroum T, Morris S, Busch KB. PGC-1 α is a master regulator of mitochondrial lifecycle and ROS stress response. Antioxidants. 2023;12(5):1075. doi: https://doi.org/10.3390/antiox12051075
- Bost F, Kaminski L. The metabolic modulator PGC-1α in cancer. Am J Cancer Res. 2019;9(2):198-211. PMID: 30906622; PMCID: PMC6405967.
- Wang F, Wang X, Liu Y, Zhang Z. Effects of Exercise-Induced ROS on the Pathophysiological Functions of Skeletal Muscle. Oxid Med Cell Longev. 2021 Oct 1;2021:3846122. doi: https://doi.org/10.1155/2021/3846122
- Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe? J Sport Heal Sci. 2020;9(5):415-25. doi: https://doi.org/10.1016/j.jshs.2020.04.001
- Wibawa JC, Arifin MZ, Herawati L. Ascorbic acid drink after submaximal physical activity can maintain the superoxide dismutase levels in east java student regiment. Indian J Forensic Med Toxicol. 2021;15(3):3383-92. doi: https://doi.org/10.37506/ijfmt.v15i3.15824
- Agostini F, Bisaglia M, Plotegher N. Linking ROS Levels to Autophagy: The Key Role of AMPK. Antioxidants.2023;12(7):1-14. doi: https://doi.org/10.3390/antiox12071406
- Arhen BB, Renwick JRM, Zedic AK, et al. AMPK and PGC-α following maximal and supramaximal exercise in men and women: a randomized cross-over study. Appl PhysiolNutr 2024;49(4):526-38. doi: https://doi.org/10.1139/apnm-2023-0256
- Parsamanesh N, Asghari A, Sardari S, et al. Resveratrol and endothelial function: A literature review. Pharmacol 2021;170(Jun):105725. doi: https://doi.org/10.1016/j.phrs.2021.105725
- Zhang Q, Lei YH, Zhou JP, et al. Role of PGC-1α in mitochondrial quality control in neurodegenerative diseases. Neurochem 2019;44(9):2031-43. doi: https://doi.org/10.1007/s11064-019-02858-6
- Steinberg GR, Carling D. AMP-activated protein kinase: the current landscape for drug development. Nat RevDrug 2019;18(7):527-51. doi: https://doi.org/10.1038/s41573-019-0019-2
- Mozaffaritabar S, Koltai E, Zhou L, et al. PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle. J Physiol Biochem. 2024;80(2):329-35. doi: https://doi.org/10.1007/s13105-024-01006-1
- Radak Z, Suzuki K, Posa A, Petrovszky Z, Koltai E, Boldogh I. The systemic role of SIRT1 in exercise mediated adaptation. Redox Biol. 2020;35(Feb):101467. doi: https://doi.org/10.1016/j.redox.2020.101467
- Xu R, Luo X, Ye X, et al. SIRT1/PGC-1α/PPAR-γ correlate with hypoxia-induced chemoresistance in non-small cell lung cancer. Front Oncol. 2021;11(Jul):1-15. doi: https://doi.org/10.3389/fonc.2021.682762
- Maissan P, Mooij EJ, Barberis M. Sirtuins-mediated system-level regulation of mammalian tissues at the interface between metabolism and cell cycle: A systematic review. Biology (Basel). 2021;10(3):1-78. doi: https://doi.org/10.3390/biology10030194
- Juan CG, Matchett KB, Davison GW. A systematic review and meta-analysis of the SIRT1 response to exercise. Sci 2023;13(1):1-14. doi: https://doi.org/10.1038/s41598-023-38843-x
- Zhou L, Pinho R, Gu Y, Radak Z. The role of SIRT3 in exercise and aging. cells. 2022;11(16):2596. doi: https://doi.org/10.3390/cells11162596
- Xu L, Li Y, Zhou L, et al. SIRT3 elicited an anti-warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis. Cancer Med. 2019;8(5):2380-91. doi: https://doi.org/10.1002/cam4.2089
- Gao S, Yao W, Zhou R, Pei Z. Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice. iScience. 2024;27(4):109351. doi: https://doi.org/10.1016/j.isci.2024.109351
- Flück M, Sanchez C, Jacquemond V, et al. Enhanced capacity for CaMKII signaling mitigates calcium release related contractile fatigue with high intensity exercise. Biochim Biophys Acta – Mol Cell Res. 2024;1871(2):119610. doi: https://doi.org/10.1016/j.bbamcr.2023.119610
- Bouviere J, Fortunato RS, Dupuy C, Werneck-De-castro JP, Carvalho DP, Louzada RA. Exercise-stimulated ros sensitive signaling pathways in skeletal muscle. Antioxidants. 2021;10(4):1-21. doi: https://doi.org/10.3390/antiox10040537
- Folgueira C, Herrera-Melle L, López JA, et al. Remodeling p38 signaling in muscle controls locomotor activity via IL-15. Sci Adv. 2024;10(33):1-18. doi: https://doi.org/10.1126/sciadv.adn5993
- You W, Knoops K, Berendschot TTJM, et al. PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration. Cell Death Discov. 2024;10(1):1-15. doi: https://doi.org/10.1038/s41420-024-01953-0
PDF
Look through: 
Authors and affiliations
Ayubi N. Universitas Negeri Surabaya, Surabaya, Jawa Timur, Indonesia e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-5196-6636
Wibawa J.C. STKIP PGRI Trenggalek, Trenggalek, Jawa Timur, Indonesia
Rizki A.Z. Universitas Negeri Surabaya, Surabaya, Jawa Timur, Indonesia
https://orcid.org/0009-0006-7025-7209
Afandi A. Universitas Negeri Surabaya, Surabaya, Jawa Timur, Indonesia
https://orcid.org/0009-0009-7161-3852
Callixte C. University of Rwanda, Kigali, Rwanda
https://orcid.org/0000-0002-9137-5515
Cite
Ayubi N., Wibawa J.C., Rizki A.Z., Afandi A., Callixte C. Physiological regulation of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in mitochondrial metabolism during physical exercises: a systematic review. Medicni perspektivi. 2025;30(2):27-37. DOI: https://doi.org/10.26641/2307-0404.2025.2.333361
Metrics
|
Poslavska O.V., Statkevych O.L., Sviatenko T.V., Chekan S.M. Distribution of dendritic cells in the pilosebaceous unit of the scalp in subversive abscessing perifolliculitis of the scalp: immunomorphological aspects
https://doi.org/10.26641/2307-0404.2025.2.333366
Abstract
Abscessing perifolliculitis of the scalp (Hoffmann's disease) is a rare but serious chronic purulent-inflammatory disease of the hair follicles, which leads to the formation of deep abscesses, cicatricial alopecia and a significant decrease in the quality of life of patients. Our observations of the increase in cases allow us to state the relevance of this problem today and the need for additional, more thorough study of the pathology of the immune system underlying this pathological process. In the skin, one of the leading places among the cells that maintain local immune homeostasis and initiate protective innate and adaptive immune responses is occupied by Langerhans cells or the so-called dendritic cells of the epithelium. The aim of the work is to investigate the number and location of skin dendritic cells (separately subpopulations of Langerhans cells and dermal dendritic cells) in subacute abscessing perifolliculitis of the head, with special attention to damage to the structures of the pilosebaceous unit of the skin. Biopsy material from patients diagnosed with abscessing perifolliculitis of the head (Hoffmann's disease) who underwent examination and treatment at the medical center of the private enterprise “Dzerkalo”, Dnipro, Ukraine, was studied. All patients were male military personnel, whose age ranged from 20 to 51 years, the average age was 35.5±11.54 years. IHC was performed according to the TermoScientific (TS) protocols with primary antibodies to dendritic cells (CD1a, RTU). The Lab Vision Quanto (TS, USA) imaging system was used with the determination of the reaction using the DAB Quanto Chromogen (TS, USA) chromogen. Studies of the number and distribution of CD1a (+) cells (epidermal Langerhans cells and dermal dendritic cells) revealed significant differences in their accumulation and branching for the comparison groups. The greatest difference was demonstrated by areas of hair follicles where Langerhans cells were absent in the control group, namely in the internal root epithelial sheath, as well as in the hair dermal papilla (all p<0.05). In comparison, in abscessing perifolliculitis of the head, CD1a (+) cells actively accumulated in these areas with spread to areas around the sebaceous glands and muscles that lift the hair, with significant infiltration of all structures of the pilosebaceous unit and the surrounding dermis or hypodermis stroma. The average number of Langerhans cells among keratinocytes in the study group significantly exceeded the control group's indicators (26.07±11.51 cells compared to 6.02±11.51 cells, respectively (p<0.05)), and also demonstrated a wide network of branched processes. The stratified squamous epithelium in abscessing perifolliculitis of the head was characterized by acanthosis, hyperplasia, and increased mitotic activity. Accumulation of CD1a (+) cells in the internal root epithelial sheath and hair dermal papilla was observed only in the study group and was absent in the control group, (p<0.05). In the outer root epithelial sheath of pilosebaceous units around the hair follicle bud roller, the number of CD1a (+) cells in the study group significantly exceeded the control group (31.44±8.86 cells compared to 4.84±1.12 cells, respectively (p<0.05)), due to which T-lymphocyte infiltration with prolonged inflammatory damage and alopecia is probably maintained in this area. A statistically significantly higher density of infiltration by CD1a (+) dendritic cells in the area of the excretory ducts of the secretory departments of the sebaceous glands in the study group compared to the control group (17.87±11.65 cells compared to 6.24±2.05 cells, respectively (p<0.05)) due to excessive antigenic stimulation may be the cause of sebaceous gland hyperplasia. The increased density of antigen-presenting cells such as CD1a (+) dendritic cells among the inflammatory infiltrate of the dermis in PCAS compared to the control group (52.50±16.77 cells compared to 6.87±3.13 cells, respectively (p<0.05)) indicates the active migration of these motile cells and the predominance of effector mechanisms of the immune response around the pilosebaceous units of the scalp.
Key words: Langerhans cells, dendritic cells, T-lymphocytes, abscessing perifolliculitis of the scalp, Hoffmann's disease, dissecting cellulitis of the scalp, abscessing and subluxing perifolliculitis of the scalp, cicatricial changes of the scalp, cicatricial alopecia, dermatology, trichology, hair diseases, skin pathomorphology, immunohistochemistry
References
- Cuellar TA, Roh DS, Sampson CE. Dissecting cellulitis of the scalp: a review and case studies of surgical reconstruction. Plast Reconstr Surg Glob Open. 2020;8(8):e3015. doi: https://doi.org/10.1097/GOX.0000000000003015
- Melo DF, Lemes LR, Pirmez R, Duque-Estrada B. Trichoscopic stages of dissecting cellulitis: a potential complementary tool to clinical assessment. An Bras Dermatol.2020;95(4):514-17. doi: https://doi.org/10.1016/j.abd.2019.10.008
- Wu Q, Bu W, Zhang Q, Fang F. Therapeutic options for perifolliculitis capitis abscedens et suffodens: A review. Dermatol 2022;35(10):e15763. doi: https://doi.org/10.1111/dth.15763
- Abbas AK, Lichtman AH, Pillai S. Basic Immunology. 7th Edition. Elsevier; 2023.
- Ronchese F, Hilligan KL, Mayer JU. Dendritic cells and the skin environment. Current Opinion in Immunology. 2020;64:56-62. doi: https://doi.org/10.1016/j.coi.2020.03.006.
- Mohamed A, Vella J, Turk MJ, Huang YH. Dendritic cells instruct differentiation of tissue resident memory T cells in the skin to promote durable tumor immunity. J 2022;208(1):57.14. doi: https://doi.org/10.4049/jimmunol.208.Supp.57.14
- Dias de Oliveira NF, Santi CG, Maruta CW, Aoki V. Plasmacytoid dendritic cells in dermatology. An Bras 2021;96:76-81. doi: https://doi.org/10.1016/j.abd.2020.08.006
- Scheib N, Tiemann J, Becker C, Probst HC, Raker VK, Steinbrink K. The Dendritic Cell Dilemma in the Skin: Between Tolerance and Immunity. Front Immunol. 2022;13:929000. doi: https://doi.org/10.3389/fimmu.2022.929000
- Sumpter TL, Balmert SC, Kaplan DH. Cutaneous immune responses mediated by dendritic cells and mast cells. JCI 2019;4(1):e123947. doi: https://doi.org/10.1172/jci.insight.123947
- Vareniuk IM, Dzerzhynskyi ME. [Methods of cyto-histological diagnosis]. Kyiv: Interservis; 2019. Ukrainian.
- Nguyen T. Immunohistochemistry: A Technical Guide to Current Practices. Cambridge: Cambridge University Press; 2022.
- Lombardo GP, Miller A, Aragona M, Messina E, Fumia A, Kuciel M, et al. Immunohistochemical Characterization of Langerhans Cells in the Skin of Three Amphibian Species. Biology. 2024;13(4):210. doi: https://doi.org/10.3390/biology13040210
- Strakhova OP, Androsov OI. [Statistical methods of processing the results of medical and biological re-search: educational and methodological manual]. Lviv: Vydavets Marchenko T.V.; 2021. Ukrainian.
- Masson R, Jeong CY, Ma E, Crew AB, Fragoso NM, Shi VY, et al. Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm. Dermatol Ther (Heidelb). 2023;13(11):2487-526. doi: https://doi.org/10.1007/s13555-023-01018-7
- Poslavska OV, Statkevych OL, Sviatenko TV, Shponka IS. Pathomorphological analysis of the qualitative composition of the inflammatory infiltrate around the pilosebaceous unit of the scalp in perifolliculitis capitis abscedens et suffodiens. Pathologia. 2025;22(1):33-40. doi: https://doi.org/10.14739/2310-1237.2025.1.314325
PDF
Look through: 
Authors and affiliations
Cite
Poslavska O.V., Statkevych O.L., Sviatenko T.V., Chekan S.M. Distribution of dendritic cells in the pilosebaceous unit of the scalp in subversive abscessing perifolliculitis of the scalp: immunomorphological aspects. Medicni perspektivi. 2025;30(2):38-45. DOI: https://doi.org/10.26641/2307-0404.2025.2.333366
Metrics
|
CLINICAL MEDICINE
|
Kozliuk A.S. Cardiomyopathies with left ventricular hypertrophy phenotype: prevalence of cardiac amyloidosis and clinical characteristics of patients
https://doi.org/10.26641/2307-0404.2025.2.333369
Abstract
Cardiac amyloidosis was long considered a rare disease, primarily affecting the elderly. However, recent studies have demonstrated a higher prevalence, highlighting the need for further investigation, particularly in Ukraine, where data remain limited. The underdiagnosis of cardiac amyloidosis is primarily due to the low specificity of its clinical manifestations, which can mimic other cardiovascular diseases, particularly those presenting with a left ventricular hypertrophy phenotype. The aim of this study was to evaluate the prevalence and clinical characteristics of patients with cardiac amyloidosis among cardiomyopathies with the left ventricular hypertrophy phenotype, based on single-center data. This study was a retrospective analysis of medical records from the outpatient and inpatient departments of the SI “NSC “Strazhesko National Scientific Center of Cardiology and Regenerative Medicine of the NAMS of Ukraine” between 2020 and 2023. Data on subjective complaints, medical history, clinical examination findings, six-minute walk test results, and screening laboratory and instrumental evaluations were analyzed. Statistical analysis included confidence interval estimation, Pearson’s χ² test, one-way analysis of variance (ANOVA), and Tukey’s post hoc test. Data from 294 patients with left ventricular hypertrophy phenotypes were examined, including 177 cases (60.2%) of non-obstructive hypertrophic cardiomyopathy, 70 cases (23.8%) of hypertrophic cardiomyopathy with left ventricular outflow tract obstruction, and 47 cases (16%) of cardiac amyloidosis. The true prevalence of cardiac amyloidosis among cardiomyopathies with a left ventricular hypertrophy phenotype was estimated at 16% (CI 95%: 7.44-24.56%). Patients with cardiac amyloidosis were characterized by older age (56.8±11.7 years, F=6.85, p≤0.01), presence of congestive heart failure in the medical history (45 cases, χ2=65.54, p≤0.001), reduced distance covered in the 6-minute walk test (248.3±131.6 meters, F=10.77, p<0.001), signs of congestion in the systemic circulation (89%, 42 cases, χ2=64.56, p<0.001), and decreased left ventricular ejection fraction (54.5±15.1%, F=11.71, p≤0.05) compared to both groups of hypertrophic cardiomyopathy. Extracardiac manifestations of cardiac amyloidosis included proteinuria (83%, 39 cases), neuropathy (59.6%, 28 cases), hepatomegaly (55.3%, 26 cases), skin involvement and bruising (34%, 16 cases), carpal tunnel syndrome (23.4%, 11 cases), macroglossia (19.1%, 9 cases), digestive disturbances (12.8%, 6 cases), weight loss (19.1%, 9 cases), and thrombotic events at various sites (14.9%, 7 cases). Thus, cardiac amyloidosis is an underrecognized pathology, accounting for 16% of cardiomyopathies with a left ventricular hypertrophy phenotype. Compared to non-obstructive and obstructive hypertrophic cardiomyopathy, these patients are characterized by older age, more severe systemic conditions, decreased left ventricular systolic function, and systemic extracardiac manifestations. Multicenter studies are required to determine the true prevalence of cardiac amyloidosis in Ukraine.
Key words: cardiac amyloidosis, cardiomyopathy, myocardial hypertrophy, AL amyloidosis, heart failure, diagnostics, epidemiology
References
- Maurer MS, Elliott P, Comenzo R, Semigran M, Rapezzi C. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis. Circulation.2017;135:1357-77. doi https://doi.org/10.1161/CIRCULATIONAHA.116.024438
- Westin O, Butt JH, Gustafsson F, Schou M, Salomo M, Køber L, et al. Two Decades of Cardiac Amyloidosis: A Danish Nationwide Study. JACC CardioOncol. 2021;3(4):522-33. doi: https://doi.org/10.1016/j.jaccao.2021.05.004
- Gilstrap LG, Dominici F, Wang Y, El-Sady MS, Singh A, Di Carli MF, et al. Epidemiology of Cardiac Amyloidosis-Associated Heart Failure Hospitalizations Among Fee-for-Service Medicare Beneficiaries in the United States. Circ Heart Fail. 2019;12(6):e005407. doi: https://doi.org/10.1161/CIRCHEARTFAILURE.118.005407
- Quock TP, Yan T, Chang E, Guthrie S, Broder MS. Epidemiology of AL amyloidosis: a real-world study using US claims data. Blood Adv. 2018;2:1046-53. doi: https://doi.org/10.1182/bloodadvances.2018016402
- Ney S, Ihle P, Ruhnke T, Günster C, Michels G, Seuthe K, et al. Epidemiology of cardiac amyloidosis in Germany: a retrospective analysis from 2009 to 2018. Clin Res 2023;112(3):401-8. doi: https://doi.org/10.1007/s00392-022-02114-y
- Kyle RA, Linos A, Beard CM, et al. Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992;79(7):1817-22. doi: https://doi.org/10.1182/blood.V79.7.1817.1817
- Ruberg FL. Cardiac Amyloidosis: A Zebra Hiding in Plain Sight? Circ Cardiovasc Imaging. 2017;10(3):e006186. doi: https://doi.org/10.1161/CIRCIMAGING.117.006186
- Kieninger B, Eriksson M, Kandolf R, Schnabel PA, Schönland S, Kristen AV, et al. Amyloid in endomyocardial biopsies. Virchows Arch. 2010;456(5):523-32.
doi: https://doi.org/10.1007/s00428-010-0909-5
- Bonderman D, Pölzl G, Ablasser K, Agis H, Aschauer S, Auer-Grumbach M, et al. Diagnosis and treatment of cardiac amyloidosis: an interdisciplinary consensus statement. Wien Klin Wochenschr.
2020;132(23-24):742-61. doi: https://doi.org/10.1007/s00508-020-01781-z
- Erdogdua T, Uysala OK, Icena YK, Alicia G, Koca M, Ibrahim Halil Kurta IH. Increased EHRA score predicts atrial fibrillation recurrence in paroxysmal atrial fibrillation patients undergoing cryoablation. Ann Med Res.2024;31(2):94-100. doi: https://doi.org/10.5455/annalsmedres.2023.11.299
- Garcia-Pavia P, Rapezzi C, Adler Y, Arad M, Basso C, Brucato A, et al. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. EurHeart 2021;42(16):1554-68. doi: https://doi.org/10.1093/eurheartj/ehab072
- Mishra P, Singh U, Pandey CM, Mishra P, Pandey G. Application of student's t-test, analysis of variance, and covariance. Ann Card Anaesth. 2019;22(4):407-11. doi: https://doi.org/10.4103/aca.ACA_94_19
- Germain DP, Altarescu G, Barriales-Villa R, Mignani R, Pawlaczyk K, Pieruzzi F, et al. An expert consensus on practical clinical recommendations and guidance for patients with classic Fabry disease. Mol Genet Metab. 2022 Sep-Oct;137(1-2):49-61. doi: https://doi.org/10.1016/j.ymgme.2022.07.010
- Castaño A, Narotsky DL, Hamid N, Khalique OK, Morgenstern R, DeLuca A, et al. Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Eur Heart J. 2017;38(38):2879-87. doi: https://doi.org/10.1093/eurheartj/ehx350
- Porcari A, Bussani R, Merlo M, Varrà GG, Pagura L, Rozze D, et al. Incidence and Characterization of Concealed Cardiac Amyloidosis Among Unselected Elderly Patients Undergoing Post-mortem Examination. FrontCardiovasc 2021;8:749523. doi: https://doi.org/10.3389/fcvm.2021.749523
- Maurizi N, Rella V, Fumagalli C, Salerno S, Castelletti S, Dagradi F, et al. Prevalence of cardiac amyloidosis among adult patients referred to tertiary centres with an initial diagnosis of hypertrophic cardiomyopathy. IntJ 2020;300:191-5. doi: https://doi.org/10.1016/j.ijcard.2019.07.051
- Rubin J, Maurer MS. Cardiac Amyloidosis: Overlooked, Underappreciated, and Treatable. Annu Rev Med. 2020;71:203-19.
doi: https://doi.org/10.1146/annurev-med-052918-020140
- Arbelo E, Protonotarios A, Gimeno JR, Arbustini E, Barriales-Villa R, Basso C, et al. ESC Scientific Document Group. 2023 ESC Guidelines for the management of cardiomyopathies. Eur Heart J. 2023;44(37):3503-626. doi: https://doi.org/10.1093/eurheartj/ehad194
- Mostbauer HV. [Cardiac amyloidosis]. Zdorovia Ukrainy. 2023;88(3):24-7. Ukrainian.
- Muchtar E, Dispenzieri A, Magen H, Grogan M, Mauermann M, McPhail ED, et al. Systemic amyloidosis from A (AA) to T (ATTR): a review. J Intern Med. 2021;289(3):268-92. doi: https://doi.org/10.1111/joim.13169
- Fend F, Dogan A, Cook JR. Plasma cell neoplasms and related entities-evolution in diagnosis and classification. Virchows Arch. 2023;482(1):163-77. doi: https://doi.org/10.1007/s00428-022-03431-3
- Imperlini E, Gnecchi M, Rognoni P, Sabidò E, Ciuffreda MC, Palladini G, et al. Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells. Sci Rep. 2017;7(1):15661.
doi: https://doi.org/10.1038/s41598-017-15424-3
- Papathanasiou M, Schlender LS, Johnson VL, Wakili R. [Arrhythmias and amyloidosis]. Herzschrittmacherther Elektrophysiol. 2024;35(3):199-204. German. doi: https://doi.org/10.1007/s00399-024-01016-y
- Chompoopong P, Mauermann ML, Siddiqi H, Peltier A. Amyloid Neuropathy: From Pathophysiology to Treatment in Light-Chain Amyloidosis and Hereditary Transthyretin Amyloidosis. Ann Neurol. 2024;96(3):423-40. doi: https://doi.org/10.1002/ana.26965
PDF
Look through: 
Authors and affiliations
Kozliuk A.S. SI “NSC “Strazhesko National Scientific Center of Cardiology and Regenerative Medicine of the NAMS of Ukraine”, Kyiv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-3832-4134
Cite
Kozliuk A.S. Cardiomyopathies with left ventricular hypertrophy phenotype: prevalence of cardiac amyloidosis and clinical characteristics of patients. Medicni perspektivi. 2025;30(2):46-53. DOI: https://doi.org/10.26641/2307-0404.2025.2.333369
Metrics
|
Kuryata O.V., Mytrokhina O.S., Stadnyk O.I. Transforming growth factor beta-1 in patients with hypertension who had COVID-19
https://doi.org/10.26641/2307-0404.2025.2.333373
Abstract
Post-covid syndrome is a multisystem disease. The totality of disorders of organs and systems, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes significant damage to human health for a long time, especially if the patient has comorbid pathology. Taking into account the concern about the impact of COVID-19 on the cardiovascular system, several mechanisms of the direct impact of SARS-CoV-2 on the specified system are considered. It should be noted that there is a limited number of studies on the observation of patients with post-covid syndrome. Today, the priority direction is the study of predictors of the adverse course of cardiovascular diseases, especially after COVID-19. Transforming growth factor β1 can be considered one of the potential markers of cardiovascular complications. The aim of our study was to evaluate the level of transforming growth factor β1 in patients with hypertension who had COVID-19. The cross-sectional study included 27 patients with hypertension after COVID-19. 16 patients with controlled hypertension (blood pressure 140/90 mm Hg) formed the first group. The second group was formed by 11 patients with uncontrolled hypertension (blood pressure ≥140/90 mm Hg). We determined the increased level of transforming growth factor β1 and its relationship with the glucose (r=0.38, p=0.049). The level of blood pressure control was associated with increasing age of patients, lower glomerular filtration rate (p<0.01), and worse glucose control (p<0.05). Thus, the data indicate that transforming growth factor β1 may be a possible factor inducing the development of cardiometabolic disorders in patients with hypertension after COVID-19.
Key words: post-COVID syndrome, arterial hypertension, transforming growth factor β1
References
- Bielecka E, Sielatycki P, Pietraszko P, et al. Elevated arterial blood pressure as a delayed complication following COVID-19 – A narrative review. Int J Mol Sci. 2024;25(3):1837. doi: https://doi.org/10.3390/ijms25031837
- National Institute for Health and Care Research. NIHR themed review: living with COVID-19 [Internet]. 2020 [cited 2024 Dec 23]. Available from: https://evidence.nihr.ac.uk/themedreview/living-with-covid19/
- World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus [Internet]. 2021 [cited 2024 Dec 23]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1
- World Health Organization. Post COVID-19 Condition (Long COVID) [Internet]. 2022 [cited 2024 Dec 23]. Available from: https://www.who.int/europe/news-room/fact-sheets/item/post-covid-19-condition
- Kuriata O, Mytrokhina O, Kushnir Yu, et al. [Post-COVID syndrome: status of carbohydrate metabolism in patients with hypertension and stable ischemic heart disease]. Mizhnar endokrynol zhurn [Internet]. 2024;20(1):31-8.Ukrainian. doi: https://doi.org/10.22141/2224-0721.20.1.2024.1354
- Cinar A, Gedikli O, Uyanik M, Terzi O. Evaluation of Coronary Artery Calcium Score (CACS) in Dipper and Non-Dipper Hypertensive Patients with Moderate and High Cardiovascular Disease Risks. Medicina.2024;60(12):1999. doi: https://doi.org/10.3390/medicina60121999
- Gemelli Against COVID-19 Post-Acute Care Study Group. Post-COVID-19 global health strategies: the need for an interdisciplinary approach. Aging Clin Exp Res. 2020;32:1613-20. doi: https://doi.org/10.1007/s40520-020-01616-x
- Strilchuk L. [Post- COVID syndrome: a new multidisciplinary challenge]. Zdorovia Ukrainy. 2021;498(5):3.
- Quinn KL, Lam GY, Walsh JF, et al. Cardiovascular Considerations in the Management of People With Suspected Long COVID. Can J Cardiol. 2023;39(6):741-53. doi: https://doi.org/10.1016/j.cjca.2023.04.003
- Kusumawardhani NY, Putra IC, Kamarullah W, et al. Cardiovascular disease in post-acute COVID-19 syndrome: a comprehensive review of pathophysiology and diagnosis approach. Rev Cardiovasc Med. 2023;24(1):28. doi: https://doi.org/10.31083/j.rcm2401028
- Nalbandian A, Sehgal K, Gupta A, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27:601-15. doi: https://doi.org/10.1038/s41591-021-01283-z
- Wan Y, Shang J, Graham R, Baric RS, Lia F. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020;94(7):e00127-20. doi: https://doi.org/10.1128/jvi.00127-20
- Tan W, Aboulhosn J. The cardiovascular burden of coronavirus disease 2019 (COVID-19) with a focus on congenital heart disease. Int J Cardiol [Internet]. 2020;309:70-7. doi: https://doi.org/10.1016/j.ijcard.2020.03.063
- Ren LL, Li XJ, Duan TT, et al. Transforming growth factor-β signaling: From tissue fibrosis to therapeutic opportunities. Chem Biol Interact. 2023;369:110289. doi: https://doi.org/10.1016/j.cbi.2022.110289
- Liu J, Tao Zhuang, Jingjiang Pi, et al. Endothelial forkhead box transcription factor P1 regulates pathological cardiac remodeling through transforming growth factor-β1–endothelin-1 signal pathway. Circulation. 2019;140(8):665-80. doi: https://doi.org/10.1161/CIRCULATIONAHA.119.039767
- Braga YL, do Carmo Neto JR, Franco PI, et al. The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review. J Cardiovasc Dev Dis. 2024;11(2):65. doi: https://doi.org/10.3390/jcdd11020065
- Randell A, Daneshtalab N. Elastin microfibril interface–located protein 1, transforming growth factor beta, and implications on cardiovascular complications. J Am Soc Hypertens. 2017;11(7):437-48. doi: https://doi.org/10.1016/j.jash.2017.04.010
- Li B, Khanna A, Sharma V, et al. TGF-β1 DNA Polymorphisms, Protein Levels, and Blood Pressure. Hypertension.1999;33(1):271-5. doi: https://doi.org/10.1161/01.HYP.33.1.271
- Matsuki K, Hathaway CK, Lawrence MG, et al. The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure. Curr Hypertens Rev. 2014;10(4):223-38. doi: https://doi.org/10.2174/157340211004150319123313
- Derhaschnig U, Shehata M, Herkner H, et al. Increased levels of transforming growth factor-β1 in essential hypertension. AmJ 2002;15(3):207-11. doi: https://doi.org/10.1016/S0895-7061(01)02327-5
- Zeng KF, Wang HJ, Deng B, et al. Ethyl ferulate suppresses post-myocardial infarction myocardial fibrosis by inhibiting transforming growth factor receptor 1. Phytomedicine.2023;121:155118. doi: https://doi.org/10.1016/j.phymed.2023.155118
- Carod-Artal F. Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved. Rev 2021;72(11):384-96. doi: https://doi.org/10.33588/rn.7211.2021230
- McEvoy JW, McCarthy CP, Bruno RM, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension: Developed by the task force on the management of elevated blood pressure and hypertension of the European Society of Cardiology (ESC) and endorsed by the European Society of Endocrinology (ESE) and the European Stroke Organisation (ESO). Eur Heart 2024;45(38):3912-4018. doi: https://doi.org/10.1093/eurheartj/ehae178.
- Dubrov SO, Kovalenko VM, Vakaliuk IP, et al. [State Expert Center of the Ministry of Health of Ukraine. Clinical guideline based on evidence «Arterial hypertension» [Internet]. 2024 [cited 2024 Nov15]. Ukrainian. Available from: https://www.dec.gov.ua/mtd/arterialna-gipertenziya-2/
- Hallek M, Adorjan K, Behrends U, et al. Post-COVID Syndrome. DTSCH Arztebl Int. 2023;120(4):48-55. doi: https://doi.org/10.3238/arztebl.m2022.0409
- Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect 2021;53(10):737-54. doi: https://doi.org/10.1080/23744235.2021.1924397
- Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney 2024;105(4S):117-314. doi: https://doi.org/10.1016/j.kint.2023.10.018
- Makhanets L, Vinnychuk O, Hryhorkiv M. [Statistics: Laboratory Workshop in STATISTICA 12: Tutorial. Chernivtsi]. Chernivets nats un-t im. Yu. Fedkovycha; 2023. 161 р. Ukrainian.
- Scherer PE, Kirwan JP, Rosen CJ. Post-acute sequelae of COVID-19: a metabolic perspective. eLife. 2022;11:e78200. doi: https://doi.org/10.7554/eLife.78200
- Al-Samerria S, Radovick S. The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth. Cells. 2021;10(10):2664. doi: https://doi.org/10.3390/cells10102664
- Kheirollahi V, Khadim A, Kiliaris G, et al. Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis. Cells. 2022;11(12):1973. doi: https://doi.org/10.3390/cells11121973
- Prlic MF, Brinar IV, Kos J, Dika Z, Ivandic E, Fucek M, et al. Serum Hepatocyte Growth Factor Concentration Correlates with Albuminuria in Individuals with Optimal Blood Pressure and Untreated Arterial Hypertension. Biomedicines.2024;12(10):2233. doi: https://doi.org/10.3390/biomedicines12102233
- Prlic MF, Brinar IV, Kos J, et al. Serum Hepatocyte Growth Factor Concentration Correlates with Albuminuria in Individuals with Optimal Blood Pressure and Untreated Arterial Hypertension. Biomedicines. 2024;12(10):2233. doi: https://doi.org/10.3390/biomedicines12102233
- Frangogiannis NG. Transforming growth factor–β in tissue fibrosis. J Exp Med. 2020;217(3):e20190103. doi: https://doi.org/10.1084/jem.20190103
- Kieć-Wilk B, Stolarz-Skrzypek K, Sliwa A, et al. Peripheral blood concentrations of TGFβ1, IGF-1 and bFGF and remodelling of the left ventricle and blood vesselsin hypertensive patients. Kardiol Pol. 2010;68(9):996-1002. PMID: 20859888
- Liu Y, Lin Y, Huang X, et al. Association of serum transforming growth factor β1 with left ventricular hypertrophy in children with primary hypertension. Eur J Pediatr.2023;182:5439-46. doi: https://doi.org/10.1007/s00431-023-05219-2
- Aula H, Skyttä T, Tuohinen S, et al. Transforming growth factor beta 1 levels predict echocardiographic changes at three years after adjuvant radiotherapy for breast cancer. Radiat 2019;14(1):155. doi: https://doi.org/10.1186/s13014-019-1366-1
- Wang L, Wang HL, Liu TT, et al. TGF-Beta as a Master Regulator of Diabetic Nephropathy. J Mol Sci. 2021;22(15):7881. doi: https://doi.org/10.3390/ijms22157881
- Liu H, Chen YG. The Interplay Between TGF-β Signaling and Cell Metabolism. Front Cell Dev Biol. 2022;10:2022. doi: https://doi.org/10.3389/fcell.2022.846723
- Xiao Y, Wang Y, Ryu J, et al. Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling. Diabetologia. 2023;66:1142-55. doi: https://doi.org/10.1007/s00125-023-05889-5
- Zhao L, Zou Y, Liu F. Transforming Growth Factor-Beta1 in Diabetic Kidney Disease. Front Cell Dev Biol. 2020;8:2020. doi: https://doi.org/10.3389/fcell.2020.00187
- [All-Ukrainian Association of Cardiologists of Ukraine. Recommendations of the All-Ukrainian Association of Cardiologists of Ukraine on diagnosis, treatment and prevention of chronic heart failure. Pocket version [Internet]. 2024 [cited 2024 Dec 15]. Ukrainian. Available from: https://cardiohub.org.ua/wp-content/uploads/2024/09/Rekomendatsii-KHSN-A6-1.pdf
- Azizi M. Aldosterone receptor antagonists Antagonistes du récepteur de l’aldostérone. Ann dEndocrinologie. 2021;82(3-4):179-81. doi: https://doi.org/10.1016/j.ando.2020.03.009
PDF
Look through: 
Authors and affiliations
Cite
Metrics
|
Deeva Yu.V., co-authors (42). Clinical efficacy and safety of high-dose ambroxol in the form of oromucosal spray in postnasal drip syndrome: results of a multicenter study in Ukraine
https://doi.org/10.26641/2307-0404.2025.2.333376
Abstract
Postnasal drip syndrome (PNDS) is one of the most common clinical conditions in the practice of otolaryngologists and family physicians, characterized by the drainage of mucous or mucopurulent secretions along the posterior wall of the pharynx and accompanied by rhinorrhea, nasal congestion, cough, and a feeling of irritation in the throat. Epidemiological studies show that approximately 20% of the adult population and 15% of children regularly suffer from manifestations of postnasal drip. The pathogenetic mechanisms of the development of PNDS are mucus hypersecretion, impaired rheological properties, dysfunction of mucociliary clearance, and local inflammation. The aim of our study was to clinically evaluate the efficacy and safety of different dosage regimens of the drug "Respx® Spray" (ambroxol) for postnasal drip on the background of common respiratory diseases. A large-scale prospective observational multicenter study was conducted, which included 1867 patients aged 12 to 65 years from 15 regions of Ukraine. The study lasted from September 2023 to March 2024. Patients had various respiratory diseases accompanied by postnasal drip: rhinopharyngitis (47.3%), acute rhinosinusitis (34.0%), vasomotor rhinitis (7.4%), tonsillopharyngitis (4.6%), acute tracheobronchitis (3.8%) and laryngitis/laryngotracheitis (2.9%). The effectiveness of the use was assessed by the dynamics of the intensity of postnasal drip on a 5-point scale at the beginning and on the 5-7th day of treatment. The safety of the drug was monitored by registering and analyzing adverse reactions. The results of the study showed a statistically significant decrease in the intensity of postnasal drip from 4.28±0.03 to 0.91±0.03 points on the 5th day of therapy (p<0.001). The highest efficiency was recorded with the dosage regimens of 4 sprays 4 times a day (decrease to 0.38±0.10 points) and 3 sprays 2 times a day (decrease to 0.60±0.15 points). Subjective assessment of the dynamics of symptoms by patients showed a rapid development of the therapeutic effect – already on the 2nd day of treatment, patients noted a moderate improvement (1.55±1.19 points), and on the 5th day a significant improvement was observed (4.66±0.99 points). The highest subjective improvement rates were recorded in patients with hypertrophic rhinitis (4.56±0.08 points) and tracheitis/acute bronchitis/acute tracheobronchitis (4.52±0.15 points). Overall satisfaction with the treatment was extremely high – 76.4% of patients rated it at 9-10 points on a 10-point scale, another 20.3% – at 7-8 points. Multivariate regression analysis revealed that the effectiveness of the treatment was significantly influenced by factors such as the dosage regimen (p<0.01), the initial intensity of the symptom (p<0.001) and the underlying disease (p<0.05). Non-serious adverse reactions were observed in only 1.2% of patients, which is a fairly low rate and indicates a good safety profile of the drug. The obtained data indicate that ambroxol in the form of a high-dose oromucosal spray is an effective and safe means for alleviating the manifestations of postnasal drip, ensuring high compliance and patient satisfaction. The choice of dosage regimen should be made taking into account the nature of the underlying disease and the initial intensity of postnasal drip syndrome. The safety of the preparation was monitored through registration and analysis of adverse reactions. The results of the study established a statistically significant reduction in the intensity of postnasal dripping from 4.28±0.03 to 0.91±0.03 points on the 5th day of therapy (p<0.001). The highest clinical efficacy was observed with dosing regimens of 4 jets 4 times a day (reduction to 0.38±0.10 points) and 3 jets 2 times a day (reduction to 0.60±0.15 points). Patients' subjective assessment of symptom dynamics indicated a rapid development of therapeutic effect – by the 2nd day of treatment, patients noted moderate improvement (1.55±1.19 points), and by the 5th day, significant improvement in condition was observed (4.66±0.99 points). The highest indicators of subjective improvement were recorded in patients with hypertrophic rhinitis (4.56±0.08 points) and tracheitis/acute bronchitis/acute tracheobronchitis (4.52±0.15 points). Overall treatment satisfaction was exceptionally high – 76.4% of patients rated it at 9-10 points on a 10-point scale, while another 20.3% gave it 7-8 points. Multivariate regression analysis revealed that treatment efficacy was significantly influenced by factors such as dosing regimen (p<0.01), baseline symptom intensity (p<0.001), and underlying disease (p<0.05). The obtained data indicate that ambroxol in the form of oromucosal spray is an effective and safe remedy for the treatment of postnasal syndrome of various etiologies, providing high compliance and patient satisfaction. The selection of dosing regimen should be tailored according to the nature of the underlying disease and the baseline intensity of the postnasal syndrome.
Key words: postnasal drip syndrome, ambroxol, oromucosal spray, postnasal dripping, rhinosinusitis, rhinopharyngitis, efficacy, safety, multicenter study
References
- Babchenko NV, Dieieva YuV, Konovalov SE, Motailo OV. [Expression indicators of mucopolysaccharides MUC 5AC and MUC 1 in the nasal mucosa in patients with postnasal drip syndrome and nasal septum curvature]. Klinichna ta profilaktychna medytsyna. 2024;(2):43-8. doi: https://doi.org/10.31612/2616-4868.2.2024.06
- Dykewicz MS, Wallace DV, Amrol DJ, et al. Rhinitis 2020: A practice parameter update. J Allergy Clin Immunol.2020;146:721-67. doi: https://doi.org/10.1016/j.jaci.2020.07.007
- Sanu A, Eccles R. Postnasal drip syndrome. Two hundred years of controversy between UK and USA. Rhinology. 2008;46(2):86-91.
- Krajewska J, Zub K, Słowikowski A, Zatoński T. Chronic rhinosinusitis in cystic fibrosis: a review of therapeutic options. Eur Arch Otorhinolaryngol. 2022:1-24. doi: https://doi.org/10.1007/s00405-021-06875-6
- Kumar A, Sharma S, Singh P, et al. Comparison of different formulations of mucolytics in post-nasal drip: a network meta-analysis. Eur Respir J. 2024;63:2302544. doi: https://doi.org/10.1183/13993003.02544-2023
- Trykhlib V, Zadorozhna V, Tkachuk S, Palatna L, Operchuk N. The Incidence of Acute Upper Respiratory Infections of Multiple or Uncertain Localization in Ukrainian Children. Actual Infectology. 2016;(3.12):83-92. doi: https://doi.org/10.22141/2312-413x.3.12.2016.81720
- Naumenko OM, Zabolotnyi DI, Dieieva YuV, Zabolotna DD. [Features of the clinical course of acute rhinosinusitis in COVID-19]. Pohlyad otorynolarynholoha. II Scientific and Practical Conference; 2021. Ukrainian. Availablefrom: http://ir.librarynmu.com/bitstream/123456789/8230/1/Особливості%20клінічного.pdf
- Scaglione F, Petrini O. Mucoactive Agents in the Therapy of Upper Respiratory Airways Infections: Fair to Describe Them Just as Mucoactive? Clin Med Insights Ear Nose 2019;12. doi: https://doi.org/10.1177/1179550618821930
- Paleari D, Rossi GA, Nicolini G, Olivieri D. Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood. Expert Opin Drug Discov. 2011;6(11):1203-14. doi: https://doi.org/10.1517/17460441.2011.629646
- Weiser T. Ambroxol: a CNS drug? CNS Neurosci Ther.2008;14(1):17-24. doi: https://doi.org/10.1111/j.1527-3458.2007.00032.x
- Malerba M, Ragnoli B. Ambroxol in the 21st century: pharmacological and clinical update. Expert Opin DrugMetab 2019;12:1-10. doi: https://doi.org/10.1080/17425255.2019.1670168
- Beeh KM, Beier J, Esperester A, Paul LD. Antiinflammatory properties of ambroxol. Eur J Med Res. 2008;13:557-62.
- Zhang ZQ, Wu QQ, Huang XM, Lu H. Prevention of respiratory distress syndrome in preterm infants by antenatal ambroxol: a meta-analysis of randomized controlled trials. Am J Perinatol. 2023;30:529-36. doi: https://doi.org/10.1055/s-0032-1329188
- Kantar A, Klimek L, Cazan D, Sperl A, Sent U, Mesquita M. An overview of efficacy and safety of ambroxol for the treatment of acute and chronic respiratory diseases with a special regard to children. Multidiscip Respir 2020;15(1):511. doi: https://doi.org/10.4081/mrm.2020.511
- Cheng X, Xie Q, Sun Y. Advances in nanomaterial-based targeted drug delivery systems. Front Bioeng Biotechnol.2023;11:1177151. doi: https://doi.org/10.3389/fbioe.2023.1177151
- Collins JC, Moles RJ. Management of respiratory disorders and the pharmacist's role: Cough, colds, and sore throats and allergies (including eyes). Encyclopedia of pharmacy practice and clinical pharmacy. 2019:282. doi: https://doi.org/10.1016/B978-0-12-812735-3.00510-0
- de Mey C, Patel J, Lakha DR, Richter E, Koelsch S. Efficacy and Safety of an Oral Ambroxol Spray in the Treatment of Acute Uncomplicated Sore Throat. DrugRes (Stuttg). 2015;65(12):658-67. doi: https://doi.org/10.1055/s-0035-1547229
- Chenot JF, Weber P, Friede T. Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis. BMC Fam 2014;15:45.
doi: https://doi.org/10.1186/1471-2296-15-45
- Brahmeshwar Mishra, Juhi Singh. Novel drug delivery systems and significance in respiratory diseases. In: Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems. Academic Press; 2020. p. 57-95. doi: https://doi.org/10.1016/B978-0-12-820658-4.00004-2
- Doulaptsi M, Prokopakis E, Seys S, Pugin B, Steelant B, Hellings P. Visual analogue scale for sino-nasal symptoms severity correlates with sino-nasal outcome test 22: paving the way for a simple outcome tool of CRS burden. Clin Transl Allergy. 2018;8:32. doi: https://doi.org/10.1186/s13601-018-0219-6
- Butcher NJ, Monsour A, Mew EJ, et al. Guidelines for Reporting Outcomes in Trial Reports: The CONSORT-Outcomes 2022 Extension. JAMA. 2022;328(22):2252-2264. doi: https://doi.org/10.1001/jama.2022.21022
- Walther C, Döring K, Schmidtke M. Comparative in vitro analysis of inhibition of rhinovirus and influenza virus replication by mucoactive secretolytic agents and plant extracts. BMC Complement Med Ther. 2020;20:380. doi: https://doi.org/10.1186/s12906-020-03173-2
- Cheng L, Liu M, Wang R, Cao S, Li R, Su B, et al. Ambroxol hydrochloride spray (Luo Runchang®) in the treatment of acute respiratory infectious diseases: a prospective, multicenter, open label, randomized controlled study.Front 2024;12:1380189. doi: https://doi.org/10.3389/fped.2024.1380189
- Alkotaji M. Azithromycin and ambroxol as potential pharmacotherapy for SARS-CoV-2. Int J Antimicrob 2020;56:106192. doi: https://doi.org/10.1016/j.ijantimicag.2020.106192
- Nakahari T, Suzuki C, Kawaguchi K, Hosogi S, Tanaka S, Asano S, et al. Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca2+ Channel, Cav1.2, via pHi Increase and [Cl−]i Decrease in the Lung Airway Epithelial Cells of Mice. Int J Mol Sci. 2023;24:16976. doi: https://doi.org/10.3390/ijms242316976
PDF
Look through: 
Authors and affiliations
Deeva Yu.V. Bogomolets National Medical University, Kyiv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-0552-1254
Fomin S.F. Poltava region, Ukraine
https://orcid.org/0009-0004-8109-1289
Kuznetsova O.V. Poltava region, Ukraine
https://orcid.org/0009-0009-8251-9933
Tsyba L.L. Sumy region, Ukraine
https://orcid.org/0009-0006-8000-0642
Lavrova N.P. Mykolaev, Ukraine
https://orcid.org/0009-0005-9792-2873
View in full ...
Karacheban A.M. Odesa region, Ukraine
https://orcid.org/0009-0005-0257-8986
Kirsanova O.G. Odesa region, Ukraine
https://orcid.org/0009-0007-6338-3706
Ladanova V.M. Odesa, Ukraine
https://orcid.org/0009-0009-9854-1342
Malchenko Ya.O. Odesa, Ukraine
https://orcid.org/0009-0004-6639-9816
Tarasenko N.V. Odesa, Ukraine
https://orcid.org/0009-0001-8768-2782
Boiev Ya.S. Odesa, Ukraine
https://orcid.org/0009-0009-6239-3448
Ivanchenko Ya.V. Odesa, Ukraine
https://orcid.org/0009-0005-2480-2272
Topalov B.M. Odesa, Ukraine
https://orcid.org/0009-0009-8996-5354
Chernyshova I.E. Odesa, Ukraine
https://orcid.org/0009-0003-9501-3196
Buravytska I.V. Odesa region, Ukraine
https://orcid.org/0009-0006-9265-7190
Buravitskyi S.I. Odesa region, Ukraine
https://orcid.org/0009-0006-0474-8317
Gaidarzhy N.I. Odesa region, Ukraine
https://orcid.org/0009-0001-4829-4701
Kornovan N.V. Odesa region, Ukraine
https://orcid.org/0009-0003-5001-5593
Leonova I.O. Odesa, Ukraine
https://orcid.org/0009-0006-6858-3056
Myrhorodska G.O. Odesa region, Ukraine
https://orcid.org/0009-0006-4832-5893
Nikolka S.O. Odesa region, Ukraine
https://orcid.org/0009-0002-2471-8132
Popova N.G. Odesa, Ukraine
https://orcid.org/0009-0007-3153-7117
Stefanyshyn A.I. Odesa, Ukraine
https://orcid.org/0009-0008-2154-5583
Sukha N.M. Odesa region, Ukraine
https://orcid.org/0009-0005-2479-6650
Sukhyi Ye.P. Odesa region, Ukraine
https://orcid.org/0009-0008-2091-9854
Chystiakova N.V. Odesa, Ukraine
https://orcid.org/0009-0004-4197-8168
Averchuk S.G. Lutsk, Ukraine
https://orcid.org/0009-0004-6494-5801
Belska A.I. Volyn region, Ukraine
https://orcid.org/0009-0000-6015-6363
Bereza O.V. Volyn region, Ukraine
https://orcid.org/0009-0009-5479-003X
Bondarchuk P.S. Volyn region, Ukraine
https://orcid.org/0009-0005-8875-5305
Litvin B.Yu. Volyn region, Ukraine
https://orcid.org/0009-0005-0463-9762
Sotnikov V.V. Volyn region, Ukraine
https://orcid.org/0009-0008-6240-4920
Duka K.Y. Rivne region, Ukraine
https://orcid.org/0009-0002-9249-3879
Diachuk N.V. Rivne region, Ukraine
https://orcid.org/0009-0006-3131-6835
Lopuga I.P. Rivne region, Ukraine
https://orcid.org/0009-0005-9527-303X
Sydoruk O.A. Rivne region, Ukraine
https://orcid.org/0009-0001-0459-549X
Fedorniak O.P. Rivne region, Ukraine
https://orcid.org/0009-0006-6833-8755
Pakhniuk A.P. Rivne region, Ukraine
https://orcid.org/0009-0005-8756-3758
Kiranchuk Z.S. Rivne region, Ukraine
https://orcid.org/0009-0005-4297-6874
Sydor O.S. Lviv region, Ukraine
https://orcid.org/0009-0000-2796-9514
Shabatiuk L.V. Lviv region, Ukraine
https://orcid.org/0009-0005-4374-2199
Chaiun Yu.S. Lviv region, Ukraine
https://orsid.org/0009-0003-0221-191X
Sytnik A.V. Dnipro, Ukraine
https://orcid.org/0009-0005-1925-4734
Cite
Deeva Yu.V., co-authors (42). Clinical efficacy and safety of high-dose ambroxol in the form of oromucosal spray in postnasal drip syndrome: results of a multicenter study in Ukraine. Medicni perspektivi. 2025;30(2):61-77. DOI: https://doi.org/10.26641/2307-0404.2025.2.333376
Metrics
|
Saienko Y.A., Koshel N.M., Pysaruk A.V., Mankovsky B.M. Prediction of coronary artery disease risk in patients with type 2 diabetes mellitus: a mathematical model
https://doi.org/10.26641/2307-0404.2025.2.333436
Abstract
Coronary artery disease (CAD) is one of the most prevalent and life-threatening complications in individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to develop a mathematical model for predicting the risk of CAD in patients with T2DM. A total of 242 patients with T2DM, aged 30-80 years, were examined. The following parameters were analyzed: patient age, age at T2DM onset, disease duration, fasting glucose levels, glycated hemoglobin levels, lipid profile parameters, blood pressure, presence of diabetic complications, lifestyle factors, family history, and parental exposure to famine in 1932-1933. The predictive mathematical model for CAD development in T2DM patients was constructed using receiver operating characteristic (ROC) analysis and multiple logistic regression. ROC analysis identified the prognostic value of each of the eight key independent variables, which do not depend on the patient's current health status and can be considered independent at the time of CAD diagnosis. In the second phase of the study, a formula for calculating CAD probability was developed, incorporating the most informative variables with predictive significance. These included the patient’s age, T2DM duration, presence of chronic kidney disease, paternal history of T2DM, maternal famine exposure during pregnancy, rural residence, and patient sex. The developed formula was used to predict CAD risk, and its sensitivity, specificity, and diagnostic performance were evaluated. The model demonstrated high predictive accuracy (AUC=0.792 [0.734–0.842], chi-square =65.1; p<0.001). The probability of CAD development was determined with an accuracy of 72.3%, and the model’s predictive efficiency was 73.6%. The obtained results allowed us to establish statistically significant associations between the studied risk factors and CAD development in T2DM patients. Based on these findings, we have developed a mathematical model for predicting CAD risk in T2DM patients, which can be implemented in clinical practice.
Key words: type 2 diabetes mellitus, coronary artery disease, mathematical model
References
- Seo DH, Kim M, Suh YJ, Cho Y, Ahn SH, Hong S, et al. Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study. Diabetes Res Clin 2024;208:111098. doi: https://doi.org/10.1016/j.diabres.2024.111098
- Huang L, Wu P, Zhang Y, Lin Y, Shen X, Zhao F, et Relationship between onset age of type 2 diabetes mellitus and vascular complications based on propensity score matching analysis. J Diabetes Investig. 2022;13(6):1062-72. doi: https://doi.org/10.1111/jdi.13763
- Kim SM, Lee G, Choi S, Kim K, Jeong SM, Son JS, et Association of early-onset diabetes, prediabetes, and early glycaemic recovery with the risk of all-cause and cardiovascular mortality. Diabetologia. 2020;63(11):2305-14. doi: https://doi.org/10.1007/s00125-020-05252-y
- Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension.J 2013;31(7):1281-9. doi: https://doi.org/10.1097/01.hjh.0000431740.32696.cc
- Goodarzi MO, Rotter JI. Genetics insights in the relationship between type 2 diab etes and coronary heart disease.Circ 2020;126(11):1326-40. doi: https://doi.org/10.1161/CIRCRESAHA.120.317103
- Ye Y, Han J, Jiang W, Natarajan P, Zhao H. Interactions between enhanced polygenic risk scores and lifestyle for cardiovascular disease, diabetes, and lipid levels. Circulation: Genomic and Precision Medicine. 2021;14(1):e003128. doi: https://doi.org/10.1161/CIRCGEN.120.003128
- Polemiti E, Baudry J, Kuxhaus O, Jäger S, Bergmann MM, Weikert C, et BMI and BMI change following incident type 2 diabetes and risk of microvascular and macrovascular complications: the EPIC-Potsdam study. Diabetologia. 2021;64(5):1084-96. doi: https://doi.org/10.1007/s00125-021-05367-x
- Nanayakkara N, Curtis AJ, Heritier S, Gadowski AM, Pavkov ME, Kenealy T, et al. Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses. Diabetologia.2021;64(2):275-87. doi: https://doi.org/10.1007/s00125-020-05319-w
- Sattar N, Rawshani A, Franzén S, Rawshani A, Svensson AM, Rosengren A, et al. Age at diagnosis of type 2 diabetes mellitus and associations with cardiovascular and mortality risks. Circulation. 2019 May 7;139(19):2228-37. doi https://doi.org/10.1161/CIRCULATIONAHA.118.037885
- de Jong M, Woodward M, Peters SAE. Duration of diabetes and the risk of major cardiovascular events in women and men: a prospective cohort study of UK biobank participants. Diabetes Res Clin Pract. 2022;188:109899. doi: https://doi.org/10.1016/j.diabres.2022.109899
- Huang JX, Liao YF, Li YM. Clinical features and microvascular complications risk factors of early-onset type 2 diabetes mellitus. Curr Med Sci. 2019;39(5):754-8. doi: https://doi.org/10.1007/s11596-019-2102-7
- Endothelial Dysfunction and Diabetic Cardiomyopathy. Front Endocrinol. 2022;13:851941. doi: https://doi.org/10.3389/fendo.2022.851941
- Saienko YaA, Pysaruk AV, Koshel NM, Mankovskyi BM. [Clinico-demographic characteristics of patients with type 2 diabetes mellitus of different age groups and their relationship with the risk of developing cardiovascular complications]. 2024;29(3):240-6. Ukrainian. doi: https://doi.org/10.22141/2224-0439
- [All-Ukrainian Association of Cardiologists of Ukraine. Recommendations of the All-Ukrainian Association of Cardiologists of Ukraine on the diagnosis, treatment and prevention of chronic heart failure]. [Internet]. 2024 [cited 2025 Feb 5]. Ukrainian. Available from:https://cardiocongress.org.ua/wp-content/uploads/2024/09/Рекомендації-ХСН-А6-1.pdf
- Chronic Kidney Disease in the Older Adult Patient with Diabetes. J Clin Med. 2024;13(2):348. doi: https://doi.org/10.3390/jcm13020348
- Saienko YaA, Pysaruk AV, Koshel NM, Mankovskyi BM. [The relationship between chronic kidney disease and cardiovascular pathology in patients with type2 diabetes of different ages]. Ukrainian J Cardiol. 2024;31(5):21-30. doi: https://doi.org/10.31928/2664-4479-2024.5.2130
- Ye Y, Chen X, Han J, Jiang W, Natarajan P, Zhao H. Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels. Circulation: Genomic and Precision Medicine.2021;14(1):e003128. doi: https://doi.org/10.1161/CIRCGEN.120.003128
- Vaiserman AM, Khalangot ND, Pisaruk AV, Mekhova LV, Kolyada AK, Kutsenko KY, et al. Predisposition to type II diabetes among those residents of Ukraine whose prenatal development coincided with the famine of 1932-1933.Adv 2011;1:362-6. doi: https://doi.org/10.1134/S2079057011040163
- Zong JC, Hengjinda P. Early Prediction of Coronary Artery Disease (CAD) by Machine Learning Method – A Comparative Study. J Artif Intell Capsule Netw. 2021;3(1):17-33. doi: https://doi.org/10.1007/s00125-020-05362-7
- Hassanzad M, Hajian-Tilaki K. Methods of determining optimal cut-point of diagnostic biomarkers with application of clinical data in ROC analysis: an update review. BMC Med Res Methodol. 2024;24:84. doi: https://doi.org/10.1186/s12874-024-02198-2
- Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314. doi: https://doi.org/10.1016/j.kint.2023.10.018
- ESC Guidelines on Chronic Coronary Syndromes. Eur Heart J. 2024;45(1):ehae177. doi: https://doi.org/10.1093/eurheartj/ehae177
PDF
Look through: 
Authors and affiliations
Saienko Y.A. D.F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-1953-1066
Koshel N.M. D.F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
https://orcid.org/0000-0003-1429-2326
Pysaruk A.V. D.F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
https://orcid.org/0000-0001-5522-0172
Mankovsky B.M. D.F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
https://orcid.org/0000-0001-8289-3604
Cite
Saienko Y.A., Koshel N.M., Pysaruk A.V., Mankovsky B.M. Prediction of coronary artery disease risk in patients with type 2 diabetes mellitus: a mathematical model. Medicni perspektivi. 2025;30(2):78-90. DOI: https://doi.org/10.26641/2307-0404.2025.2.333436
Metrics
|
Duka R.V., Bilov O.V., Duka M.V. Changes in the function of external breathing in patients who underwent lung decortication after post-pneumonic pleurisy
https://doi.org/10.26641/2307-0404.2025.2.333439
Abstract
This article explores changes in pulmonary function in patients who underwent lung decortication as a method of treating complications caused by post-pneumonic pleurisy. It is emphasized that complications such as post-pneumonic pleurisy may lead to the formation of pulmonary fibrosis, which results in a progressive decrease in the effectiveness of external respiratory function. The objective of this research was to assess the clinical effectiveness of surgical lung decortication in individuals with complicated post-pneumonic pleurisy during the early postoperative period based on comparative analysis of spirometric indicators measured both before and after the surgical procedure. A total of 36 patients who suffered from post-pneumonic pleurisy and underwent decortication were included in this study. The primary diagnostic tool used was spirometry. Pulmonary function tests were performed in full compliance with the guidelines of the European Respiratory Society, ensuring accuracy and consistency of results. Statistical analysis using the Wilcoxon test for dependent samples confirmed that decortication led to a statistically significant improvement (p<0.05) in ventilation performance. The procedure was especially effective for addressing restrictive ventilatory impairments caused by fibrotic changes in the pleura, which develop due to the complicated course of pleurisy. Indications for decortication included severe impairment of lung ventilation, radiological signs of fibrin adhesions, and failure of less invasive interventions such as pleural puncture. The operation enables to noticeably improve the quality of life of patients, achieved through the restoration of respiratory function and decrease of restrictive disorders already in early postoperative period: a 16% increase in forced vital capacity and a 13% improvement in forced expiratory volume in the first second. These outcomes correspond with those documented in international clinical studies, confirming the value and effectiveness of the procedure.
Key words: decortication, pleurisy, pleural effusion, functions of external respiration
References
- Koshak YuF. [Analysis of results of surgical treatment of patients with tuberculous pleural empyema]. Achievements of clinical and experimental medicine. 2020;1:106-12. Ukrainian. doi: https://doi.org/10.11603/1811-2471.2020.v.i1.11077
- Madhi S, Boudaya MS, Attig YB, Rammeh M, Souissi F, Dhou AB, et al. Video-assisted thoracoscopic surgery for pleural decortication in empyema. European Respiratory Journal. 2024;64(Suppl 68):PA3159. doi: https://doi.org/10.1183/13993003.congress-2024.PA3159
- Dokhan AL, Ibrahim IM, Hagag M. Video-assisted thoracoscopic surgery versus open decortication in chronic pleural empyema. The Egyptian cardiothoracic surgeon. 2022;4(4):68-72. doi: https://doi.org/10.35810/ects.v4i4.222
- Makarov VV, Tsivenko ОІ. [Early complications by patients with decortications of lung in empyema pleural: causes, methods of prevention]. World Science. 2020;4(56):24-8. doi: https://doi.org/10.31435/rsglobal_ws/30042020/7020
- Kondov G, Colanceski R, Kondova Topuzovska I, Spirovski Z, Caeva Jovkovska B, Kokareva A, et al. Analysis of lung function test in patients with pleural empyema treated with thoracotomy and decortication. Prilozi. 2011;12:259-71.
- Özer КВ, Tükel M, Özdemir A, Cesur EE, Demirhan R. The Effects of Pleural Decortication on Respiratory Functions of the Patients with Pleural Empyema. South Clin Ist Euras. 2018;29(2):99-104. doi: https://doi.org/10.14744/scie.2018.85866
- Elsheikh A, Bhatnagar M, Rahman NM. Diagnosis and management of pleural infection. Breathe. 2023;19(4):230146. doi: https://doi.org/10.1183/20734735.0146-2023
- Cheikhrouhou T, Dhaou MB, Elleuch A, Hbaieb M, Zouari M, et al. The thoracoscopic approach in the management of parapneumonic pleural effusion in children. J Pulmonol Respir Res. 2022;6:025-9. doi: https://doi.org/10.29328/journal.jprr.1001041
- Duzhyi ID. [Features of the diagnosis of pleural diseases: monograph]. 2 ed. Sumy: Sumy State University; 2021. 716 p. Ukrainian.
- Roberts ME, Rahman NM, Maskell NA, Bibby AC, Blyth KG, Corcoran P, et al. British Thoracic Society Guideline for pleural disease. Thorax. 2023;78(Suppl 3);s1-s42. doi: https://doi.org/10.1136/thorax-2022-219784
- Savenkov YuF. [Rational phthisiosurgery]. Dnipro: Dmitrieva G.V.; 2022. 115 p. Russian.
- Gokce M, Okur E, Baysungur V, Ergene G, Sevilgen G, Halezeroglu S. Lung decortication for chronic empyaema: effects on pulmonary function and thoracic asymmetry in the late period. Eur J Cardiothorac Surg. 2009;36:754-8. doi: https://doi.org/10.1016/j.ejcts.2009.04.043
- Abraham SV, Chikkahonnaiah P. Change in pulmonary function following decortication for chronic pleural empyema. Turk Thorac J. 2020;21(1):27-31. doi: https://doi.org/10.5152/TurkThoracJ.2019.180146
- Rai SP, Kaul SK, Tripathi RK, Bhattacharya D, Kashyap M. Decortication in chronic pleural empyema. Lung 2006;23:100-2. doi: https://doi.org/10.4103/0970-2113.44399
- Ryzhov OA, Penkin YuM. [Statistical methods of processing the results of medical and biological research]. Magnolia; 2022. 160 p. Ukrainian.
- Bhatnagar M, Najib NC, Rahman NM, Stanton AE. Front-door thoracic ultrasound in patients with community-acquired pneumonia to diagnose and predict pleural infection – a prospective study. ERJ Open Research. 2024;10(4):00662-2023. doi: https://doi.org/10.1183/23120541.00662-2023
PDF
Look through: 
Authors and affiliations
Cite
Duka R.V., Bilov O.V., Duka M.V. Changes in the function of external breathing in patients who underwent lung decortication after post-pneumonic pleurisy. Medicni perspektivi. 2025;30(2):91-97. DOI: https://doi.org/10.26641/2307-0404.2025.2.333439
Metrics
|
Khanyukov O.O., Krotova V.Yu., Panina S.S., Khramtsova V.V., Yegorov K.Yu., Shchukina O.S. Experience of using psychological support for 6th year medical university students in conditions of high stress levels and reduced quality of life indicators
https://doi.org/10.26641/2307-0404.2025.2.333441
Abstract
This article explores changes in pulmonary function in patients who underwent lung decortication as a method of treating complications caused by post-pneumonic pleurisy. It is emphasized that complications such as post-pneumonic pleurisy may lead to the formation of pulmonary fibrosis, which results in a progressive decrease in the effectiveness of external respiratory function. The objective of this research was to assess the clinical effectiveness of surgical lung decortication in individuals with complicated post-pneumonic pleurisy during the early postoperative period based on comparative analysis of spirometric indicators measured both before and after the surgical procedure. A total of 36 patients who suffered from post-pneumonic pleurisy and underwent decortication were included in this study. The primary diagnostic tool used was spirometry. Pulmonary function tests were performed in full compliance with the guidelines of the European Respiratory Society, ensuring accuracy and consistency of results. Statistical analysis using the Wilcoxon test for dependent samples confirmed that decortication led to a statistically significant improvement (p<0.05) in ventilation performance. The procedure was especially effective for addressing restrictive ventilatory impairments caused by fibrotic changes in the pleura, which develop due to the complicated course of pleurisy. Indications for decortication included severe impairment of lung ventilation, radiological signs of fibrin adhesions, and failure of less invasive interventions such as pleural puncture. The operation enables to noticeably improve the quality of life of patients, achieved through the restoration of respiratory function and decrease of restrictive disorders already in early postoperative period: a 16% increase in forced vital capacity and a 13% improvement in forced expiratory volume in the first second. These outcomes correspond with those documented in international clinical studies, confirming the value and effectiveness of the procedure.
Key words: decortication, pleurisy, pleural effusion, functions of external respiration
References
- Babych MS. [Personal and academic stress in students receiving higher education in a different specialty]. Kyiv: Natsionalnyi linhvistychnyi universytet; 2023. 74 p. Ukrainian.
- Schwabe L, Wolf OT. Timing matters: Temporal dynamics of stress effects on memory retrieval. Cogn AffectBehav 2014;14(3):1041-8. doi: https://doi.org/10.3758/s13415-014-0256-0
- Liu Q, Liu Y, Leng X, Han J, Xia F, Chen H. Impact of Chronic Stress on Attention Control: Evidence from Behavioral and Event-Related Potential Analyses. Neurosci 2020;36(11):1395-410. doi: https://doi.org/10.1007/s12264-020-00549-9
- Lukasik КМ, Waris О, Soveri А, Lehtonen М, Laine M. The Relationship of Anxiety and Stress With Working Memory Performance in a Large Non-depressed Sample. Front Psychol Sec Cognition. 2019;10:4. doi: https://doi.org/10.3389/fpsyg.2019.00004
- Deng Y, Cherian J, Khan NUN, Kumari K, Sial MS, Comite U, et al. Family and Academic Stress and Their Impact on Students' Depression Level and Academic Performance.Front 2022;13:869337. doi: https://doi.org/10.3389/fpsyt.2022.869337
- Barbayannis G, Bandari M, Zheng X, Baquerizo H, Pecor KW, Ming X. Academic Stress and Mental Well-Being in College Students: Correlations, Affected Groups, and COVID-19. Front Psychol. 2022;13:886344. doi: https://doi.org/10.3389/fpsyg.2022.886344/
- Akanpaadgi Е, Binpimbu F, Naalu Kuuyelleh E. The impact of stress on students’ academic performance. J Educational 2023;2(1):60-7. doi: https://doi.org/10.56773/ejer.v2i1.17
- Solis AC, Lotufo-Neto F. Predictors of quality of life in Brazilian medical students: a systematic review and meta-analysis. Braz J Psychiatry. 2019 Nov-Dec;41(6):556-67.
doi: https://doi.org/10.1590/1516-4446-2018-0116
- Ramón-Arbués E, Echániz-Serrano E, Martínez-Abadía B, Antón-Solanas I, Cobos-Rincón A, Santolalla-Arnedo I, et al. Predictors of the Quality of Life of University Students: A Cross-Sectional Study. Int JEnviron Res Public Health. 2022;19(19):12043. doi: https://doi.org/10.3390/ijerph191912043
- Omodaka Y, Sato T. The Quality of Life of Students With Difficulties Accessing Support. Inquiry. 2023;60:469580231159728. doi: https://doi.org/10.1177/00469580231159728
- Kordunova N, Mudrak I, Dmytriiuk N. [Features of vitality and adaptability of students in crisis situations]. Psychological Prospects Journal. 2021;38:96-109. Ukrainian. doi: https://doi.org/10.29038/2227-1376-2021-38-96-109
- Noreen A, Iqbal N, Hassan B, Ali SA. Relationship between psychological distress, quality of life and resilience among medical and non-medical students. J Pak Med 2021;71(9):2181-5. doi: https://doi.org/10.47391/JPMA.04-611
- Fechenko YuI, Mostovoy YuM, Babiychuk YuV. [The procedure of adaptation of international quality of life questionnaire MOS SF-36 in Ukraine. The experience of administration in asthma patient]. Ukrainskiy pulmonologichniy Journal. 2002;3:9-11. Ukrainian.
- Zlivko VL, Lukomska CO, Fedan OV. [Psychodiagnostics of personality in life crisis situations]. Kyiv: Pedagogichna dumka; 2016. 219 р. Ukrainian.
- Kolesnichenko OS. [Applied psychodiagnostics in the National Guard of Ukraine]. Kharkiv: NANGU; 2020. 338 р. Ukrainian.
- Kireeva ZO, Odnostalko OS, Biron BV. [Psychometric analysis of the adapted version of the resilience scale]. 2020;14:110-6. Ukrainian. doi: https://doi.org/10.32843/2663- 5208.2020.14.17
- Panok VG, Rybalka VV, Shandruk SK, et al. [Methods of psychological support of participants in the educational process in wartime conditions: practical manual]. Kyiv: UNMC of practical psychology and social work; 2023. 212 р. Ukrainian.
- Moskalenko VF, Gulchiy OP, Golubchikov MV. [Biostatistics]. Kyiv: Knyga Plus; 2009. 217 р. Ukrainian.
- Korda M, Shulhai A, Shevchuk O, Shulhai O, Shulhai A-M. Psychological well-being and academic performance of Ukrainian medical students under the burder of war: a cross-sectional study. Front Public Health. 2025 Jan 6;12:1457026. doi: https://doi.org/10.3389/fpubh.2024.1457026
- Dzeruzhynska N, Gindych A. [Research on the mental health of students affected by war: comorbidity, quality of life and effective therapeutic approaches]. Psychosomatic medicine and general practice [Internet]. 2025[cited 2024 Dec 17];10(1). doi: https://doi.org/10.26766/pmgp.v10i1.596
- Chachko SL, Travinina EI. [Experience of prolonged traumatic stress of war by higher education students]. Scientific notes of the Tavria National University named V.I. Vernandsky. Psychology. 2024;35(74)(3):67-75. Ukrainian.
doi: https://doi.org/10.32782/2709-3093/2024.3/10
- Sholubka T. [Content-organizational aspects of building a program for the formation of psychological resilience of students in war conditions]. Bulletin of Lviv University. Psychological Sciences. 2023;Issue 17:73-82. doi: https://doi.org/10.30970/PS.2023.19.9
- Moskalets VP, Fedyk OV. [Psychological resilience of students in the conditions of the criminal war of Muscovy against Ukraine]. Slobozhanskyi scientific bulletin. Ser.: Psychology; 2024;1:116-25. Ukrainian. doi: https://doi.org/10.32782/psyspu/2024.1.21
PDF
Look through: 
Authors and affiliations
Khanyukov O.O. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0003-4146-0110
Krotova V.Yu. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0003-2517-435X
Panina S.S. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0003-1080-7185
Khramtsova V.V. State institution "Ukrainian State Institute of Medical and Social Problems of Disability Ministry of Public Health of Ukraine", Dnipro, Ukraine
https://orcid.org/0000-0001-7007-249711
Yegorov K.Yu. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0002-4524-1014
Shchukina O.S. Dnipro State Medical University, Dnipro, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-9543-1545
Cite
Khanyukov O.O., Krotova V.Yu., Panina S.S., Khramtsova V.V., Yegorov K.Yu., Shchukina O.S. Experience of using psychological support for 6th year medical university students in conditions of high stress levels and reduced quality of life indicators. Medicni perspektivi. 2025;30(2):97-107. DOI: https://doi.org/10.26641/2307-0404.2025.2.333441
Metrics
|
Ogorenko V.V., Mavropulo T.K., Borysova I.S., Shusterman T.Y., Nikolenko A.Ye., Plekhanova T.M. Burnout and depression in medical interns: causes, impact of war and coping strategies
https://doi.org/10.26641/2307-0404.2025.2.333442
Abstract
This article presents the findings of a study on the causes, impact of war and coping strategies for burnout and depression among medical interns. The study aimed to identify the factors contributing to burnout and depression in interns, the effects of war on these conditions, and respondents’ suggested strategies for managing them, to develop preventive and psychoeducational measures. The study involved 63 medical interns from the Dnipro State Medical University, undergoing training at the Department of Psychiatry, Narcology and Medical Psychology, and the Department of Pediatrics 3 and Neonatology. The interns were divided into two groups based on their specialty: "Psychiatry" (Group 1) – 31 individuals, and "Pediatrics" (Group 2) – 32 individuals. A psychodiagnostic method was employed, utilizing a custom-designed questionnaire inspired by a Medscape survey. The questionnaire focused on burnout and depression in medical interns during wartime and consisted of 21 questions structured into five clusters. The study revealed a high prevalence of symptoms of depression and burnout syndrome. Specifically, 51,6% of Group 1 and 56,3% of Group 2 reported such symptoms. War significantly impacted the psychological state of respondents, as reported by 67,7% of Group 1 and 96,9% of Group 2. Key factors included information overload, air raid alarms, and working with war-affected individuals. Female respondents were more likely to report a significant impact of war, while male respondents noted reduced attentiveness and irritability in workplace relationships. Approximately 22% of participants considered changing their profession due to burnout, with higher rates observed in Group 2 (34,4% versus 9,7%). The main coping strategies were communication with loved ones (68,3%) and creating a comfortable work environment (84,1%). However, some respondents, particularly from Group 1, resorted to isolation or psychoactive substance use (25,8%). Despite the prevalence of these issues, only 25,4% sought psychological help, with some avoiding disclosure due to stigma. The findings highlight the urgent need to develop targeted psychoeducational and preventive programs to address professional burnout and depression, particularly during wartime and in the post-war period.
Key words: burnout, depression, intern doctor, war, coping
References
- Khan R, Hodges BD, Martimianakis MA. Constructing "Burnout": A Critical Discourse Analysis of Burnout in Postgraduate Medical Education. Acad Med. 2023Nov 1;98(11S):S116-S122. doi: https://doi.org/10.1097/ACM.0000000000005358
- Khatab Z, Hanna K, Rofaeil A, Wang C, Maung R, Yousef GM. Pathologist workload, burnout, and wellness: connecting the dots. Crit Rev Clin Lab Sci. 2024 Jun;61(4):254-74. doi: https://doi.org/10.1080/10408363.2023.2285284
- Kramuschke M, Renner A, Kersting A. [Burnout: Symptoms, diagnostics and treatment approaches]. Nervenarzt.2024 May;95(5):484-93. doi: https://doi.org/10.1007/s00115-024-01649-x
- Vinkers CH, Schaafsma FG. Burnout urgently needs robust research. Nature. 2021 Apr;592(7853):188. doi: https://doi.org/10.1038/d41586-021-00896-1
- Panse N, Panse S, Ravi S, Mankar H, Karanjkar A, Sahasrabudhe P. Burnout among Plastic Surgery Residents in India: An Observational Study. Indian J Plast 2020 Dec;53(3):387-93. doi: https://doi.org/10.1055/s-0040-1719238
- Smoktunowicz E, Lesnierowska M, Cieslak R, et al. Efficacy of an Internet-based intervention for job stress and burnout among medical professionals: study protocol for a randomized controlled trial. Trials. 2019;20(338):1-12.
doi: https://doi.org/10.1186/s13063-019-3401-9
- Rotstein S, Hudaib AR, Facey A, Kulkarni J. Psychiatrist burnout: a meta-analysis of Maslach Burnout Inventory means. Australas Psychiatry. 2019 Jun;27(3):249-54. doi: https://doi.org/10.1177/1039856219833800
- Zhang XJ, Song Y, Jiang T, Ding N, Shi TY. Interventions to reduce burnout of physicians and nurses: An overview of systematic reviews and meta-analyses. Medicine(Baltimore). 2020 Jun 26;99(26):e20992. doi: https://doi.org/10.1097/MD.0000000000020992
- Yang S, Tan GKJ, Sim K, Lim LJH, Tan BYQ, Kanneganti A, et al. Stress and burnout amongst mental health professionals in Singapore during Covid-19 endemicity. PLoS One. 2024 Jan 11;19(1):e0296798. doi: https://doi.org/10.1371/journal.pone.0296798
- Negri L, Cilia S, Falautano M, Grobberio M, Niccolai C, Pattini M, et al. Job satisfaction among physicians and nurses involved in the management of multiple sclerosis: the role of happiness and meaning at work. Neurol 2022 Mar;43(3):1903-10. doi: https://doi.org/10.1007/s10072-021-05520-8
- Tsybuliak N, Suchikova Y, Shevchenko L, Popova A, Kovachev S, Hurenko O. Burnout dynamic among Ukrainian academic staff during the war. Sci Rep. 2023 Oct20;13(1):17975. doi: https://doi.org/10.1038/s41598-023-45229-6
- The Universal Declaration on Bioethics and Human Rights. International Social Science Journal. 2005;57(186):745-53.
doi: https://doi.org/10.1111/j.1468-2451.2005.00592.x
- World Medical Association. World Medical Association Declaration of Helsinki. JAMA. 2013;310(20):2191-4. doi: https://doi.org/10.1001/jama.2013.281053
- Cataldo R, Arancibia M, Stojanova J, Papuzinski C. General concepts in biostatistics and clinical epidemiology: Observational studies with cross-sectional and ecological designs. 2019 Sep 25;19(8):e7698. doi: https://doi.org/10.5867/medwave.2019.08.7698
- Rotenstein LS, Torre M, Ramos MA, Rosales RC, Guille C, et al. Prevalence of Burnout Among Physicians: A Systematic Review. JAMA. 2018 Sep 18;320(11):1131-50. doi: https://doi.org/10.1001/jama.2018.12777
- De Hert S. Burnout in Healthcare Workers: Prevalence, Impact and Preventative Strategies. Local Reg Anesth.2020 Oct 28;13:171-83. doi: https://doi.org/10.2147/LRA.S240564
- du Prel JB, Koscec Bjelajac A, Franić Z, Henftling L, Brborović H, Schernhammer E, et al. The Relationship Between Work-Related Stress and Depression: A Scoping Review. Public Health Rev. 2024 May 1;45:1606968. doi: https://doi.org/10.3389/phrs.2024.1606968
- De Hert S. Burnout in Healthcare Workers: Prevalence, Impact and Preventative Strategies. Local Reg Anesth.2020 Oct 28;13:171-83. doi: https://doi.org/10.2147/LRA.S240564
- Medscape National Physician Burnout & Suicide Report 2020: The Generational Divide [Internet]. [cited 2025 Feb 20].Available from: https://www.medscape.com/slideshow/2020-lifestyle-burnout-6012460
- Sanfilippo F, Palumbo GJ, Noto A, Pennisi S, Mineri M, Vasile F, et al. Prevalence of burnout among intensive care physicians: a systematic review. Rev Bras Ter 2020 Jul-Sep;32(3):458-67. doi: https://doi.org/10.5935/0103-507X.20200076
- Al-Youbi RA, Jan MM. Burnout syndrome in pediatric practice. Oman Med J. 2013 Jul;28(4):252-4. doi: https://doi.org/10.5001/omj.2013.71
- Rivas-García A, Míguez-Navarro MC, Ferrero-García-Loygorri C, Marañón R, Vázquez-López P; en representación del Grupo para el estudio del Burnout de la Red de Investigación de la Sociedad española de Urgencias Pediátricas (RISeuP-SPERG). Burnout syndrome in paediatricians working in paediatric emergency care settings. Prevalence and associated factors: a multilevel analysis. An Pediatr (Engl Ed). 2023 Feb;98(2):119-28. doi: https://doi.org/10.1016/j.anpede.2023.01.004
- Jagannath G. Burnout syndrome in healthcare professionals. Telangana J Psychiatry. 2020;6(2):105-9. doi: https://doi.org/10.18231/j.tjp.2020.023
PDF
Look through: 
Authors and affiliations
Ogorenko V.V. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0003-0549-4292
Mavropulo T.K. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0001-9351-3080
Borysova I.S. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0003-4703-6046
Shusterman T.Y. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0001-5422-1624
Nikolenko A.Ye. Dnipro State Medical University, Dnipro, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-5523-8858
Plekhanova T.M. Dnipro State Medical University, Dnipro, Ukraine
https://orcid.org/0000-0002-9243-5399
Cite
Ogorenko V.V., Mavropulo T.K., Borysova I.S., Shusterman T.Y., Nikolenko A.Ye., Plekhanova T.M. Burnout and depression in medical interns: causes, impact of war and coping strategies. Medicni perspektivi. 2025;30(2):108-119. DOI: https://doi.org/10.26641/2307-0404.2025.2.333442
Metrics
|
Shabani Zamira, Haxhija Edona, Pjetri Emiljano, Shala Irena, Bushati Nevila, Malevija Amela. The situation with vaccination in Shkodra region after the first year of implementation of human papillomavirus vaccine
https://doi.org/10.26641/2307-0404.2025.2.333445
Abstract
Human papillomavirus (HPV) is a common sexually transmitted infection with potentially serious health consequences, including anogenital and oropharyngeal cancers and genital warts. In 2022, Albania implemented an HPV vaccination program for girls aged 13-20 years, offering a single dose of the bivalent or quadrivalent vaccine. This study aims to evaluate the status of HPV vaccination in the Shkodra region after its first year of implementation and explore reasons for non-vaccination. This retrospective study collected data from official vaccination registers at health centers in the Shkodra region for the period 2022-2023. Additionally, face-to-face interviews were conducted with nurses responsible for administering vaccinations (vaccinators) and with parents present at the centers. Quantitative data were obtained and validated by the Chief Vaccination Office in the Epidemiology Sector at the Local Health Care Unit in Shkodra. A simple descriptive and comparative method was employed. Data for this study were gathered from two main sources: official vaccination records and interviews conducted with nurses and parents. Quantitative data were processed and analyzed using Microsoft Office Excel 2010. The vaccination coverage plan aimed to vaccinate 812 girls, with 67% (n=546) from urban areas and 33% (n=266) from rural areas. Overall, vaccination coverage was 51% (n=412 girls). Coverage was higher in rural areas (72.6%, n=193 girls) than in urban areas (40%, n=219 girls). This study highlights the challenges and successes of the HPV vaccination program in the Shkodra region during its first year of implementation. Vaccination coverage was higher in rural areas (72.6%) compared to urban areas (40%). Key barriers to vaccine uptake included parental refusal, lack of information, and fear of side effects.
Key words: human papillomavirus, HPV, vaccine, vaccination, immunization, public health, healthcare
References
- Dunne EF, Unger ER, Sternberg M, McQuillan G, Swan DC, Patel SS, et al. Prevalence of HPV Infection Among Females in the United States. JAMA. 2007 Feb 28;297(8):813. doi: https://doi.org/10.1001/jama.297.8.813
- Smith JS, Gilbert PA, Melendy A, Rana RK, Pimenta JM. Age-Specific Prevalence of Human Papillomavirus Infection in Males: A Global Review. Journal of Adolescent 2011 Jun;48(6):540-52. doi: https://doi.org/10.1016/j.jadohealth.2011.03.010
- Winer RL, Feng Q, Hughes JP, O’Reilly S, Kiviat NB, Koutsky LA. Risk of Female Human Papillomavirus Acquisition Associated with First Male Sex Partner. JInfect 2008 Jan 15;197(2):279-82. doi: https://doi.org/10.1086/524875
- Baandrup L, Blomberg M, Dehlendorff C, Sand C, Andersen KK, Kjaer SK. Significant Decrease in the Incidence of Genital Warts in Young Danish Women After Implementation of a National Human Papillomavirus Vaccination Program. Sex Transm Dis. 2013 Feb;40(2):130-5. doi: https://doi.org/10.1097/OLQ.0b013e31827bd66b
- Chaturvedi AK. Beyond Cervical Cancer: Burden of Other HPV-Related Cancers Among Men and Women. Journal of Adolescent Health. 2010 Apr;46(4):S20-6. doi: https://doi.org/10.1016/j.jadohealth.2010.01.016
- Giuliano AR, Anic G, Nyitray AG. Epidemiology and pathology of HPV disease in males. Gynecol Oncol. 2010 May;117(2):S15-9. doi: https://doi.org/10.1016/j.ygyno.2010.01.026
- Giuliano AR, Palefsky JM, Goldstone S, Moreira ED, Penny ME, Aranda C, et al. Efficacy of Quadrivalent HPV Vaccine against HPV Infection and Disease in Males. New England Journal of Medicine. 2011 Feb 3;364(5):401-11. doi: https://doi.org/10.1056/NEJMoa0909537
- Hariri S, Markowitz LE, Dunne EF, Unger ER. Population Impact of HPV Vaccines: Summary of Early Evidence. Journal of Adolescent Health. 2013 Dec;53(6):679-82. doi: https://doi.org/10.1016/j.jadohealth.2013.09.018
- Parkin DM, Bray F. Chapter 2: The burden of HPV-related cancers. Vaccine. 2006 Aug;24:S11-25. doi: https://doi.org/10.1016/j.vaccine.2006.05.111
- Forhan SE, Gottlieb SL, Sternberg MR, Xu F, Datta SD, McQuillan GM, et al. Prevalence of Sexually Transmitted Infections Among Female Adolescents Aged 14 to 19 in the United States. Pediatrics. 2009 Dec 1;124(6):1505-12. doi: https://doi.org/10.1542/peds.2009-0674
- Giuliano AR, Lu B, Nielson CM, Flores R, Papenfuss MR, Lee J, et al. Age‐Specific Prevalence, Incidence, and Duration of Human Papillomavirus Infections in a Cohort of 290 US Men. J Infect Dis. 2008 Sep 15;198(6):827-35. doi: https://doi.org/10.1086/591095
- Etter DJ, Zimet GD, Rickert VI. Human papillomavirus vaccine in adolescent women. Curr Opin Obstet Gynecol.2012 Oct;24(5):305-10. doi: https://doi.org/10.1097/GCO.0b013e3283567005
- Fisher WA. Understanding Human Papillomavirus Vaccine Uptake. Vaccine. 2012 Nov;30:F149-56. doi: https://doi.org/10.1016/j.vaccine.2012.04.107
- Stupiansky NW, Alexander AB, Zimet GD. Human papillomavirus vaccine and men. Curr Opin Infect Dis.2012 Feb;25(1):86-91. doi: https://doi.org/10.1097/QCO.0b013e32834ed5be
- Markowitz LE. dvisory Committee on Immunization Practices (ACIP). Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2007;2(56):1-24. doi: https://doi.org/10.1037/e601292007-001
- Dunne EF; MLE; CHCCRSMGJUER. Recommendations on the Use of Quadrivalent Human Papillomavirus Vaccine in Males – Advisory Committee on Immunization Practices (ACIP), 2011. MMWR Morb Mortal Wkly Rep. 2011 Dec 23;60(50):1705-8. PMID: 22189893
- Curtis CR YDJJDCSSMJHS. National and State Vaccination Coverage Among Adolescents Aged 13-17 years – United States, 2012. MMWR Morb Mortal Wkly Rep. 2013 Aug 30;62(34):685-93. PMID: 23985496.
- Nolan KM, Seaton B, Antonello J, Zhang Y, Cook L, Delfino K, et al. Development and Validation of Two Optimized Multiplexed Serologic Assays for the 9-Valent Human Papillomavirus Vaccine Types. mSphere. 2023 Apr 20;8(2):e0096221. doi: https://doi.org/10.1128/msphere.00962-21
- Borah P, Kim S, Xiao X, Lee DKL. Correcting misinformation using theory-driven messages: HPV vaccine misperceptions, information seeking, and the moderating role of reflection. Atl J Commun. 2022 May 27;30(3):316-31. doi: https://doi.org/10.1080/15456870.2021.1912046
- Adekanmbi V, Sokale I, Guo F, Ngo J, Hoang TN, Hsu CD, et al. Human Papillomavirus Vaccination and Human Papillomavirus–Related Cancer Rates. JAMA Netw Open.2024 Sep 5;7(9):e2431807. doi: https://doi.org/10.1001/jamanetworkopen.2024.31807
- Dorji T, Nopsopon T, Tamang ST, Pongpirul K. Human papillomavirus vaccination uptake in low-and middle-income countries: a meta-analysis. EclinicalMedicine.2021 Apr;34:100836. doi: https://doi.org/10.1016/j.eclinm.2021.100836
- Dykens JA, Peterson CE, Holt HK, Harper DM. Gender neutral HPV vaccination programs: Reconsidering policies to expand cancer prevention globally. Front Public Health.2023 Feb 21;11:1067299. doi: https://doi.org/10.3389/fpubh.2023.1067299
- Athanasiou A, Bowden S, Paraskevaidi M, Fotopoulou C, Martin-Hirsch P, Paraskevaidis E, et al. HPV vaccination and cancer prevention. Best Pract Res Clin Obstet 2020 May;65:109-24. doi: https://doi.org/10.1016/j.bpobgyn.2020.02.009
- Pojani E, Bozo S, Capparelli E, Hoxha B. Cervical Cancer and HPV vaccination: Insights into knowledge, attitudes, and practices among Albanian women. Vaccine 2025 Jan;22:100594. doi: https://doi.org/10.1016/j.jvacx.2024.100594
- Merkuri L, Kamberi F, Qorri E, Shapo L. Assessment of the Albanian University female students’ knowledge, attitudes, and practices on cervical cancer. The Journal of Infection in Developing Countries. 2023 Apr 30;17(04):534-41. doi: https://doi.org/10.3855/jidc.18121
- Bakiri F, Abazi E, Lika M. Albanian Male Students Perception and Knowledge of Human Papillomavirus (HPV). Journal of Biological Studies. 2023 Dec 31;6(4):273-81. doi: https://doi.org/10.62400/jbs.v6i4.8727
- Shin MB, Sloan KE, Martinez B, Soto C, Baezconde-Garbanati L, Unger JB, et al. Examining multilevel influences on parental HPV vaccine hesitancy among multiethnic communities in Los Angeles: a qualitative analysis. BMC Public Health. 2023 Mar 22;23(1):545. doi: https://doi.org/10.1186/s12889-023-15318-2
- Kennedy J. Vaccine Hesitancy: A Growing Concern. Pediatric Drugs. 2020 Apr 19;22(2):105-11. doi: https://doi.org/10.1007/s40272-020-00385-4
- Kong WY, Oh NL, Kennedy KL, Carlson RB, Liu A, Ozawa S, et al. Identifying Healthcare Professionals With Lower Human Papillomavirus (HPV) Vaccine Recommendation Quality: A Systematic Review. Journal of Adolescent Health. 2024 May;74(5):868-77. doi: https://doi.org/10.1016/j.jadohealth.2023.11.016
- Vahabi M, Mishra G, Pimple S, Wong JPH, Khan M, Prakash V, et al. Effectiveness of family-centred sexual health education and HPV self-sampling in promoting cervical cancer screening among hard-to-reach indian women in rural and tribal areas: a community-based pilot study. BMC Public Health. 2023 Apr 11;23(1):671. doi: https://doi.org/10.1186/s12889-023-15602-1
- ICO/IARC Information Centre on HPV and Cancer. Albania. Human Papillomavirus and Related Cancers. Fact Sheet 2023 [Internet]. 2023 Mar 10 [cited 2025 Jan 11].Available from: https://hpvcentre.net/statistics/reports/ALB.pdf
- Beavis AL, Krishnamoorthi MS, Adler S, Fleszar LG, Moran MB, Rositch AF. Contemporary provider perspectives on how to address HPV vaccine hesitancy in the US: A qualitative study. Vaccine X. 2024 Oct;20:100533. doi: https://doi.org/10.1016/j.jvacx.2024.100533
PDF
Look through: 
Authors and affiliations
Shabani Zamira University of Shkodra “Luigj Gurakuqi” Faculty of Natural Sciences, Shkoder, Albania e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-8021-5391
Haxhija Edona University of Shkodra “Luigj Gurakuqi” Faculty of Natural Sciences, Shkoder, Albania
https://orcid.org/0000-0002-9454-8485
Pjetri Emiljano University of Shkodra “Luigj Gurakuqi” Faculty of Natural Sciences, Shkoder, Albania
https://orcid.org/0009-0004-7299-0346
Shala Irena University of Shkodra “Luigj Gurakuqi” Faculty of Natural Sciences, Shkoder, Albania
https://orcid.org/0000-0002-3726-6115
Bushati Nevila University of Shkodra “Luigj Gurakuqi” Faculty of Natural Sciences, Shkoder, Albania
https://orcid.org/0000-0001-7913-9088
Malevija Amela University of Shkodra “Luigj Gurakuqi” Faculty of Natural Sciences, Shkoder, Albania
https://orcid.org/0009-0005-6314-0355
Cite
Shabani Zamira, Haxhija Edona, Pjetri Emiljano, Shala Irena, Bushati Nevila, Malevija Amela. The situation with vaccination in Shkodra region after the first year of implementation of human papillomavirus vaccine. Medicni perspektivi. 2025;30(2):120-127. DOI: https://doi.org/10.26641/2307-0404.2025.2.333445
Metrics
|
Savchuk T.V., Leshchenko I.V. Coronavirus disease 2019 (COVID-19) or preeclampsia: pathomorphological differential diagnosis of placental changes
https://doi.org/10.26641/2307-0404.2025.2.333460
Abstract
Coronavirus disease 2019 (COVID-19) and preeclampsia (PE) have shared clinical and pathological manifestations, creating a diagnostic challenge. The aim of the study was to identify pathomorphological changes in the placenta that are diagnostically significant for COVID-19 and preeclampsia. We studied the placenta in full-term pregnancies with maternal COVID-19 (Group I, n=80; Subgroup I.1 – COVID-19 at 19–34 weeks of gestation, n=48; Subgroup I.2 – COVID-19 at 35–40 weeks, n=32), the placenta in cases of preeclampsia (PE, n=30) – Group II (Subgroup II.1 – with mild PE; Subgroup II.2 – with moderate and severe PE), and the placenta in the comparison group, n=40. Macroscopic, microscopic, immunohistochemical, morphometric, and statistical methods were used. Placentae in the main groups were characterized by circulatory disorders. Placentitis was present exclusively in Group I. Arteriolosclerosis with vascular lumen obliteration was predominantly detected in Group II and was associated with arteriolar wall hyalinosis: Subgroup II.1 – 75% (95% CI: 49.5%–93.5%), Subgroup II.2 – 100% (95% CI: 87.3%–100%) compared to 25% (95% CI: 13.6%–38.4%) in Subgroup I.1, where it was caused by the proliferation of smooth muscle cells in the arteriolar wall followed by fibrosis, and was not observed in Subgroup I.2. A reduction in the number of terminal chorionic villi was observed in Subgroup I.1 and Subgroup II.2: 16.6 [10; 25] and 12.8 [12; 14], respectively. This was attributed to delayed villous maturation caused by vascular damage in the stem villi. The placenta in Subgroup I.2 was characterized by stromal edema of terminal villi, which led to external compression of the vessels, resulting in a reduced percentage of vessels within the villi – 26.9% [20.9%; 35.6%]. The reduction in vessel percentage in Group II.2 – 29.0% [25.6%; 34.2%] was associated with fibrosis of the chorionic villous stroma. These indicators significantly differed (p<0.0001) from Group I.1 and II.1: 45.2% [40.9%; 48.3%] and 57.6% [50.2%; 64.1%], respectively, and from the comparison group: 67.8% [58.78%; 73.7%]. Compensatory changes, such as an increase in syncytial knots, were observed in Subgroup I.2 and Subgroup II.1, with densities of 12.8 [11; 14] and 9.1 [8; 10], respectively, compared to 5.7 [5; 7] in the comparison group. A reduction in the percentage of the intervillous space was observed in Subgroup I.2 and Subgroup II.1: 26.0% [20.7%; 33.8%] and 29.2% [18.9%; 42.2%], respectively, versus 44.9% [40.5%; 49.6%] in the comparison group; p<0.0001. Placentitis is the main pathomorphological difference in placental changes in COVID-19 compared to preeclampsia. Pathomorphological changes in the placenta during the acute phase of COVID-19 and in mild preeclampsia, despite differences in disease pathogenesis, shared common features: microcirculatory disturbances and an increased number of syncytial knots as a compensatory response to reduced intervillous space (caused by villous stromal edema in COVID-19 and angiomatous changes in terminal villi in preeclampsia). Placental changes in moderate and severe preeclampsia, characterized by infarctions, arteriolosclerosis, and delayed villous maturation (distal villous hypoplasia), were similar to changes observed in COVID-19 in the second trimester of pregnancy.
Key words: placenta, COVID-19, SARS-CoV-2, preeclampsia, pregnancy, chorionic villi
References
- Palomo M, Youssef L, Ramos A, Torramade-Moix S, Moreno-Castaño AB, Martinez-Sanchez J, et al. Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy. American Journal of Obstetrics and Gynecology. 2022 Aug;227(2):277.e1-16. doi: https://doi.org/10.1016/j.ajog.2022.03.048
- Naeh A, Berezowsky A, Yudin MH, Dhalla IA, Berger H. Preeclampsia-Like Syndrome in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19). 2022 Feb 1;44(2):193-5. doi: https://doi.org/10.1016/j.jogc.2021.09.015
- Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, et al. Preeclampsia and eclampsia: the conceptual evolution of a syndrome. American Journal of Obstetrics and Gynecology. 2022 Feb;226(2):S786-803. doi: https://doi.org/10.1016/j.ajog.2021.12.001
- Sankar KD, Bhanu PS, Kiran S, Ramakrishna BA, Shanthi V. Vasculosyncytial membrane in relation to syncytial knots complicates the placenta in preeclampsia: a histomorphometrical study. Anat Cell Biol. 2012 Jun;45(2):86-91. doi: https://doi.org/10.5115/acb.2012.45.2.86
- Shaw LJ, Patel K, Lala-Trindade A, Feltovich H, Vieira L, Kontorovich A, et al. Pathophysiology of Preeclampsia-Induced Vascular Dysfunction and Implications for Subclinical Myocardial Damage and Heart Failure. JACC: 2024 Jun;3(6):100980. doi: https://doi.org/10.1016/j.jacadv.2024.100980
- Serrano B, Bonacina E, Garcia-Ruiz I, Mendoza M, Garcia-Manau P, Garcia-Aguilar P, et al. Confirmation of preeclampsia-like syndrome induced by severe COVID-19: an observational study. American Journal of Obstetrics & Gynecology MFM. 2023 Jan;5(1):100760. doi: https://doi.org/10.1016/j.ajogmf.2022.100760
- Mendoza M, Garcia‐Ruiz I, Maiz N, Rodo C, Garcia‐Manau P, Serrano B, et al. Pre‐eclampsia‐like syndrome induced by severe COVID‐19: a prospective observational study. BJOG: An International Journal of Obstetrics & Gynaecology. 2020 Jun 21;127(11):1374-80. doi: https://doi.org/10.1111/1471-0528.16339
- Turpin CA, Sakyi SA, Owiredu WK, Ephraim RKD, Anto EO. Association between adverse pregnancy outcome and imbalance in angiogenic regulators and oxidative stress biomarkers in gestational hypertension and preeclampsia. BMC Pregnancy and Childbirth. 2015 Aug 25;15(1):189. doi: https://doi.org/10.1186/s12884-015-0624-y
- Kreutz R, Algharably EAEH, Azizi M, Dobrowolski P, Guzik T, Januszewicz A, et al. Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19. Cardiovascular Research. 2020 Aug 1;116(10):1688-99. doi: https://doi.org/10.1093/cvr/cvaa097
- Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, et al. Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System. Circulation Research. 2020 May 8;126(10):1456-74. doi: https://doi.org/10.1161/CIRCRESAHA.120.317015
- Deanfield JE, Halcox JP, Rabelink TJ. Endothelial Function and Dysfunction. Circulation. 2007 Mar 13;115(10):1285-95. doi: https://doi.org/10.1161/CIRCULATIONAHA.106.652859
- Gychka SG, Brelidze TI, Kuchyn IL, Savchuk TV, Nikolaienko SI, Zhezhera VM, et al. Placental vascular remodeling in pregnant women with COVID-19. PLOS 2022 Jul 29;17(7):e0268591. doi: https://doi.org/10.1371/journal.pone.0268591
- Savchuk T, Malysheva T, Vaslovych V, Chernenko O, Leshchenko I, Gychka S. Pathomorphological changes of the placenta in the acute period of coronavirus disease 2019 (COVID-19) at 37–41 weeks of gestation. Proc Shevchenko Sci Soc Med Sci [Internet]. 2024 Dec 24 [cited2025 Jan 8];76(2). doi: https://doi.org/10.25040/ntsh2024.02.12
- Nunes PR, Mattioli SV, Sandrim VC. NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions. Cells. 2021 Nov 1;10(11):2828. doi: https://doi.org/10.3390/cells10112828
- Savchuck TV, Gychka SG, Leshchenko IV. Pathomorphological changes of the placenta in coronavirus disease (COVID 19). Patologìâ. 2021 Aug 20;18(2):128-35.doi: https://doi.org/10.14739/2310-1237.2021.2.231461
- Sara S, Peter L, Ajlana L, Matts O, Francisco ON, Jan W, et al. OP003. Placental perfusion in normal pregnancy and in early and late preeclampsia: A magnetic resonance imaging study. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. 2013 Apr;3(2):63. doi: https://doi.org/10.1016/j.preghy.2013.04.019
- Savchuk T. Pathomorphological changes of the placenta in coronavirus disease (COVID-19) in pregnant women at 19-32 weeks of gestation. Proceeding of the Shevchenko Scientific Society. Medical Sciences [Internet]. 2024 Jun 28 [cited 2024 Jun 30];73(1). doi: https://doi.org/10.25040/ntsh2024.01
- Savchuk T. Pathomorphological changes of the placenta in the acute period of COVID-19 in pregnant women. Eastern Ukrainian Medical Journal [Internet]. 2024 Jun 24 [cited 2024 Jun 30];12(2):323-34. doi: https://doi.org/10.21272/eumj.2024;12(2):323-334
- Savchuk TV. Pathomorphological changes of the placenta in coronavirus disease (COVID-19) in pregnant women in the second and third trimesters of pregnancy. Medicni perspektivi. 2024;29(4):84-94. doi: https://doi.org/10.26641/2307-0404.2024.4.319224
- Aeffner F, Zarella MD, Buchbinder N, Bui MM, Goodman MR, Hartman DJ, et al. Introduction to Digital Image Analysis in Whole-slide Imaging: A White Paper from the Digital Pathology Association. Journal of pathology informatics [Internet]. 2019;10(1):9. doi: https://doi.org/10.4103/jpi.jpi_82_18
- Savchuk TV, Leshchenko IV, inventors; Bogomolets National medical university (UA), assignee. [Method for quantitative determination of delayed placental maturation]. Patent Ukraine u202400917. 2024 Dec 18. Ukrainian.
- Shackelford C, Long G, Wolf J, Okerberg C, Herbert R. Qualitative and Quantitative Analysis of Nonneoplastic Lesions in Toxicology Studies. Toxicologic Pathology. 2002 Jan;30(1):93-6. doi: https://doi.org/10.1080/01926230252824761
- Kruskal WH, Wallis WA. Use of Ranks in One-Criterion Variance Analysis. Journal of the American Statistical Association. 1952;47(260):583-621. doi: https://doi.org/10.1080/01621459.1952.10483441
- Sharps MC, Hayes DJL, Lee S, Zou Z, Brady CA, Almoghrabi Y, et al. A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection. Placenta. 2020 Nov;101:13-29. doi: https://doi.org/10.1016/j.placenta.2020.08.018
- Turyanytsya SМ, Korchins’ka OO, Sabova АV, Baloga OА, Petrov VO. Influence of SARS-CoV-2 acute respiratory viral disease on pregnancy and childbirth. Reproductive health of woman. 2021 Apr 1;2:15-8. doi: https://doi.org/10.30841/2708-8731.2.2021.232515
- Yamada S, Asakura H. Coagulopathy and Fibrinolytic Pathophysiology in COVID-19 and SARS-CoV-2 Vaccination. International Journal of Molecular Sciences. 2022 Mar 19;23(6):3338. doi: https://doi.org/10.3390/ijms23063338
- Garg R, Agarwal R, Yadav D, Singh S, Kumar H, Bhardwaj R. Histopathological Changes in Placenta of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Infection and Maternal and Perinatal Outcome in COVID-19. J Obstet Gynaecol India. 2023 Feb;73(1):44-50. doi: https://doi.org/10.1007/s13224-022-01666-3
- Bodnarchuk ОV. [Тhe metabolic aspects of preeclampsia development]. Collection of scientific papers of the Association of Obstetricians and Gynecologists of Ukraine. 2022 Sep 21;1(49):5-15. Ukrainian.
doi: https://doi.org/10.35278/2664-0767.1(49).2022.266320
- Burton GJ. The Fine Structure of the Human Placental Villus as Revealed by Scanning Electron Microscopy. Scanning Microscopy. 1987;1(4):29
PDF
Look through: 
Authors and affiliations
Cite
Savchuk T.V., Leshchenko I.V. Coronavirus disease 2019 (COVID-19) or preeclampsia: pathomorphological differential diagnosis of placental changes. Medicni perspektivi. 2025;30(2):128-139. DOI: https://doi.org/10.26641/2307-0404.2025.2.333460
Metrics
|
Andreieva S.V., Korets K.V., Skorokhod I.M., Hartovska I.R., Melnyk U.I. Comparative characteristics of quantitative and structural chromosome abnormalities at the time of diagnosis and in relapses of acute myeloid leukemias
https://doi.org/10.26641/2307-0404.2025.2.333463
Abstract
Acute myeloid leukemias (AML) are a heterogeneous group of neoplasms of hematopoietic tissue, to determine the subtypes of which cytomorphological and cytochemical methods, immunophenotyping, cytogenetic and molecular genetic studies are carried out. Numerous genetic studies have identified criteria for diagnosis and prognosis of the course of the disease, which play a decisive role in the algorithms for stratifying clinical risk groups, which in turn contributes to the choice of optimal treatment tactics. However, the effectiveness of chemotherapy may lose its importance due to the lack of response to therapy and the development of relapses. The aim of the work was to establish ways to form resistance to therapy by comparing the features of quantitative and structural chromosome abnormalities at the time of diagnosis and in relapse of AML. Karyotyping was performed on bone marrow cells of 14 patients at the time of diagnosis of AML, sex ratio 1.0:1.0, mean age 44.0±3.6 years and 9 patients in relapsed disease: sex ratio 1.0:0.8, mean age 31.0±5.9 years. The analysis of the results included a comparison of the features of karyotype formation by clone structure, assessment of clones in relation to ploidy, balanced and unbalanced structural rearrangements and the frequency of chromosome involvement in such rearrangements. Subsequently, the formation of the stages of clonal chromosome abnormalities evolution was reconstructed and the frequencies of the cytogenetic prognosis groups were compared. As a result of the studies, the heterogeneity of quantitative (monosomies, trisomies) and structural balanced (translocations, inversions, insertions) and unbalanced chromosome abnormalities (deletions, isochromosomes, additional material of unknown origin, marker chromosomes) were determined, both in diagnosis and in relapse of AML. Mosaic karyotypes were almost three times more likely to occur in relapses than at the time of diagnosis (100% vs. 35.7%). At the time of diagnosis, an increased percentage of hyperdiploid clones (28.6%) was registered due to trisomies of chromosomes 2, 8×2, 13, 19, 20 and complex karyotypes (21.4%); chromosome 17 (20.8%) was more often involved in structural rearrangements, the group of intermediate cytogenetic prognosis dominated (57.1%). In relapses, chromosomes 8 and 9 were more often involved in structural rearrangements (17.6% each) and the group of unfavorable cytogenetic prognosis dominated (55.6%).
Key words: chromosomal abnormalities, acute myeloid leukemias, diagnosis making, relapse
References
- Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of haematolymphoid tumors: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022 June;36(7):1703-19. doi: http://doi.org/10.1038/s41375-022-01613-1
- Mrozek K, Heerema NA, Bloomfield CD. Cytogenetics in acute leukemia. Blood Rev. 2004 Jun;18(2):115-36. doi: http://doi.org/10.1016/S0268-960X(03)00040-7
- Desai RH, Zandvakili N, Bohlander S. Dissecting the genetic and non-genetic heterogeneity of acute myeloid leukemia using next-generation sequencing and in vivo models.Cancer (Basel). 2022 Apr;14(9):2182. doi: http://doi.org/10.3390/cancers14092182
- Acute myeloid leukemia. NCCN Clinical Practice Guidelines in Oncology. NCCN Evidence Blocks. Version 3. 2024 [Internet]. 2024 [cited 2025 Mar 16]. Availablefrom: http://www.nccn.org/professionals/physician_gls/pdf/
- Thol F, Ganser A. Treatment of relapsed acute myeloid leukemia. Curr Treat Options Oncol. 2020 Jun;21(8):66. doi: http://doi.org/10.1007/s11864-020-00765-5
- Hackl H, Astanina K, Wieser R. Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia. Journal of hematology & 2017 Feb;10(1):51. doi: http://doi.org/10.1186/s13045-017-0416-0
- [Acute myeloid leukemia. Evidence-based clinical guidelines. Ministry of Health of Ukraine]. [Internet]. 2023 [cited 2025 Mar 16]. Ukrainian. Available from: https://www.dec.gov.ua/wp-content/uploads/2023/10/2023_kn-gml.pdf
- SilvaM, Leeuw N, Mann K, et al. European guidelines for constitutional cytogenomic analysis. European Journal of Human Genetics. 2018 Jan;27(1):16. doi: http://doi.org/10.1038/s41431-018-0244-x
- McGowan-Jordan J, Hastings RJ, Moore S. An International System for Human Cytogenomic Nomenclature: Karger AG, Basel; 2020. 163 p.
- Arber DA, Orazi A, Hasserjian R, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022 Sep;140(11):1200-28. doi: https://doi.org/10.1182/blood.2022015850
- Kurzer JH, Weinberg OK. Updates in molecular genetics of acute myeloid leukemia. Seminars in diagnostic pathology.2023 May;40(3):140-51. doi: https://doi.org/10.1053/j.semdp.2023.04.002
- Anelli L, Pasciolla C, Zagaria A, et al. Monosomal karyotype in myeloid neoplasias a literature review. Onco Targets 2017 Apr;10:2163-71. doi: http://doi.org/10.2147/OTT.S133937
- Dwivedi AK. How to write statistical analysis section in medical research. J Investig Med. 2022 Dec;70(8):1759-70. doi: https://doi.org/10.1136/jim-2022-002479
- White NM, Balasubramaniam T, Nayak R, Barnett AG. An observational analysis of the trope "A p-value of< 0.05 was considered statistically significant" and other cut-and-paste statistical methods. PLo SOne. 2022;17(3):e0264360. doi: https://doi.org/10.1371/journal.pone.0264360
- Mrozek K, Eisfeld A, Kohlschmidt J, et al. Complex karyotype in de novo acute myeluod leukemia: typical and atypical subtypes differ molecularly and clinically. Leukemia.2019 Jul;33(7):1620-34. doi: http://doi.org/10.1038/s41375-019-0390-3
- Ansar Z, Alam H, Shariq M, et al. Acute myeloid leukemia with hyperdiopoidy. AMP case report. CAP TODAY [Inretnet]. 2024 Mar [cited 2025 Mar 16]:1-3. Availablefrom: https://www.amp.org/AMP/assets/File/clinical-practice/0324_26-27_AMPcase-Ansar-reprint_HiRes.pdf?pass=98
- Yeh W, Tirado C. Hypodiploidy in AML. J Assoc Genet Technol. 2021;47(3):122-6. PMID: 34491230
PDF
Look through: 
Authors and affiliations
Andreieva S.V. SI “National Research Center for radiation medicine, hematology and oncology of the national academy of medical science of Ukraine”, Kyiv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-3029-4444
Korets K.V. SI “National Research Center for radiation medicine, hematology and oncology of the national academy of medical science of Ukraine”, Kyiv, Ukraine
https://orcid.org/0000-0001-6519-8626
Skorokhod I.M. Limited Liability Company «Institute of medical molecular diagnostics», Kyiv, Ukraine
https://orcid.org/0000-0002-2219-5713
Hartovska I.R. Municipal Non-Profit Enterprise of the Kyiv Regional Council "Kyiv Regional Oncology Dispensary", Kyiv, Ukraine
https://orcid.org/0000-0002-8283-429X
Melnyk U.I. Municipal Non-Profit Enterprise "Kyiv City Clinical Hospital No. 9", Kyiv, Ukraine
https://orcid.org/0009-0006-7026-7669
Cite
Andreieva S.V., Korets K.V., Skorokhod I.M., Hartovska I.R., Melnyk U.I. Comparative characteristics of quantitative and structural chromosome abnormalities at the time of diagnosis and in relapses of acute myeloid leukemias. Medicni perspektivi. 2025;30(2):140-148. DOI: https://doi.org/10.26641/2307-0404.2025.2.333463
Metrics
|
Brunina L. Bridging the gap: evaluating emollients and emulsifiers in dermatology for long-term skin health and barrier recovery
https://doi.org/10.26641/2307-0404.2025.2.333650
Abstract
This study addresses the significant gap in existing literature regarding the long-term effects of emollients and emulsifiers on skin health to systematically evaluate the impact of these substances on Trans-Epidermal Water Loss (TEWL) and skin barrier functions across various skin conditions. The main aim of this research is to evaluate the effects of commonly used emollients and emulsifiers on skin barrier function across different skin conditions to provide insights that will contribute to the development of optimized skincare formulations for individuals with compromised skin barriers. A literature search was conducted across multiple databases, including PubMed, Scopus, Web of Science, and Google Scholar, using targeted search strings to gather relevant studies published over the last 20 years. The inclusion criteria focused on peer-reviewed studies that provided empirical data on the effects of emollients and emulsifiers on TEWL and skin barrier functions, specifically in human subjects. A total of 88 articles were initially identified, with 41 meeting the strict inclusion criteria after quality assessment using Joanna Briggs Institute checklists. The review revealed varied effects of emollients and emulsifiers on skin health. Natural oils were found to enhance skin barrier functions and reduce TEWL, whereas synthetic emollients raised concerns about their occlusive properties and potential to worsen skin conditions over time. Emulsifiers showed dual effects; some exacerbated TEWL in normal skin but reduced it in damaged skin, highlighting the complexity of their interaction with skin barrier components. The findings emphasize the need for standardized research methodologies and long-term studies to better understand the mechanisms by which emollients and emulsifiers influence skin health, particularly regarding TEWL measurement techniques while products do exhibit dual behavior and scientific evidence should guide the selection of emulsifiers and emollients in skincare products to ensure both efficacy and long-term safety as well as the special assessment of the safer alternative what support both human health and environmental sustainability.
Key words: emollients, skin diseases, homeostasis, lipids, humans
References
- Schrader A, Siefken W, Kueper T, Breitenbach U, Gatermann C, Sperling G, et al. Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin. Skin Pharmacology and Physiology.2012;25(4):192-9. doi: https://doi.org/10.1159/000338190
- Basson R, Baguneid M, Foden P, Al Kredly R, Bayat A. Functional testing of a skin topical formulation in vivo: Objective and quantitative evaluation in human skin scarring using a double-blind volunteer study with Sequential Punch Biopsies. Advances in Wound Care. 2019 May;8(5):208-19. doi: https://doi.org/10.1089/wound.2018.0864
- Draelos ZD. A clinical evaluation of the comparable efficacy of hyaluronic acid-based foam and ceramide-containing emulsion cream in the treatment of mild-to-moderate atopic dermatitis. Journal of Cosmetic Dermatology. 2011 Sept;10(3):185-8. doi: https://doi.org/10.1111/j.1473-2165.2011.00568.x
- van Smeden J, Janssens M, Kaye EC, Caspers PJ, Lavrijsen AP, Vreeken RJ, et al. The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients. Experimental Dermatology. 2013 Dec 30;23(1):45-52. doi: https://doi.org/10.1111/exd.12293
- Green M, Feschuk AM, Kashetsky N, Maibach HI. “Normal” tewl‐how can it be defined? A systematic review. Experimental Dermatology. 2022 Jul 31;31(10):1618-31. doi: https://doi.org/10.1111/exd.14635
- Glatz M, Jo J-H, Kennedy EA, Polley EC, Segre JA, Simpson EL, et al. Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis. PLOS ONE. 2018 Feb 28;13(2):e0192443. doi: https://doi.org/10.1371/journal.pone.0192443
- Lee H-J, Kim M. Skin barrier function and the microbiome. International Journal of Molecular Sciences. 2022 Oct 28;23(21):13071. doi: https://doi.org/10.3390/ijms232113071
- Danby SG, Chalmers J, Brown K, Williams HC, Cork MJ. A functional mechanistic study of the effect of emollients on the structure and function of the Skin Barrier. British Journal of Dermatology. 2016 Aug 23;175(5):1011-9. doi: https://doi.org/10.1111/bjd.14684
- Vaillant L, Georgescou G, Rivollier C, Delarue A. Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double‐blind, crossover study in healthy volunteers with Dry Skin. Journal of Cosmetic Dermatology. 2019 Sept 18;19(6):1399-403. doi: https://doi.org/10.1111/jocd.13163
- Chuberre B, Araviiskaia E, Bieber T, Barbaud A. Mineral oils and waxes in cosmetics: An overview mainly based on the current European regulations and the safety profile of these compounds. Journal of the European Academy of Dermatology and Venereology. 2019 ;33(S7):5-14. doi: https://doi.org/10.1111/jdv.15946
- Ogorzałek M, Klimaszewska E, Mirowski M, Kulawik-Pióro A, Margula K, Tomasiuk R. Natural or synthetic emollients? Physicochemical properties of body oils in relation to selected parameters of epidermal barrier function. Appl 2024;14(7):2783. doi: https://doi.org/10.3390/app14072783
- Monteiro R, Nikam V, Dandakeri S, Bhat R. Transepidermal water loss in psoriasis: A case-control study. Indian Dermatology Online Journal. 2019;10(3):267. doi: https://doi.org/10.4103/idoj.idoj_180_18
- Pereira G, Fernandes C, Dhawan V, Dixit V. Preparation and development of nanoemulsion for skin moisturizing. In: Nanotechnology for the Preparation of Cosmetics Using Plant-Based Extracts. 2022. р. 27-47. doi: https://doi.org/10.1016/b978-0-12-822967-5.00008-4
- Mawazi SM, Ann J, Othman N, Khan J, Alolayan SO, Al thagfan SS, et al. A review of moisturizers; history, preparation, characterization and applications. Cosmetics. 2022 Jun 9;9(3):61. doi: https://doi.org/10.3390/cosmetics9030061
- Armstrong J, Rosinski NK, Fial A, Ansah S, Haglund K. Emollients to prevent eczema in high-risk infants. MCN: The American Journal of Maternal/Child Nursing. 2022 May;47(3):122-9. doi: https://doi.org/10.1097/nmc.0000000000000809
- Blanks KJ, Musaba MW, Ren L, Burgoine K, Mukunya D, Clarke A, et al. Neonatal emollient therapy and massage practices in Africa: A scoping review. International Health. 2023 Jul 22;16(2):152-64. doi: https://doi.org/10.1093/inthealth/ihad052
- Techasatian L, Kiatchoosakun P. Effects of an emollient application on newborn skin from birth for prevention of atopic dermatitis: A randomized controlled study in Thai neonates. Journal of the European Academy of Dermatology and Venereology. 2021;36(1):76-83. doi: https://doi.org/10.1111/jdv.17675
- Mehling A, Haake H‐M, Poly W. Differential deposition of emollients from tripartite formulation systems. International Journal of Cosmetic Science. 2010 Mar 3;32(2):117-26. doi: https://doi.org/10.1111/j.1468-2494.2009.00546.x
- Schoenfelder H, Liu Y, Lunter DJ. Systematic investigation of factors, such as the impact of emulsifiers, which influence the measurement of skin barrier integrity by in-vitro trans-epidermal water loss (TEWL). International Journal of Pharmaceutics. 2023 May;638:122930. doi: https://doi.org/10.1016/j.ijpharm.2023.122930
- Leoty-Okombi S, Gillaizeau F, Leuillet S, Douillard B, Le Fresne-Languille S, Carton T, et al. Effect of sodium lauryl sulfate (SLS) applied as a patch on human skin physiology and its microbiota. Cosmetics. 2021 Jan 6;8(1):6. doi: https://doi.org/10.3390/cosmetics8010006
- Ruiz PS, Serafini MR, Alves IA, Novoa DM. Recent progress in self-emulsifying drug delivery systems: A systematic patent review (2011-2020). Critical Reviews<sup>TM</sup> in Therapeutic Drug Carrier Systems. 2022;39(2):1-77. doi: https://doi.org/10.1615/critrevtherdrugcarriersyst.2021038490
- Schoenfelder H, Wiedemann Y, Lunter DJ. Development and characterization of topical formulation for maintenance therapy containing Sorbitan monostearate with and without peg‐100‐stearate. Int J Cosmet Sci. 2025 Apr;47(2):223-33. doi: https://doi.org/10.1111/ics.13023
- Sherif G, Naguib Y, Mady F, Khaled K. Polyethylene Glycol: Properties, applications, and challenges. Journal of advanced Biomedical and Pharmaceutical Sciences. 2023 Dec 21;0(0):26-36. doi: https://doi.org/10.21608/jabps.2023.241685.1205
- Fu J, Wu E, Li G, Wang B, Zhan C. Anti-PEG antibodies: Current situation and countermeasures. Nano Today. 2024 Apr;55:102163. doi: https://doi.org/10.1016/j.nantod.2024.102163
- Liu L, Zeng L, Gao L, Zeng J, Lu J. Ozone therapy for skin diseases: Cellular and Molecular Mechanisms. International Wound Journal. 2022 Dec 16;20(6):2376-85. doi: https://doi.org/10.1111/iwj.14060
- Pham Le Khanh H, Nemes D, Rusznyák Á, Ujhelyi Z, Fehér P, Fenyvesi F, et al. Comparative investigation of cellular effects of polyethylene glycol (PEG) derivatives. Polymers. 2022 Jan 11;14(2):279. doi: https://doi.org/10.3390/polym14020279
- Hirano A, Goto M, Mitsui T, Hashimoto-Hachiya A, Tsuji G, Furue M. Antioxidant artemisia princeps extract enhances the expression of filaggrin and loricrin via the ahr/OVOL1 pathway. International Journal of Molecular Sciences. 2017 Sept 11;18(9):1948. doi: https://doi.org/10.3390/ijms18091948
- Maroto-Morales D, Montero-Vilchez T, Arias-Santiago S. Study of skin barrier function in psoriasis: The impact of Emollients. Life. 2021 Jul 4;11(7):651. doi: https://doi.org/10.3390/life11070651
- Ryczaj K, Dumycz K, Spiewak R, Feleszko W. Contact allergens in moisturizers in preventative emollient therapy – A systematic review. Clinical and Translational Allergy. 2022 Jun 5;12(6):e12150. doi: https://doi.org/10.1002/clt2.12150
- Akdeniz M, Gabriel S, Lichterfeld-Kottner A, Blume-Peytavi U, Kottner J. Transepidermal water loss in healthy adults: A systematic review and meta-analysis update. British Journal of Dermatology. 2018 Sept 9;179(5):1049-55. doi: https://doi.org/10.1111/bjd.17025
- Kang S-Y, Um J-Y, Chung B-Y, Lee S-Y, Park J-S, Kim J-C, et al. Moisturizer in patients with inflammatory skin diseases. Medicina. 2022 Jul 1;58(7):888. doi: https://doi.org/10.3390/medicina58070888
- Roso A, Kern C, Cambos S, Garcia C. Diversity Challenge in skin care: Adaptations of a simple emulsion for efficient moisturization across multiple geographies. Applied Sciences. 2023 Dec 12;13(24):13175. doi: https://doi.org/10.3390/app132413175
- Rajkumar J, Chandan N, Lio P, Shi V. The skin barrier and moisturization: Function, disruption, and mechanisms of repair. Skin Pharmacology and Physiology. 2023;36(4):174-85. doi: https://doi.org/10.1159/000534136
- Jung Y-O, Jeong H, Cho Y, Lee E-O, Jang H-W, Kim J, et al. Lysates of a probiotic, lactobacillus rhamnosus, can improve skin barrier function in a reconstructed human epidermis model. International Journal of Molecular Sciences. 2019 Sept 2;20(17):4289. doi: https://doi.org/10.3390/ijms20174289
- Kouassi M-C, Grisel M, Gore E. Multifunctional active ingredient-based delivery systems for skincare formulations: A Review. Colloids and Surfaces B Biointerfaces. 2022 Sept;217:112676. doi: https://doi.org/10.1016/j.colsurfb.2022.112676
- Jung S-W, Park GH, Kim E, Yoo KM, Kim HW, Lee JS, et al. Rosmarinic acid, as an NHE1 activator, decreases skin surface ph and improves the skin barrier function. International Journal of Molecular Sciences. 2022 Mar 31;23(7):3910. doi: https://doi.org/10.3390/ijms23073910
- Sounouvou HT, Lechanteur A, Piel G, Evrard B. Silicones in dermatological topical drug formulation: Overview and advances. International Journal of Pharmaceutics. 2022 Sept;625:122111. doi: https://doi.org/10.1016/j.ijpharm.2022.122111
- Eskens O, Amin S. Challenges and effective routes for formulating and delivery of epidermal growth factors in skin care. International Journal of Cosmetic Science. 2021 Jan 15;43(2):123-30. doi: https://doi.org/10.1111/ics.12685
- Stefanov SR, Andonova VY. Lipid Nanoparticulate Drug Delivery Systems: Recent advances in the treatment of skin disorders. Pharmaceuticals. 2021 Oct 26;14(11):1083. doi: https://doi.org/10.3390/ph14111083
- Kouassi M-C, Grisel M, Gore E. Multifunctional active ingredient-based delivery systems for skincare formulations: A Review. Colloids and Surfaces B Biointerfaces. 2022 Sept;217:112676. doi: https://doi.org/10.1016/j.colsurfb.2022.112676
- Barradas TN, de Holanda e Silva KG. Nanoemulsions of essential oils to improve solubility, stability and permeability: A Review. Environmental Chemistry Letters. 2020 Nov 23;19(2):1153-71. doi: https://doi.org/10.1007/s10311-020-01142-2
PDF
Look through: 
Authors and affiliations
Cite
Metrics
|
Denysiuk M.V., Dubrov S.O., Poniatovska H.B., Lianskorunskyi V.M. Analysis of the structure and features of traumatic injuries in victims with combat trauma
https://doi.org/10.26641/2307-0404.2025.2.333655
Abstract
The aim of this study was to determine the structure and characteristics of traumatic injuries in patients with mine-blast and gunshot wounds, serving as a basis for developing a comprehensive approach to medical care. The study included 127 individuals with combat-related injuries who received treatment at a healthcare facility between February 24, 2022, and October 30, 2023. Medical records, including case histories and reporting forms, were analyzed. The structure and localization of injuries, types of trauma, and the frequency of combined and multiple injuries were assessed. Statistical analysis was performed using MS Office Excel (2010) and STATISTICA v.6.1 (Statsoft Inc., USA). In this study, the nature of traumatic injuries in hospitalized patients with mine-blast and gunshot wounds was analyzed. Results: 45.7% of patients sustained combined or multiple injuries, while 54.3% had injuries limited to a single anatomical region. The most common injury traumas of were the chest (18.9%), head and neck (16.5%), and abdomen (14.2%). Penetrating wounds to the chest and head were often associated with more severe consequences, such as pneumohemothorax and traumatic brain injuries. In mine-blast injuries, non-penetrating trauma predominated, in particular injuries of the extremities and pelvic bones, observed in 80 patients. A significant proportion of patients also experienced bleeding, exceeding 750 ml, which led to hemorrhagic shock in 63.6% of cases. The overall mortality rate was 13.4%, with most deaths occurring in the early stages of treatment, primarily due to the severity of injuries and the development of purulent-septic complications. Combat trauma is predominantly associated with mine-explosive mechanisms, characterized by a high frequency of multiple and combined injuries, significantly complicating the provision of medical care and necessitating a multidisciplinary approach.
Key words: mine-explosive trauma, gunshot trauma, traumatic injuries, bleeding
References
- Tin D, Barten DG, Granholm F, Kovtonyuk P, Burkle FM, Ciottone GR. Hybrid warfare and counter-terrorism medicine. European Journal of Trauma and Emergency Surgery. 2023;2:583-93. doi: https://doi.org/10.1007/s00068-023-02230-y
- Jarrassier A, Py N, de Rocquigny G, Raux M, Lasocki S, Dubost C, et al. Lessons learned from the war in Ukraine for the anesthesiologist and intensivist: A scoping review. Anaesthesia Critical Care & Pain Medicine. 2024 Jul 30;43(5):101409. doi: https://doi.org/10.1016/j.accpm.2024.101409
- Spagnolello O, Gatti S, Shahir MAA, Afzali MF, Portella G, Baiardo Redaelli M. Civilian war victims in Afghanistan: five-year report from the Kabul EMERGENCY NGO hospital. European Journal of Trauma and Emergency Surgery. 2022 Nov 30;49(3):1401-5. doi: https://doi.org/10.1007/s00068-022-02137-0
- Kuchyn I, Horoshko V. Chronic pain in patients with gunshot wounds. BMC Anesthesiol. 2023;23(1):47. doi: https://doi.org/10.1186/s12871-023-02005-3
- Wightman JM, Springer BL, Pickett JR. Blast injury management for operators and tactical emergency medical support providers. The Tactical Edge [Internet]. 2018 [cited 2025 Mar 07];(Fall):74-8. Available from: https://www.researchgate.net/publication/361594434_Blast_injury_management_for_operators_and_TEMS_providers
- Kobayashi L, Coimbra R, Goes AMO Jr, et al. American Association for the Surgery of Trauma-World Society of Emergency Surgery guidelines on diagnosis and management of peripheral vascular injuries. J Trauma Acute Care Surg. 2020;89(6):1183-96. doi: https://doi.org/10.1097/TA.0000000000002967
- Alarhayem AQ, Cohn SM, Cantu-Nunez O, Eastridge BJ, Rasmussen TE. Impact of time to repair on outcomes in patients with lower extremity arterial injuries. J Vasc Surg. 2019;69(5):1519-23. doi: https://doi.org/10.1016/j.jvs.2018.07.075
- [On approval of the procedures for providing first aid to persons in emergency conditions. Order of the Ministry of Health of Ukraine dated 2022 Mar 9 441]. [Internet]. 2022 [cited 2025 Mar 07]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/z0356-22#Text
- Owens BD, Kragh JF Jr, Wenke JC, Macaitis J, Wade CE, Holcomb JB. Combat wounds in operation Iraqi Freedom and operation Enduring Freedom. J Trauma. 2008;64(2):295-9. doi: https://doi.org/10.1097/TA.0b013e318163b875
- Khomenko IP, Korol SO, Khalik SV, Shapovalov VY, Yenin RV, Нerasimenko OS, Tertyshnyі SV. Clinical and Epidemiological analysis of the structure of combat surgical injury during Antiterrorist operation “Clinical and Epidemiological Analysis of the Structure of Combat Surgical Injury During Antiterrorist Operation. Joint Forces Operation. Ukrainian Journal of Military Medicine. 2021;2(2):5-13. doi: https://doi.org/10.46847/ujmm.2021.2(2)-005
- Trentzsch H, Goossen K, Prediger B, Schweigkofler U, Hilbert-Carius P, Hanken H, et al. Stop the bleed “ – Prehospital bleeding control in patients with multiple and/or severe injuries – A systematic review and clinical practice guideline – A systematic review and clinical practice guideline. European Journal of Trauma and Emergency Surgery. 2025 Feb 5;51(1):92. doi: https://doi.org/10.1007/s00068-024-02726-1
- O'Banion LA, Dirks R, Saldana-Ruiz N, et al. Contemporary outcomes of traumatic popliteal artery injury repair from the popliteal scoring assessment for vascular extremity injury in trauma study. J Vasc Surg. 2021;74(5):1573-80.e2. doi: https://doi.org/10.1016/j.jvs.2021.04.064
- Patel JA, White JM, White PW, Rich NM, Rasmussen TE. A contemporary, 7-year analysis of vascular injury from the war in Afghanistan. J Vasc Surg. 2018;68(6):1872-9. doi: https://doi.org/10.1016/j.jvs.2018.04.038
- Danford JR, Reyes F, Gurney JM, Smith JP, Stinner DJ. Optimizing Advanced Trauma Life Support (ATLS®) to Maximize Readiness. Mil Med. 2024 Aug 30;189(9-10):e2206-10. doi: https://doi.org/10.1093/milmed/usae073
- Pape HC, Lefering R, Butcher N, et al. The definition of polytrauma revisited: An international consensus process and proposal of the new 'Berlin definition. J Trauma Acute Care Surg. 2014;77(5):780-6. doi: https://doi.org/10.1097/TA.0000000000000453
- Chen Y, Liu Z, Zhang P, Huang W. [Consistency of injury severity scores in patients with severe trauma]. Medical and health technology. 2024;56(1):157-60. Chinese. doi: https://doi.org/10.19723/j.issn.1671-167X.2024.01.024
- Hardy BM, Varghese A, Adams MJ, Enninghorst N, Balogh ZJ. The outcomes of the most severe polytrauma patients: a systematic review of the use of high ISS cutoffs for performance measurement. Eur J Trauma Emerg Surg. 2024;50(4):1305-12. doi: https://doi.org/10.1007/s00068-023-02409-3
PDF
Look through: 
Authors and affiliations
Cite
Denysiuk M.V., Dubrov S.O., Poniatovska H.B., Lianskorunskyi V.M. Analysis of the structure and features of traumatic injuries in victims with combat trauma. Medicni perspektivi. 2025;30(2):156-163. DOI: https://doi.org/10.26641/2307-0404.2025.2.333655
Metrics
|
Brodska E.V., Makarenko O.V., Dronov S.M. Clinical and economic analysis of the prescription of drugs for postoperative support of total hip arthroplasty
https://doi.org/10.26641/2307-0404.2025.2.333657
Abstract
A well-founded choice of means of medical support for patients after total hip arthroplasty and rational use of financial resources for this purpose allow to achieve the maximum possible socio-economic effect in the future. Its methodological basis is made up of clinical and economic concepts based on the concepts of cost (price, expenses) and clinical effectiveness of the intervention (treatment results).The aim of the study was to determine the financial component of medical support in the postoperative period of total hip arthroplasty using ABC/VEN analysis (Vital Essential Non-essential). In the current study, the ranking of medical products when conducting both ABC/VEN analysis was carried out by the number of prescriptions. The number of prescriptions is a more indicative approach, as it demonstrates the real frequency of drug use in practice, the relevance and demand for specific medications in real-world conditions, allowing for a more accurate determination of priority drugs for clinical use and, accordingly, providing a more relevant and practical assessment of drug needs. The number of observations (n), minimum and maximum values (min – max) were used to describe the variables, quantitative data were presented as the arithmetic mean and standard deviation. Qualitative data - in the format n (%). Results – analysis of prescriptions from medical records of patients with dysplastic coxarthrosis revealed that 6548 prescriptions were made for 367 people during the study period. The results of the integrated ABC/VEN analysis showed that in the context of the most costly group “A”, the main financial resources were spent on providing long-term antithrombotic therapy to prevent pulmonary embolism and lower limb vein thrombosis, the total amount for 2754 prescriptions (42.1% of all prescriptions) was 1,745,478.90 UAH. Less costly (group “B”, 2351 prescriptions) were drugs prescribed for antibiotic prophylaxis of infectious complications. In general, the costs of drugs in group “B” (35.9% of all prescriptions) amounted to 552,820.30 UAH, which corresponded to 21.6% of the financial costs for medical support of patients after TEP. The least expensive group "C" consisted mostly of secondary category N means, which accounted for 17.9% (1173 out of 6548) of the total number of prescriptions and accounted for 6.7% (171,986.75 out of 2,559,353.23 UAH) of the total amount of expenses. «Vital» category V means in this analysis group accounted for 4.1% (270 out of 6548) of all prescriptions, and the expenses for them were 3.5% (89,067.28 out of 2,559,353.23 UAH). The share of financial expenses for these means amounted to half (52.8%) of the total budget for medical support of patients after total hip arthroplasty, which in monetary equivalent was 1,350,380.53 UAH. The leading positions in terms of costs were occupied by vital category V drugs – the synthetic selective inhibitor of activated factor X fondaparinux (“Arixtra”) and the competitive reversible direct thrombin inhibitor dabigatran etexilate (“Pradaxa”), the share of prescriptions of which was 89.4% and 82.3%, respectively.
Key words: clinical-economic analysis, ABC-analysis, postoperative period, hip joint, endoprosthetics, financial costs
References
- Jerrhag D, Englund M, Karlsson MK, Rosengren BE. Epidemiology and time trends of distal forearm fractures in adults – a study of 11.2 million person-years in Sweden. BMC Musculoskelet Disord. 2017;18(1):240. doi: https://doi.org/10.1186/s12891-017-1596-z
- Loskutov OYe, Oliinyk OE, Loskutov OO, Synehubov DA. [Development of national joint endoprosthesis (results of 30-year research)]. Transplantatsiia ta shtuchni organy. 2021;2:37-50. Ukrainian. doi: https://doi.org/10.30702/transpaorg/10_21.2710/0437-50/451.30(477)
- Turchin VM, Loskutov OYe, Savynska OYu. [On the optimal choice of hip joint implant]. Issues of applied mathematics and mathematical modeling. 2020;20:163-74. Ukrainian. doi: https://doi.org/10.15421/322016
- Dudko S, Kusz D, Kopeć K, Wojciechowski P, Kwiatkowska K, Niemiec D. Pseudotumor as a Complication of Total Hip Replacement. Ortop Traumatol Rehabil.2022 Aug 31;24(4):273-80. doi: https://doi.org/10.5604/01.3001.0015.9991
- Yakovlieva LV, Bezditko NV, Herasymova OO, Mishchenko OYa, Karbusheva IV, Tkachova OV, et al. [Pharmacoeconomics: a textbook for university students]. Vinnytsia: NOVA KNYHA; 2009. 208 р. Ukrainian.
- Ubohov SH, Trokhymchuk VV, Todorova VI, Zahoriy VA. Process model of the pharmaceutical integrated management systems. Wiadomości Lekarskie. 2019;72(2):201-8. doi: https://doi.org/10.36740/WLek201902112
- Hruzieva TS, Lekhan VM, Ohniev VA, Haliienko LI, Kriachkova LV, Palamar BI, et al. [Biostatistics]. 2020. 384 p. Ukrainian.
- Goodman SM, Springer BD, Chen AF, Davis M, Fernandez DR, Figgie M, et al. 2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty. Arthritis Care Res (Hoboken). 2022 Sep;74(9):1399-408. doi: https://doi.org/10.1002/acr.24893
- Khalid T, Ben-Shlomo Y, Bertram W, Culliford L, Henderson EJ, Jepson M, et al. Prehabilitation for frail patients undergoing hip and knee replacement in the UK: Joint PREP feasibility study for a randomised controlled trial. BMJ Open. 2024 Sep 17;14(9):e084678. doi: https://doi.org/10.1136/bmjopen-2024-084678
PDF
Look through: 
Authors and affiliations
Cite
Brodska E.V., Makarenko O.V., Dronov S.M. Clinical and economic analysis of the prescription of drugs for postoperative support of total hip arthroplasty. Medicni perspektivi. 2025;30(2):164-170. DOI: https://doi.org/10.26641/2307-0404.2025.2.333657
Metrics
|
Davydenko V.Yu., Davydenko H.M., Sokolovska V.M., Khilinich Ye.S., Tarashevska Yu.Ye. Rehabilitation of a patient with manifistations of intolerance to dental materials in the oral cavity (clinical case)
https://doi.org/10.26641/2307-0404.2025.2.333658
Abstract
Significant achievements in modern dental materials science, improvements in all-ceramic technologies, microprosthetics, and inert removable prosthetics have not eliminated the relevance of assessing the biocompatibility of dental construction materials with the tissues of the prosthetic bed. Currently, almost 47% of the global population suffers from food, drugs, various materials, and chemical compounds intolerances. Aim of the study – to present a clinical case of intolerance to structural materials, and to demonstrate the prediction and prevention of their adverse effects on the whole organism through biocompatibility testing with the tissues of the prosthetic bed. A 62-years-old male patient sought prosthodontic care with complaints of pain, bleeding, redness, and swelling at the sites where metal-ceramic crowns contacted the oral mucosa, along with itching, burning sensations, and halitosis. Approximately two weeks after fixing the bridge prostheses, skin rashes appeared on the neck, accompanied by itching and tingling sensations. Given that the patient associated symptom onset with the fixation of full-cast metal-ceramic bridges, and based on the clinical picture in the oral cavity and results of epicutaneous patch testing, a diagnosis was established: “Intolerance to dental materials. Localized periodontitis complicated by Kennedy Class II, Subclass 2 maxillary and Class I, Subclass 1 mandibular edentulous areas. Masticatory efficiency loss according to Agapov – 84%.” Due to positive patch test results and clinical findings, removal of the metal-ceramic constructions from the oral cavity was deemed necessary. After extraction of all mobile teeth and their destroyed roots, it was planned to restore the edentulous spaces with zirconia bridge prostheses and fabricate clasp dentures based on polyamide for both jaws.
Key words: biocompatibility, individual sensitivity, material intolerance, tests
References
- Schmalz G, Watts DC, Darvell BW. Dental materials science: research, testing and standards. Dent Mater. 2021;37(3):379-81. doi: https://doi.org/10.1016/j.dental.2021.01.027
- Arakelyan M, Spagnuolo G, Iaculli F, Dikopova N, Antoshin A, Timashev P, et al. Minimization of adverse effects associated with dental alloys. Materials (Basel). 2022;15(21):7476. doi: https://doi.org/10.3390/ma15217476
- Bousquet J, Pfaar O, Agache I, Bedbrook A, Akdis CA, Canonica GW, et al. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy. Clinical and Translational Allergy. 2021;11(4):e12014. doi: http://dx.doi.org/10.1002/clt2.12014
- Domic I, Budmir J, Novak I, Mravak-Stipetic M, Lugovic-Mihic L. Assessment of allergies to food and additives in patients with angioedema, burning mouth syndrome, cheilitis, gingivostomatitis, oral lichenoid reactions, and perioral dermatitis. Acta Clin Croat. 2021;60(2):276-81. doi: https://doi.org/10.20471/acc.2021.60.02.14
- Schmalz G, Jakubovics N, Schwendicke F. Normative approaches for oral health: standards, specifications, and guidelines. J Dent Res. 2022;101(5):489-94. doi: https://doi.org/10.1177/00220345211049695
- Budimir J, Mravak-Stipetic M, Bulat V, Fercek I, Japundzic I, Lugovic-Mihic L. Allergic reactions in oral and perioral diseases-what do allergy skin test results show? Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127(1):40-8. doi: https://doi.org/10.1016/j.oooo.2018.08.001
- Itoh E, Furumura M, Furue M. Rate of actual metal allergy prior to dental treatment in subjects complaining of possible metal allergy. Asian Pac J Allergy Immunol. 2020;38(3):186-9. doi: https://doi.org/10.12932/ap-241018-0425
- Gryzodub DV, Gryzodub VI, Gryzodub YeV, vynakhidnyky; Kharkivska medychna akademiia pisliadyplomnoi osvity MOZ Ukrainy, patentovlasnyk. [Method for determining individual sensitivity to dental materials]. Patent Ukrainy No. 91624. 2014.04.10. Ukrainian.
- Fletcher R, Harrison W, Crighton A. Dental material allergies and oral soft tissue reactions. Br Dent J. 2022;232(9):620-25.
doi: https://doi.org/10.1038/s41415-022-4195-9
- Sokolovska V, Tsvetkova N, Davydenko V, Pysarenko O, Tarashevska Y. Dental rehabilitation of a patient with a decrease in bite height due to pathological abrasion of hard tooth tissues (clinical case). Medicni Perspektivi. 2024;(29):245-53.
doi: https://doi.org/10.26641/2307-0404.2024.2.307778
- Sokolovska V, Tsvetkova N. [Displays of unbearableness of stomatological materials are in cavity of mouth (clinical case)]. Ukr Dent Alm. 2022;4:48-52. Ukrainian.
doi: https://doi.org/10.31718/2409-0255.4.2022.08
- Alarcon-Sanchez MA, Heboyan A, Fernandes GVO, Castro-Alarcon N, Romero-Castro NS. Potential impact of prosthetic biomaterials on the periodontium: a comprehensive review. Molecules. 2023;28(3):1075. doi: https://doi.org/10.3390/molecules28031075
- Forkel S, Schubert S, Corvin L, Heine G, Lang CCV, Oppel E, et al. Contact allergies to dental materials in patients. Br J Dermatol. 2024;190(6):895-903. doi: https://doi.org/10.1093/bjd/ljad525
- Müller-Heupt LK, Schiegnitz E, Kaya S, Jacobi-Gresser E, Kämmerer PW, Al-Nawas B. Diagnostic tests for titanium hypersensitivity in implant dentistry: a systematic review of the literature. Int J Implant Dent. 2022;8(1):29. doi: https://doi.org/10.1186/s40729-022-00428-0
- Sousa‐Pinto B, Sa‐Sousa A, Vieira RJ, Amaral R, Klimek L, Czarlewski W, et al. Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK‐air® real‐world data. Allergy. 2022;77(9):2699-711. doi: http://dx.doi.org/10.1111/all.15275
- Can A, Karabacak DE, Yalcin BK, Demir S, Buyukozturk S, Colakoglu B, et al. How important is patch testing with dental materials in real-life clinical practice? AllergyAsthma 2023;44(2):136-44. doi: https://doi.org/10.2500/aap.2023.44.220074
- Lugovic-Mihic L, Ilic I, Budimir J, Pondeljak N, Mravak Stipetic M. Common allergies and allergens in oral and perioral diseases. Acta Clin Croat. 2020;59(2):318-28. doi: https://doi.org/10.20471/acc.2020.59.02.16
- Forkel S, Schubert S, Corvin L, Heine G, Lang CCV, Oppel E, et al. Contact allergies to dental materials in patients. Br J Dermatol. 2024;190(6):895-903. doi: https://doi.org/10.1093/bjd/ljad525
- Bacchi A, Cesar PF. Advances in ceramics for dental applications. Dent Clin North Am. 2022 Oct;66(4):591-602. doi: https://doi.org/10.1016/j.cden.2022.05.007
- Muntian LM, Kulyhin OB. [Dynamics of biophysical and biochemical changes in oral fluid parameters during orthopedic treatment of patients with fixed dentures and their prognostic significance]. Novyny stomatolohii. 2010;1:47-51. Ukrainian.
- Zemelka-Wiacek M. Metal Allergy: State-of-the-art mechanisms, biomarkers, hypersensitivity to implants. JClin 2022;11(23):6971. doi: https://doi.org/10.3390/jcm11236971
- Kilic K, Koc AN, Tekinsen FF, Yildiz P, Kilic D, Zararsiz G, et al. Assessment of Candida species colonization and denture-related stomatitis in barand locator-retained overdentures. J Oral Implantol. 2014;40(5):549-56. doi: https://doi.org/10.1563/AAID-JOI-D-12-00048
- Brown A, Mandelberg NJ, Munoz-Mendoza D, Palys V, Schalock PC, Mogilner A, et al. Allergy considerations in implanted neuromodulation devices. Neuromodulation. 2021;24(8):1307-16. doi: https://doi.org/10.1111/ner.13332
- Grizodub DV. [Analysis of the frequency of somatic complications in patients with intolerance to constructional dental materials and with fixed bridge prostheses]. Problemy bezperervnoi medychnoi osvity ta nauky. 2019;(1):64-7. Ukrainian.
PDF
Look through: 
Authors and affiliations
Davydenko V.Yu. Poltava state medical university, Poltava, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-4231-7343
Davydenko H.M. Poltava state medical university, Poltava, Ukraine
https://orcid.org/0000-0001-6219-2376
Sokolovska V.M. Poltava state medical university, Poltava, Ukraine
https://orcid.org/0000-0002-8944-5828
Khilinich Ye.S. Poltava state medical university, Poltava, Ukraine
https://orcid.org/0000-0001-7970-944X
Tarashevska Yu.Ye. Poltava state medical university, Poltava, Ukraine
https://orcid.org/0000-0003-2983-1708
Cite
Davydenko V.Yu., Davydenko H.M., Sokolovska V.M., Khilinich Ye.S., Tarashevska Yu.Ye. Rehabilitation of a patient with manifistations of intolerance to dental materials in the oral cavity (clinical case). Medicni perspektivi. 2025;30(2):171-179. DOI: https://doi.org/10.26641/2307-0404.2025.2.333658
Metrics
|
Grygus I., Grynova M., Gamma T., Hodlevskyi P., Zukow W. Physiological adaptations and functional changes in young soccer players' organisms aged 11-14 years following a 12-week specialized training program: a sports medicine perspective
https://doi.org/10.26641/2307-0404.2025.2.333676
Abstract
This study investigated the physiological adaptations and functional consequences of a 12-week specialized training program in youth soccer players, focusing on musculoskeletal development, cardiorespiratory responses, and neuromuscular adaptations during the critical growth period of 11-14 years. Sixty male youth soccer players (mean age: 12.5±1.2 years; height: 156.3±8.7 cm; weight: 45.8±7.2 kg) underwent comprehensive medical screening before randomization to experimental (n=30) or control (n=30) groups. Initial screening included growth plate assessment and cardiovascular fitness testing. The intervention included continuous monitoring of physiological parameters including heart rate variability, oxygen consumption, blood lactate levels, and musculoskeletal development markers. Weekly medical monitoring assessed recovery markers and growth indicators to ensure safe adaptation to training loads. The experimental group showed significant physiological adaptations (p<0.001): resting heart rate decreased by 8.4% (95% CI: 6.2-10.6%), peak oxygen consumption increased by 12.3% (95% CI: 9.8-14.8%), bone density improved by 6.2%, muscle mass increased by 8.5%, neuromuscular coordination improved by 24.3% (95% CI: 20.1-28.5%), and recovery time between high-intensity efforts improved by 42%. Growth plate safety markers remained within normal ranges throughout the intervention. The 12-week program produced significant positive physiological adaptations in youth athletes without compromising growth patterns. The study establishes evidence-based guidelines for safe training prescription during crucial developmental periods, emphasizing the importance of medical monitoring in youth sports. These findings contribute to sports medicine protocols for youth athlete development, demonstrating that properly structured training can enhance physiological development while maintaining growth safety parameters.
Key words: youth sports medicine, physiological adaptation, growth and development, cardiovascular response, musculoskeletal development, neuromuscular adaptation, training safety
References
- LloydRS, Faigenbaum AD, Stone MH, Meyer GD, Gregory D, Myer GD, et al. Position statement on youth resistance training: the 2014 International Consensus. Br J Sports Med. 2014;48(7):498-505. doi: https://doi.org/10.1136/bjsports-2013-093614
- GranacherU, Lesinski M, Büsch D, Muehlbauer T, Prieske O, Puta C, et al. Effects of resistance training in youth athletes on muscular fitness and athletic performance: a conceptual model for long-term athlete development. Front 2016;7:164. doi: https://doi.org/10.3389/fphys.2016.00164
- BehmDG, Young JD, Whitten JHD, Reid JC, Quigley PJ, Low J, et al. Effectiveness of traditional strength vs. power training on muscle strength, power and speed with youth: a systematic review and meta-analysis. Front 2017;8:423. doi: https://doi.org/10.3389/fphys.2017.00423
- Ford P, De Ste Croix M, Lloyd R, Meyers R, Moosavi M, Oliver J, et al. The long-term athlete development model: physiological evidence and application. J Sports 2011;29(4):389-402. doi: https://doi.org/10.1080/02640414.2010.536849
- Malina RM, Rogol AD, Cumming SP, Coelho e Silva MJ, Figueiredo AJ. Biological maturation of youth athletes: assessment and implications. Br J Sports Med. 2015;49(13):852-9.
doi: https://doi.org/10.1136/bjsports-2015-094623
- Myer GD, Faigenbaum AD, Ford KR, Best TM, Bergeron MF, Hewett TE. When to initiate integrative neuromuscular training to reduce sports-related injuries and enhance health in youth? Curr Sports Med Rep. 2011;10(3):155-66. doi: https://doi.org/10.1249/JSR.0b013e31821b1442
- Fort-Vanmeerhaeghe A, Romero-Rodriguez D, Lloyd RS, Kushner A, Myer GD. Integrative neuromuscular training in youth athletes. Part II: Strategies to prevent injuries and improve performance. Strength Cond J. 2016;38(4):9-27. doi: https://doi.org/10.1519/SSC.0000000000000229
- Lesinski M, Prieske O, Granacher U. Effects and dose-response relationships of resistance training on physical performance in youth athletes: a systematic review and meta-analysis. Br J Sports Med. 2016;50(13):781-95. doi: https://doi.org/10.1136/bjsports-2015-095497
- Faigenbaum AD, Lloyd RS, MacDonald J, Myer GD. Citius, Altius, Fortius: beneficial effects of resistance training for young athletes. Br J Sports Med. 2016;50(1):3-7.
doi: https://doi.org/10.1136/bjsports-2015-094621
- Bergeron MF, Mountjoy M, ArmstrongN, Chia M, Côté J, Emery CA, et al. International Olympic Committee consensus statement on youth athletic development. Br J Sports Med. 2015;49(13):843-51. doi: https://doi.org/10.1136/bjsports-2015-094962
- Moran J, Sandercock GR, Ramírez-Campillo R, Meylan C, Collison J, Parry DA. A meta-analysis of maturation-related variation in adolescent boy athletes' adaptations to short-term resistance training. J Sports Sci. 2017;35(11):1041-51. doi: https://doi.org/10.1080/02640414.2016.1209306
- Lubans DR, Morgan PJ, Cliff DP, Barnett LM, Okely AD. Fundamental movement skills in children and adolescents: review of associated health benefits. Sports Med.2010;40(12):1019-35. doi: https://doi.org/10.2165/11536850-000000000-00000
- Brownlee TE, O'Boyle A, Morgans R, Morton JP, Erskine RM, Drust B. Training duration may not be a predisposing factor in potential maladaptations in talent development programmes. Int J Sports Sci Coach. 2018;13(5):674-8. doi: https://doi.org/10.1177/1747954118758744
- Haugen TA, Tønnessen E, Seiler S. Speed and countermovement-jump characteristics of elite female soccer players, 1995-2010. Int J Sports Physiol Perform. 2014;9(5):906-13.
doi: https://doi.org/10.1123/ijspp.2013-0096
- Deprez D, Fransen J, Boone J, Lenoir M, Philippaerts R, Vaeyens R. Characteristics of high-level youth soccer players: variation by playing position. J Sports Sci. 2015;33(3):243-54. doi: https://doi.org/10.1080/02640414.2014.934707
- Rössler R, Junge A, Bizzini M, Verhagen E, Chomiak J, Fünten K, et al. A multinational cluster randomised controlled trial to assess the efficacy of '11+ Kids'. Sports Med.2018;48(6):1493-504. doi: https://doi.org/10.1007/s40279-017-0834-8
- Read PJ, Oliver JL, De Ste Croix MBA, Myer GD, Lloyd RS. Neuromuscular risk factors for knee and ankle ligament injuries in male youth soccer players. Sports Med. 2016;46(8):1059-66.
doi: https://doi.org/10.1007/s40279-016-0479-z
- Bahr R. Why screening tests to predict injury do not work and probably never will...: a critical review. Br J Sports 2016;50(13):776-80. doi: https://doi.org/10.1136/bjsports-2016-096256
- Seifert L, Button C, Davids K. Key properties of expert movement systems in sport. Sports Med. 2013;43(3):167-78.
doi: https://doi.org/10.1007/s40279-012-0006-9
- Meylan C, Cronin J, Oliver J, Hughes M. Talent identification in soccer: The role of maturity status on physical, physiological and technical characteristics. Int J SportsSci 2010;5(4):571-92. doi: https://doi.org/10.1260/1747-9541.5.4.571
- Williams AM, Ford PR. Expertise and expert performance in sport. Int Rev Sport Exerc Psychol. 2008;1(1):4-18. doi: https://doi.org/10.1080/17509840701836867
- Jaakkola T, Yli-Piipari S, Huotari P, Watt A, Liukkonen J. Fundamental movement skills and physical fitness as predictors of physical activity: A 6-year follow-up study. Scand J Med Sci Sports. 2016;26(1):74-81. doi: https://doi.org/10.1111/sms.12407
- Vandorpe B, Vandendriessche J, Vaeyens R, Pion J, Lefevre J, Philippaerts R, et al. Factors discriminating gymnasts by competitive level. Int J Sports Med. 2011;32(8):591-7.
doi: https://doi.org/10.1055/s-0031-1275300
- McKeown I, Taylor‐McKeown K, Woods C, Ball N. Athletic ability assessment: a movement assessment protocol for athletes. Int J Sports Phys Ther. 2014;9(7):862-73. PMID: 25540702
- Radnor JM, Oliver JL, Waugh CM, Myer GD, Moore IS, Lloyd RS. The influence of growth and maturation on stretch-shortening cycle function in youth. Sports Med.2018;48(1):57-71. doi: https://doi.org/10.1007/s40279-017-0785-0
- Fort-Vanmeerhaeghe A, Romero-Rodriguez D, Montalvo AM, Kiefer AW, Lloyd RS, Myer GD. Integrative neuromuscular training and injury prevention in youth athletes. Part I: Identifying risk factors. Strength Cond 2016;38(3):36-48. doi: https://doi.org/10.1519/SSC.0000000000000229
- Chaouachi A, Hammami R, Kaabi S, Chamari K, Drinkwater EJ, Behm DG. Olympic weightlifting and plyometric training with children provides similar or greater performance improvements than traditional resistance training. J Strength Cond Res. 2014;28(6):1483-96. doi: https://doi.org/10.1519/JSC.0000000000000305
- Pichardo AW, Oliver JL, Harrison CB, Maulder PS, Lloyd RS. Integrating models of long-term athletic development to maximize the physical development of youth. Int J Sports Sci Coach. 2018;13(6):1189-99. doi: https://doi.org/10.1177/1747954118785487
- O'Connor D, Larkin P, Williams AM. What learning environments help improve decision-making? Phys EducSport 2017;22(6):647-60. doi: https://doi.org/10.1080/17408989.2017.1294678
- Balyi I, Way R, Higgs C. Long-term athlete development. Champaign, IL: Human Kinetics; 2013. ISBN: 978-0736092180
- Lloyd RS, Oliver JL, Faigenbaum AD, Howard R, De Ste Croix MB, Williams CA, et al. Long-term athletic development, part 1: a pathway for all youth. J Strength Cond 2015;29(5):1439-50. doi: https://doi.org/10.1519/JSC.0000000000000756
- McKay D, Broderick C, Steinbeck K. The adolescent athlete: a developmental approach to injury risk. PediatrExerc 2016;28(4):488-500. doi: https://doi.org/10.1123/pes.2016-0021
- Faigenbaum AD, Myer GD. Resistance training among young athletes: safety, efficacy and injury prevention effects. Br J Sports Med. 2010;44(1):56-63. doi: https://doi.org/10.1136/bjsm.2009.068098
- Moran J, Sandercock G, Rumpf MC, Parry DA. Variation in responses to sprint training in male youth athletes: a meta-analysis. Int J Sports Med. 2017;38(1):1-11. doi: https://doi.org/10.1055/s-0042-114526
- Smith JJ, Eather N, Morgan PJ, Plotnikoff RC, Faigenbaum AD, Lubans DR. The health benefits of muscular fitness for children and adolescents: a systematic review and meta-analysis. Sports Med. 2014;44(9):1209-23. doi: https://doi.org/10.1007/s40279-014-0196-4
- Gabbett TJ, Whyte DG, Hartwig TB, Wescombe H, Naughton GA. The relationship between workloads, physical performance, injury and illness in adolescent male football players. Sports Med. 2014;44(7):989-1003. doi: https://doi.org/10.1007/s40279-014-0179-5
- Young WB, Dawson B, Henry GJ. Agility and change-of-direction speed are independent skills: implications for training for agility in invasion sports. Int J SportsSci 2015;10(1):159-69. doi: https://doi.org/10.1260/1747-9541.10.1.159
- Opstoel K, Pion J, Elferink-Gemser M, Hartman E, Willemse B, Philippaerts R, et al. Anthropometric characteristics, physical fitness and motor coordination of 9 to 11 year old children participating in a wide range of sports. PloS 2015;10(5):e0126282. doi: https://doi.org/10.1371/journal.pone.0126282
- Lloyd RS, Oliver JL, Hughes MG, Williams CA. The influence of chronological age on periods of accelerated adaptation of stretch-shortening cycle performance in pre and post-pubescent boys. J Strength Cond Res. 2011;25(7):1889-97. doi: https://doi.org/10.1519/JSC.0b013e3181e7faa8
- Viru A, Loko J, Harro M, Volver A, Laaneots L, Viru M. Critical periods in the development of performance capacity during childhood and adolescence. Eur J Phys 1999;4(1):75-119. doi: https://doi.org/10.1080/1740898990040107
- Castagna C, Manzi V, Impellizzeri F, Weston M, Álvarez J. Relationship between endurance field tests and match performance in young soccer players. J Strength Cond Res. 2010;24(12):3227-33. doi: https://doi.org/10.1519/jsc.0b013e3181e72709
- Dridi R. Regular soccer training improves pulmonary diffusion capacity in 6 to 10 year old boys. BMC Sports Sci Med Rehabil.2023;15(1):146. doi: https://doi.org/10.1186/s13102-023-00757-6
- Lechner S, Ammar A, Boukhris O, Trabelsi K, Glenn J, SchwarzJ, et al. Monitoring training load in youth soccer players: effects of a six-week preparatory training program. Biol 2023;40(1):63-75. doi: https://doi.org/10.5114/biolsport.2023.112094
- Machado Mapping talent pathways: a comparative study of developmental activities and practice structure in Brazilian and Spanish U-18 elite youth male soccer players. Int J Sports Sci Coach. 2024;19(5):2006-15. doi: https://doi.org/10.1177/17479541241241487
- MarshallD, Lopatina E, Lacny S, Emery Economic impact study: neuromuscular training reduces the burden of injuries and costs compared to standard warm-up in youth soccer. Br J Sports Med. 2016;50(22):1388-93. doi: https://doi.org/10.1136/bjsports-2015-095666
- ReadP, Oliver J, De Ste Croix M, Myer G, Lloyd A review of field-based assessments of neuromuscular control and their utility in male youth soccer players. J Strength Cond Res. 2019;33(1):283-99. doi: https://doi.org/10.1519/jsc.0000000000002069
- SogiY, Hagiwara Y, Yabe Y, Sekiguchi T, Momma H, Tsuchiya M, et Association between trunk pain and lower extremity pain among youth soccer players: a cross-sectional study. BMC Sports Sci Med Rehabil. 2018;10(1):13.
doi: https://doi.org/10.1186/s13102-018-0102-8
- UnnithanV, Beaumont A, Rowland T, George K, Sculthorpe N, Lord R, et al. Left ventricular responses during exercise in highly trained youth athletes: echocardiographic insights on function and adaptation. J Cardiovasc Dev 2022;9(12):438. doi: https://doi.org/10.3390/jcdd9120438
- Jovanović Prevalence of potential risk of eating disorders among young, unprofessional European athletes: results of the Erasmus+ project SCAED. Front Nutr. 2024;11:1398464. doi: https://doi.org/10.3389/fnut.2024.1398464
- TadesseT, Asmamaw A, H/Mariam S, Edo A survey of contextual factors and psychological needs satisfaction as correlates of youth athletes' developmental outcomes in the Ethiopian sports academy context. BMC Sports Sci Med Rehabil. 2022;14(1):156. doi: https://doi.org/10.1186/s13102-022-00545-8
- DiCesareC, Montalvo A, Foss K, Thomas S, Ford K, Hewett T, et al. Lower extremity biomechanics are altered across maturation in sport-specialized female adolescent athletes. Front Pediatr. 2019;7:268. doi: https://doi.org/10.3389/fped.2019.00268
- JacobssonJ, Bergin D, Timpka T, Nyce J, Dahlström Ö. Injuries in youth track and field are perceived to have multiple‐level causes that call for ecological (holistic‐developmental) interventions: a national sporting community perceptions and experiences. Scand J Med Sci Sports. 2017;28(1):348-55. doi: https://doi.org/10.1111/sms.12929
- Xiao S. Characteristics and prevention of sports injuries in taekwondo training. Rev Bras Med Esporte. 2022;28(1):37-9. doi: https://doi.org/10.1590/1517-8692202228012021_0436
PDF
Look through: 
Authors and affiliations
Grygus I. National University of Water and Environmental Engineering, Rivne, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-2856-8514
Grynova M. Poltava V. G. Korolenko National Pedagogical University, Poltava, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-3912-9023
Gamma T. National University of Water and Environmental Engineering, Rivne, Ukraine
https://orcid.org/0000-0001-9295-3375
Hodlevskyi P. National University of Water and Environmental Engineering, Rivne, Ukraine
https://orcid.org/0000-0001-8655-4546
Zukow W. Nicolaus Copernicus University, Torun, Poland e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-7675-6117
Cite
Grygus I., Grynova M., Gamma T., Hodlevskyi P., Zukow W. Physiological adaptations and functional changes in young soccer players' organisms aged 11-14 years following a 12-week specialized training program: a sports medicine perspective. Medicni perspektivi. 2025;30(2):180-189. DOI: https://doi.org/10.26641/2307-0404.2025.2.333676
Metrics
|
Sirenko P.O., Storozhenko I.P., Sirenko R.R., Yuzyk O.P., Kindrat V.K., Lietuviete D., Kolesnyk T.V. Resilience of individual health and endogenous response to determinants of motor activity of athletes
https://doi.org/10.26641/2307-0404.2025.2.333679
Abstract
The issue of specialized multicomponent studies of defining the functional state of the organism under the influence of personalized factors of external influence in sport is not sufficiently studied in the scientific and methodological literature. It needs to be expanded and supplemented. The aim of the study was to determine the resilience of an individual's health and the components of the endogenous response to the determinants of athlets's motor activity. The study involved 15 experienced football players, whose average age was 25.47±4.66 years.To achieve this goal, based on the analysis of scientific and methodological literature and the questionnaire, we identified the factors of exogenous influence and the main determinants of motor activity of athletes. An additional specialized questionnaire was conducted to assess the personalized general state of health. According to the previous diagnostic data and on the basis of empirical components, a programme for the development of certain motor qualities (general, power endurance) as a specialized training was developed, which was coordinated with the training process of athletes. Before the beginning of the formed programme the testing of the background assessment of development of aerobic functional capabilities was carried out. In the context of the research the programme with the use of certain determinants of motor activity was implemented. We repeatedly tested the development of aerobic capabilities, determined the resilience of an individual's health and the impact of the research block of exogenous agents on the state of the cardiovascular and muscular systems. We also used a repeated questionnaire to assess the general state of health and health resilience of the individual. We determined the conditions for the implementation and effectiveness of the use of determinants of motor activity as exogenous factors of influence on the health resilience of an individual. Specialized questionnaires and protocols have been created to determine the priority personalized factors of exogenous influence and the operational state of the organism. Based on the data obtained, a programme for the development of motor skills was developed and scientifically and methodically regulated. A systematic assessment of the functional state of athlets on the basis of test models and statistical processing unit was carried out. Defining determinants of motor activity of athletes, resilience of health of an individual and specialized methods of assessment of influence of exogenous factors requires statistically confirmed efficiency of the offered methods in the structure of experimental and research check of their use. The methodology for applying an individual programme for the development of functional capabilities of the motor systems of the body of athletes has been established and substantiated. The effectiveness of the influence of exogenous means on the state of functional systems of the organism in the direction of general and power endurance is statistically substantiated. The positive influence on the general state of health (according to the questionnaire, monitoring of heart rate and intensity of movement, analysis of graphic images built on the obtained indicators) is established.
Key words: health resilience, endogenous response, motor activity of athletes
References
- [WHO. Physical activity and health. Global report on physical activity]. [Intenet]. 2022 [cited 2025 Apr 12]. Ukrainian. Available from: https://resources.physio-pedia.com/uk/resource/global-status-report-on-physical-activity-2022-uk/
- Nikitina LP. [Biological and medical aspects of a healthy lifestyle]. Zaporizhzhia: ZDMU; 2021. p. 50-65. Ukrainian.
- Yuzyk O, Honcharuk V, Pelekh Y, Bilanych L, Sirenko P, Voitovych I, et al. Research on Generative Artificial Intelligence Technologies in Education: Opportunities, Challenges, and Ethical Aspects. BRAIN Broad Research in Artificial Intelligence and Neuroscience. 2025;16(Supl 1):139-51. doi: https://doi.org/10.70594/brain/16.S1/12
- Dyachenko PA, Kurhanska VO, Dyachenko AG, Smiianova OI. A rural-based medical and sociological study on the results of the primary care reform. Wiadomosci Lekarskie.2020;73(5):963-6. doi: https://doi.org/10.36740/WLek202005123
- Ivakhniuk TV, Holubnycha VM, Smiianov VA, Rudenko LA, Smiianov YV. Basic principles of behavioral economics and prospects for their application in the public health system. Wiadomosci Lekarskie. 2020;73(9):2036-41. doi: https://doi.org/10.36740/WLek202009231
- Kohl HW, Murray TD. Foundations of Physical Activity and Public Health. Human Kinetics; 2021. р. 50-65.
- Krustrup P, Mohr M, Nybo L, Jensen JM, Nielsen JJ, Bangsbo J. The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer. Med Sci Sports Exerc. 2006 Sep;38(9):1666-73. doi: https://doi.org/10.1249/01.mss.0000227538.20799.08
- Sallis JF, Cervero RB, Ascher W, Henderson KA, Kraft MK, Kerr J. An Ecological Approach to Creating Active Living Communities. Annual Review of Public Health. 2006;27:297-322. doi: https://doi.org/10.1146/annurev.publhealth.27.021405.102100
- Sartorius N. The Meanings of Health and its Promotion. Croat Med J. 2006 Aug;47(4):662-4. PMID: 16909464; PMCID: PMC2080455. Functional Training and Flexibility: Modern Approaches. Cambridge: Cambridge University Press; 2020. р. 112-8.
- Sirenko PO, Storozhenko IP, Žīdens J, Zuša A, Yuzyk OP, Lietuviete D, et al. Functional testing of the lower extremity muscles. Medicni perspektivi. 2023;28(2):150-63.
doi: https://doi.org/10.26641/2307-0404.2023.2.283388
- Sirenko PO, Istomin AH, Sirenko RR, Khorkavyi BV, Rybchych IE. Special and preventive exercises for hamstring muscles in the training process of experienced football players. Pedagogy of Physical Culture and Sports, 2022;26(5):344-52. doi: https://doi.org/10.15561/26649837.2022.0509
- Hampel FR. The Influence Curve and Its Rolein Robust Estimation. Journal of the American Statistical Association. 1974;69(346):383-93. doi: https://doi.org/10.1080/01621459.1974.10482962
- Wilcoxon F. Individual comparis ons by ranking methods. Biometrics. 1945;1(6):80-83. doi: https://doi.org/10.2307/3001968
- Mann HB, Whitney DR. On a test of whether one of two random variablesis stochastically larger than the other. The Annals of Mathematical Statistics. 1947;18(1):50-60. doi: https://doi.org/10.1214/aoms/1177730491
- Shapiro SS, Wilk MB. An analysis of variance test for normality (complete samples). Biometrika. 1965;52(3/4):591-611. doi: https://doi.org/10.1093/biomet/52.3-4.591
- Yuzyk O, Pelekh Y, Voitovych I, Pavlova N, Briukhovetska I, Sirenko P, et al. Peculiarities of Professional Training of Informatics and Mathematics Teachers at Universities in Poland and Ukraine. In: Štarchoň P, Fedushko S, Gubíniová K, editors. Data-Centric Business and Applications. Lecture Notes on Data Engineering and Communications Technologies. Springer, Cham; 2024. doi: https://doi.org/10.1007/978-3-031-62213-7_1
- Smith J. Training Principles for Athletes. Oxford: Oxford University Press; 2018. р. 150-67.
- Warburton DER, Nicol CW, Bredin SS. Health Benefits of Physical Activity. CMAJ. 2006;174(6):801-9. doi: https://doi.org/10.1503/cmaj.051351
PDF
Look through: 
Authors and affiliations
Sirenko P.O. Rīga Stradiņš University, Rīga, Latvia e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-2787-6497
Storozhenko I.P. State Biotechnological University, Kharkiv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-7344-242X
Sirenko R.R. Private higher education institution "Lviv medical university", Lviv, Ukraine e-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-9100-4709
Yuzyk O.P. Rivne State University of the Humanities, Rivne, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-9586-6015
Kindrat V.K. Rivne State University of the Humanities, Rivne, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
htths://orcid.org/0000-0002-7475-3385
Lietuviete D. Clinic Aiwa, Riga, Latvia e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0009-0000-2821-3559
Kolesnyk T.V. Shupyk National University of Health Care, Kyiv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-4849-5615
Cite
Sirenko P.O., Storozhenko I.P., Sirenko R.R., Yuzyk O.P., Kindrat V.K., Lietuviete D., Kolesnyk T.V. Resilience of individual health and endogenous response to determinants of motor activity of athletes. Medicni perspektivi. 2025;30(2):190-203. DOI: https://doi.org/10.26641/2307-0404.2025.2.333679
Metrics
|
PREVENTIVE MEDICINE
|
Nikolaieva Ya.Yu. Regulation of the non-steroid anti-inflammatory drug «Diclofenac sodium» in the air environment of populated places
https://doi.org/10.26641/2307-0404.2025.2.333685
Abstract
The most common group of drugs today are non-steroidal anti-inflammatory drugs, among which diclofenac sodium is one of the most widely used. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect by inhibiting the synthesis of prostaglandins. This active pharmaceutical ingredient belongs to the second class of the Biopharmaceutical classification system, which has a high degree of permeability through biological membranes, which leads to the possibility of absorption of diclofenac sodium already in the stomach, thereby causing unwanted side and negative effects. Considering the large volumes of production and possible serious side effects of this active pharmaceutical ingredient, it is advisable to control the level of this substance in atmospheric air. The purpose of this work was to scientifically substantiate the hygienic regulation of diclofenac sodium in the atmospheric air of populated areas based on studies of the toxicological properties of this active pharmaceutical ingredient. Experimental animals (102 non-linear white mice, 136 non-linear white rats of both sexes, 60 short-haired mice) were divided into experimental and control groups of 6 individuals each. Based on the obtained indicators of lethality of experimental animals, using the method of probit analysis, the indicators of toxicity during acute exposure of the substance were determined – semi-lethal dose with a single intragastric administration of DL50 for female rats (54.83 mg/kg), DL50 for mice (550 mg/kg), DL50 for rats-females (104.4 mg/kg), and CL50 for male rats (243.11 mg/m3), CL50 for mice (71.61 mg/m3). According to subchronic exposure, it was established that diclofenac sodium has supercumulative activity, since the cumulative coefficients for subacute administration to mice and rats are <1 (0.94 and 0.96, respectively). It was determined that this substance does not have a pronounced irritating effect on the mucous membrane of the eyes and does not exhibit allergenic properties. Does not cause sensitization of the body. It is shown that the possibility of developing acute poisoning from a single inhalation exposure to diclofenac sodium is unlikely, which is confirmed by the coefficient of the possibility of inhalation poisoning (CPIP=0.000032). In turn, the low value of the Limch indicator (1.18 mg/m3) indicates the real danger of developing chronic inhalation poisoning with diclofenac sodium. Zbiol is 60.7, which indicates a significant sign of the ability to accumulate in the body. Expressed cumulative properties of this substance increase the risk of chronic poisoning. The maximum one-time maximum permissible concentration (MPC) in the atmospheric air of populated areas at the level of 0.03 mg/m3 was determined and substantiated. Thus, it is expedient to control and monitor the air environment during the production of medicinal products in order to prevent diclofenac sodium from entering the sanitary protection zones.
Key words: diclofenac sodium, nonsteroidal anti-inflammatory drugs, toxicological studies, regulation, atmospheric air
References
- ICH hаrmonised guideline biopharmaceutics classification system – based biowaivers M9. Final version Adopted on 20 November 2019 [Internet]. 2019 [cited 2024 May 06].Available from: https://database.ich.org/sites/default/files/M9_Guideline_Step4_2019_1116.pdf
- Imai T, Hazama K, Kosuge Y, Suzuki S, Ootsuka S. Preventive effect of rebamipide on NSAID-induced lower gastrointestinal tract injury using FAERS and JADER. Scientific reports. 2022;12(1):2631. doi: https://doi.org/10.1038/s41598-022-06611-y
- Bocci G, Oprea TI, Benet LZ. State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. AAPS J. 2022 Feb 23;24(2):37. doi: https://doi.org/10.1208/s12248-022-00687-0
- Erhirhie EO, Ihekwereme CP, Ilodigwe EE. Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance. Interdiscip Toxicol. 2018;11(1):5-12. doi: https://doi.org/10.2478/intox-2018-0001
- Vohra F, Raut A. Comparative efficacy, safety, and tolerability of diclofenac and aceclofenacin musculoskeletal pain management: A systematic review. Indian J of 2019;30(1):1-69. doi: https://doi.org/10.4103/0970-5333.173431
- Yehudina ED. [Nonsteroidal anti-inflammatory drugs: evidence of effectiveness, facts, myths]. Neurology aspects of treatment. 2021;3:20-1. Ukrainian.
- [On the approval of state medical and sanitary standards for the permissible content of chemical and biological substances in the atmospheric air of populated areas. Order of the Ministry of Health of Ukraine dated 2024 May 10 No. 813] [Internet]. 2024 [cited 2024 Jul 14]. Ukrainian.Available from: https://zakon.rada.gov.ua/laws/show/z0763-24#Text
- UNEP/WHO – United Nations Environment Programme/World Health Organization. State-of-the-Science of Endocrine Disrupting Chemicals [Internet]. 2012 [cited 2024 Oct 10].Available from: https://www.unep.org/resources/publication/state-science-endocrine-disputing-chemicals-ipcp-2012
- Diclofenac (sodium salt). Safety data sheet. Cayman chemical [Internet]. 2022 [cited 2024 May 24]. Availablefrom: https://cdn.caymanchem.com/cdn/msds/70680m.pdf
- Panchal N, Kaur M, Tharmatt A, Thakur S, Jain SK. Development, Characterization and Evaluation of Parenteral Formulation of Diclofenac Sodium. AAPS PharmSciTech.2020;21(6):219. doi: https://doi.org/10.1208/s12249-020-01729-6
- Diclofenac sodium. National Library of Medicine. National Center for Biotechnology Information [Internet]. 2022 [cited 2024 May 24]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac-sodium
- [On approval of guidelines "Justification of the maximum permissible concentrations of drugs in the air of the working area and the atmospheric air of populated areas". Order of the MH of Ukraine dated 2005 Oct 21 544]. [Internet] 2005 [cited 2024 Jun 22]. Ukrainian. Available from: https://zakon.rada.gov.ua/rada/show/v0544282-05#Text
- Smith AJ. Guidelines for planning and conducting high-quality research and testing on animals. Lab Anim Res. 2020 Jul 10;36:21. doi: https://doi.org/10.1186/s42826-020-00054-0
- Eyme KM, Carvalho L, Badr CE. Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models. STAR Protocols. 2021;2(1):100290. doi: https://doi.org/10.1016/j.xpro.2020.100290
- Halmi MI, Rahim MB, Othman AR. Estimation of LC50 and its Confidence Interval for the Effect of Ferrous Sulphate on Catla catla. JEMAT. 2018;6(1):21-3. doi: https://doi.org/10.54987/jemat.v6i1.402
- Novosad NV. [Laboratory animals and technique of biological experiment]. Zaporizhzhia: ZNU; 2011. 85 р. Ukrainian.
- Lim KS, et al. A method for the evaluation of cumulation and tolerance by the determination of acute and subchronic median effective doses. Arch Intern Pharmacodyn Ther. 1961;130:336-42.
- Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. Кyiv: MYCz "Medynform"; 2018. 579 р. Ukrainian.
- Kim HS, Kang GH, Yang MJ, Ahn HJ, Han SC, Hwang JH. Toxicity of diclofenac sodium salt in Yucatan minipigs (Sus scrofa) following 4 weeks of daily intramuscular administration. Toxicol Rep. 2021 Feb 26;8:557-570. doi: https://doi.org/10.1016/j.toxrep.2021.02.022
- Nikolaieva YI, Hlavachek DO. [Study of acute toxicity parameters of Diclofenac sodium by different methods of administration]. Bulletin of the Vinnytsia National Medical University. 2023;27(4):548-53. Ukrainian. doi: https://doi.org/10.31393/reports-vnmedical-2023-27(4)-02
- Patel JH, Thanagari BS, Fefar DT, Prajapati KS, Jivani BM, Thakor KB, et al. Haemato-biochemical alterations induced by diclofenac sodium toxicity in Swiss albino mice. Vet World. 2012;5(7):417-9. doi: https://doi.org/10.5455/vetworld.2012.417-419
PDF
Look through: 
Authors and affiliations
Nikolaieva Ya.Yu. State Institution "Marzieiev Institute for Public Health of the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-4031-9967
Cite
Metrics
|
Lototska-Dudyk U.B., Kuzminov B.P., Lototska L.B., Klyuchivska O.Yu., Stoika R.S. Search for biological mechanisms of toxic action of shoe glues: cell viability in vitro, albumin damage and free radical generation
https://doi.org/10.26641/2307-0404.2025.2.333689
Abstract
The combined use of cellular, extracellular research methods for studying the toxic effect of shoe glues is an additional tool for screening and assessing the potential risks of their use. The aim of the work was to investigate the mechanisms of the toxic effect of shoe glues at the cellular, molecular and biochemical levels. Rubber, polychloroprene and polyurethane shoe glues were used. Three experimental approaches were applied: measurement of survival of mammalian cells, a spectroscopic study of conformational changes of albumin, and a free radical measurement. Cytotoxicity testing was performed on murine fibroblasts Balb/c-3T3 line, human embryonic kidney cells HEK-293 and human keratinocytes of the HaCaT line treated for 24 and 72 hours with glues samples. A survival of treated cells was monitored using MTT-test. Changes in the spectral characteristics of albumin were monitored during exposure for 24 hours and 21 days with "fresh" and "dried" samples of glues. Content of free radicals was evaluated in the reaction with DPPH reagent. The cytotoxicity was increased with increasing exposure time, and depended on both the type of glue and the type of treated cells. The polyurethane glue demonstrated the most pronounced cytotoxic effect. Balb/c-3T3 fibroblasts were the most sensitive to the action of all types of glues, a reliable maximum increase in cell death was manifested in 72 hours exposure (28.9-19.1% of living cells).While cells of HEK-293 and НаСаТ lines were more resistant. At 24 hours contact, their viability was 99.12-79.22% and 99.0-56.9%, respectively. Increased exposure up to 72 hours reliably caused a decrease in the survival of these cell lines – 96.24-68.1% and 82.2-51.7%. The loss of the solvent didn’t affect the cytotoxic effect of the studied glues. Conformation changes in albumin were manifested during its long-term contact with both "fresh" and "dried" glues. Manifestations of the toxic effect of glues on biomolecules were increased in the sequence: rubber > polyurethane > polychloroprene. Shoe glues demonstrated an ability to generate free radicals in the sequence: rubber > polychloroprene > polyurethane. These manifestations were increased in a time period of 4 hours – 24 hours. That may create risks when they are used. The results can be used to determine the targets and mechanisms of the toxic effect of shoe glues and to obtain new knowledge in the field of research of industrial toxicants.
Key words: shoe glues, in vitro method, cytotoxicity, conformational changes of albumin, radicals activity
References
- Kuzminov BP, Lototska-Dudyk UB. [Occupational factors and their influence on the health of workers of shoe productions]. Ukrainian journal of occupational health. 2016;1(46):74-83. doi: https://doi.org/10.33573/ujoh2016.01.074
- Lukács J, Präßler J, Gebhardt M, Elsner P. Adhesives and Glues. In: Kanerva’s Occupational Dermatology. Springer; 2020. р. 891-900. doi: https://doi.org/10.1007/978-3-319-68617-2_59
- Orgiles-Calpena ME, Aran-Ais F, Torro-Palau AM, et al. Adhesives in the footwear industry: a critical review. Rev Adhesion Adhesives. 2019;7(1):69-91. doi: https://doi.org/10.7569/RAA.2019.097303
- Lototska-Dudyk UB. [Research of the assortment of shoes glues and their components as potential harmful factors of the production environment of footwear industry]. Aktualni problemy profilaktychnoi medytsyny. 2020;20:151-61. Ukrainian.
- Heuser VD, de Andrade VM, da Silva J, Erdtmann B. Comparison of genetic damage in Brazilian footwear-workers exposed to solvent-based or water-based adhesive. Mutat 2005;583(1):85-94. doi: https://doi.org/10.1016/j.mrgentox.2005.03.002
- Domanski W, Makles Z. [Chemical hazards when working with solvent-based adhesives]. Medicina pracy. 2012;63(1):31-8. Polish.
- Savira YM, Tejamaya MB, Putri AA. A case study: Chemical health risk assessment in three footwear small industries in Bogor-Indonesia year 2019. Gaceta Sanitaria.2021;35(2):374-8. doi: https://doi.org/10.1016/j.gaceta.2021.10.054
- Umicevic N, Kotur-Stevuljevic J, Paleksic V, et al. Liver function alterations among workers in the shoe industry due to combined low-level exposure to organic solvents. Drug Chem Toxicol. 2022;45(4):1907-14. doi: https://doi.org/10.1080/01480545.2021.1894703
- Cozigou G, Crozier J, Hendriksen C, et al. The European Partnership for Alternative Approaches to Animal Testing (EPAA): promoting alternative methods in Europe and beyond. J Am Assoc Lab Anim Sci. 2015;54(2):209-13.PMID: 25836968; PMCID: PMC4382626.
- Zazulyak TS. [Theoretical and applied aspects of the application of alternative methods of toxicity research in the implementation of hygienic regulation of chemical factors of production]. Experimental and clinical physiology and biochemistry. 2019;88(4):73-81. Ukrainian. doi: https://doi.org/10.25040/ecpb2019.04.073
- Dmytrukha NM. [Аpplication of alternative in vitro test models for assessing the toxicity of heavy metal compounds]. Actual problems of preventive medicine. 2023;26:27-36. Ukrainian. doi: https://doi.org/10.32782/2786-9067-2023-26-3
- Maestri E. The 3Rs principle in animal experimentation: A legal review of the state of the art in Europe and the case in Italy. BioTech (Basel). 2021;10(2):9. doi: https://doi.org/10.3390/biotech10020009
- Laroche C, Annys E, Bender H, et al. Finding synergies for the 3Rs - repeated dose toxicity testing: Report from an EPAA Partners' Forum. Regul Toxicol Pharmacol.2019;108:104470. doi: https://doi.org/10.1016/j.yrtph.2019.104470
- Tolosa L, Donato MT, Gómez-Lechón MJ. General cytotoxicity assessment by means of the MTT assay. Protocols in vitro hepatocyte research. 2015;1250:333-48. doi: https://doi.org/10.1007/978-1-4939-2074-7_26
- Singhal A, Saini U, Chopra B, et al. UV-Visible Spectroscopy: A review on its pharmaceutical and bio-allied sciences applications. Current Pharmaceutical Analysis.2024;20(3):161-77. doi: https://doi.org/10.2174/0115734129300562240408042614
- Kedare SB, Singh RP. Genesis and development of DPPH method of antioxidant assay. J Food Sci Technol. 2011;48(4):412-22.
doi: https://doi.org/10.1007/s13197-011-0251-1
- Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. Кyiv: Medynform; 2018. 579 p. Ukrainian.
- Caloni F, De Angelis I, Hartung T. Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi. Arch Toxicol. 2022;96(7):1935-50.
doi: https://doi.org/10.1007/s00204-022-03299-x
- Han P, Li X, Yang J, et al. Advancing toxicity predictions: a review on in vitro to in vivo extrapolation in next-generation risk assessment. Environ Health (Wash). 2024;2(7):499-513. doi: https://doi.org/10.1021/envhealth.4c00043
- Trachtenberg IM, Dmytrukha NM. [Industrial toxicology: main directions, results and prospects of scientific activity]. Ukrainian journal of occupational health. 2019;15(2):87-101. doi: https://doi.org/10.33573/ujoh2019.02.087
- Croute F, Poinsot J, Gaubin Y, et al. Volatile organic compounds cytotoxicity and expression of HSP72, HSP90 and GRP78 stress proteins in cultured human cells. BiochimBiophys 2002;1591(1-3):147-55. doi: https://doi.org/10.1016/s0167-4889(02)00271-9
- Wu Sh, Li F, Wang M, et al. Cytotoxicity of eight organic solvents towards Balb/3T3 and 293T Cells. In: 5th International Conference on Bioinformatics and Biomedical Engineering. 2011. р. 1-4. doi: https://doi.org/10.1109/icbbe.2011.5781580
- Grzęda D, Węgrzyk G, Nowak A, et al. Cytotoxic properties of polyurethane foams for biomedical applications as a function of isocyanate index. Polymers. 2023;15(12):2754. doi: https://doi.org/10.3390/polym15122754
- Khan Z, Ali SA. Isocyanate induces cytotoxicity via activation of phosphorylated alpha synuclein protein, nitrosative stress, and apoptotic pathway in Parkinson's disease model-SHSY-5Y cells. Neurol Res. 2023;45(7):676-87. doi: https://doi.org/10.1080/01616412.2023.2181919
- Boyer JC, Taylor LW, Nylander-French LA. Viability of cultured human skin cells treated with 1,6-hexamethylene diisocyanate monomer and its oligomer isocyanurate in different culture media. Sci Rep. 2021;11:23804.
doi: https://doi.org/10.1038/s41598-021-02811-0
- Schuppe-Koistinen I. Molecular profiling and prediction of toxicity. ATLA. 2001;29(30):287-9.
- Hongzhao X, Qiaomei S, Wenjing W, et al. Study of conformational and functional changes caused by binding of environmental pollutant tonalide to human serum albumin. Chemosphere. 2021;270:129431. doi: https://doi.org/10.1016/j.chemosphere.2020.129431
- Peng J, Yu Zh, Yifan Zh, et al. Probing the toxic interactions between polyvinyl chloride microplastics and human serum albumin by multispectroscopic techniques. SciTotal 2020;734:139219. doi: https://doi.org/10.1016/j.scitotenv.2020.139219
- Shasha L, Long S, Mei S, et al. Influence of para-substituted benzaldehyde derivatives with different push/pull electron strength groups on the conformation of human serum albumin and toxicological effects in zebrafish. Int J Biol Macromol. 2024;266(1):131246. doi: https://doi.org/10.1016/j.ijbiomac.2024.131246
- Amal SA, Hussein Mohgah Sh, et al. Antioxidants in of shoe-makers exposed to organic solvents. Journal of Applied Sciences Research. 2008;4(9):1107-17.
- Gulcin I, Saleh H. DPPH radical scavenging assay. Processes. 2023;11(8):2248. doi: https://doi.org/10.3390/pr11082248
PDF
Look through: 
Authors and affiliations
Lototska-Dudyk U.B. Danylo Halytsky Lviv National Medical University, Lviv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-7587-8457
Kuzminov B.P. Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
https://orcid.org/0000-0002-8693-1046
Lototska L.B. Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
https://orcid.org/0000-0002-2690-1793
Klyuchivska O.Yu. Institute of cell biology of the NAS of Ukraine, Lviv, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-8657-5945
Stoika R.S. Institute of cell biology of the NAS of Ukraine, Lviv, Ukraine
https://orcid.org/0000-0001-5719-2187
Cite
Lototska-Dudyk U.B., Kuzminov B.P., Lototska L.B., Klyuchivska O.Yu., Stoika R.S. Search for biological mechanisms of toxic action of shoe glues: cell viability in vitro, albumin damage and free radical generation. Medicni perspektivi. 2025;30(2):212-221. DOI: https://doi.org/10.26641/2307-0404.2025.2.333689
Metrics
|
SOCIAL MEDICINE
|
Ozerniuk H.V., Balan O.S., Prokopenko O., Stasiuk Yu.M., Krupskyi O.P. The system of medical rehabilitation of the disabled people: experience of the leading EU and NATO countries
https://doi.org/10.26641/2307-0404.2025.2.333692
Abstract
Timeliness, purposefulness, patient centeredness, consistency, and continuity are the general principles of rehabilitation and the defining tasks of developed countries, especially in the context of ensuring the realization of the rights and opportunities of people with disabilities. The purpose of the study was to identify the features of medical rehabilitation systems for persons with disabilities in the leading EU and NATO countries that have experience in rehabilitating combatants and to substantiate proposals for improving the current system of medical rehabilitation in Ukraine. The study is based on the analysis of the conceptual principles of building rehabilitation systems in eight countries with developed democratic institutions, experience of military operations and belonging to classical models of social protection: Canada, France, Germany, Italy, Poland, Spain, the United Kingdom, the United States. The methods of comparative analysis, structural analysis, objectivity and consistency were used. The main results of the study are the identification of weaknesses of the Ukrainian medical rehabilitation system, such as fragmentation of service provision, lack of unified management coordination, insufficient information and uneven location of institutions. The advantages of foreign systems are analyzed: targeting medical rehabilitation, use of outsourcing, involvement of the community and volunteers, creation of competition between medical institutions, emphasis on mental rehabilitation, and use of sanatorium and resort facilities. It is proposed to create a single state body for coordinating medical services, develop a national roadmap for rehabilitation measures, encourage volunteers and expand the range of rehabilitation professions. The experience of the leading EU and NATO countries demonstrates the need for a systemic restructuring of medical rehabilitation in Ukraine through the introduction of modern approaches and methods aimed at improving the quality and accessibility of services. Successful implementation of foreign experience will create an effective national system capable of meeting the current challenges and needs of people with disabilities.
Key words: medical rehabilitation system, persons with disabilities, EU countries, NATO countries, war, peacekeeping operations
References
- Garg A, Skempes D, Bickenbach J. Legal and Regulatory Approaches to Rehabilitation Planning: A Concise Overview of Current Laws and Policies Addressing Access to Rehabilitation in Five European Countries. International Journal of Environmental Research and Public Health. 2020 Jun 18;17(12):4363. doi: https://doi.org/10.3390/ijerph17124363
- Barth CA, Wladis A, Blake C, Bhandarkar P, O’Sullivan C. Users of rehabilitation services in 14 countries and territories affected by conflict. 1988–2018. Bulletin of the World Health Organization. 2020 Jul 8;98(9):599-614. doi: https://doi.org/10.2471/blt.19.249060
- Iravani M, Riahi L, Abdi K, et al. A Comparative Study of the Rehabilitation Services Systems for People With Disabilities. Journal of Rehabilitation. 2021 Jan 1;21(4):544-63. doi:https://doi.org/10.32598/rj.21.4.3225.1
- Smarżewska D, Wereda WS, Jończyk JA. Assessment of the Health Care System in Poland and Other OECD Countries Using the Hellwig Method. International Journal of Environmental Research and Public Health. 2022 Dec 13;19(24):16733. doi: https://doi.org/10.3390/ijerph192416733
- Duarte Cuervo C. Conflicto armado, paz y terapia ocupacional en Colombia: recorridos y desafíos. Cadernos Brasileiros de Terapia Ocupacional. 2023;31(spe):e3514. doi: https://doi.org/10.1590/2526-8910.ctoao273435143
- Berlinets IA. [Foreign experience in the field of medical rehabilitation: prospects of use in Ukraine]. Derzhavne upravlinnya: udoskonalennya ta rozvytok [Internet]. 2019 Apr 25 [cited 2024 Sep 18];(4). Ukrainian. doi: https://doi.org/10.32702/2307-2156-2019.4.100 Available from: http://www.dy.nayka.com.ua/?op=1&z=1416
- Kondratenko OO. International experience in ensuring state social protection of war veterans. State and Regions [Internet]. 2018 [cited 2024 Sep 18];1(61):102-6. Available from: http://pa.stateandregions.zp.ua/eng/archive/1_2018/20.pdf
- Deshko L, Kostenko Y, Koval I, Mikhailina T, Oliinyk O. The right to health: Ukraine's international obligations and financial activity of public authorities in the context of reforming the national healthcare system. Georgian Med News [Internet]. 2020 Jul [cited 2024 Sep 18];1(304-305):177-82. Available from: https://pubmed.ncbi.nlm.nih.gov/32965271/
- Deshko L, Vasylchenko O, Sherbak I, Galai V, Medvid A. Ukraine's international liabilities on initiation of measures for public health protection and the role of local authorities in implementation of health care policy. Georgian Med News [Internet]. 2021 [cited 2024 Sep 18];(312):163-8. Available from: https://pubmed.ncbi.nlm.nih.gov/33964846/
- Thomson C, Mader M, Münchow F, Reifler J, Schoen H. European public opinion: united in supporting Ukraine divided on the future of NATO. International Affairs.2023 Nov 6;99(6):2485-500. doi: https://doi.org/10.1093/ia/iiad241
- Nazarko Y, Iliashko O, Kaminska N. Implementation of the right to health care in the countries of the European Union. Wiad Lek. 2019 [cited 2024 Sep 18];72(7):1337-42. doi: https://doi.org/10.36740/WLek201907120
- Ivanishyn-Hayduchok L, Shapovalova V, Shapovalov V. ICD-11: Organizational and Legal, Medical and Pharmaceutical, Social and Economic Issues of Implementation of the Program of State Guarantees of Medical Care in 2022 in Ukraine, based on The Fundamental Principles of the European Union. SSP Modern Pharmacy and Medicine. 2022 Jun 24;2(2):1-14. doi:https://doi.org/10.53933/sspmpm.v2i2.53
- Muliar G, Zhuravel Y, Muzyka A, Cherniak O, Kachynska M, Orlovska I. International and legal, regional and specialized medical standards in the health care sector: experience of Ukraine. Georgian medical news. 2022 Feb;323:167-74. PMID: 35271491
- Roser M, Ritchie H, Ortiz-Ospina E. Democracy index. Our World in Data [Internet]. 2024 May 22 [cited 2024 Sep 16]. Available from: https://ourworldindata.org/grapher/democracy-index-eiu?tab=table
- Latysheva O, Yevtushenko M, Pronin S, Budoviy M. Social Protection of the State: the Essence. Models and Features of Security. Herald of the Economic Sciences of Ukraine. 2020;2(39):95-104. doi: https://doi.org/10.37405/1729-7206.2020.2(39).95-104
- Melkonyan AG. Specificity and features of functioning of Western public governance models. Public Administration and Governance. 2020;15:11-5. doi: https://doi.org/10.32843/2663-5240-2020-15-2
- United Nations Office for Disaster Risk Reduction. 2023 Global Survey Report on Persons with Disabilities and Disasters [Internet]. 2023 Oct 11 [cited 2024 Sep 18]. Available from: https://reliefweb.int/report/world/2023-global-survey-report-persons-disabilities-and-disasters
- Alanazi AM, Almutairi AM, Aldhahi MI, Alotaibi TF, AbuNurah HY, Olayan LH, et al. The Intersection of Health Rehabilitation Services with Quality of Life in Saudi Arabia: Current Status and Future Needs, Healthcare. 2023 Jan 30;11(3):389. doi: https://doi.org/10.3390/healthcare11030389
- Frontera WR, DeGroote W, Ghaffar A, Axen I, Ehab Azim M, Battistella L, et al. Importance of Health Policy and Systems Research for Strengthening Rehabilitation in Health Systems: A Call to Action to Accelerate Progress. Advances in Rehabilitation Science and Practice [Internet]. 2023 Nov 23 [cited 2024 Sep 16];4. doi: https://doi.org/10.3389/fresc.2023.1303135
- United Nations. Convention on the Rights of Persons with Disabilities [Internet]. 2006 Dec 13 [cited 2024 Sep 16]. Available from: https://www.ohchr.org/en/instruments-mechanisms/instrumentsconvention-rights-personsdisabilities
- World Health Organization. Strengthening rehabilitation in health systems. Executive board. 152nd session EB152(10) [Internet]. 2023 Feb 2 [cited 2024 Sep 16]. Available from: https://apps.who.int/gb/ebwha/pdf_files/EB152/B152(10)-en.pdf
- World Health Organization. Strengthening rehabilitation in health systems. Seventy-sixth world health assembly WHA76.6 [Internet]. 2023 May 30 [cited 2024 Sep 16]. Available from: https://apps.who.int/gb/ebwha/pdf_files/WHA76/A76_R6-en.pdf
- Musenyente E, Han ML, Knigge M. Implementation of UN Convention on the Rights of Persons with Disabilities in public and private schools in three districts of Uganda. African Journal of Disability. 2022 Oct 27;11:908. doi: https://doi.org/10.4102/ajod.v11i0.908
- Fortune N, Madden RH, Clifton S. Health and Access to Health Services for People with Disability in Australia: Data and Data Gaps. International Journal of Environmental Research and Public Health. 2021 Nov 8;18(21):11705. doi: https://doi.org/10.3390/ijerph182111705
- Stavert J. The CRPD and mental health law reform in Scotland. International Journal of Law and Psychiatry. 2024 May;94:101991. doi: https://doi.org/10.1016/j.ijlp.2024.101991
- Ministry of Veterans Affairs of Ukraine. Analytical information based on data from the Ministry of Veterans Affairs of Ukraine [Internet]. 2022 [cited 2024 Sep 18]. Available from: https://data.mva.gov.ua/?fbclid=IwAR2OWnHkc9i1eRcNxWI4T6gvQz61X7A3tEqQP5-FOYeYoPcaq0EBNRyXSYI
- Ipatov AV, Moroz OM, Golik VA, Perepelychna RY, Khanyukova IY, Korobkin YI, et al. [Key indicators of disability and activities of medical-social expert commissions of Ukraine for 2015: analytical and informational reference book]. Dnipro: Accent PP; 2016. 162 p. Ukrainian.
- Ipatov AV, Moroz OM, Khanyukova IYa, et al. [Key indicators of disability and activities of medical and social expert commissions of Ukraine for 2018: analytical and informational reference book]. Dnipro: Accent PP; 2019. 180 p. Ukrainian.
- Ipatov AV, Moroz OM, Khanyukova IYa, Kuzmina LV, Ulyanova AM. [Key indicators of disability and activities of medical and social expert commissions of Ukraine for 2021: analytical and informational reference book]. Dnipro: Accent PP; 2022. 188 p. Ukrainian.
- Ipatov AV, Moroz OM, Khanyukova IuA, Gondulenko NO, Sanina NA, Ulyanova AM. [Key indicators of disability and activities of medical and social expert commissions of Ukraine for 2020: analytical and informational reference book]. Dnipro: Aktsent PP; 2021. 188 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook]. Kyiv; 2019. 123 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook for 2019]. Kyiv; 2020. 115 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook for 2020]. Kyiv; 2021. 121 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook for 2022]. Kyiv; 2023. 116 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook]. Kyiv; 2018. 121 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook]. Kyiv; 2017. 122 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook]. Kyiv; 2016. 124 p. Ukrainian.
- [Social Protection of the Population of Ukraine. Statistical Yearbook]. Kyiv; 2015. 124 p. Ukrainian.
- Shevchuk VI, Yavorovenko OB, Belyaeva NM, Kurylenko IV. Medical Rehabilitation System and Its Quality Control in Developed Countries of The World. Wiadomości 2020;73(9):2040-3. doi: https://doi.org/10.36740/wlek202009227
- Light Joints Physiotherapy. Military Rehabilitation: A Short UK Defense History [Internet]. 2022 Jun 21 [cited 2024 Sep 18]. Available from: https://www.linkedin.com/pulse/military-rehabilitation-short-uk-defence-history-
- Osborne A, McGill A, Kiernan MD. Pathways into Mental Health Services for UK Veterans [Internet]. 2021 Mar [cited 2024 Sep 18]. Available from: https://covenantfund.org.uk/wp-content/uploads/2021/03/2021-Pathways_into_Mental_Health_Services_for_UK_Veterans.pdf
- Aitken D, Kinane C. An Evaluation of Veteran-Led Peer Support Services for UK Veterans with Complex Mental Health Needs. Journal of Veterans Studies. 2024;10(1):76-84. doi: https://doi.org/10.21061/jvs.v10i1.480
- [Spanish Society of Rehabilitation and Physical Medicine (SERMEF). Inpatient rehabilitation care is one of the greatest shortcomings in the Spanish healthcare system]. [Internet]. 2024 Mar 23 [cited 2024 Sep 18]. Spanish. Available from: https://www.sermef.es/la-atencion-rehabilitadora-en-regimen-hospitalaria-es-una-de-las-mayores-carencias-de-la-sanidad-espanola/
- European Observatory on Health Systems and Policies. Spain: Country Health Profile 2023 [Internet]. 2023 [cited 2024 Sep 18]. Available from: https://eurohealthobservatory.who.int/publications/m/spain-country-health-profile-2023
- Citarella A, Sánchez Iglesias AI, González Ballester S, Gentil Gutiérrez AA, Maldonado Briegas JJ, Vicente Castro F, et al. Being disabled persons in Spain: policies, stakeholders and services. Revista INFAD de Psicología International Journal of Developmental and Educational Psychology. 2020 Jun 29;1(1):507-16. doi: https://doi.org/10.17060/ijodaep.2020.n1.v1.1869
- European Commission. Spain: Country Health Profile 2023 [Internet]. 2023 [cited 2024 Sep 17]. Available from: https://health.ec.europa.eu/document/download/2d9493b1-3e86-4d30-b603-1e6f6503284c_en?filename=2023_chp_es_english_0.pdf
- [Ministry of Defense. Order DEF/83/2016, of January 25, establishing the Office for Disability Assistance in the Armed Forces. Official State Gazette]. [Internet]. 2016 Feb 2 [cited 2024 Sep 18]. Spanish. Available from: https://www.boe.es/buscar/act.php?id=BOE-A-2016-955
- Ministerodella Salute. Riabilitazione [Internet]. Rome: Ministerodella Salute; 2024 [cited 2024 Sep 18]. Available from: https://www.salute.gov.it/portale/lea/dettaglioContenutiLea.jsp?lingua=italiano&id=4720&area=Lea&menu=ospedaliera
- General Inspectorate of Military Medical Services. Italian Republic. Military Medicine Worldwide [Internet]. 2024 Jan 31 [cited 2024 Sep 18]. Available from: https://military-medicine.com/almanac/67-italian-republic.html
- Caminsky NG, Wong EG. Trauma systems in Canada: striving for quality across an expansive landmass. Emergency and Critical Care Medicine. 2023 Sep;3(3):89-93. doi: https://doi.org/10.1097/ec9.0000000000000102
- Canadian Institute for Health Information. National Rehabilitation Reporting System Privacy Impact Assessment. 2022 [Internet]. 2022 [cited 2024 Sep 18]. Available from: https://www.cihi.ca/sites/default/files/document/national-rehab-reporting-system-pia-en.pdf
- Standing Committee on National Defense. Canadian Armed Forces Health Care and Transition Services [Internet]. 2023 Nov [cited 2024 Sep 18]. Available from: https://www.ourcommons.ca/Content/Committee/441/NDDN/Reports/RP12673550/nddnrp06/nddnrp06-e.pdf
- Tien H. The Canadian Forces trauma care system. Canadian Journal of Surgery. 2011 Dec 1;54(6):S112-7. doi: https://doi.org/10.1503/cjs.025311
- Gerdes N, Zwingmann C, Jäckel WH. The system of rehabilitation in Germany. Rehabilitation (Stuttg) [Internet]. 2001 [cited 2024 Sep 12];40(5):317-25. Available from: https://www.researchgate.net/publication/239572127_The_system_of_rehabilitation_in_Germany
- Perreau E. Financing of Care Services for Persons with Disabilities: Fact Sheet Germany. European Association of Service Providers for Persons with Disabilities [Internet]. 2020 [cited 2024 Sep 16]. Available from: https://easpd.eu/fileadmin/user_upload/Publications/EAS_008-21_factsheet_financing_care_services_DE_v2.pdf
- Rehabilitation for soldiers. REHACARE [Internet]. [cited 2024 Sep 16]. Available from: https://www.rehacare.com/en/business/rehabilitation-for-soldiers
- Kosycarz E. Rehabilitation in the Polish health system and its financing methods. Finance [Internet]. 2018 [cited2024 Sep 12];1(11):161-75. doi: https://doi.org/10.24425/finanse.2018.125398
- [National Health Fund. Annex No. 1: Description of the POZ PLUS pilot program. Białystok]. [Internet]. 2017 [cited 2024 Sep 16]. Polish. Available from: https://www.nfz-bialystok.pl/wp-content/uploads/2017/06/Zał.-1_Opispilotażu.docx
- Organisation for Economic Co-operation and Development (OECD). France. Country Health Profile 2023 [Internet]. 2023 Dec 15 [cited 2024 Sep 16].
Available from: https://www.oecd.org/en/publications/france-country-health-profile-2023_07c48f9f-en.html
- Centre des Liaisons Européennes et Internationales de SécuritéSociale (CLEISS). The French health care system [Internet]. 2021 [cited 2024 Sep 16]. Available from: https://www.cleiss.fr/particuliers/venir/soins/ue/systeme-de-sante-en-france_en.html
- [France Ministry of the Armed Forces. Order of December 20, 2021 on the organization of the armed forces health service]. [Internet]. 2021 Dec 20 [cited 2024 Sep 16]. French. Available from: https://www.legifrance.gouv.fr/jorf/id/JORFTEXT000044553939
- Smolinski G, Licina D. After the Trauma: The Role of Rehabilitation Medicine in U.S. DoD Global Health Engagement. Military Medicine. 2022 Oct 14;188(1-2):3-5. doi: https://doi.org/10.1093/milmed/usac302
- Number of veterans in the United States in 2022, by service-connected disability status [Internet]. 2024 [cited 2024 Sep 16]. Available from: https://www.statista.com/statistics/250316/us-veterans-by-disability-status/
- Kamenov K, Mills JA, Chatterji S, Cieza A. Needs and unmet needs for rehabilitation services: a scoping review. Disability and Rehabilitation. 2018 Jan 5;41(10):1227-37. doi: https://doi.org/10.1080/09638288.2017.1422036
- The Lancet. Prioritising disability in universal health coverage. The Lancet. 2019 Jul;394(10194):187. doi: https://doi.org/10.1016/s0140-6736(19)31638-1
- Negrini S, Kiekens C, Heinemann AW, Özçakar L, Frontera WR. Prioritizing people with disabilities implies furthering rehabilitation. The Lancet. 2020 Jan;395(10218):111. doi:https://doi.org/10.1016/s0140-6736(19)32623-6
- Bressi F, Rogliani R. Health policies and rehabilitation. Giornale Italiano di Medicina Riabilitativa [Internet]. 2023 Dec [cited 2024 Sep 16];39(4). Available from: https://springerhealthcare.it/mr/archivio/politiche-sanitarie-e-riabilitazione/
- World Population by Country in 2021 [Internet]. 2024 [cited 2024 Sep 16]. Available from: https://database.earth/population/by-country/2021
- Federal Statistical Office of Germany. Key table: Gross domestic product (GDP). current prices [Internet]. 2024 [cited 2024 Sep 16]. Available from: https://www.destatis.de/EN/Themes/Countries-Regions/International-Statistics/Data-Topic/Tables/BasicData_GDP.html
- World Bank. Current health expenditure (% of GDP) [Internet]. 2024 [cited 2024Sep 16]. Available from: https://data.worldbank.org/indicator/SH.XPD.CHEX.GD.ZS
- Hospital beds by function and type of care [Internet]. 2024 [cited 2024Sep 16]. Available from: https://ec.europa.eu/eurostat/databrowser/view/hlth_rs_bds1/bookmark/table?lang=en&bookmarkId=13462546-495b-4885-88e9-06087c90e3f4
- Community hospital beds per 1.000 U.S. population from 2000 to 2022 [Internet]. 2024 [cited 2024Sep 16]. Available from: https://www.statista.com/statistics/184546/community-hospital-beds-per-1000-population-in-the-us/
- Density of hospital beds in Canada from 1976 to 2021 [Internet]. 2024 [cited 2024Sep 16]. Available from: https://www.statista.com/statistics/831668/density-of-hospital-beds-canada/
- Number of hospital beds in the United Kingdom (UK) from 2000 to 2022 [Internet]. 2024 [cited 2024Sep 16]. Available from: https://www.statista.com/statistics/473264/number-of-hospital-beds-in-the-united-kingdom-uk/
- [Center for Medical Statistics of the Ministry of Health of Ukraine. Health indicators and utilization of healthcare resources in Ukraine (general). 2022]. [Internet]. 2022 [cited 2024Sep 16]. Ukrainian. Available from: http://medstat.gov.ua/im/upload/DOV_1_ZAG-2021.zip
- World Health Organization. Density of physicians (per 10 000 population) [Internet]. 2024 [cited 2024Sep 16]. Available from: https://data.who.int/indicators/i/CCCEBB2/217795A#disclaimer-maps
- Number of nurses per 1.000 inhabitants in selected countries worldwide [Internet]. 2024 [cited 2024Sep 16]. Available from: https://www.statista.com/statistics/283124/selected-countries-nurses-per-1-000-inhabitants/
- Statistics Canada. Canadian Survey on Disability. 2017 to 2022 [Internet]. 2023Dec 1 [cited 2024 Sep 16]. Available from: https://www150.statcan.gc.ca/n1/daily-quotidien/231201/dq231201b-eng.htm
- Disability in the U.S.: statistics and facts [Internet]. 2024 [cited 2024 Sep 16]. Available from: https://www.statista.com/topics/4380/disability-in-the-us/#topicOverview
- Kirk-WadeE, Stiebahl S, Wong UK disability statistics: prevalence and life experiences. House of Commons Library [Internet]. 2024 Oct 2 [cited 2024 Sep 16]. Available from: https://researchbriefings.files.parliament.uk/documents/CBP-9602/CBP-9602.pdf
- [Convention on the Rights of Persons with Disabilities]. [Internet]. 2006 [cited 2024Sep 16]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/995_g71#Text
- [Ministry of Health of Ukraine. International Classification of Functioning. Disability and Health (ICF)]. [Internet]. [cited 2024Jan 18]. Ukrainian. Available from: https://moz.gov.ua/uk/mkf
- PoliakovaO, Petrusha S, Bayda Analytical Report: Access to Rehabilitation Services for Adults and Children with Disabilities [Internet]. 2023 [cited 2024 Jan 18]. Ukrainian. Available from: https://naiu.org.ua/wp-content/uploads/2023/06/NAPD_2003_EN.pdf
- Nagoriyanskii Improvement of public administration of the medical rehabilitation system as an integral part of public health policy. Clinical and Preventive Medicine. 2021 Jun 25;(2):63-9. doi: https://doi.org/10.31612/2616-4868.2(16).2021.08
- RomaniukP, Semigina Ukrainian health care system and its chances for successful transition from Soviet legacies. Globalization and Health [Internet]. 2018 Nov 23;14(1):116. doi: https://doi.org/10.1186/s12992-018-0439-5
- HavlovskyOD, Holovanova IA, Khorosh MV, Tovstyak The importance of research on the dynamics of disability in Ukraine among the participants of the war to determine volume of medical assistance and rehabilitation. Clinical and Preventive Medicine. 2019 Oct 17;(3-4):22-30. doi: https://doi.org/10.31612/2616-4868.3(9).2019.03
- MarunychVV, Shevchuk VI, Yavorovenko [Methodological manual on rehabilitation of persons with disabilities. Manual]. Vinnytsia: O. Vlasiuk; 2006. 212 p. Ukrainian.
- StriukovVV, Grynko TV, Krupskyi OP, Vazov Current state and strategic directions of development of state management of nursing education in Ukraine. Medicni perspektivi. 2022 Mar 30;27(1):174-83. doi: https://doi.org/10.26641/2307-0404.2022.1.254469
- Parovyshnyk OV. [Ensuring the rights of persons with disabilities in Ukraine: theoretical and practical foundations of administrative and legal regulation]. Kharkiv: Pravo; 2016. 264 p.
- [Assessment of the system of disability limitation and rehabilitation in Ukraine. Summary of the WHO Consultative Mission Report – International Society of Physical and Rehabilitation Medicine]. Ukrainskyi Visnyk Medyko-Sotsialnoi Ekspertyzy [Internet]. 2016 [cited 2024 Feb 1];(1):21-5. Available from: http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?C21COM=2&I21DBN=UJRN&P21DBN=UJRN&IMAGE_FILE_DOWNLOAD=1&Image_file_name=PDF/ujmse_2016_1_8.pdf
- Bogdanov SG. [Government mechanism of organization of medical rehabilitation system in Ukraine]. Public Administration and Governance in Ukraine. 2020;(16):40-5. Ukrainian. doi: https://doi.org/10.32843/2663-5240- 2020-16-7
- National Health Service of Ukraine. Contracts for medical care under the program of medical guarantees [Internet]. 2024 Jan 5 [cited 2024 Feb 1]. Available from: https://edata.e-health.gov.ua/e-data/dashboard/pmg-contracts
- Analytical report on the provision of rehabilitation services for adults and children with disabilities. All-Ukrainian Public Association "National Assembly of People with Disabilities of Ukraine" within the project "Response and Recovery with the Needs of People with Disabilities under the Leadership and Coordination of Organizations of Persons with Disabilities", funded by the European Disability Forum and Christian Blind Mission (CBM) [Internet]. 2023 May 30 [cited 2024 Feb 1]. Available from: https://naiu.org.ua/wp-content/uploads/2023/07/2023_NAIU_AnaliticalReport-Rehabilitation_v02-1.pdf
PDF
Look through: 
Authors and affiliations
Ozerniuk H.V. Odesa Politechnic National University, Odesa, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-5030-6356
Balan O.S. Odesa Politechnic National University, Odesa, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Prokopenko O. Estonian Entrepreneurship University of Applied Sciences, Tallinn, Estonia e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-1362-478X
Stasiuk Yu.M. Oles Honchar Dnipro National University, Dnipro, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-6644-8658
Krupskyi O.P. Oles Honchar Dnipro National University, Dnipro, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-1086-9274
Cite
Ozerniuk H.V., Balan O.S., Prokopenko O., Stasiuk Yu.M., Krupskyi O.P. The system of medical rehabilitation of the disabled people: experience of the leading EU and NATO countries. Medicni perspektivi. 2025;30(2):222-234. DOI: https://doi.org/10.26641/2307-0404.2025.2.333692
Metrics
|
Kriachkova L.V., Simon K.I. Medico-social rationale for the development of digital personnel potential in healthcare
https://doi.org/10.26641/2307-0404.2025.2.333698
Abstract
The digital transformation of the healthcare system is a key factor in improving the efficiency of medical services and sector management. One of the critical aspects of this transformation is the development of digital workforce potential, which includes the formation and enhancement of digital competencies among healthcare professionals. The aim of the study was to provide a medical and social justification and develop a conceptual model for the development of the digital potential of healthcare personnel to improve the sector's operational efficiency. A comprehensive approach was applied in the research, including a sociological survey of 162 healthcare professionals (practicing physicians, managers, and researchers), an analysis of strategic documents, the conceptual modeling method, and statistical analysis using standard tests conducted via Jupyter Notebook (https://jupyter.org). The findings indicate that the overall self-assessed level of digital competencies among healthcare professionals is moderate – 2.63 (95% CI 2.53-2.74) on a 5-point scale – suggesting potential for further growth. The highest competency level was recorded in general digital literacy, while the lowest was in digital tools and applications. Statistically significant differences were identified (p<0.001), as well as a positive correlation between the level of digital skills and the awareness of their importance for professional activities. The study identified the key stages in the cycle of forming, developing, and consolidating digital competencies among healthcare personnel while building digital human resource potential in healthcare. The most important stakeholder groups were also highlighted, with the top three, as identified by respondents, being: the Ministry of Health, higher medical education institutions, and healthcare institutions. Other key stakeholders include healthcare professionals and patients. Among the measures for developing digital competencies in healthcare personnel, respondents rated infrastructure development as the most significant at the systemic and organizational levels (over 40% of top ratings). A conceptual model for the digital potential of healthcare personnel in the healthcare system has been proposed. This model could serve as a foundation for developing further strategies in this area and contribute to achieving the primary goal of the sector – improving public health.
Key words: efficiency of the health care system, digitalization, management, health workforce, competencies, conceptual model
References
- Robertsone G, Lapiņa I. Digital transformation as a catalyst for sustainability and open innovation. Journal of Open Innovation: Technology, Market, and Complexity. 2023 Mar 1;9(1):100017. doi: https://doi.org/10.1016/j.joitmc.2023.100017
- Odone A, Buttigieg S, Ricciardi W, Azzopardi-Muscat N, Staines A. Public health digitalization in Europe: EUPHA vision, action and role in digital public health. European Journal of Public Health. 2019 Oct 1;29(Suppl 3):28-35. doi: https://doi.org/10.1093/eurpub/ckz161
- Ziadlou D. Strategies during digital transformation to make progress in achievement of sustainable development by 2030. Leadership in Health Services. 2021 Jun 25;34(4):375-91. doi: https://doi.org/10.1108/LHS-08-2020-0056
- Trenerry B, Chng S, Wang Y, Suhaila ZS, Lim SS, Lu HY, et al. Preparing Workplaces for Digital Transformation: An Integrative Review and Framework of Multi-Level Factors. Frontiers in Psychology. 2021 Mar 23;12:620766. doi: https://doi.org/10.3389/fpsyg.2021.620766
- Golinelli D, Boetto E, Carullo G, Nuzzolese AG, Landini MP, Fantini MP. Adoption of Digital Technologies in Health Care During the COVID-19 Pandemic: Systematic Review of Early Scientific Literature. Journal of Medical Internet Research. 2020 Nov 6;22(11):e22280. doi: https://doi.org/10.2196/22280
- Health system performance assessment: A framework for policy analysis. Copenhagen (Denmark): European Observatory on Health Systems and Policies. [Internet]. 2022 [cited 2025 Jan 18]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK590192/
- Sharma A, Harrington RA, McClellan MB, Turakhia MP, Eapen ZJ, Steinhubl S, et al. Using Digital Health Technology to Better Generate Evidence and Deliver Evidence-Based Care. Journal of the American College of Cardiology. 2018 Jun 12;71(23):2680-90. doi: https://doi.org/10.1016/j.jacc.2018.03.523
- Avagyan A, Minasyan E, Khachatryan H, Gevorgyan S. Possible Process Optimization: Innovative Digital Health Implementation Models. In: Kozlakidis Z, Muradyan A, Sargsyan K, editors. Digitalization of Medicine in Low- and Middle-Income Countries: Paradigm Changes in Healthcare and Biomedical Research. Cham: Springer InternationalPublishing; p. 103-23. doi: https://doi.org/10.1007/978-3-031-62332-5_10
- Librarian I. Developing Competencies and Professional Standards for Health Promotion Capacity Building in Europe. The CompHP Project Handbooks [Internet]. [cited 2025 Jan 18]. Available from: https://www.hrhresourcecenter.org/node/4546.html
- Chukwu E, Mechael P, Edelman JK, Layer E. State of digital health 2023. Global Digital Health Monitor [Internet]. 2023 [cited 2025 Jan 18]. Available from: https://digitalhealthmonitor.org/stateofdigitalhealth23
- Long LA, Pariyo G, Kallander K. Digital Technologies for Health Workforce Development in Low- and Middle-Income Countries: A Scoping Review. Global Health: Science and Practice. 2018 Oct 10;6(Suppl 1):S41-S48. doi: https://doi.org/10.9745/GHSP-D-18-00167
- Brommeyer M, Liang Z. A Systematic Approach in Developing Management Workforce Readiness for Digital Health Transformation in Healthcare. International Journal of Environmental Research and Public Health. 2022 Jan;19(21):13843. doi: https://doi.org/10.3390/ijerph192113843
- Adeniran IA, Efunniyi CP, Osundare OS, Abhulimen AO. Data-driven decision-making in healthcare: Improving patient outcomes through predictive modeling. International Journal of Scholarly Research in Multidisciplinary Studies. 2024 Aug 30;5(1):059-67. doi: https://doi.org/10.56781/ijsrms.2024.5.1.0040
- Future of digital health systems: report on the WHO symposium on the future of digital health systems in the European region: Copenhagen, Denmark, 6-8 February 2019. World Health Organization. Regional Office for Europe [Internet]. 2019 [cited 2025 Jan 10]. Available from: https://iris.who.int/handle/10665/329032
- Digital Health in the European Region: the ongoing journey to commitment and transformation. World Health Organization. Regional Office for Europe [Internet]. 2023 [cited 2025 Mar 18]. Available from: https://iris.who.int/handle/10665/372051
- Rajan D, Rohrer K, Koch K, Kunjumen T, Diallo K, Berumen AV, et al. Health system performance assessment: A framework for policy analysis. European Observatory on Health Systems and Policies. Resource generation [Internet]. 2022 [cited 2025 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK590195/
- Data and digital health in the WHO European Region in 2023: a year in review. World Health Organization [Internet]. 2024 [cited 2025 Mar 18]. Available from: https://iris.who.int/handle/10665/375768
- Health and care workforce in Europe: time to act. World Health Organization. Regional Office for Europe. World Health Organization [Internet]. 2022 [cited 2025 Mar 18]. Available from: https://iris.who.int/handle/10665/362379
- Langins M, Borgermans L. Strengthening a competent health workforce for the provision of coordinated/integrated health services: working document [Internet]. 2015 [cited 2025 Jan 10]. Available from: https://iris.who.int/handle/10665/362099
- [Digital Competence Framework for Healthcare Workers of Ukraine. Version 1.0]. [Internet]. 2023 [cited 2025 Mar 18]. Ukrainian. Available from: https://cutt.ly/ue4RmmzV
- [On the Approval of Priority Directions for the Development of the Healthcare Sector for 2023-2025. Order Ministry of Health of Ukraine 2022 Oct 07 No. 1832]. Ministerstvo okhorony zdorovia Ukrainy [Internet]. 2022 [cited 2025 Jan 10]. Ukrainian. Available from: https://zakon.rada.gov.ua/go/v1832282-22
- [On the Approval of the Strategy for the Development of the Healthcare System Until 2030 and the Operational Action Plan for Its Implementation in 2025–2027. Ordinance Cabinet of Ministers of Ukraine of 2025 Jan 17 No. 34-r, Kyiv]. [Internet]. 2025 [cited 2025 Jan 10]. Ukrainian. Available from: https://www.kmu.gov.ua/npas/pro-skhvalennia-stratehii-rozvytku-systemy-okhorony-zdorovia-na-period-do-2030-roku-ta-zatverdzhennia-operatsiinoho-planu-zakhodiv-z-ii-realizatsii-u-20252027-rokakh-34r-170125
- Saigí-Rubió F, Romeu T, Encuentra EH, Guitert M, Andrés E, Reixach E. Design, Implementation, and Analysis of an Assessment and Accreditation Model to Evaluate a Digital Competence Framework for Health Professi onals: Mixed Methods Study. JMIR Medical Education.2024 Oct 17;10(1):e53462. doi: https://doi.org/10.2196/53462
- Hautz SC, Hoffmann M, Exadaktylos AK, Hautz WE, Sauter TC. Digital competencies in medical education in Switzerland: an overview of the current situation. GMS Journal for Medical Education. 2020 Nov 16;37(6):Doc62. doi: https://doi.org/10.3205/zma001355
- Simon KI, Kriachkova LV, Zakharov SV, Zaitsev VV. [Using digital competencies to develop leadership and management potential in higher medical education students]. Klinichna ta profilaktychna medytsyna. 2024 May 8;(3):115-24. Ukrainian. doi: https://doi.org/10.31612/2616-4868.3.2024.14
- Kriachkova LV, Simon KI, Borvinko EV, Semenova LS. [Using digital competencies to develop leadership and management potential in higher medical education students]. Klinichna ta profilaktychna medytsyna. 2022;2(20):73-80. doi: https://doi.org/10.31612/2616-4868.2(20).2022.09
- Kriachkova LV, Korobko MIu. [Involvement of different stakeholder groups in ensuring children’s dental public health: analysis and perspectives]. Klinichna ta profilaktychna medytsyna. 2024 Mar 15;(1):79-86. Ukrainian. doi: https://doi.org/10.31612/2616-4868.1.2024.10
- Lang TA, Secic M. How to Report Statistics in Medicine: Annotated Guidelines for Authors , Editors, and Reviewers. ACP Press; 2006. 512 p.
- Mainz A, Nitsche J, Weirauch V, Meister S. Measuring the Digital Competence of Health Professionals: Scoping Review. JMIR Medical Education. 2024 Mar 29;10:e55737. doi: https://doi.org/10.2196/55737
- Mauro M, Noto G, Prenestini A, Sarto F. Digital transformation in healthcare: Assessing the role of digital technologies for managerial support processes. Technological Forecasting and Social Change. 2024 Dec 1;209:123781. doi: https://doi.org/10.1016/j.techfore.2024.123781
- Stoumpos AI, Kitsios F, Talias MA. Digital Transformation in Healthcare: Technology Acceptance and Its Applications. International Journal of Environmental Research and Public Health. 2023 Feb 15;20(4):3407. doi: https://doi.org/10.3390/ijerph20043407
- Zettelmann A, Cano JA. How Change Management Activates Digital Transformation in Healthcare [Internet]. HealthManagement.org. 2024 May 24 [cited 2025 Mar 18];24(2):101-3. Available from: https://healthmanagement.org/c/healthmanagement/IssueArticle/how-change-management-activates-digital-transformation-in-healthcare
- Global strategy on digital health 2020-2025. World Health Organization [Internet]. 2021 [cited 2025 Mar 18]. 50 p. Available from: https://www.who.int/publications/i/item/9789240020924
- Konopik J, Blunck D. Development of an Evidence-Based Conceptual Model of the Health Care Sector Under Digital Transformation: Integrative Review. Journal of Medical Internet Research. 2023 Jun 8;25:e41512. doi: https://doi.org/10.2196/41512
- Abernethy A, Adams L, Barrett M, et al. The Promise of Digital Health: Then, Now, and the Future. NAM Perspectives.2022 Jun 27;2022:10.31478/202206e. doi: https://doi.org/10.31478/202206e
- [About the approval of the plan for approaching the implementation of the concept for the development of electronic health care. Cabinet of Ministers of Ukraine. Order of 2021 Sept 29, No. 1175-r, Kyiv]. [Internet]. 2021 [cited 2025 Mar 18]. Ukrainian. Available from: https://zakon.rada.gov.ua/go/1175-2021-р
- Bonny S, Cahlikova T. Evaluating the effects of collaborative governance: Case of a digital education project. Evaluation and Program Planning. 2024 Nov 30;109:102522. doi: https://doi.org/10.1016/j.evalprogplan.2024.102522
- Tortorella GL, Fogliatto FS, Espôsto KF, Mac Cawley AF, Vassolo R, Tlapa D, et al. Healthcare costs’ reduction through the integration of Healthcare 4.0 technologies in developing economies. Total Quality Management & Business Excellence. 2022 Feb 17;33(3-4):467-87.
doi: https://doi.org/10.1080/14783363.2020.1861934
- Kakale MA. Of digital transformation in the healthcare (systematic review of the current state of the literature). Health and Technology. 2024 Jan 1;14(1):35-50. doi: https://doi.org/10.1007/s12553-023-00803-w
- Canfell OJ, Woods L, Meshkat Y, Krivit J, Gunashanhar B, Slade C, et al. The Impact of Digital Hospitals on Patient and Clinician Experience: Systematic Review and Qualitative Evidence Synthesis. Journal of Medical Internet Research. 2024 Mar 11;26:e47715. doi: https://doi.org/10.2196/47715
- Simon KI. [Approaches to Assessing the Compliance of Healthcare Institution Websites with Modern Digital Standards]. Intermedical journal. 2024 Nov 28;(2):161-6.
doi: https://doi.org/10.32782/2786-7684/2024-2-28
- Alanazi AT. Digital Leadership: Attributes of Modern Healthcare Leaders. Cureus. 2022 Feb 7;14(2):e21969. doi: https://doi.org/10.7759/cureus.21969
PDF
Look through: 
Authors and affiliations
Cite
Metrics
|
Vlasenko I.O., Gladyshev V.V., Zaliska О.M., Davtian L.L. Study of affordability of pharmaceutical provision for type 2 diabetes therapy in Ukraine
https://doi.org/10.26641/2307-0404.2025.2.333711
Abstract
Increasing the availability and affordability of medical and pharmaceutical care to the population is the most important task of all levels of government. The purpose of the work is to study the affordability of glucose-lowering drugs for the treatment of type 2 diabetes in Ukraine. Research materials are: State Register of Medicinal Products and price of glucose-lowering drugs. Marketing, analytical, graphic and pharmacoeconomic analysis were used. On the pharmaceutical market of Ukraine 161 glucose-lowering drugs are registered, which contain 16 international non-proprietary names and 8 international non-proprietary names combinations. It was established that the cost of Defined Daily Dose for mono glucose-lowering drugs varies from UAH 1,1 for glibenclamide up to UAH 90,7 for liraglutide. Most of the Ukrainian-made and foreign drugs are highly affordable, but foreign preparations of modern groups are moderately affordable, only one foreign drug, Liraglutide, is unaffordable ratio. But the analysis of affovailability for pensioners only metformin (Ukrainian production), glibenclamide, gliclazide, and glimepiride are highly affordable, three of which are already subject to reimbursement. Modern glucose-lowering drugs, both of foreign and Ukrainian production, is scarcely affordable, which makes it practically impossible to use them in the majority of retirees with diabetes. Thus, the analysis showed that in order to implement modern treatment schemes for type 2 diabetes, which according to the current legislation can be used in Ukraine, it is necessary to expand the list of glucose-lowering drugs included in the reimbursement program. This will improve treatment results, which in turn will reduce the development of diabetes complications and improve the quality of life of patients.
Key words: affordability, diabetes melitus, glucose-lowering drugs, reimbursement, solvency adequacy ratio, pharmacoeconomic research
References
- Diabetes Atlas. International diabetes federation. 10th edition [Internet]. [cited 2024 Mar 01]. Available from:http://www.diabetesatlas.org
- Ozawa S, Higgins CR, Yemeke TT, Nwokike JI, Evans L, Hajjou M, et al. Importance of medicine quality in achieving universal health coverage. PLoS One. 2020;15(7):e0232966. doi: https://doi.org/10.1371/journal.pone.0232966
- Huang Y, Jiang Y, Zhang L, Mao W, van Boven JFM, Postma MJ, et al. Availability, use, and affordability of medicines in urban China under universal health coverage: an empirical study in Hangzhou and Baoji. BMC healthservices 2018;18(1):218. doi: https://doi.org/10.1186/s12913-018-2993-1
- Onarheim KH, Sisay MM, Gizaw M, Moland KM, Norheim OF, Miljeteig I. Selling my sheep to pay for medicines-household priorities and coping strategies in a setting without universal health coverage. BMC health services research. 2018;18(1):153. doi: https://doi.org/10.1186/s12913-018-2943-y
- Chow CK, Ramasundarahettige C, Hu W, Alhabib K, Avezum A, Cheng X, et al. Availability and affordability of essential medicines for diabetes across high-income, middle-income, and low-income countries: A prospective epidemiological study. Lancet Diabetes Endocrinol.2018;6:798-808. doi: https://doi.org/10.1016/S2213-8587(18)30233-X
- Nguyen TN, Yusuf S, Chow CK. Availability and Affordability of Medicines for Diabetes and Cardiovascular Disease across Countries: Information Learned from the Prospective Urban Rural Epidemiological Study. Diabetology.2022;3(1):236-45. doi: https://doi.org/10.3390/diabetology3010014
- Nemchenko A, Nazarkyna V. [Improvement of modern approaches to reference pricing for insulin preparations]. Farmatsevtychnyi zhurnal. 2020;5:23-33. Ukrainian. doi: https://doi.org/32352/0367-3057.5.20.03
- Chumak І. [Intensification of therapyof type 2 diabetes according to modern guidelines]. Diabetology, Thyroidology, Metabolic disorders. 2021;1:53. Ukrainian.
- [Solvency adequacy ratio]. [Internet]. [cited 2024 Mar 01]. Ukrainian. Available from: https://www.pharmencyclopedia.com.ua/article/8076/koeficiyent-adekvatnosti-platospromozhnosti
- Zaliska O, Maksymovych N, Zabolotnya Z, Zalisky B. [Analysis of the list and availability of medicines used for the treatment of atopic dermatitis in Ukraine]. Farmatsevtychnyi Zhurnal. 2022;77(2):25-37. Ukrainian. doi: https://doi.org/10.32352/0367-3057.2.22.03
- Yakovleva L, Matyashova N, Stalna O. [Analysis of the assortment and economic availability of means affecting the structure and mineralization of bones presented on the pharmaceutical market of Ukraine]. Farmatsevtychnyi Zhurnal.2018;1-2:5-11. Ukrainian. doi: https://doi.org/10.32352/0367-3057.1-2.18.01
- [Analysis of the treatment system and calculation of economic losses from diabetes in Ukraine]. Kyiv; 2020. 30 p. Ukrainian.
- Chekman IS, Bondur VV, Klymenko OV. [Combined pharmacotherapy of type 2 diabetes]. Ratsionalna farmakoterapiia. 2016;2(39):25-31. Ukrainian.
- American Diabetes Association. Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(1):S1-S2. doi: https://doi.org/10.2337/dc21-Sint
- Kovalevska IV, Ruban OA, Yevtushenko OM. [Researches of the assortment of drugs for the treatment of diabetes II type оn the pharmaceutical market of Ukraine]. Farmatsevtychnyi Zhurnal. 2019;2:13-23. Ukrainian. doi: https://doi.org/10.32352/0367-3057.2.19.02
- American Diabetes Association. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes. Diabetes 2022;45(1):125-43. doi: https://doi.org/10.2337/dc22-S009
- [On approval of the list of medicines and medical products for free and (or) discounted outpatient provision of certain categories of citizens of the Republic of Kazakhstan with certain diseases (conditions)]. [Internet]. [cited 2024 Mar 01]. Kazakh. Available from: https://adilet.zan.kz/kaz/docs/V2100023885
PDF
Look through: 
Authors and affiliations
Vlasenko I.O. Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-5530-4189
Gladyshev V.V. Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-5935-4856
Zaliska О.M. Danylo Halytsky Lviv National Medical University, Lviv, Ukraine е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-1845-7909
Davtian L.L. Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
https://orcid.org/0000-0001-7827-2418
Cite
Vlasenko I.O., Gladyshev V.V., Zaliska О.M., Davtian L.L. Study of affordability of pharmaceutical provision for type 2 diabetes therapy in Ukraine. Medicni perspektivi. 2025;30(2):247-254. DOI: https://doi.org/10.26641/2307-0404.2025.2.333711
Metrics
|
Sharashenidze A., Cherniavskyi B., Buleishvili M., Sanikidze T., Krasnikova N. Remediation strategies and systemic improvements in health care after COVID-19: an analysis of international practices in hospital financing
https://doi.org/10.26641/2307-0404.2025.2.333807
Abstract
During the coronavirus pandemic, health care systems worldwide encountered serious challenges. Many patients were hospitalized, and hospital sectors in numerous countries struggled to handle the crisis. The pandemic caused disruptions in health care delivery and heavily impacted hospital financing. The financial sustainability of hospitals differed among countries, depending on reliance on outpatient and elective services and other features. These gaps drove health organizations to develop new crisis management plans. This review analyzed changes in hospital financing during the pandemic in Poland, Bulgaria, the Czech Republic, Slovakia, Estonia, Latvia, Lithuania, and Georgia. We selected typical post-socialist nations in Central Europe that share similar geopolitical contexts and membership in the European Union, transitioning from centrally planned to market economies with distinct health financing models, as well as Georgia, which aims to become a member of the European Union. The aim of the present study is a comprehensive analysis of international practices of hospital sector financing under the conditions of the COVID-19 pandemic, based on a comparative analysis of crisis response mechanisms in eight countries, with an emphasis on identifying effective remediation strategies and systemic healthcare improvements in the context of financial sustainability, digitalization, and integration into the public health system. Comparing these countries reveals how they adapted to pandemic pressures, employed financial regulations, and addressed challenges, offering insights for similar health systems worldwide. The analysis indicates that the strength and structure of a country’s health financing, especially having an established diagnosis-related group system and comprehensive public health insurance, were crucial for managing the pandemic. Countries with robust systems, such as the Czech Republic, Poland, and Estonia, had better capacity to mobilize resources, adjust funding mechanisms, and support hospitals and staff. In contrast, countries with less well-funded structures, including Bulgaria, Latvia, and Georgia, experienced greater obstacles in their pandemic responses. Remediation of the public health sector within socio-ecological and socio-economic frameworks is essential. It covers a wide spectrum of pressing issues, proposing integrated solutions that safeguard health and improve social and environmental living conditions.
Key words: COVID-19 pandemic, health financing system, financial sustainability, public health sector, remediation, health development strategy
References
- COVID-19: Impact of the pandemic on healthcare delivery. The third of five BMA reports. [Internet]. 2024 Sep 18 [cited 2025 Jan 14]. Available from: https://www.bma.org.uk/advice-and-support/covid-19/what-the-bma-is-doing/covid-19-impact-of-the-pandemic-on-healthcare-delivery#heading_bc72014323af4e31990d37ce4b3cef63
- Haldane V, De Foo C, Abdalla SM, et al. Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries. Nat Med. 2021;27:964-80. doi: https://doi.org/10.1038/s41591-021-01381-y
- Pujolar G, Oliver-Anglès A, Vargas I, Vázquez ML. Changes in Access to Health Services during the COVID-19 Pandemic: A Scoping Review. Int J Environ ResPublic 2022;19(3):1749. doi: https://doi.org/10.3390/ijerph19031749
- Ranney ML, Griffeth V, Jha AK. Critical supply shortages – The need for ventilators and personal protective equipment during the COVID-19 pandemic. N EnglJ 2020;382:1181-3. doi: https://doi.org/10.1056/NEJMp2006141
- Benatar M, Fregonese F, Muiruri C. COVID-19-related healthcare impacts: An uncontrolled, segmented time-series analysis of tuberculosis diagnosis services in Mozambique, 2017-2020. BMJ Glob Health. 2022;7(4):e007878. doi: https://doi.org/10.1136/bmjgh-2021-007878
- Lippi G, Plebani M. The Critical Role of Laboratory Medicine during Coronavirus Disease 2019 (COVID-19) and Other Viral Outbreaks. Clinical Chemistry and Laboratory 2020;58:1063-9. doi: https://doi.org/10.1515/cclm-2020-0240
- Paltiel AD, Zheng A, Zheng A. Assessment of SARS-CoV-2screening strategies. JAMA. 2020;324(2):140-1. doi: https://doi.org/10.1001/jamanetworkopen.2020.16818
- Cohen J, van der Meulen Rodgers Y. Contributing factors to personal protective equipment shortages during the COVID-19 pandemic. Prev Med. 2020;141:106263. doi: https://doi.org/10.1016/j.ypmed.2020.106263
- Kaye AD, Okeagu CN, Pham AD, Silva RA, Hurley JJ, Arron BL, et al. Economic impact of COVID-19 pandemic on healthcare facilities and systems: International perspectives. Best Pract Res Clin Anaesthesiol. 2021;35(3):293-306. doi: https://doi.org/10.1016/j.bpa.2020.11.009
- Khullar D, Bond AM, Schpero WL. COVID-19 and the financial health of US hospitals. JAMA. 2020;323(21):2127. doi: https://doi.org/10.1001/jama.2020.6269
- Sharashenidze A. Analysis of COVID-19 Hospital Services Financing Practices (Based on the Examples of Austria and Germany) (in Georgian). Economics. 2022;105(03):159-64. doi: https://doi.org/10.36962/ecs105/3/2022-159
- Bambra C, Riordan R, Ford J, Matthews F. The COVID-19 pandemic and health inequalities. J Epidemiol Community 2020 Nov;74(11):964-8. doi: https://doi.org/10.1136/jech-2020-214401
- Ala A, Wilder J, Jonassaint NL, Coffin CS, Brady C, Reynolds A, et al. COVID-19 and the Uncovering of Health Care Disparities in the United States, United Kingdom and Canada: Call to Action. Hepatol Commun. 2021 Oct;5(10):1791-800. doi: https://doi.org/10.1002/hep4.1790
- Miszczyńska K, Miszczynski PM. Measuring the efficiency of the healthcare sector in Poland–a window-DEA evaluation. Int J Prod Perform Manag. 2021;71(7):2743-70. doi:https://doi.org/10.1108/IJPPM-06-2020-0276
- Łyszczarz B, Abdi Z. Factors Associated with Out-of-Pocket Health Expenditure in Polish Regions. Healthcare(Basel). 2021;9(12):1750. doi: https://doi.org/10.3390/healthcare9121750
- Global Health Expenditure Database [Internet]. 2023 Apr 03 [cited 2025 Jan 14]. Available from: https://ghdx.healthdata.org/record/who-global-health-expenditure-database
- European Commission [Internet]. 2020 Jan 29 [cited2025 Jan 14]. Available from: https://ec.europa.eu/commission/presscorner/detail/en/ip_20_124
- Sowada C, Sagan A, Kowalska-Bobko I, Maretso A. Poland: Health system summary. WHO [Internet]. 2022 [cited 2025 Jan 14]. Available from:https://iris.who.int/bitstream/handle/10665/365287/9789289059275-eng.pdf?sequence=1
- European Commission. State of Health in the EU: Poland country health profile 2020 [Internet]. 2023 [cited 2025 Jan 14].Available from: https://ec.europa.eu/health/state/country_profiles_en
- Krzeczewski B, Hassan C. Health models – Financing and effects: A comparative study of the models in Poland and Italy. Finanse i Prawo Finansowe [Internet]. 2024 Feb 27 [cited 2025 Jan 14]. Available from: https://api.semanticscholar.org/CorpusID:268138098
- Czechia – Public Health – European Commission [Internet]. 2023 [cited 2025 Jan 14]. Available from: https://ec.europa.eu/health/state/country_profiles_en
- Health at a Glance 2021: OECD Indicators. OECD Publishing, Paris [Internet]. 2021 Nov 9 [cited 2025 Jan 14]. Availablefrom: https://www.oecd.org/en/publications/health-at-a-glance-2021_ae3016b9-en.html
- Bryndová L, Šlegerová L, Votápková J, Hrobon P, Shuftan N, Spranger A. Czechia: Health System Review. Health Syst Transit. 2023 Mar;25(1):1-216.
- World Health Organization. World health statistics 2023: Monitoring health for the SDGs, Sustainable Development Goals [Internet]. 2023 May 19 [cited 2025 Jan 14].Available from: https://www.who.int/publications/i/item/9789240074323
- Country Health Profiles 2023. OECD [Internet]. 2024 Feb 06 [cited 2025 Jan 14]. Available from: https://web-archive.oecd.org/temp/2024-02-06/455310-country-health-profiles-eu.htm
- Ministry of Health of the Slovak Republic [Internet]. [cited 2025 Jan 14]. Available from: https://www.health.gov.sk/?minister-of-health-eng-verzia
- Dimova A, Rohova M, Koeva S, Atanasova E, Koeva-Dimitrova L, Kostadinova T, et al. Bulgaria: Health System Summary. WHO Regional Office for Europe [Internet]. 2022 Jul [cited 2025 Jan 14]. Available from: https://iris.who.int/handle/10665/365286
- OECD Economics Outlook. Volume 2023, Issue 1. A long unwinding road. OECD [Internet]. 2023 Jun 07 [cited 2025 Jan 14]. Available from: https://www.oecd.org/en/publications/oecd-economic-outlook/volume-2023/issue-1_ce188438-en.html
- Living and working in Europe 2021 [Internet]. 2022 May 09 [cited 2025 Jan 14]. Available from: https://www.eurofound.europa.eu/en/publications/2022/living-and-working-europe-2021
- World Health Organization. Out-of-pocket spending on health in Europe: Monitoring policies and progress [Internet]. 2024 [cited 2025 Jan 14]. Available from: https://gateway.euro.who.int/en/indicators/h2020_29-out-of-pocket-expenditures/#id=17097
- World Health Organization. European Health Information Gateway. Bulgaria – statistical data [Internet].2024 [cited 2025 Jan 14]. Available from: https://gateway.euro.who.int/en/country-profiles/bulgaria/
- Behmane D, Dudele A, Villerusa A, Misins J, Klavina K, Mozgis D, et al. Latvia: Health system review. Health Syst Transit. 2019;21(4):1-165. PMID: 32863240.
- World Bank. Georgia: Health sector reform [Internet]. 2022 [cited 2025 Jan 14]. Available from:https://documents1.worldbank.org/curated/en/099802505242216398/pdf/IDU07bfac40d035c20431a0bc1b0755ced4057df.pdf
- TBC Capital. Overview of Healthcare sector in Georgia [Internet]. 2023 Jul [cited 2025 Jan 14]. Available from:https://tbccapital.ge/static/file/202307072806-healthcare-eng.pdf
- Indicators of Health Care, 2022. Geostat [Internet]. 2022[cited 2025 Jan 14]. Available from: https://www.geostat.ge/en/single-news/2900/indicators-of-health-care-2022
- COVID-19 Health System Response. WHO EUROHEALTH [Internet]. 2020 [cited 2025 Jan 14]. Availablefrom: https://iris.who.int/bitstream/handle/10665/336263/Eurohealth-26-2-2020-eng.pdf?sequence=1
- Sastry S, Basu A. How to Have (Critical) Method in a Pandemic: Outlining a Culture-Centered Approach to Health Discourse Analysis. Frontiers in Communication[Internet]. 2020 Oct [cited 2025 Jan 14];14;5. doi: https://doi.org/10.3389/fcomm.2020.585954
- Balan O, Shepel M, Savelich L. Healthcare Institution Manager’s Deontological Culture as a Component of the Professional Image. Economics: time realities. 2022 Dec 27;6(64):14-24. doi: https://doi.org/10.15276/etr.06.2022.2
- Vazov R, Kanazireva R, Grynko TV, Krupskyi OP. Strategies for Healthcare Disaster Management in the Context of Technology Innovation: the Case of Bulgaria. Medychni perspektyvy. 2024 Jun 28;29(2):215-28. doi: https://doi.org/10.26641/2307-0404.2024.2.307703
- Krishnan K, Lin Y, Prewitt KRM, Potter DA. Multidisciplinary Approach to Brain Fog and Related Persisting Symptoms Post COVID-19. Journal of Health Service 2022 Feb;48(1):31-8. doi: https://doi.org/10.1007/s42843-022-00056-7
- Intraprise Health. 5 steps to creating a healthcare risk remediation plan [Internet]. [cited 2025 Jan 14]. Available from: https://intraprisehealth.com
- Lypynska O, Sviridova S, Balan O. The quality of providing medical services through the prism of management decisions. Economic journal Odessa polytechnic 2023 Aug 30;3(25):119-26. doi: https://doi.org/10.15276/ej.03.2023.13
- Chakraborty S, Raut RD, Rofin TM, Chakraborty S. A comprehensive and systematic review of multi-criteria decision-making methods and applications in healthcare. Healthcare Analytics. 2023 Dec;4:100232. doi: https://doi.org/10.1016/j.health.2023.100232
- Cherniavska T, Cherniavskyi B, Sanikidze T, Sharashenidze A, Tortladze M, Buleishvili M. Optimization of medical logistics with bee colony algorithms in emergency, military conflict and post-war remediation settings [Internet]. In: Shakhovska N, Jiao J, Izonin I, Chretien S, editors. Proceedings of the 7th International Conference on Informatics & Data-Driven Medicine (IDDM 2024); 2024 Nov 14-16; Birmingham, United Kingdom. Aachen: CEUR-WS.org; 2024 [cited 2025 Apr 16]. p. 220-235. Available from: https://ceur-ws.org/Vol-3892/paper16.pdf
- Cherniavska T, Cherniavskyi B. Architecture-Oriented Agent-Based Model (AOAM) for Optimizing Transport Evacuation Management and Emergency Medical Assistance in the Context of the War in Ukraine: Challenges and Prospects [Internet]. In: Shakhovska N, Jiao J, Izonin I, Chretien S, editors. Proceedings of the 7th International Conference on Informatics & Data-Driven Medicine (IDDM 2024); 2024 Nov 14-16; Birmingham, United Kingdom. Aachen: CEUR-WS.org; 2024 [cited 2025 Apr 16]. p. 319-336. Available from: https://ceur-ws.org/Vol-3892/paper21.pdf
PDF
Look through: 
Authors and affiliations
Sharashenidze A. Georgian Technical University, Tbilisi, Georgia e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
http://orcid.org/0009-0008-8289-1850
Cherniavskyi B. University of Applied Science in Konin, Konin, Poland e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
http://orcid.org/0000-0001-9174-6139
Buleishvili M. European University, Tbilisi, Georgia e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0009-0004-2657-8473
Sanikidze T. Tbilisi State Medical University, Tbilisi, Georgia e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
http://orcid.org/0000-0003-1618-5276
Krasnikova N. Oles Honchar Dnipro National University, Dnipro, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-6484-2050
Cite
Sharashenidze A., Cherniavskyi B., Buleishvili M., Sanikidze T., Krasnikova N. Remediation strategies and systemic improvements in health care after COVID-19: an analysis of international practices in hospital financing. Medicni perspektivi. 2025;30(2):255-271. DOI: https://doi.org/10.26641/2307-0404.2025.2.333807
Metrics
|
A CASE FROM PRACTICE
|
Romaniuk T.V., Moroz V.S. Lekan R.Io. Pseudoaneurysm of the thoracic aorta (clinical case)
https://doi.org/10.26641/2307-0404.2025.2.333827
Abstract
The purpose of the work is to publicize a complex clinical case of the disease – pseudoaneurysm of the thoracic aorta, based on the results of the patient's examination and treatment. Analysis of surgical treatment tactics, description of applied surgical techniques during radical surgery, the results of a clinical study of a patient with a thoracic aortic pseudoaneurysm are presented. For this purpose, echocardioscopy, coronary angiography, contrast-enhanced computed tomography, general clinical laboratory tests, and microbiological examination of biological fluids and tissues were used. Based on the diagnostic data, the primary clinical diagnosis was established: Ischemic heart disease. Stable angina pectoris, functional class III, post-infarction cardiosclerosis with hypokinesis of the posterior wall of the middle and basal segments of the left ventricle. Polytopic supraventricular extrasystole of the type of bigeminia and trigeminia. Hypertensive disease of the 2nd stage, 3rd stage. Thoracic aortic aneurysm. CHF IIa stage. A clinical case of surgical treatment of thoracic aortic pseudoaneurysm is described: the course of primary surgical treatment of thoracic aortic aneurysm (Supracoronary prosthesis of the ascending aorta, aortic valve revision. CABG (Ao-PDA) in conditions of artificial blood circulation), postoperative observation, as well as the prerequisites for the occurrence of thoracic aortic pseudoaneurysm. The course of this complication is directly described, with a description of the course of surgical treatment: Resternotomy. Elimination of prosthetic pseudoaneurysm of the ascending aorta. Plastic surgery of the distal anastomosis and plastic surgery of a linear rupture of the right ventricle in conditions of complete circulatory arrest (18°C, 38 min.), as well as the features of the postoperative period after it. Conclusions have been made that may help prevent the occurrence of thoracic aortic pseudoaneurysm and treat it more effectively. In particular, its infection was established as a factor in the cause of the defect of the distal anastomosis of the prosthesis. The described surgical technical method of peripheral cannulation with artificial blood circulation, with heart drainage, with cold arrest up to 18°C, within 38 minutes allowed to quickly localize the pseudoaneurysm of the thoracic aorta, bleeding from the defect of the distal anastomosis of the prosthesis, which occurred during resternotomy; to perform the main stage of surgical intervention – elimination of prosthetic pseudoaneurysm of the ascending aorta, plastic surgery of the distal anastomosis and plastic surgery of the linear rupture of the right ventricle.
Key words: pseudoaneurysm of the thoracic aorta, surgical treatment, surgical technique
References
- Gouveia E Melo R, Silva Duarte G, Lopes A, Alves M, Caldeira D, Fernandes E Fernandes R, et al. Incidence and Prevalence of Thoracic Aortic Aneurysms: A Systematic Review and Meta-analysis of Population-Based Studies. Semin Thorac Cardiovasc Surg. 2022 Spring;34(1):1-16. doi: https://doi.org/10.1053/j.semtcvs.2021.02.029
- Atik FA, Navia JL, Svensson LG, Vega PR, Feng J, Brizzio ME, et al. Surgical treatment of pseudoaneurysm of the thoracic aorta. J Thorac Cardiovasc Surg. 2006 Aug;132(2):379-85. doi: https://doi.org/10.1016/j.jtcvs.2006.03.052
- Aebert H, Birnbaum DE. Tuberculous pseudoaneurysms of the aortic arch. J Thorac Cardiovasc Surg. 2003 Feb;125(2):411-2. doi: https://doi.org/10.1067/mtc.2003.130
- Katsumata T, Moorjani N, Vaccari G, Westaby S. Mediastinal false aneurysm after thoracic aortic surgery. Ann Thorac Surg. 2000 Aug;70(2):547-52. doi: https://doi.org/10.1016/S0003-4975(00)01300-X
- Kang T, Kang MJ. Aortic pseudoaneurysm misdiagnosed as lung cancer on unenhanced CT: a case report. Shanghai 2024;8(23):1-5. doi: https://doi.org/10.21037/shc-24-17
- Takahara Y, Nishiki K, Nakase K, Mizuno S. Ruptured pseudoaneurysm of the thoracic aorta mimicking lung cancer: A case report. Thorac Cancer. 2021;12(5):685-9. doi: https://doi.org/10.1111/1759-7714.13783
- Sleem M, Abdelsalam M, Hafiz S, Yusuf A, Ngoc D, Nguyen C. Ruptured thoracic aortic aneurysm secondary to syphilitic aortitis: a case report. Chest. 2024;166(4):3048-9. doi: https://doi.org/10.1016/j.chest.2024.06.1836
- Sousa J, Oliveira-Pinto J, Soares T, Lachat M, Teixeira J. Symptomatic Distal Anastomotic Pseudo-aneurysm After the Bentall Procedure Successfully Treated by Supra-aortic Trunk Debranching and Zone 0 Thoracic Endovascular Aneurysm Repair. EJVES Vasc Forum. 2020 Jan 8;47:90-6. doi: https://doi.org/10.1016/j.ejvssr.2019.12.003
- Basu R, Zhang J, Zaheer S, Grimm J, Szeto W, Kalapatapu V. Ascending aorta thoracic endovascular aortic repair for infected pseudoaneurysm. J Vasc Surg Cases Innov Tech. 2022 Mar 9;8(2):244-7. doi: https://doi.org/10.1016/j.jvscit.2022.02.005
- Recicarova S, Jonak M, Netuka I. Comprehensive multi-modality treatment of thoracic aorta pseudoaneurysms: a single-center experience. Gen Thorac Cardiovasc Surg. 2024;72:387-94. doi: https://doi.org/10.1007/s11748-023-01986-9
PDF
Look through: 
Authors and affiliations
Romaniuk T.V. Municipalnon-profitenterprise «Ternopil Regional Clinical Hospital» Ternopil City Council; I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-9279-3711
Moroz V.S. Municipalnon-profitenterprise «Ternopil Regional Clinical Hospital» Ternopil City Council, Ternopil, Ukraine
https://orcid.org/0009-0002-5925-2694
Lekan R.Io. Municipalnon-profitenterprise «Ternopil Regional Clinical Hospital» Ternopil City Council, Ternopil, Ukraine
https://orcid.org/0000-0002-5969-9886
Cite
Metrics
|
Talash V.V., Katerenchuk I.P., Kostrikova Yu.A., Yarmola T.I., Нutsalenko O.O., Pustovoyt Н.L., Tkachenko L.A., Mokhnachev O.V., Rustamіan S.T., Talash V.V., Sarychev L.P., Savchenko R.B. Systemic lupus erythematosus as a multidisciplinary problem (clinical case)
https://doi.org/10.26641/2307-0404.2025.2.333835
Abstract
Systemic lupus erythematosus (SLE) is a prognostically unfavorable systemic connective tissue disease with heterogeneous clinical manifestations, development of complications, and an unpredictable wave-like course, which complicates the diagnosis of this pathology. The relevance of this clinical case is determined by a number of features: the debut of SLE with isolated kidney damage, an 11-year delay in the date of diagnosis, and the occurrence of an extremely rare complication – lupus crisis (LC), which became fatal for the patient. The aim of the work: to analyze a clinical case as unique in terms of the features of the debut and clinical course of systemic lupus erythematosus, which has become a multidisciplinary problem, to highlight the reasons for the delay in diagnosis verification, to assess, in dynamics, the effectiveness of the prescribed treatment and to report on the development of a multiorgan lupus crisis. The article analyzes data from the medical documents of a 31-year-old inpatient. An illustrative clinical case of SLE, which debuted with glomerulonephritis at the age of 16, 11 years before the appearance of specific clinical symptoms that met the criteria of the American College of Rheumatology and the European League Against Rheumatism 2019, is presented. The level of immunological indicators specific for SLE – antinuclear antibodies to double-stranded deoxyribonucleic acid increased in the patient in 2023, i.e. 4 years later. The patient’s refusal of nephro biopsy, starting from the debut of the disease and from pathogenetic therapy at the stage of diagnosis and during the next 4 years. led to increased SLE activity, frequent relapses with the development of polymorbid pathology and, incompatible with life, multiorgan lupus crisis. The article describes in detail the dynamics of clinical manifestations of SLE and LC. The stages of diagnostic search, features of differential diagnosis and treatment of SLE and LC are discussed on the example of a clinical case. Based on the results of a review of the medical literature, analysis of articles, databases PubMed, SCOPUS, Web of Science, MedScape, the current state of the problem is highlighted, literature data on the incidence, features of the clinical course, diagnosis and treatment of SLE, its complications are summarized. The description of the clinical case, analysis of the literature is an addition to modern information about the possible clinical manifestations and consequences of SLE with the development of a severe, extremely rare complication – lupus crisis.
Key words: systemic lupus erythematosus, lupus crisis, lupus nephritis, renal failure
References
- Hoi A, Igel T, Mok CC, Arnaud L. Systemic lupus erythematosus. Lancet. 2024;403(10441):2326-38. doi: https://doi.org/10.1016/S0140-6736(24)00398-2
- Kant S, Kronbichler A, Sharma P, Geetha D. Advances in Understanding of Pathogenesis and Treatment of Immune-Mediated Kidney Disease: A Review. Am J Kidney Dis. 2022;79(4):582-600. doi: https://doi.org/10.1053/j.ajkd.2021.07.019
- Ameer MA, Chaudhry H, Mushtaq J, Khan OS, Babar M, Hashim T, et al. Overview of Systemic Lupus Erythematosus (SLE) Pathogenesis, Classification, and Management. Cureus. 2022;14(10):e30330. doi: https://doi.org/10.7759/cureus.30330
- Siegel CH, Sammaritano LR. Systemic Lupus Erythematosus: A Review. JAMA. 2024;331(17):1480-91. doi: https://doi.org/10.1001/jama.2024.2315
- Davidenko K. [Lupus nephritis: diagnosis and treatment]. Ukr Med J [Internet]. 2019 [cited 2024 Dec 13];5(133 Pt 1):1-3. Ukrainian. Available from: https://umj.com.ua/uk/publikatsia-162408-vovchakovij-nefrit-diagnostika-ta-likuvannya
- Protsenko HO, Dubas VV. [Systemic lupus erythematosus: the state of the problem in Ukraine and the world]. Ukr J Rheumatol. 2020;4(82):25-34. Ukrainian. doi: https://doi.org/10.32471/rheumatology.2707-6970.82.15749
- Christou EAA, Banos A, Kosmara D, Bertsias GK, Boumpas DT. Sexual dimorphism in SLE: above and beyond sex hormones. Lupus. 2019;28(1):3-10. doi: https://doi.org/10.1177/0961203318815768
- Dzhus MB, Ivashkivskyi OI, Karasevska TA, Potomka RA, Novytska AL, Mikuksts VYa, et al. [Soft tissue calcifications in systemic lupus erythematosus. A clinical case and literature review]. Ukr J Rheumatol. 2021;1(83):64-73. Ukrainian. doi: https://doi.org/10.32471/rheumatology.2707-6970.83.16006
- Protsenko HO, Dubas VV, Uzun SV, Tsokalo YaV, Zbarashchenko-Hasan MI. [Cutaneous manifestations in systemic lupus erythematosus (a case report)]. Ukr J Rheumatol. 2020;4(82):25-34. Ukrainian. doi: https://doi.org/10.32471/rheumatology.2707-6970.91.17654
- Gilcrease W, Manfredi L, Sciascia S, Ricceri F. From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases. Rheumatol Ther. 2025 Feb;12(1):1-24.
doi: https://doi.org/10.1007/s40744-024-00724-8
- Zhdan VM, Tkachenko MV, Babanina MYu, Volchenko HV, Kitura YeM, Ivanytskyi IV. [Insulin resistance in systemic lupus erythematosus]. Family medicine. European practices. 2024;2:49-54. Ukrainian. doi: https://doi.org/10.30841/2786-720X.2.2024.307530
- Baumann P, Völkl A, Bäuerle M, Schmidmaier R, Oduncu FS. Aplastic crisis as primary manifestation of systemic lupus erythematosus. Onkologie. 2011;34(8-9):452-4. doi: https://doi.org/10.1159/000331069
- Ungprasert P, Chowdhary VR, Davis MD, Makol A. Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil. Lupus. 2016;25(4):427-30. doi: https://doi.org/10.1177/0961203315615221
- Piga M, Arnaud L. The Main Challenges in Systemic Lupus Erythematosus: Where Do We Stand? J Clin Med. 2021;10(2):243. doi: https://doi.org/10.3390/jcm10020243
- Hailu GT, Hussen SU, Getachew S, Berha AB. Management practice and treatment outcomes of adult patients with Lupus Nephritis at the Renal Clinic of St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. BMC Nephrol. 2022;23(1):214. doi: https://doi.org/10.1186/s12882-022-02846-z
- Anders HJ, Saxena R, Zhao MH, Parodis I, Salmon JE, Mohan C. Lupus nephritis. Nat Rev Dis Primers. 2020;6(1):7.
doi: https://doi.org/10.1038/s41572-019-0141-9
- Wallace ZS, Naden RP, Chari S, Choi HK, Della-Torre E, Dicaire JF, et al. The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease. Ann Rheum Dis. 2020;79(1):77-87. doi: https://doi.org/10.1136/annrheumdis-2019-216561
- Heikki Ju. [Guideline 00446. Systemic lupus erythematosus (SLE)]. [Internet]. 2017 [cited 2024 Dec 13]. 17 p. Ukrainian. Available from: http://guidelines.moz.gov.ua/documents/2918
- Kostopoulou M, Fanouriakis A, Cheema K, Boletis J, Bertsias G, Jayne D, et al. Management of lupus nephritis: a systematic literature review informing the 2019 update of the joint EULAR and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations. RMD Open. 2020;6(2):e001263.
doi: https://doi.org/10.1136/rmdopen-2020-001263
- Fanouriakis A, Kostopoulou M, Cheema K, Anders HJ, Aringer M, Bajema I, et al. 2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis. Ann Rheum Dis. 2020;79(6):713-23. doi: https://doi.org/10.1136/annrheumdis-2020-216924
- [KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases]. Kidneys. 2021;10(4):201-28. Ukrainian. doi: https://doi.org/10.22141/2307-1257.10.4.2021.247896С
- Fanouriakis A, Kostopoulou M, Andersen J, Aringer M, Arnaud L, Bae SC, et al. EULAR recommendations for the management of systemic lupus erythematosus: 2023 update. Ann Rheum Dis. 2024;83(1):15-29. doi: https://doi.org/10.1136/ard-2023-224762
- [KDIGO 2024 Clinical Practice Guideline for the Management of Lupus Nephritis]. Kidneys. 2024;13(1):18-25. Ukrainian. doi: https://doi.org/10.22141/2307-1257.13.1.2024.437
- Ivanov DD. [Chronic kidney disease: differential tactics of renoprotection]. Ukr Med J [Internet]. 2018 [cited 2024 Dec 13];2(124):1-5. Ukrainian. Available from: https://umj.com.ua/uk/publikatsia-124335-hronichna-hvoroba-nirok-diferentsijna-taktika-renoprotektsiyi
- Siniscalchi С, Rossetti P, Carolla G, Micco P, Stella A, Riva M. A review on management of antiphospholipid syndrome in clinical practice. Ital J Med. 2023;17(2):1649. doi: https://doi.org/10.4081/itjm.2023.1649
- Тaran OI. [Thrombotic thrombocytopenic microangiopathy]. Kidneys. 2022;2(4):66-9. Ukrainian. doi: https://doi.org/10.22141/2307-1257.0.2.04.2013.85358
- Kobeliatskyi YuYu. [Intensive care of haemolytic uremic syndrome in pregnant women]. Surg. Orthop. Traumatol. Int care [Internet]. 2021 [cited 2024 Dec 23];2(45):14-5. Ukrainian. Available from: https://health-ua.com/multimedia/6/5/8/2/0/1624020515.pdf
- Herrinton LJ, Liu L, Goldfien R, Michaels MA, Tran TN. Risk of Serious Infection for Patients with Systemic Lupus Erythematosus Starting Glucocorticoids with or without Antimalarials. J Rheumatol. 2016;43(8):1503-9. doi: https://doi.org/10.3899/jrheum.150671
- Shuba NM. [Emergency conditions in patients with rheumatic diseases: modern approaches to treatment]. Ukr J Rheumatol [Internet]. 2009 [cited 2024 Dec 13];3(37):41-8. Ukrainian. Available from: https://www.rheumatology.kiev.ua/wp/wp-content/uploads/magazine/37/41.pdf
- Kiss E, Tarr T, Soltész P, Szegedi G. [Crisis states in systemic lupus erythematosus]. Orv Hetil. 2006;147(51):2469-73. Hungarian.
- Kovalenko VM, Rekalov DH, Yatsyshchyn RI, Holovach IYu, Stanislavchuk MA, Ter-Vartanian SKh, et al. [Systemic lupus erythematosus. Clinical guidelines]. Kyiv; 2020. 76 p. Ukrainian.
- Katerenchuk IP, Tkachenko LA, Yarmola TI, Talash VV. Microscopic polyangiitis – a view of the problem through the lens of a nephrologist. Wiad Lek. 2021;74(4):1024-31. doi: https://doi.org/10.36740/WLek202104140
- Yarmola TI, Gutsalenko OO, Katerenchuk IP, Tkachenko LA, Kostrikova YА, Talash VV. Microscopic polyangiitis hiding behind the mask of COVID-19: A case series and minireview. Ukr J Nephrol Dial. 2023;2(78):5-21. doi: https://doi.org/10.31450/ukrjnd.2(78).2023.02
- Hsu T, Nguyen P, Petronic-Rosic V. A case of systemic lupus erythematosus with cutaneous granulomatous vasculitis. JAAD Case Rep. 2022;21:93-6. doi: https://doi.org/10.1016/j.jdcr.2022.01.006
- Botero B JD, Bernal-Macías S, Celis P CA, Lasso A JI, Rodríguez J, Arias Álvarez L, et al. Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation. Lupus. 2022;31(4):495-9. doi: https://doi.org/10.1177/09612033221084519
- Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78(9):1151-9. doi: https://doi.org/10.1136/annrheumdis-2018-214819
- Abrahamovych UO, Abrahamovych OO, Tsyhanyk LV, Farmaha ML, Synenkyi OV. [A Method to Determine Functional Class of Systemic Lupus Erythematosus in Patients]. World Sci. 2020;2(5(57):10-9. Ukrainian. doi: https://doi.org/10.31435/rsglobal_ws/31052020/7076
- National Kidney Foundation. KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update. Am J Kidney Dis. 2012;60(5):850-86. doi: https://doi.org/10.1053/j.ajkd.2012.07.005
- KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl [Internet]. 2012 [cited 2024 Sept 11];3(1):1-150. Available from: https://kdigo.org/wp-content/uploads/2017/02/KDIGO_2012_CKD_GL.pdf
- Yu C, Li P, Dang X, Zhang X, Mao Y, Chen X. Lupus nephritis: new progress in diagnosis and treatment. J 2022;132:102871. doi: https://doi.org/10.1016/j.jaut.2022.102871
- Julkunen H. Guideline 00446. Systemic lupus erythematosus (SLE) [Internet]. 2017 [updated 2017 Jul 31; cited 2024 Dec 13]. Available from: https://guidelines.moz.gov.ua/documents/3299
- Kato K, Kawamura T, Terashima R, Tsuchiya Y, Takahashi Y, Kasai K, et al. A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings. Case Rep Nephrol.2020;2020:5698708. doi: https://doi.org/10.1155/2020/5698708
- Rossi GP, Bisogni V, Rossitto G, Maiolino G, Cesari M, Zhu R, et al. Practice Recommendations for Diagnosis and Treatment of the Most Common Forms of Secondary Hypertension. High Blood Press Cardiovasc Prev. 2020;27(6):547-60. doi: https://doi.org/10.1007/s40292-020-00415-9
- Soyuöz A, Karadağ Ö, Karaağaç T, Kılıç L, Bilgen ŞA, Özcebe Oİ. Therapeutic plasma exchange for refractory SLE: A comparison of outcomes between different sub-phenotypes. Eur J Rheumatol. 2018;5(1):32-6. doi: https://doi.org/10.5152/eurjrheum.2017.17088
- Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension.2020;75(6):1334-57. doi: https://doi.org/10.1161/HYPERTENSIONAHA.120.15026
- Cheung AK, Chang TI, Cushman WC, Furth SL, Hou FF, Ix JH, et al. Executive summary of the KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021;99(3):559-69. doi:https://doi.org/10.1016/j.kint.2020.10.026
- Kaidashev I, Shlykova O, Izmailova O, Torubara O, Yushchenko Y, Tyshkovska T, et al. Host gene variability and SARS-CoV-2 infection: A review article. Heliyon.2021;7(8):e07863. doi: https://doi.org/10.1016/j.heliyon.2021.e07863
- Honkanen E. [Guideline 00225. Acute kidney injury]. [Internet]. 2017 [cited 2024 Sept 11]. 9 p. Ukrainian. Availablefrom: https//guidelines.moz.gov.ua/documents/3113
- Tarasenko SO, Dubrov SO, Suslov HH. [Diagnostic criteria for disseminated intravascular coagulation syndrome and sepsis-induced coagulopathy]. Pain, Anaesth & Int Care. 2021;2(95):25-38. doi: https://doi.org/10.25284/2519-2078.2(95).2021.238302
- Yaremenko OB, Sydorova AO. [Hemophagocytic syndrome in a patient with paniculitis: a case report]. Ukr J 2021;2(84):1-5. Ukrainian. doi: https://doi.org/10.32471/rheumatology.2707-6970.84.16101
- Driouach S, Mounir A, Elkhader S, Zinebi A, Moudden MK. [Pancytopenia secondary to autoimmune myelofibrosis revealing a male case of systemic lupus]. Ann Biol Clin (Paris). 2019;77(3):327-30. French. doi: https://doi.org/10.1684/abc.2019.1443
- Protsenko HO, Dubas VV. [Analysis of delayed diagnosis in systemic lupus erythematosus]. Ukr J Rheumatol.2022;1(87):1-6. doi: https://doi.org/10.32471/rheumatology.2707-6970.87.16747
- Solhjoo M, Goyal A, Chauhan K. Drug-Induced Lupus Erythematosus. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [updated 2023 Apr 3; cited 2024 Nov 14]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441889
- Aaltonen S. [Guideline 00229. Glomerulonephrites]. [Internet]. 2017 [updated 2017 May 22; cited 2024 Dec 13]. Ukrainian. Availablefrom: https://guidelines.moz.gov.ua/documents/3117
- Ahn SS, Yoon T, Song JJ, Park YB, Lee SW. Serum adipokine profiles in patients with microscopic polyangiitis and granulomatosis with polyangiitis: An exploratory analysis. PLoS One. 2021;16(7):e0254226. doi: https://doi.org/10.1371/journal.pone.0254226
- Banos A, Thomas K, Garantziotis P, Filia A, Malissovas N, Pieta A, et al. The genomic landscape of ANCA-associated vasculitis: Distinct transcriptional signatures, molecular endotypes and comparison with systemic lupus erythematosus. Front Immunol. 2023;14:1072598. doi: https://doi.org/10.3389/fimmu.2023.1072598
- Khil J, Nguyen TM, Troxell ML, Zheng S. Systemic Lupus Erythematosus and ANCA-Associated Vasculitis Overlap Syndrome: A Case Report. Kidney Med. 2022;4(11):100544. doi: https://doi.org/10.1016/j.xkme.2022.100544
- Borzykh O, Belan O, Mormol I, Avramenko Y, Іengalychev T, Markina T. Characteristics of the course of leucocytoclastic vasculitis with skin lesions. analysis of clinical cases. Med and Ecol Probl. 2023;27(1-2):35-41. doi: https://doi.org/10.31718/mep.2023.27.1-2.07
- Mucke J, Aringer M. [EULAR recommendations 2023 on the treatment of systemic lupus erythematosus-Implications for treatment in Germany]. Z Rheumatol. 2024;83(6):431-8. doi: https://doi.org/10.1007/s00393-024-01544-5
- Velichuk A. [Systemic lupus erythematosus. A clinical case]. In: Topical issues of clinical medicine: Collection of materials of the All-Ukrainian scientific and practical conference of interns; 2023 May 25; Poltava, UA [Internet]. Poltava; 2023 [cited 2024 Oct 3]. p. 103-4. Ukrainian. Available from: https://repository.pdmu.edu.ua/handle/123456789/21453
- Mormol I, Borzykh O, Gerasymenko N, Esanu C, Ozarchuk L. [Lesions of the hematopoietic system in a patient with systemic lupus erythematosus and the effectiveness of treatment with mycophenolate mofetil]. Med and Ecol Probl. 2022;26(5-6):7-10. Ukrainian. doi: https://doi.org/10.31718/mep.2022.26.5-6.02
- Newman K, Owlia MB, El-Hemaidi I, Akhtari M. Management of immune cytopenias in patients with systemic lupus erythematosus – Old and new. Autoimmun Rev.2013;12(7):784-91. doi: https://doi.org/10.1016/j.autrev.2013.02.001
- Shoenfeld Y, Zandman-Goddard G, Levy Y. Comment on published article in Lupus: Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil; IVIG in myelofibrosis in SLE. Lupus.2017;26(2):224. doi: https://doi.org/10.1177/0961203316662725
- Wibowo T, Kawada S, Ishida Y, Yoshimine Y, Ishikawa N, Kawamoto K, et al. Autoimmune myelofibrosis associated with systemic lupus erythematosus: a case report. Mod Rheumatol Case Rep. 2020;4(1):28-33. doi: https://doi.org/10.1080/24725625.2019.1650697
- Üsküdar Cansu D, Üsküdar Teke H, Işiksoy S, Korkmaz C. Bone marow as a target organ of systemic lupus erythematosus: analysis of cases with myelofibrosis. IntJ Rheum 2018;21(5):1049-59. doi: https://doi.org/10.1111/1756-185X.13308
- Putra RS, Najirman. Treatment of Systemic Lupus Erythematosus with Anti SSA and SSB Positive Pregnancies. Biosmed.2022;6(3):1523-9. doi: https://doi.org/10.37275/bsm.v6i3.470
- Joy GM, Arbiv OA, Wong CK, Lok SD, Adderley NA, Dobosz KM, et al. Prevalence, imaging patterns and risk factors of interstitial lung disease in connective tissue disease: a systematic review and meta-analysis. Eur Respir Rev. 2023;32(167):220210. doi: https://doi.org/10.1183/16000617.0210-2022
- Kanapathy A, Nik Jaafar NR, Shaharir SS, Chan LF, Rozita M, Ch'ng SS. Prevalence of cognitive impairment using the Montreal Cognitive Assessment questionnaire among patients with systemic lupus erythematosus: a cross-sectional study at two tertiary centres in Malaysia. Lupus. 2019;28(7):854-61. doi: https://doi.org/10.1177/0961203319852153
- Koliadenko DI, Yaremenko OB, Nahirna MI. [Neuropsychiatric manifestations in patients with systemic lupus erythematosus: prevalence, clinical and laboratory associations]. Ukr J Rheumatol. 2023;1(91):1-7. Ukrainian. doi: https://doi.org/10.32471/rheumatology.2707-6970.91.17688
- Abrahamovych U, Abrahamovych О, Nadashkevich О, Farmaha М, Kobak L. Pathogenetic Association of Digestive System Lesions with Systemic Lupus Erythematosus: Characteristics and Prevalence. PMGP. 2020;5(1):e0501225. doi: https://doi.org/10.26766/pmgp.v5i1.225
- Fanouriakis A, Kostopoulou M, Alunno A, Aringer M, Bajema I, Boletis JN, et al. 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus Annals of the Rheumatic Diseases. Ann Rheum Dis. 2019;78(6):736-45. doi: https://doi.org/10.1136/annrheumdis-2019-215089
- Prokhorov EV, Borysova TP. [Features of the current course and therapy of systemic lupus erythematosus in children and adolescents]. Child Health. 2007;2(5):60-6. Russian.
- Furie R, Rovin BH, Houssiau F, Malvar A, Teng YKO, Contreras G, et al. Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis. N Engl J 2020;383(12):1117-28. doi: https://doi.org/10.1056/NEJMoa2001180
- Fanouriakis A, Bertsias G, Boumpas DT. Response to: 'Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus' by Wu et al. Ann Rheum Dis. 2022;81(5):e76. doi: https://doi.org/10.1136/annrheumdis-2020-217804
PDF
Look through: 
Authors and affiliations
Talash V.V. Poltava State Medical University, Poltava, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-5700-557X
Katerenchuk I.P. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0003-3765-4895
Kostrikova Yu.A. Poltava State Medical University, Poltava, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-8675-8896
Yarmola T.I. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0002-7428-0223
Hutsalenko O.O. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0001-8313-3201
Pustovoyt H.L. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0001-6879-8088
Tkachenko L.A. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0001-9356-6385
Mokhnachev O.V. Poltava State Medical University, Poltava, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-4247-6926
Rustamіan S.T. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0003-4348-6365
Talash V.V. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0001-7758-767X
Sarychev L.P. Poltava State Medical University, Poltava, Ukraine
https://orcid.org/0000-0003-3257-4845
Savchenko R.B. Poltava State Medical University, Poltava, Ukraine e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-9790-8821
Cite
Talash V.V., Katerenchuk I.P., Kostrikova Yu.A., Yarmola T.I., Нutsalenko O.O., Pustovoyt Н.L., Tkachenko L.A., Mokhnachev O.V., Rustamіan S.T., Talash V.V., Sarychev L.P., Savchenko R.B. Systemic lupus erythematosus as a multidisciplinary problem (clinical case). Medicni perspektivi. 2025;30(2):278-292. DOI: https://doi.org/10.26641/2307-0404.2025.2.333835
Metrics
|